Identifiers and Description

Gene Model Identifier

TTHERM_00221140

Standard Name

ARS2 (Alanyl-tRNA Synthetase 2)

Aliases

PreTt22442 | 18.m00468 | 3701.m00225

Description

ARS2 alanine-tRNA ligase/alanyl-tRNA synthetase protein; Alanyl-tRNA synthetase family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• cytoplasm (IEA) | GO:0005737

Molecular Function

• alanine-tRNA ligase activity (IEA) | GO:0004813
• ATP binding (IEA) | GO:0005524
• ligase activity, forming aminoacyl-tRNA and related compounds (IEA) | GO:0016876
• nucleotide binding (IEA) | GO:0000166

Biological Process

• alanyl-tRNA aminoacylation (IEA) | GO:0006419
• translation (IEA) | GO:0006412
• tRNA aminoacylation (IEA) | GO:0043039

Domains

• ( PF01411 ) tRNA synthetases class II (A)
• ( PF07813 ) LTXXQ motif family protein
• ( PF07973 ) Threonyl and Alanyl tRNA synthetase second additional domain
• ( TIGR00344 ) alanyl-tRNA synthetase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_25370	0
	Description: None
Tetrahymena borealis	EI9_06795.1	9.997093137033517e-262
	Description: alanyl-tRNA synthetase (976 aa)
Oxytricha	Contig17366.0.g58	9.997093137033517e-262
	Description: tRNA synthetases class II (A)
SGD	YOR335C	7.998336109808381e-38
	Description: ALA1 Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
DictyBase	DDB_G0277823	1.9994920269952867e-34
	Description: alaS on chromosome: 3 position 919657 to 922497
WormBase	WBGene00000197	4.000352986427571e-28
	Description: locus:aars-2 Alanine--tRNA ligase, cytoplasmic status:Confirmed UniProt:O01541 protein_id:CCD70212.1
Tetrahymena borealis	EI9_07731.1	4.000352986427571e-28
	Description: hypothetical protein (202 aa)

