Identifiers and Description

Gene Model Identifier

TTHERM_00194149

Standard Name

THD18

Aliases

16.m05354

Description

Chromatin regulatory protein sir2; SIR2 family transcriptional regulator

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF02146 ) transcriptional regulator, Sir2 family
• ( TIGR00071 ) tRNA pseudouridine synthase A

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_03683.1	2.0004037638327014e-151
	Description: chromatin regulatory protein sir2 (273 aa)
WormBase	WBGene00015461	2.0004037638327014e-151
	Description: KRR1 small subunit processome component status:Confirmed UniProt:O16311 protein_id:CCD63088.1
DictyBase	DDB_G0283917	1.999576471039937e-58
	Description: sir2A on chromosome: 4 position 1272110 to 1273864
Oxytricha	Contig9367.0.g58	3.998564387823535e-58
	Description: Sir2 family
WormBase	WBGene00004800	4.9986056260133516e-43
	Description: locus:sir-2.1 NAD-dependent protein deacetylase sir-2.1 status:Partially_confirmed UniProt:Q21921 protein_id:CAA94364.1
Tetrahymena borealis	EI9_01247.1	4.9986056260133516e-43
	Description: Na,H/K antiporter P-type ATPase, alpha subunit protein (1197 aa)
SGD	YPL015C	3.998097515166115e-39
	Description: HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
Stentor Coeruleus	SteCoe_18027	9.602680054508676e-24
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00194149(coding)
ATGGGATAACTAAATATTTTTAAATCAAATCCACCTACCAATTCATTTACAAAAGAAGAA
TTTGTAAATTTCTTAAAGGAAAGAAGATTTAAAAAAATCATTGTTTTGACAGGAGCTGGT
ATTAGTACAAATGCTGGAATTCCAGATTTTCGTAGTAAAGATACTGGCCTTTATGCAAGA
TTAAAAAAATCTGGTTAGTTTTCTTATCCAGAATAGATTTTTACTATCGATTACTATCAA
TAGAACCACAAGCCTTTTTATGAAATATGCAGAGAGTTTGTTTAAAAAGAGTATGAACCT
TAATAATCCCATAAATTTATAACTGAACTTGCTAAATAAAATCTTCTTTACTTAAATATC
ACTTAAAATATTGATGGATTAGAGCTGAAGGCAGGACTTGATAAAAAATATTTGATTTAA
GCACATGGTAATCTGGAAAAAAGTCACTGCATTGAGTGCCATAAAGAAGACACCATAGAA
TATTTCAAAGAGGGAGTGCTAAAATCTGATGATGCAGTTAATTGCAGAAAGACTAAGAAT
TGTTAAGGAAAATTAAAACCTTCGGTTACTTTCTTTGGAGAGAAATTACCATTTTACTTT
TACAAAATACCTCTATAAATGAGATTTGCTGATTTAATTATTGTAATGGGTACATCTTTG
AAAGTATAGCCTTTCGCAAGTCTCCTTTCCTACAAGTCAAAATCTACTCCATTAGTTGTT
TTAAATAGTGAGAATGTAGTGAGTGATTGCTCACTTTTTATAGGTGGGGATATAGACAAA
AATTTGGAAGAAATAATGTAAGAATTATTATAATAGCAAAATTAAGAGAAAGAATAATGA

>TTHERM_00194149(gene)
ATGGGATAACTAAATATTTTTAAATCAAATCCACCTACCAATTCATTTACAAAAGAAGAA
TTTGTAAATTTCTTAAAGGAAAGAAGATTTAAAAAAATCATTGTTTTGACAGGAGCTGGT
ATTAGTACAAATGCTGGAATTCCAGATTTTCGTAGTAAAGATACTGGCCTTTATGCAAGA
TTAAAAAAATCTGGTTAGTTTTCTTATCCAGAATAGATTTTTACTATCGATTACTATCAA
TAGAACCACAAGCCTTTTTATGAAATATGCAGAGAGTTTGTTTAAAAAGAGTATGAACCT
TAATAATCCCATAAATTTATAACTGAACTTGCTAAATAAAATCTTCTTTACTTAAATATC
ACTTAAAATATTGATGGATTAGAGCTGAAGGCAGGACTTGATAAAAAATATTTGATTTAA
GCACATGGTAATCTGGAAAAAAGTCACTGCATTGAGTGCCATAAAGAAGACACCATAGAA
TATTTCAAAGAGGGAGTGCTAAAATCTGATGATGCAGTTAATTGCAGAAAGACTAAGAAT
TGTTAAGGAAAATTAAAACCTTCGGTTACTTTCTTTGGAGAGAAATTACCATTTTACTTT
TACAAAATACCTCTATAAATGAGATTTGCTGATTTAATTATTGTAATGGGTACATCTTTG
AAAGTATAGCCTTTCGCAAGTCTCCTTTCCTACAAGTCAAAATCTACTCCATTAGTTGTT
TTAAATAGTGAGAATGTAGTGAGTGATTGCTCACTTTTTATAGGTGGGGATATAGACAAA
AATTTGGAAGAAATAATGTAAGAATTATTATAATAGCAAAATTAAGAGAAAGAATAATGA

>TTHERM_00194149(protein)
MGQLNIFKSNPPTNSFTKEEFVNFLKERRFKKIIVLTGAGISTNAGIPDFRSKDTGLYAR
LKKSGQFSYPEQIFTIDYYQQNHKPFYEICREFVQKEYEPQQSHKFITELAKQNLLYLNI
TQNIDGLELKAGLDKKYLIQAHGNLEKSHCIECHKEDTIEYFKEGVLKSDDAVNCRKTKN
CQGKLKPSVTFFGEKLPFYFYKIPLQMRFADLIIVMGTSLKVQPFASLLSYKSKSTPLVV
LNSENVVSDCSLFIGGDIDKNLEEIMQELLQQQNQEKEQ