Identifiers and Description

Gene Model Identifier

TTHERM_00242580

Standard Name

THD9 (Tetrahymena Histone Deacetylase 9)

Aliases

PreTt18995 | 20.m00459 | 3706.m00223

Description

THD9 SIR2 family transcriptional regulator; Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF00205 ) Thiamine pyrophosphate enzyme, central domain
• ( PF02146 ) Sir2 family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_07749.1	9.997093137033517e-262
	Description: transcriptional regulator, Sir2 family protein (446 aa)
WormBase	WBGene00000098	9.997093137033517e-262
	Description: locus:air-1 status:Confirmed UniProt:G5EDL3 protein_id:CCD64757.1
Oxytricha	Contig19063.0.g74	4.001202823045957e-54
	Description: Sir2 family
Stentor Coeruleus	SteCoe_10597	2.9374821117108028e-30
	Description: None
DictyBase	DDB_G0283917	8.999890565246037e-26
	Description: sir2A on chromosome: 4 position 1272110 to 1273864
WormBase	WBGene00004803	2.999534586690157e-23
	Description: locus:sir-2.4 NAD-dependent protein deacetylase sir-2.4 status:Confirmed UniProt:Q95Q89 protein_id:CCD61225.1
SGD	YOL068C	3.001003044337619e-17
	Description: HST1 NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00242580(coding)
ATGAAAATTAATAAATTCATTAAAAAAGCGTTCTCTACTATTTAGGAAAGCGAATATAGC
AAATACTTTTCTAAAAACTCTGTATACCATTAGAAAGATAAGTTCTTGTTTAATCCTAGA
CTTAAAGATACTTAAGAGCATTAAGATTCACCAGAATAAATAGATACCAAAGTAAATCAG
CTTATAGAATTACTTTAAAAAAGTAAGAATGCTGTGATATTAACTGGAGCTGGAGTTAGT
ACAGCTTCAGGTATACCTGATTATAGAAGTGGTGCAAATACTATTTTAAAAACAGGACCT
GGTAAGTGGGAATTAGAGGAAAACAAAAAAAAATTTTTGGAAGAAAAAGGTAAGCCATAA
ATAATATTAGCAATAAATGCATTCCCTTCTCCAACTCATATGGCAATTTCAAAACTATAT
AAAGAGAATTTGATAAAATCAGTAATTACTTAAAATGTTGATAACTTGCATCATTAAAGT
GGTATTCCAAGGAAAGATATTCATGAGCTGCATGGGAATATTATTTCAGAGAGATGTGAA
AAGTGTAATTATGTCCATTATAGAGATTTTTATACTCGTTTAAAACATTTGAAATGGGGA
GATCCACATAACACTGGAAGAATTTGCTAAAAAAATGGATGTGATGGATAATTGCACGAC
ACTTTGGTATTTTTTGGAGAATCAGTATTACAAAATATAAAATAATCAGCATAAGAATAA
ATTGAAAGTGCAGATTTGTGCATAGTGGTAGGAACGAGCTTGACAGTTTAATCTGCAGCT
AGGTTAGTTTGGATTTCTTAGTAAAGAGGAATTCCTATAGTAATAATAAATCTACAAAAA
ACAAGCTATGATTCGAAGGCACTTAAAATTAATGGTTTATGTGAACCTATCTTTGATTTG
ATTCTTAAAAAACTTAATTTCTAGCCCGATAAATTTACAGTTTAAAGGGATATTATATTG
AGATTTTAGAAAACTGGGTTTTGCAGCTTTGATTTGTTTGCTGACTGTGAAAGTTTTGAT
GGAAGCCATTTGAGTGCTATTAAATAATTAGAAATTTGGTATAGAAAAGAAAATGGAAAT
TAATTATATAAAAGCTTTGAAGGTCATCCATACTATTTTTAAGCTGAAGATTCATTTAAC
ATAGATCAAATTAAATTAAATTTTTTTTCTCACCATAAAGAAAAGAGTCACTTTATTTAT
GACTAGGAGGTATTATAAAATGGATAGCTATTTAGTATGAGCTCTCCAGGGTCATTAATT
TTCCTTACATCTAAATTAACATATGAATTTTAAGATTAAAAAGATGAATGGATTGCTTAA
CATAAAATTGAAAGCTACAAATGA

