Identifiers and Description

Gene Model Identifier

TTHERM_00218760

Standard Name

TEB1 (TElomerase DNA Binding subunit 1; also known as Telomerase- (or TERT-) associated protein of 82 kDa )

Aliases

PreTt22303 | 18.m00329 | 3701.m00089

Description

TEB1 telomerase-associated protein; Telomerase holoenzyme subunit p82; essential gene; knockdown induces telomere shortening- a heterotrimer of telomerase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• telomerase holoenzyme complex (IDA) | GO:0005697

Biological Process

• telomerase holoenzyme complex assembly (IDA) | GO:1905323

Domains

• ( PF01336 ) OB-fold nucleic acid binding domain
• ( PF08646 ) Replication factor-A C terminal domain
• ( PF08792 ) A2L zinc ribbon domain
• ( TIGR00161 ) conserved hypothetical protein TIGR00161
• ( TIGR00617 ) replication factor-a protein 1 (rpa1)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_06651.1	9.997093137033517e-262
	Description: hypothetical protein (690 aa)
WormBase	WBGene00015387	9.997093137033517e-262
	Description: locus:kcnl-3 Uncharacterized protein C03F11.1 status:Partially_confirmed UniProt:Q11122 protein_id:CCD62774.2
Oxytricha	Contig13699.0.g10	0.00008003872323201264
	Description: Replication factor-A C terminal domain
SGD	YAR007C	0.00020003864201578029
	Description: RFA1 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination

General Information

No Data fetched for General Information

Associated Literature

1. Ref:27895115: Upton HE, Chan H, Feigon J, Collins K (2017) Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes. The Journal of biological chemistry 292(1):217-228
2. Ref:25225329: Upton HE, Hong K, Collins K (2014) Direct single-stranded DNA binding by Teb1 mediates the recruitment of Tetrahymena thermophila telomerase to telomeres. Molecular and cellular biology 34(22):4200-12
3. Ref:23918804: Hong K, Upton H, Miracco EJ, Jiang J, Zhou ZH, Feigon J, Collins K (2013) Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub. Molecular and cellular biology 33(19):3962-71
4. Ref:20363756: Min B, Collins K (2010) Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. The Journal of biological chemistry 285(22):16434-43

Sequences

>TTHERM_00218760(coding)
ATGAAATTAACTAAAGGTGGGTCGTATATACTTAAAAAAGTGGACAGAAAATAGTTTTAT
TAAGATGAAGAAATAGTCATGTAAATAAAAAAAATACTTGGTTAAAAAACTACAGATTGC
AAACAATACATAAAATGTGAGTGTATAGATGGTTTGGGAGATGAAGCATTGATTTACTTT
GAGATGCTTGCTAATTAAAATCAGCATTTACAAAAAAACGATGTCATAATGATTTAAGAT
TATTTAAATGATAAAACATAAAACGACAAAATAGTTGTTTTAGTTACAAGGTTTTAATTT
TGTAAAGCCAGTCATGTTTAGCCTAAAACCGCCCAAAAAGAATCCATATAACTATTAAAT
ACTGAAAAAACAATAATTTAAAAGAGTAAAATTACTAAAAATCCAGCTGAAGAAGTTTTA
AAATTTATAGAAGTAAACGAAAAAGATAATAGTTCAAACAGTGAAGATATGATAATTGAA
TAGTAGAAATAAGAAATTAAGAATAATTAAAAAGAAAAACAAAGTATAAATGGATTTAAT
TTGGAAGATAGCTATTCAAATATTTCTGATATTACTAATTTTGGAGGGAAATCTAATTTT
AATATTGGATCACTTTCTGATTAACTTAGTAAATAGACACTGCTAATTTCTTAGTTGTAA
GTAGGTAAAAATAGATTTTCTTTTAAGTTCGAAGGAAGAGTTGTATATAAAAGTAGTACA
TTCCAGAATTAGCAAGACTCTAAGTATTTTTTCATCACAGCATAAGACGCTAATAATTAA
GAAATTAATTTGTCTTTTTGGCAAAAAGTTGATTAAAGCTATTAAACTTTGAAAGTAGGA
TAATATTATTACTTTATAGGAGGAGAAGTTAAATAGTTCAAAAATAATCTAGAATTAAAA
TTTAAGTTTGGAGACTACTAAATAATTCCTAAAGAGACTCTTTCTGCGAATTATGTATAA
CCTTTGGCATTACAACCTTCAAAATAATTTGGAAATGACTCAATAGGAGACTCTGATTAT
TCTATTCATAATTTAATTGAAAAGGAGGAAAGCATCGCTTAAAAGGGCTATAATGGATAA
AAGAATAATAAATATAGATAAAATAACAATAATAGCAAGCATACACTCTTAATATCTGAA
GTATTAAAAACTTCTAAATAATATTTATCAGTATTAGCATAAGTTGTTGATATTCAAAGT
TCAGATAAAAATATAAGATTAAAAATATGTGATAATAGCTGTAATTAAGAACTCAAAGTA
GTCATTTTTCCAGATTTATGCTATGAGTGGAGAGATAAATTTAGTATAAATAAATGGTAT
TATTTTAATGAGTTTGTTAGATAAATTTATAATGATGAAGTTTAGTTGAAAAATAACATT
CATTCTTCAATTAAAGAATCTGATGATTAAAGAAAAGTTATTACTTATAATTAAGAATAG
GGTGTTTTTAAAAAATCAATCTCAATTAATAGCAATGATAGTTTTGAAATTAAGCCTAAA
ATTTCATATAAAAACAATTCTAACTAAGAATAAAGGATTTATTCTTCAATTGAAGAAATA
ATCTAATAAGCATAGGCTTCAGAAATAGGTCAAAAAAAAGAATTCTATGTTTATGGAAAC
TTAGTTTCAATATAGATGAAAAATAAGCTTTATTATTATAGGTGTACTTGTTAGGGTAAG
TCAGTCTTAAAATATCACGGAGATTCATTTTTTTGTGAAAGTTGCTAGTAGTTCATAAAT
CCTTAGGTGCATTTGATGCTTAGAGCATTTGTTTAAGATTCTACAGGGACAATTCCTGTT
ATGATTTTCGATCAGCAGTCAAGCCAACTTATCAACTAAATTGATCCATCAATTCATGTC
TAAGAAGCAGGTTAATATGTTAAAAATTGTATTGAAAATGGATAAGAAGAAATTATAAGA
TAGTTATTTAGTAAATTAGACTTTGCTAGATTTATATTTGAAATTTAATTTGAAAATAAA
GAATTTAATAACGAATAAGAGATAGCATACAAAGTATTAAAAATTGAAAAAGAAAATATT
AAAGAAGAATCTAAATATCTACTAAAAAAGTTAGAGCACTTAATAAACAATAATCAAAAT
AACTGA