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00221140(coding)
ATGGAAAATTTTGAAGAAAAGGTAGAAGAAGCCACATTAGTTGCTGCCAAGACTCCTAAG
GAAATGAAGGCTATGTACAGACCTGAATTCTAAAAGAACCCTTAAAAGTATTATCCCACT
TAAGTTTTTGCTAAGTTTGGCTACTCTAGACACCAATGTCCTAAATGCCAAAACTTTTAT
TGGAGATTCTCTGAAAAGCAAGATACTTGTGGTGACTCTGCTTGTGTTGGCAAGTACACT
TTTATTGGTGAACCCACTGGTATTGGTAAGGAAGAAAAGTTGACTTATGATGGAGCTTGG
AAGAACTTCGAAAAGTCTTTCACTTCTGCAAGAAAACCTTGCACAGCTATCAAGAGATAT
CCCGTTGTTGCAAGATGGAGAAATGATGTTGACTTTGTTGCTGCTGGTATCTACTGCTTC
TAACCCTACTGCATGACTGGTGAATTATAACCCCCTGCTAATCCTTTGATCCAACCTCAA
TTCTGCGTTAGATTCAATGATTTAGATAACATTGGATTAACTGGTAGACATTACAGTGGT
TTCATTATGATTGGTATTCAATCTTTCTGCTATCCTGGAACTGAAGATAAGACTTTCTTC
AGTGAAGAATGTGTTGAATTCAACTTGAACTGGCTTATTGATGGTCTTAAGATTCCTAAG
GATGAAATTACTCTCATTGAAGATATCTGGTCTGGCGGTGGTAACTTAGGTTCTTGCGTT
GAATACTTCGTTAAGGGTCTCGAAGTTGGTAACATGGTCTTCACCATGTATAAGTATTAC
CCCGATGGTAAGCTTGAAGATTTAGAAATTAAAGTTATTGATGTTGGTATTGGTATGGAA
AGAATTCCTTGGTTAATTAATGGTACTCCTACTTCATATATGGATGTTTTCGATACTTCC
TACAAATATCTTTAAGAAAAGTTATAAGTAGAAACAAGCACTGAAATTTGGAAGTAGATT
GGTCCTTACACTTGCCATCTTAATGCTGATGAATCAGATGATATGGAAAAAACATGGTAA
ATGGTTGCTTCCAGCATTGGAAAAACTGTCTAAGAATGCAAGCAAGCTATCACTCCTGTT
AAGGATCTCTACATTGTCCTCGATCACACTAGAGCTGCTTTAGTTCTCATTTAAGATGGT
GCTTTACCTTCAAATACTGGTGGTGGTTCAAATATCAGAAATATCATCAGAAGAGTATTT
GCTATCATGAAGAAAAATGGATGGTGGGATAAGTTAGGTAAAACAAAGGAAGAATAAATG
AAGAACTTCTTGACATTGTTCGACATGCATCAATAAGATTTAGAAAAACTTTATGGTAAG
TTCCCTGAATACAAATCTTTCGGAAGCATTATTGAAATTGAATATGAAAAGTGGAGCAGC
ACTGATAAGGCTCAACAAAAGAAGATTGTAGACTCTTTCAATAAGAAGAAAGCTCTTACT
CTTAATGATTGGATCGTAGCTATCGAATCTTGGGGTTTGTCTCCTGATACTATCACAGAA
GTTACTGGACTTCCTTAACCTGATAACCTATACAATGAAATGGAATTAAGAAAGATGAAA
TTAACTAAAGCTCCTGAACAAATTCTTTACTAAACTGCCAACATTTAAGAAACTGTTCAT
CTCTTCTATGAACACCAAAATAAATTTGATTTTGAAGCTAAAATAGTAGAAATTTTCGCT
GATTATAAGAACGTTGAAAACCGTAACATCGTAATCCTCGATTAATCATGTTTCTATCCC
ACATCTGGTGGTTAACAAAATGACATTGGTGTCATGACCGTCGACGGTTAAAAGTATAAT
GTTGTTGATGTTATTAAGGTTGGTAAATGTGTTCTTCACATTTTAGATAGATCCCTCCCT
AATCCTGATAATTCCCATTACATTGGATAAAAAGTTCATGCTGTTGTTGATGAAAACAGA
AGAAAAATTCTTCGTAATCATCACACTTCTACTCATATTGTTTTTGCTGCTTGCAGACAA
GTTTTAGGTCCTCATGTCTGGTAAAATGGTGCTAAGAAAACTGTTGATATGGCTCACTTG
GACATAACTCATTATGCATCATTGACTGAAGAATAAGAAATGGAAATCGAAAAAATTGCT
AACACTATCGTTTTCAGTAGCAAGAATATCAACAAAGAATTTGTTAATAAAGCTGAAGCT
GAAAAAGAACATGGTTTCCGTCTTTATTAAGGTGGTGTTGTACCAGGTGATACTTTGAGA
GTAGTCAATATTGAAGGAACTGATGTTGAAGCCTGTTGTGGTACTCACTGCGATAACACC
TCTGAAGTTGGTATTATTAGAATTTTAAAGACTAACAGAATTTCAGATGGTATTATCAGA
TTATACTTTGTTGCTGGTGAAAGATCTCTCCAAAAACTCTCAACTTAAACTAAGGTCCTT
GTTGATTTACAAAATATCTTCAAGGTAAAAGAATCAGATCTTGTCAGCACTTCCTTAAAG
TTCTTTACTGAAAGAAATAAATTCATTGAACGTCACAAATCTGCAACTTAAAAGGTTTTA
AATCTTCAAATGGAATTATTCCTTGCTAAGGATAAATACAAAAACATCTTTGTAAAGTCT
ACTGAATCTGAAGCAACATTATATTTCTCTTTCATGGGCAACTTTATTAAAGCTCAAAAG
GATGCTGGTAAAGGTATAGTTTTTGTTGGAGAAGGAGAAAAAGGTTTTGTCTTTGGTTAA
TTCGGTAATAAATCTGACTTTGATCAAGAAAAGTTCTTAGCTTTATTATAAGAAGATAAT
CCAGGAGTCACATATAAAAAATGCTTAACTTCAATCACTGCTAACAAAGTTAAACTTGAC
AACGTTTTACAATTCTCTTTCAGTGGCAAAGTTAAATATGAAAAAGTAAAGAAAGATTTA
ATTACTCTTGGTCTTATTGAAGCAGATCTCTGA

