Identifiers and Description

Gene Model Identifier

TTHERM_00218760

Standard Name

TEB1 (TElomerase DNA Binding subunit 1; also known as Telomerase- (or TERT-) associated protein of 82 kDa )

Aliases

PreTt22303 | 18.m00329 | 3701.m00089

Description

TEB1 telomerase-associated protein; Telomerase holoenzyme subunit p82; essential gene; knockdown induces telomere shortening, a heterotrimer of telomerase; Replication factor A, C-terminal

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• telomerase holoenzyme complex (IDA) | GO:0005697

Biological Process

• telomerase holoenzyme complex assembly (IDA) | GO:1905323

Domains

• ( PF08646 ) Replication factor-A C terminal domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:27895115: Upton HE, Chan H, Feigon J, Collins K (2017) Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes. The Journal of biological chemistry 292(1):217-228
2. Ref:25225329: Upton HE, Hong K, Collins K (2014) Direct single-stranded DNA binding by Teb1 mediates the recruitment of Tetrahymena thermophila telomerase to telomeres. Molecular and cellular biology 34(22):4200-12
3. Ref:23918804: Hong K, Upton H, Miracco EJ, Jiang J, Zhou ZH, Feigon J, Collins K (2013) Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub. Molecular and cellular biology 33(19):3962-71
4. Ref:20363756: Min B, Collins K (2010) Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. The Journal of biological chemistry 285(22):16434-43

Sequences

>TTHERM_00218760(coding)
ATGAAATTAACTAAAGGTGGGTCGTATATACTTAAAAAAGTGGACAGAAAATAGTTTTAT
TAAGATGAAGAAATAGTCATGTAAATAAAAAAAATACTTGGTTAAAAAACTACAGATTGC
AAACAATACATAAAATGTGAGTGTATAGATGGTTTGGGAGATGAAGCATTGATTTACTTT
GAGATGCTTGCTAATTAAAATCAGCATTTACAAAAAAACGATGTCATAATGATTTAAGAT
TATTTAAATGATAAAACATAAAACGACAAAATAGTTGTTTTAGTTACAAGGTTTTAATTT
TGTAAAGCCAGTCATGTTTAGCCTAAAACCGCCCAAAAAGAATCCATATAACTATTAAAT
ACTGAAAAAACAATAATTTAAAAGAGTAAAATTACTAAAAATCCAGCTGAAGAAGTTTTA
AAATTTATAGAAGTAAACGAAAAAGATAATAGTTCAAACAGTGAAGATATGATAATTGAA
TAGTAGAAATAAGAAATTAAGAATAATTAAAAAGAAAAACAAAGTATAAATGGATTTAAT
TTGGAAGATAGCTATTCAAATATTTCTGATATTACTAATTTTGGAGGGAAATCTAATTTT
AATATTGGATCACTTTCTGATTAACTTAGTAAATAGACACTGCTAATTTCTTAGTTGTAA
GTAGGTAAAAATAGATTTTCTTTTAAGTTCGAAGGAAGAGTTGTATATAAAAGTAGTACA
TTCCAGAATTAGCAAGACTCTAAGTATTTTTTCATCACAGCATAAGACGCTAATAATTAA
GAAATTAATTTGTCTTTTTGGCAAAAAGTTGATTAAAGCTATTAAACTTTGAAAGTAGGA
TAATATTATTACTTTATAGGAGGAGAAGTTAAATAGTTCAAAAATAATCTAGAATTAAAA
TTTAAGTTTGGAGACTACTAAATAATTCCTAAAGAGACTCTTTCTGCGAATTATGTATAA
CCTTTGGCATTACAACCTTCAAAATAATTTGGAAATGACTCAATAGGAGACTCTGATTAT
TCTATTCATAATTTAATTGAAAAGGAGGAAAGCATCGCTTAAAAGGGCTATAATGGATAA
AAGAATAATAAATATAGATAAAATAACAATAATAGCAAGCATACACTCTTAATATCTGAA
GTATTAAAAACTTCTAAATAATATTTATCAGTATTAGCATAAGTTGTTGATATTCAAAGT
TCAGATAAAAATATAAGATTAAAAATATGTGATAATAGCTGTAATTAAGAACTCAAAGTA
GTCATTTTTCCAGATTTATGCTATGAGTGGAGAGATAAATTTAGTATAAATAAATGGTAT
TATTTTAATGAGTTTGTTAGATAAATTTATAATGATGAAGTTTAGTTGAAAAATAACATT
CATTCTTCAATTAAAGAATCTGATGATTAAAGAAAAGTTATTACTTATAATTAAGAATAG
GGTGTTTTTAAAAAATCAATCTCAATTAATAGCAATGATAGTTTTGAAATTAAGCCTAAA
ATTTCATATAAAAACAATTCTAACTAAGAATAAAGGATTTATTCTTCAATTGAAGAAATA
ATCTAATAAGCATAGGCTTCAGAAATAGGTCAAAAAAAAGAATTCTATGTTTATGGAAAC
TTAGTTTCAATATAGATGAAAAATAAGCTTTATTATTATAGGTGTACTTGTTAGGGTAAG
TCAGTCTTAAAATATCACGGAGATTCATTTTTTTGTGAAAGTTGCTAGTAGTTCATAAAT
CCTTAGGTGCATTTGATGCTTAGAGCATTTGTTTAAGATTCTACAGGGACAATTCCTGTT
ATGATTTTCGATCAGCAGTCAAGCCAACTTATCAACTAAATTGATCCATCAATTCATGTC
TAAGAAGCAGGTTAATATGTTAAAAATTGTATTGAAAATGGATAAGAAGAAATTATAAGA
TAGTTATTTAGTAAATTAGACTTTGCTAGATTTATATTTGAAATTTAATTTGAAAATAAA
GAATTTAATAACGAATAAGAGATAGCATACAAAGTATTAAAAATTGAAAAAGAAAATATT
AAAGAAGAATCTAAATATCTACTAAAAAAGTTAGAGCACTTAATAAACAATAATCAAAAT
AACTGA