>TTHERM_00218760(gene)
ATGAAATTAACTAAAGGTGGGTCGTATATACTTAAAAAAGTGGACAGAAAATAGTTTTAT
TAAGATGAAGAAATAGTCATGTAAATAAAAAAAATACTTGGTTAAAAAACTACAGATTGC
AAACAATACATAAAGTAATCAAAATATATAACTTATCTAAAAAGAAAACAAATTGAGAAT
AAAAAAAATACAAATATAGATGTGAGTGTATAGATGGTTTGGGAGATGAAGCATTGATTT
ACTTTGAGATGCTTGCTAATTAAAATCAGCATTTACAAAAAAACGATGTCATAATGATTT
AAGATTATTTAAATGATAAAACATAAAAGTAAACTTTTAATATTAAAATGAGATAACAAA
ATTAATAAATATTTTTAAAAATCAAGCGACAAAATAGTTGTTTTAGTTACAAGGTTTTAA
TTTTGTAAAGCCAGTCATGTTTAGCCTAAAACCGCCCAAAAAGAATCCATATAACTATTA
AATACTGAAAAAACAATAATTTAAAAGAGTAAAATTACTAAAAATCCAGCTGAAGAAGTA
ATTAGTAGCTTATTTGCAAAGCTGAATGAATATATTATTTTTACATTGAATATATTATTT
TTACGAAATATTTTAGGTTTTAAAATTTATAGAAGTAAACGAAAAAGATAATAGTTCAAA
CAGTGAAGATATGATAATTGAATAGTAGAAATAAGAAATTAAGAATAATTAAAAAGAAAA
ACAAAGTATAAATGGTATTATTTATTTATTTATTAATCAATCTATCAATAATTTAATTTG
AAAATTTTGAGTGAAAAATCCTTGATAAATTTTTTGAACCACTTAGAATTTCTTTGAATA
TGATTTTTTTGTTTTTGATTAGGATTTAATTTGGAAGATAGCTATTCAAATATTTCTGAT
ATTACTAATTTTGGAGGGAAATCTAATTTTAATATTGGATCACTTTCTGATTAACTTAGT
AAATAGACACTGCTAATTTCTTAGTTGTAAGTAGGTAAAAATAGATTTTCTTTTAAGTTC
GAAGGAAGAGTTGTATATAAAAGTAGTACATTCCAGAATTAGCAAGACTCTAAGTATTTT
TTCATCACAGCATAAGACGCTAATAATTAAGAAATTAATTTGTCTTTTTGGCAAAAAGTT
GATTAAAGCTATTAAACTTTGAAAGTAGGATAATATTATTACTTTATAGGAGGAGAAGTT
AAATAGTTCAAAAATAAGTTAATTTATTTCTTTTTTTTTTTAATTTAAATAAAATTTTAT
ATTATAAAAATAGTCTAGAATTAAAATTTAAGTTTGGAGACTACTAAATAATTCCTAAAG
AGACTCTTTCTGCGAATTATGTATAACCTTTGGCATTACAACCTTCAAAATAATTTGGAA
ATGACTCAATAGGAGACTCTGATTATTCTATTCATAATTTAATGTAAAAGTATTTATTAA
AATCAATTTGTTTTGATATTTTTATGAACTTTTTTATAGTGAAAAGGAGGAAAGCATCGC
TTAAAAGGGCTATAATGGATAAAAGAATAATAAATATAGATAAAATAACAATAATAGCAA
GCATACACTCTTAATATCTGAAGTATTAAAAACTTCTAAATAATATTTATCAGTATTAGC
ATAAGTTGTTGTAAGATAATTACTAAGAGGTTTATATGTAGGTATTAATATGTATTTTAT
TTTAAATGAATAGGATATTCAAAGTTCAGATAAAAATATAAGATTAAAAATATGTGATAA
TAGCTGTAATTAAGAACTCAAAGTAGTCATTTTTCCAGATTTATGCTATGAGTGGAGAGA
TAAATTTAGTATAAATAAATGGTATTATTTTAATGAGTTTGTTAGATAAATTTATAATGA
TGAAGTTTAGTTGAAAAATAACATTCATTCTTCAATTAAAGAATCTGATGATTAAAGAAA
AGTTATTACTTATAATTAAGAATAGGGTGTTTTTAAAAAATCAATCTCAATTAATAGCAA
TGATAGTTTTGAAATTAAGCCTAAAATTTCATATAAAAACAATTCTAACTAAGAATAAAG
GATTTATTCTTCAATTGAAGAAATAATCTAATAAGCATAGGCTTCAGAAATAGGTCAAAA
AAAAGAATTCTATGTTTATGGAAACTTAGTTTCAATATAGATGAAAAATAAGCTTTATTA
TTATAGGTGTACTTGTTAGGGTAAGTCAGTCTTAAAATATCACGGAGATTCATTTTTTTG
TGAAAGTTGCTAGTAGTTCATAAATCCTTAGGTGCATTTGATGCTTAGAGCATTTGTTTA
AGATTCTACAGGGACAATTCCTGTTATGATTTTCGATCAGCAGTCAAGCCAACTTATCAA
CTGTAAATTTTTTTGGAAAAAATTAAATAAATTCATAAAATATTTGTTAAATAGAAATTG
ATCCATCAATTCATGTCTAAGAAGCAGGTTAATATGTTAAAAATTGTATTGAAAATGGAT
AAGAAGAAATTATAAGATAGTTATTTAGTAAATTAGACTTTGCTAGATTTATATTTGAAA
TTTAATTTGAAAATAAAGAATTTAATAACGAATAAGAGATAGCATACAAAGTATTAAAAA
TTGAAAAAGAAAATATTAAAGAAGAATCTAAATATCTACTAAAAAAGTTAGAGCACTTAA
TAAACAATAATCAAAATAACTGA