>TTHERM_00221140(gene)
ATGGAAAATTTTGAAGAAAAGGTAGAAGAAGCCACATTAGTTGCTGCCAAGACTCCTAAG
GTATCCTTACAGATTTATATATTTATGAGAGATTAAAAAGATTAAACTTTAATCAGCATT
TTTGCTAATTTATATTTCATTTAAAAATAGGAAATGAAGGCTATGTACAGACCTGAATTC
TAAAAGAACCCTTAAAAGTATTATCCCACTTAAGTTTTTGCTAAGTTTGGCTACTCTAGA
CACCAATGTCCTAAATGCCAAAACTTTTATTGGAGATTCTCTGAAAAGCAAGATACTTGT
GGTGACTCTGCGTAATATATTATTCTTACTTTAATTATTATCCAATAATACTAAAAAACT
CTTTTAAAATACATTTATATCGAGGTATCTCCATATTATTATTAAAATTCGACATGTATT
TTATTTAAGGGAGAGCTATTTAATTAAGAAATAAATAATATTTTATTAAATAAATTTAAA
ACTGAATAGTATATTTAACCGAAGAAATTTTAACAAAGTATCAATAAAATAGCATTAATT
GTAAATTCATTTTTATATAAATATAGTTGTGTTGGCAAGTACACTTTTATTGGTGAACCC
ACTGGTATTGGTAAGGAAGAAAAGTTGACTTATGATGGAGCTTGGAAGAACTTCGAAAAG
TCTTTCACTTCTGCAAGAAAACCTTGCACAGCTATCAAGAGATATCCCGTTGTTGCAAGA
TGGAGGTAAAATTTATATTTATAGCTATTTTTTTAAACTTAGACATAATCATGTTTTATT
AATTTTGCTTATTGAAAATGTTTTATAAGCTGTTTTTTGTTAAAAAAAATTTAAAAAACG
AATTTTTCGAAGTTGTTAATCAAAGTTGGAATTATTATAAAATCAAGAATTAAAGTTTGG
CGGAATTCTTTTAAAAGAAACAAACGATAATAATTTATGTCTTTGATTTGTGTCTTAAAT
ATTGATAGATTATACTTTTTGCTAACAATAAAAAATATCTTTTTGATTTTAGAATTTTAA
TTAATTTAAATTAAAAAACAAAAGAAATGATGTTGACTTTGTTGCTGCTGGTATCTACTG
CTTCTAACCCTACTGCATGACTGGTGAATTATAACCCCCTGCTAATCCTTTGATCCAACC
TCAATTCTGCGTTAGATTCAATGATTTAGATAACATTGGATTAACTGGTAGACATTACAG
TGGTTTCATTATGATTGGTATTCAATCTTTCTGCTATCCTGGAACTGAAGATAAGACTTT
CTTCAGTGAAGAATGTGTTGAATTCAACTTGAACTGGCTTATTGATGGTCTTAAGATTCC
TAAGGATGAAATTACTCTCATTGAAGATATCTGGTCTGGCGGTGGTAACTTAGGTTCTTG
CGTTGAATACTTCGTTAAGGGTCTCGAAGTTGGTAACATGGTCTTCACCATGTATAAGTA
TTACCCCGATGGTAACATTTAGCATTTTATAATAATCAATATTTTTTAAATAATTTTTAT
TTACCAAACAGGTAAGCTTGAAGATTTAGAAATTAAAGTTATTGATGTTGGTATTGGTAT
GGAAAGAATTCCTTGGTTAATTAATGGTACTCCTACTTCATATATGGATGTTTTCGATAC
TTCCTACAAATATCTTTAAGAAAAGTTATAAGTAGAAACAAGCACTGAAATTTGGAAGTA
GATTGGTCCTTACACTTGCCATCTTAATGCTGATGAATCAGATGATATGGAAAAAACATG
GTAAATGGTTGCTTCCAGCATTGGAAAAACTGTCTAAGAATGCAAGCAAGCTATCACTCC
TGTTAAGGATCTCTACATTGTCCTCGATCACACTAGAGCTGCTTTAGTTCTCATTTAAGA
TGGTGCTGTAACTAAACAAAAAAATCTATAATTTAAAAAATATAATAATTTTTTCATAAA