>TTHERM_00218760(gene)
TTTTTTACTTTTAGATATAAAAACAAATCATAAATTAAAAGAAATTTTTCAAGATAAAGT
AAAAACTTTAAAACAATATTTTAAAGCCACTCCTAAATTTTAAAAGAAATGAAATTAACT
AAAGGTGGGTCGTATATACTTAAAAAAGTGGACAGAAAATAGTTTTATTAAGATGAAGAA
ATAGTCATGTAAATAAAAAAAATACTTGGTTAAAAAACTACAGATTGCAAACAATACATA
AAATGTGAGTGTATAGATGGTTTGGGAGATGAAGCATTGATTTACTTTGAGATGCTTGCT
AATTAAAATCAGCATTTACAAAAAAACGATGTCATAATGATTTAAGATTATTTAAATGAT
AAAACATAAAACGACAAAATAGTTGTTTTAGTTACAAGGTTTTAATTTTGTAAAGCCAGT
CATGTTTAGCCTAAAACCGCCCAAAAAGAATCCATATAACTATTAAATACTGAAAAAACA
ATAATTTAAAAGAGTAAAATTACTAAAAATCCAGCTGAAGAAGTTTTAAAATTTATAGAA
GTAAACGAAAAAGATAATAGTTCAAACAGTGAAGATATGATAATTGAATAGTAGAAATAA
GAAATTAAGAATAATTAAAAAGAAAAACAAAGTATAAATGGATTTAATTTGGAAGATAGC
TATTCAAATATTTCTGATATTACTAATTTTGGAGGGAAATCTAATTTTAATATTGGATCA
CTTTCTGATTAACTTAGTAAATAGACACTGCTAATTTCTTAGTTGTAAGTAGGTAAAAAT
AGATTTTCTTTTAAGTTCGAAGGAAGAGTTGTATATAAAAGTAGTACATTCCAGAATTAG
CAAGACTCTAAGTATTTTTTCATCACAGCATAAGACGCTAATAATTAAGAAATTAATTTG
TCTTTTTGGCAAAAAGTTGATTAAAGCTATTAAACTTTGAAAGTAGGATAATATTATTAC
TTTATAGGAGGAGAAGTTAAATAGTTCAAAAATAATCTAGAATTAAAATTTAAGTTTGGA
GACTACTAAATAATTCCTAAAGAGACTCTTTCTGCGAATTATGTATAACCTTTGGCATTA
CAACCTTCAAAATAATTTGGAAATGACTCAATAGGAGACTCTGATTATTCTATTCATAAT
TTAATTGAAAAGGAGGAAAGCATCGCTTAAAAGGGCTATAATGGATAAAAGAATAATAAA
TATAGATAAAATAACAATAATAGCAAGCATACACTCTTAATATCTGAAGTATTAAAAACT
TCTAAATAATATTTATCAGTATTAGCATAAGTTGTTGATATTCAAAGTTCAGATAAAAAT
ATAAGATTAAAAATATGTGATAATAGCTGTAATTAAGAACTCAAAGTAGTCATTTTTCCA
GATTTATGCTATGAGTGGAGAGATAAATTTAGTATAAATAAATGGTATTATTTTAATGAG
TTTGTTAGATAAATTTATAATGATGAAGTTTAGTTGAAAAATAACATTCATTCTTCAATT
AAAGAATCTGATGATTAAAGAAAAGTTATTACTTATAATTAAGAATAGGGTGTTTTTAAA
AAATCAATCTCAATTAATAGCAATGATAGTTTTGAAATTAAGCCTAAAATTTCATATAAA
AACAATTCTAACTAAGAATAAAGGATTTATTCTTCAATTGAAGAAATAATCTAATAAGCA
TAGGCTTCAGAAATAGGTCAAAAAAAAGAATTCTATGTTTATGGAAACTTAGTTTCAATA
TAGATGAAAAATAAGCTTTATTATTATAGGTGTACTTGTTAGGGTAAGTCAGTCTTAAAA
TATCACGGAGATTCATTTTTTTGTGAAAGTTGCTAGTAGTTCATAAATCCTTAGGTGCAT
TTGATGCTTAGAGCATTTGTTTAAGATTCTACAGGGACAATTCCTGTTATGATTTTCGAT
CAGCAGTCAAGCCAACTTATCAACTAAATTGATCCATCAATTCATGTCTAAGAAGCAGGT
TAATATGTTAAAAATTGTATTGAAAATGGATAAGAAGAAATTATAAGATAGTTATTTAGT
AAATTAGACTTTGCTAGATTTATATTTGAAATTTAATTTGAAAATAAAGAATTTAATAAC
GAATAAGAGATAGCATACAAAGTATTAAAAATTGAAAAAGAAAATATTAAAGAAGAATCT
AAATATCTACTAAAAAAGTTAGAGCACTTAATAAACAATAATCAAAATAACTGAAAATAA
ACTTCTGCAG