>TTHERM_00218760(protein)
MKLTKGGSYILKKVDRKQFYQDEEIVMQIKKILGQKTTDCKQYIKCECIDGLGDEALIYF
EMLANQNQHLQKNDVIMIQDYLNDKTQNDKIVVLVTRFQFCKASHVQPKTAQKESIQLLN
TEKTIIQKSKITKNPAEEVLKFIEVNEKDNSSNSEDMIIEQQKQEIKNNQKEKQSINGFN
LEDSYSNISDITNFGGKSNFNIGSLSDQLSKQTLLISQLQVGKNRFSFKFEGRVVYKSST
FQNQQDSKYFFITAQDANNQEINLSFWQKVDQSYQTLKVGQYYYFIGGEVKQFKNNLELK
FKFGDYQIIPKETLSANYVQPLALQPSKQFGNDSIGDSDYSIHNLIEKEESIAQKGYNGQ
KNNKYRQNNNNSKHTLLISEVLKTSKQYLSVLAQVVDIQSSDKNIRLKICDNSCNQELKV
VIFPDLCYEWRDKFSINKWYYFNEFVRQIYNDEVQLKNNIHSSIKESDDQRKVITYNQEQ
GVFKKSISINSNDSFEIKPKISYKNNSNQEQRIYSSIEEIIQQAQASEIGQKKEFYVYGN
LVSIQMKNKLYYYRCTCQGKSVLKYHGDSFFCESCQQFINPQVHLMLRAFVQDSTGTIPV
MIFDQQSSQLINQIDPSIHVQEAGQYVKNCIENGQEEIIRQLFSKLDFARFIFEIQFENK
EFNNEQEIAYKVLKIEKENIKEESKYLLKKLEHLINNNQNN