ATAAATAAATAAAGTTACCTTCAAATACTGGTGGTGGTTCAAATATCAGAAATATCATCA
GAAGAGTATTTGCTATCATGAAGAAAAATGGATGGTGGGATAAGTTAGGTAAAACAAAGG
AAGAATAAATGAAGAACTTCTTGACATTGTTCGACATGCATCAATAAGATTTAGAAAAAC
TTTATGGTAAGTTCCCTGAATACAAATCTTTCGGAAGCATTATTGAAATTGAATATGAAA
AGTGGAGCAGCACTGATAAGGCTCAACAAAAGAAGATTGTAGACTCTTTCAATAAGAAGA
AAGCTCTTACTCTTAATGATTGGATCGTAGCTATCGAATCTTGGGGTTTGTCTCCTGATA
CTATCACAGAAGTTACTGGACTTCCTTAACCTGATAACCTATACAATGAAATGGAATTAA
GAAAGATGAAATTAACTAAAGCTCCTGAACAAATTCTTTACTAAACTGCCAACATTTAAG
AAACTGTTCATCTCTTCTATGAACACCAAAATAAATTTGATTTTGAAGCTAAAATAGTAG
AAATTTTCGCTGATTATAAGAACGTTGAAAACCGTAACATCGTAATCCTCGATTAATCAT
GTTTCTATCCCACATCTGGTGGTTAACAAAATGACATTGGTGTCATGACCGTCGACGGTT
AAAAGTATAATGTTGTTGATGTTATTAAGGTTGGTAAATGTGTTCTTCACATTTTAGATA
GATCCCTCCCTAATCCTGATAATTCCCATTACATTGGATAAAAAGTTCATGCTGTTGTTG
ATGAAAACAGAAGAAAAATTCTTCGTAATCATCACACTTCTACTCATATTGTTTTTGCTG
CTTGCAGACAAGTACTTATTTATTTATTTCAATAATAAAATTGAATTCCATTAAATTCAA
ATATCTGAATAATTTTTTTTATTTAGGTTTTAGGTCCTCATGTCTGGTAAAATGGTGCTA
AGAAAACTGTTGATATGGCTCACTTGGACATAACTCATTATGCATCATTGACTGAAGAAT
AAGAAATGGAAATCGAAAAAATTGCTAACACTATCGTTTTCAGTAGCAAGAATATCAACA
AAGAATTTGTTAATAAAGCTGAAGCTGAAAAAGAACATGGTTTCCGTCTTTATTAAGGTG
GTGTTGTACCAGGTGATACTTTGAGAGTAGTCAATATTGAAGGAACTGATGTTGAAGCCT
GTTGTGGTACTCACTGCGATAACACCTCTGAAGTTGGTATTATTAGAATTTTAAAGACTA
ACAGAATTTCAGATGGTATTATCAGATTATACTTTGTTGCTGGTGAAAGATCTCTCCAAA
AACTCTCAACTTAAACTAAGGTCCTTGTTGATTTACAAAATATCTTCAAGGTAAAAGAAT
CAGATCTTGTCAGCACTTCCTTAAAGTTCTTTACTGAAAGAAATAAATTCATTGAACGTC
ACAAATCTGCAACTTAAAAGGTTTTAAATCTTCAAATGGAATTATTCCTTGCTAAGGATA
AATACAAAAACATCTTTGTAAAGTCTACTGAATCTGAAGCAACATTATATTTCTCTTTCA
TGGGCAACTTTATTAAAGCTCAAAAGGTAATAATTTTATTTTTTTTATATTATTTTAAAT
AAATAATATTAAAATCTATTTAGGATGCTGGTAAAGGTATAGTTTTTGTTGGAGAAGGAG
AAAAAGGTTTTGTCTTTGGTTAATTCGGTAATAAATCTGACTTTGATCAAGAAAAGTTCT
TAGCTTTATTATAAGAAGATAATCCAGGAGTCACATATAAAAAATGCTTAACTTCAATCA
CTGCTAACAAAGTTAAAGTAATTTTAAATAAATATATTTTAATACAATAAGTTTTATTTT
TTTATTTAACAAAAAAGCTTGACAACGTTTTACAATTCTCTTTCAGTGGCAAAGTTAAAT
ATGAAAAAGTAAAGAAAGATTTAATTACTCTTGGTCTTATTGAAGCAGATCTCTGA