>TTHERM_00218760(protein)
MKLTKGGSYILKKVDRKQFYQDEEIVMQIKKILGQKTTDCKQYIKCECIDGLGDEALIYF
EMLANQNQHLQKNDVIMIQDYLNDKTQNDKIVVLVTRFQFCKASHVQPKTAQKESIQLLN
TEKTIIQKSKITKNPAEEVLKFIEVNEKDNSSNSEDMIIEQQKQEIKNNQKEKQSINGFN
LEDSYSNISDITNFGGKSNFNIGSLSDQLSKQTLLISQLQVGKNRFSFKFEGRVVYKSST
FQNQQDSKYFFITAQDANNQEINLSFWQKVDQSYQTLKVGQYYYFIGGEVKQFKNNLELK
FKFGDYQIIPKETLSANYVQPLALQPSKQFGNDSIGDSDYSIHNLIEKEESIAQKGYNGQ
KNNKYRQNNNNSKHTLLISEVLKTSKQYLSVLAQVVDIQSSDKNIRLKICDNSCNQELKV
VIFPDLCYEWRDKFSINKWYYFNEFVRQIYNDEVQLKNNIHSSIKESDDQRKVITYNQEQ
GVFKKSISINSNDSFEIKPKISYKNNSNQEQRIYSSIEEIIQQAQASEIGQKKEFYVYGN
LVSIQMKNKLYYYRCTCQGKSVLKYHGDSFFCESCQQFINPQVHLMLRAFVQDSTGTIPV
MIFDQQSSQLINQIDPSIHVQEAGQYVKNCIENGQEEIIRQLFSKLDFARFIFEIQFENK
EFNNEQEIAYKVLKIEKENIKEESKYLLKKLEHLINNNQNN