Identifiers and Description

Gene Model Identifier

TTHERM_00245100

Standard Name

TPA1 (Tetrahymena P-type ATPase )

Aliases

PreTt02406 | 21.m00237

Description

TPA1 Na-H/K antiporter P-type ATPase alpha subunit family protein; P-type ATPase; putative Na(+)/K(+) or H(+)/K(+) ATPase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039
• membrane (IEA) | GO:0016020

Molecular Function

• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824
• hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (IEA) | GO:0016820
• P-type ion transporter activity (ISS) | GO:0015662
• P-type ion transporter activity (IEA) | GO:0015662

Biological Process

• ATP biosynthetic process (IEA) | GO:0006754
• metabolic process (IEA) | GO:0008152
• monoatomic cation transport (IEA) | GO:0006812

Domains

• ( PF00122 ) E1-E2 ATPase
• ( PF00689 ) Cation transporting ATPase, C-terminus
• ( PF00690 ) Cation transporter/ATPase, N-terminus
• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( PF03720 ) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding
• ( PF07670 ) transporter gate domain protein
• ( PF08282 ) haloacid dehalogenase-like hydrolase
• ( TIGR00338 ) phosphoserine phosphatase SerB
• ( TIGR01106 ) Na,H/K antiporter P-type ATPase, alpha
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01487 ) SPP-like hydrolase, Archaeal
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( TIGR01497 ) K+-transporting ATPase, B subunit
• ( TIGR01511 ) copper-translocating P-type ATPase
• ( TIGR01512 ) cadmium-translocating P-type ATPase
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
• ( TIGR01523 ) potassium/sodium efflux P-type ATPase, fungal-type
• ( TIGR01524 ) magnesium-translocating P-type ATPase
• ( TIGR01525 ) heavy metal translocating P-type ATPase
• ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
• ( TIGR01657 ) P-type ATPase of unknown pump

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_24478	0
	Description: None
WormBase	WBGene00001137	9.997093137033517e-262
	Description: locus:eat-6 status:Confirmed UniProt:P90735 protein_id:CAB02694.1
Tetrahymena borealis	EI9_01247.1	9.997093137033517e-262
	Description: Na,H/K antiporter P-type ATPase, alpha subunit protein (1197 aa)
DictyBase	DDB_G0267924	9.997093137033517e-262
	Description: DDB_G0267924 on chromosome: 1 position 1128799 to 1132710
Oxytricha	Contig21999.0.g128	9.997093137033517e-262
	Description: E1-E2 ATPase
SGD	YGL167C	1.0002857351297358e-115
	Description: PMR1 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease

General Information

No Data fetched for General Information

Associated Literature

1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
3. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60
4. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28