>TTHERM_00221140(protein)
MENFEEKVEEATLVAAKTPKEMKAMYRPEFQKNPQKYYPTQVFAKFGYSRHQCPKCQNFY
WRFSEKQDTCGDSACVGKYTFIGEPTGIGKEEKLTYDGAWKNFEKSFTSARKPCTAIKRY
PVVARWRNDVDFVAAGIYCFQPYCMTGELQPPANPLIQPQFCVRFNDLDNIGLTGRHYSG
FIMIGIQSFCYPGTEDKTFFSEECVEFNLNWLIDGLKIPKDEITLIEDIWSGGGNLGSCV
EYFVKGLEVGNMVFTMYKYYPDGKLEDLEIKVIDVGIGMERIPWLINGTPTSYMDVFDTS
YKYLQEKLQVETSTEIWKQIGPYTCHLNADESDDMEKTWQMVASSIGKTVQECKQAITPV
KDLYIVLDHTRAALVLIQDGALPSNTGGGSNIRNIIRRVFAIMKKNGWWDKLGKTKEEQM
KNFLTLFDMHQQDLEKLYGKFPEYKSFGSIIEIEYEKWSSTDKAQQKKIVDSFNKKKALT
LNDWIVAIESWGLSPDTITEVTGLPQPDNLYNEMELRKMKLTKAPEQILYQTANIQETVH
LFYEHQNKFDFEAKIVEIFADYKNVENRNIVILDQSCFYPTSGGQQNDIGVMTVDGQKYN
VVDVIKVGKCVLHILDRSLPNPDNSHYIGQKVHAVVDENRRKILRNHHTSTHIVFAACRQ
VLGPHVWQNGAKKTVDMAHLDITHYASLTEEQEMEIEKIANTIVFSSKNINKEFVNKAEA
EKEHGFRLYQGGVVPGDTLRVVNIEGTDVEACCGTHCDNTSEVGIIRILKTNRISDGIIR
LYFVAGERSLQKLSTQTKVLVDLQNIFKVKESDLVSTSLKFFTERNKFIERHKSATQKVL
NLQMELFLAKDKYKNIFVKSTESEATLYFSFMGNFIKAQKDAGKGIVFVGEGEKGFVFGQ
FGNKSDFDQEKFLALLQEDNPGVTYKKCLTSITANKVKLDNVLQFSFSGKVKYEKVKKDL
ITLGLIEADL