Identifiers and Description

Gene Model Identifier

TTHERM_00194150

Standard Name

THD16 (Tetrahymena Histone Deacetylase 16)

Aliases

PreTt06699 | 16.m00355 | THD16

Description

THD16 Sir2 family transcriptional regulator; Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones; homolog of yeast SIR2

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• chromatin silencing complex (IEA) | GO:0005677

Molecular Function

• DNA binding (IEA) | GO:0003677

Biological Process

• chromatin silencing (IEA) | GO:0006342
• regulation of DNA-templated transcription (IEA) | GO:0006355

Domains

• ( PF01583 ) Adenylylsulphate kinase
• ( PF01926 ) 50S ribosome-binding GTPase
• ( PF02492 ) CobW/HypB/UreG, nucleotide-binding domain
• ( PF03205 ) Molybdopterin guanine dinucleotide synthesis protein B
• ( PF07683 ) Cobalamin synthesis protein cobW C-terminal domain
• ( TIGR00073 ) hydrogenase accessory protein HypB
• ( TIGR02475 ) cobalamin biosynthesis protein CobW
• ( TIGR02881 ) stage V sporulation protein K

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_03684.1	9.997093137033517e-262
	Description: transcriptional regulator, Sir2 family protein (335 aa)
DictyBase	DDB_G0281589	2.0008958828286524e-54
	Description: DDB_G0281589 on chromosome: 3 position 4676319 to 4677638
Oxytricha	Contig13731.0.g81	4.999083770298882e-50
	Description: CobW/HypB/UreG, nucleotide-binding domain
SGD	YNR029C	4.001033848388204e-30
	Description: YNR029C Putative protein of unknown function, deletion confers reduced fitness in saline

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00194150(coding)
ATGGAAAAGCAAAACCAAAAAACAGCTATGGTATTACTTACAGGATATTTAGGTTCTGGT
AAGACTACTCTGATATCATATATTTTAAAAGAATAAAACACATATAAAGTTGCTGTTGTT
TAAAATGAATTCGCTGACGAAATGGGTATAGAAGCACCATTAATGCAAGATTCAGAAGGT
AAGCCCTTTGATAAATTCTACGAACTTCCTAATGGTTGTATATGCTGTACTGCAAAAGAT
GATTTACTTACTGCTGTAGAGTATTTGATTTAGAATGAAAAGTCTAAACTAGATTTTATT
TTAGTCGAAACAAATGGATTAGCTGATCCTTCTTCTACCATAAAAAGCTTTTGGGTTGAT
GAAAATATAGATTTTCCTGCAGAATTAAGGGCTATTCATACAGTTGTACCTGTGCATAGA
TATGAGTAACTTAAAAGCGATTAAATTTTCTAAAGATAAATTTTATATGCTGATAATATA
CTGTTAAATTAGATAGATAAATCTAATGAAGAAGAAATCTAGAATGTGGAAAAGTAAATT
CGTCAACTCAATCCAATTGCCAAATTTGAAAGGTCTTCTTATTGCAAAATAGACTTAAAT
AGAATTTTTGAAATTGATGGGTTTAACTTGAGAAAGAGTAAATCAGAGGCAATCGAAATA
TTAAATAAAATTAGCTAGGAACATGAGCATGATCATGCTCATGCAGATGGAGATATTTAA
TATCAATTTTTTGAATATGCTGCAAACCCTTTTGATGAAAAGGAATTAGAAATCAAGTTA
GGTGAATTACTTTGGGAGAATGAAAAAATAAAAGTTTTAAGAATGAAAGGTTTGATTCAC
ATTAAAGACGATGATTTTATGTATTCTCTCTAAGGTGTAGAAGACATATTTGAAATCAAA
AAAACAGATGTAATGTGGCCAGAAACCCAACAGAGGAAATCAAAATTTTTATTTATTTGC
TAGAATGCTACAAAATAAGAATTGATAGATATCATTACAAATTGA