>TTHERM_00242580(gene)
ATGAAAATTAATAAATTCATTAAAAAAGCGTTCTCTACTATTTAGGAAAGCGAATATAGC
AAATACTTTTCTAAAAACTCTGTATACCATTAGAAAGATAAGTTCTTGTTTAATCCTAGA
CTTAAAGATACTTAAGAGCATTAAGATTCACCAGAATAAATAGATACCAAAGTAAATCAG
CTTATAGAATTACTTTAAAAAAGTAAGAATGCTGTGATATTAACTGGAGCTGGAGTTAGT
ACAGCTTCAGGTATACCTGATTATAGAAGTGGTGCAAATACTATTTTAAAAACAGGACCT
GGTAAGTGGGAATTAGAGGAAAACAAAAAAAAATTTTTGGAAGAAAAAGGTAAGCCATAA
ATAATATTAGCAATAAATGCATTCCCTTCTCCAACTCATATGGCAATTTCAAAACTATAT
AAAGAGAATTTGATAAAATCAGTAATTACTTAAAATGTTGATAACTTGCATCATTAAAGT
GGTATTCCAAGGAAAGATATTCATGAGCTGCATGGGAATATTATTTCAGAGAGATGTGAA
AAGTGTAATTATGTCCATTATAGAGATTTTTATACTCGTTTAAAACATTTGAAATGGGGA
GATCCACATAACACTGGAAGAATTTGCTAAAAAAATGGATGTGATGGATAATTGCACGAC
ACTTTGGTATTTTTTGGAGAATCAGTATTACAAAATATAAAATAATCAGTAAAATTAATA
TGAGAATTAGGGATTTAAATATACTTTTATTTAATTAATTAATAAACTCTACTTATAAAG
TAGAAAAAAGACTATACCTCCTTTATTTAATTTAATTTTTTTATTAATATTAAAAGGCAT
AAGAATAAATTGAAAGTGCAGATTTGTGCATAGTGGTAGGAACGAGCTTGACAGTTTAAT
CTGCAGCTAGGTTAGTTTGGATTTCTTAGTAAAGAGGAATTCCTATAGTAATAATAAATC
TACAAAAAACAAGCTATGATTCGAAGGCACTTAAAATTAATGGTTTATGTGAACCTATCT
TTGATTTGATTCTTAAAAAACTTAATTTCTAGCCCGATAAATTTACAGTTTAAAGGTAAA
TATTTGAATTTATTTTTTAAAATGTAAAGCTACTTGTGTCAAATTAATATAATTTCGCTA
AAAGAAATATTTAATCTTACTCATTAAATTTTTATTTAAAAAAAAGCTTTTTTACATTTT
GCATTAAATTTTTTTAAATACATATTTTTGTTTTTTAATATGAAATTAAGGGATATTATA
TTGAGATTTTAGAAAACTGGGTTTTGCAGCTTTGATTTGTTTGCTGACTGTGAAAGTTTT
GATGGAAGCCATTTGAGTGCTATTAAATAATTAGAAATTTGGTATAGAAAAGAAAATGGA
AATTAATTATATAAAAGCTTTGAAGGTCATCCATACTATTTTTAAGCTGAAGATTCATTT
AACATAGATCAAATTAAATTAAATTTTTTTTCTCACCATAAAGAAAAGAGTCACTTTATT
TATGACTAGGAGGTATTATAAAATGGATAGCTATTTAGTATGAGCTCTCCAGGGTCATTA
ATTTTCCTTACATCTAAATTAACATATGAATTTTAAGATTAAAAAGATGAATGGATTGCT
TAACATAAAATTGAAAGCTACAAATGA

>TTHERM_00242580(protein)
MKINKFIKKAFSTIQESEYSKYFSKNSVYHQKDKFLFNPRLKDTQEHQDSPEQIDTKVNQ
LIELLQKSKNAVILTGAGVSTASGIPDYRSGANTILKTGPGKWELEENKKKFLEEKGKPQ
IILAINAFPSPTHMAISKLYKENLIKSVITQNVDNLHHQSGIPRKDIHELHGNIISERCE
KCNYVHYRDFYTRLKHLKWGDPHNTGRICQKNGCDGQLHDTLVFFGESVLQNIKQSAQEQ
IESADLCIVVGTSLTVQSAARLVWISQQRGIPIVIINLQKTSYDSKALKINGLCEPIFDL
ILKKLNFQPDKFTVQRDIILRFQKTGFCSFDLFADCESFDGSHLSAIKQLEIWYRKENGN
QLYKSFEGHPYYFQAEDSFNIDQIKLNFFSHHKEKSHFIYDQEVLQNGQLFSMSSPGSLI
FLTSKLTYEFQDQKDEWIAQHKIESYK