>TTHERM_00194150(gene)
ATGGAAAAGCAAAACCAAAAAACAGCTATGGTATTACTTACAGGATATTTAGGTTCTGGT
AAGACTACTCTGATATCATATATTTTAAAAGAATAAAACACATATAAAGTTGCTGTTGTT
TAAAATGAATTCGCTGACGGTAATTATTTATTTATTTAATTACTAAATTACAAAAAAAAA
TGAGTAGAATTTATTATTCAAATCCATCTTTTTCTTAAGATGTCTTTTTGAATTTTAGAC
TTTGTAAGAAATTAAACATAAATATAATAGAAATGGGTATAGAAGCACCATTAATGCAAG
ATTCAGAAGGTAAGCCCTTTGATAAATTCTACGAACTTCCTAATGGTTGTATATGCTGTA
CTGCAAAGTATTTTAAACTTACTTTACTAATAAAGATATTAAAATTAACAATTAACAATT
TTCATCATTTATAGAGATGATTTACTTACTGCTGTAGAGTATTTGATTTAGAATGAAAAG
TCTAAACTAGATTTTATTTTAGTCGAAACAAATGGATTAGCTGATCCTTCTTCTGTAAAT
ATATTTTTATTTTTAATAATTTATAAAATATTTATATAAAATAGACCATAAAAAGCTTTT
GGGTTGATGAAAATATAGATTTTCCTGCAGAATTAAGGGCTATTCATACAGTTGTACCTG
TGCATAGATATGAGTAACTTAAAAGCGATTAAATTTTCTAAAGATAAATTTTATATGCTG
ATAATATACTGTTAAATTAGATAGTAATTACTATTTATTCAATTAGCAATTATAAAGTTA
AACTTACTATTAAAGGATAAATCTAATGAAGAAGAAATCTAGAATGTGGAAAAGTAAATT
CGTCAACTCAATCCAATTGCCAAATTTGAAAGGTTATAATTATAGATAATATAATAACTA
AAAATTTAATCTAAAAAATAATTCTTAGGTCTTCTTATTGCAAAATAGACTTAAATAGAA
TTTTTGAAATTGATGGGTTTAACTTGAGAAAGAGTAAATCAGAGGCAATCGAAATATTAA
ATAAAATTAGCTAGGAACATGAGCATGATCATGCTCATGCAGATGGAGATATTTAATATC
AATTTTTTGAATATGCTGCAAACCCTTTTGATGAAAAGGAATTAGAAATCAAGTTAGGTG
AATTACTTTGGGAGAATGAAAAAATAAAAGTTTTAAGAATGAAAGGTTTGATTCACATTA
AAGACGATGATTTTATGTATTCTCTCTAAGGGTAATTAGATATTTTTAGCTGTTTTTATT
CATTCAGAAATTTTAAAATATTTTTATTTTATATGTATGTATTGATCACTATAATTTATT
TTTTTGACTTAATAGTGTAGAAGACATATTTGAAATCAAAAAAACAGATGTAATGTGGCC
AGAAACCCAACAGAGGAAATCAAAATTTTTATTTATTTGCTAGAATGCTACAAAATAAGA
ATTGATAGATATCATTACAAATTGA

>TTHERM_00194150(protein)
MEKQNQKTAMVLLTGYLGSGKTTLISYILKEQNTYKVAVVQNEFADEMGIEAPLMQDSEG
KPFDKFYELPNGCICCTAKDDLLTAVEYLIQNEKSKLDFILVETNGLADPSSTIKSFWVD
ENIDFPAELRAIHTVVPVHRYEQLKSDQIFQRQILYADNILLNQIDKSNEEEIQNVEKQI
RQLNPIAKFERSSYCKIDLNRIFEIDGFNLRKSKSEAIEILNKISQEHEHDHAHADGDIQ
YQFFEYAANPFDEKELEIKLGELLWENEKIKVLRMKGLIHIKDDDFMYSLQGVEDIFEIK
KTDVMWPETQQRKSKFLFICQNATKQELIDIITN