Sequences

>TTHERM_00245100(coding)
ATGAGTTAGACTAATATTCGTTAGTCAATGAATGGTGTTCGATAGTCAACGTCGAATATA
GCAAGAAAATTTGAAGAAATGAGACAGTCTATATAGCTTAAGAACTCCCAATAAGAAGTT
AGATAGAGCTAGTAAATGCGTAGATATGAAGGTGATTAAGATGATGGAAACAAAGTGGCA
CATTACAATCGCGAGTTAATGGAAGACCATCAACCTATACATACTGAAACAATTATGCTT
TAAGGTACTTCTTCTTAACATGATACTCACTAAAAACCATCAGCTCCAGCAGATAAAAAG
GAGGTTTCTAAAGAAGATTAATCAAAGCAAGCTCTTGTAGAAAAAGTTGATCACAAAATT
TCGTTAGAAGAGCTTAAGGAGAAGTATCAGACAGATTATTAAAAAGGTTTAACTGATTAG
TAAGCTGAACATTTACTTAGAGTCAATGGAGAAAACAAACTTTCAGCTAAAGCAGGTGTC
CCTTTATGGTTAAAGCTTTTGAGAGAAATGACCAATGGATTTTCTATTATGCTTTGGGTA
AGTGCAGGTCTTTGCTTTCTTGCTGAAGGTTTACAGCCTAATCCTTCAAATATCTATTTA
GCTGTTGTGTTAATTATTGTCATTCTAATTACTACAGCAATTACATTTTAATAGAATGCT
AAAAGTGAGGCTTTGATGAACTCCTTCAAGAATTTTATTCCTGCAAAAACTGTAGTTATT
AGAGGGGGCGATACTAAATCAATTGATGCAGCTCATCTTGTTGTTGGTGATATAGTCGTA
ATAAGACTGGGTGAAAAAATTCCTGCTGATATTCGTATTCTTGAATCTAACGAAATGAAA
GTTGACAATTCTCCCTTGACAGGTGAAAGTGAACCCTTACTACGTACGATTGAATGCTCT
CACCCTGAGAGTTATCTTGAAACCTCAAATATAGCCTTCTTCGGAACTCTGTGCAAAGAA
GGTACTGGAAAAGGTATTGTAATTGCCACTGGTGATCGTACTATGCTTGGACAAATTGCT
GATTTATCTTCTGGCGAAAAGAAAACTAAAACTCCTCTTCGTGTTGAACTCGATCGTTTT
GTTATTTTGATTACAGTAATTGCAATCTTCCTTGGTGTCCTCTTTTTCTTACTCGCTTTA
TTGTATATGAAGTATAAATTTAATGATTGCTTAGTCTTCGGTATAGGTATCCTTGTTGCG
AATGTACCTGAAGGTTTGCTAGGTTGCATTACTATCTCTCTCGCTATCACAGCAAAGAAC
CTATCTGCTAAAAGTGTCTTAGTTAAAAACTTAGAAGCCGTTGAAACTCTAGGTTCTACT
TCCTGTATTTGCTCTGACAAAACAGGTACTCTCACATAAAATGTTATGTCAGTCAAAAAC
TTGTGGTACAAAGATAGAATTTACCTATCTAAGAATAAAGTCTAACTTAAGTAAGGAGAA
TTACCTGAATATGACACTGAAGATGTTGATTTTAAAATTCTTTAAAAGGCAGCTATGCTC
AGCAGTGAGGCTCGTTTCGATACCTCTACTGTTAAGGACTAATAAAATATTGACTATTTG
ACCTGTCCTGTATTAGGTGATGCGACTGAAACAGGTATTATTAGATTCTATTAGTATATT
GAAGATGTTAACACCTTCCGTAATAGATATTAAATTGCTAAAAATCCAGATGGTACATTT
GGTAAAATGCCTTTCAATTCTTAGGTTAAGTTTGCTTTAACAATTATTGAAGAACAAACA
TAGGACAGCTTTTATACAGTTTACATAAAAGGTGCTCCAGAAAAAATTTGGACTTACTGC
TCATCAGTTATTGTTAATGGAAGGCCATAGAATTTAGATCAAACTTGGTAGAAAAAATTC
AAAGCTGTTAATCTTACTTTTGGTAAAGGAGGAGAAAGAGTGCTTGGTTTTGCTAAATTA
CATTTACCAGCTACTAAATATCCTCATGGATTTACATTCAATGTATCATCATTACAAAAA
TTCCCTTTTAAACTCGCTGACTTTTAATTTTGCGGTTTAGTCTCCTTGATGGATCCTCCT
AAGACAAGAGTTCCTTATGCTATCTTAGAATGTAGATCTGCTGGTGTGAAAGTTGTCATG
GTAACTGGTGATTAACCTCCTACAGCCGCTGCAATTGCCAAAGAAGTCAATATTATTCCT
AGGGACATTTTAACTAACGAAGATCTTATGGAAAGAGACCCTACCCTTAGCTGGTGGGAT
GCAAGCAAACAGTGTGAAGCTATTATTGTTCACGGCGATAGAATTACAGAATCCTATGAA
AAATCTTTAGGAGAATAAAAGGAAGAACAATTTTATTTAAGAAGCTGGGTTGTAAAGCCT
TATTGTGTTTTTGCAAGAACTACTCCTGCTTAAAAACTATAAATTGTTGATGCCTGTTAA
AAAGAAGGATTTATTGTTGCTGCTACTGGTGATGGTGTTAACGACTCCCCTGCAATCAAG
AAAGCAGATATTGGTATTTCTATGAATCTGTCTGGATCTGATGTAACCAAAGATGCTGCA
GACATGGTTTTAATTGATGACGATTTTGCTTCAATTGTTAACGGTGTTGAAGAAGGAAGA
AAAATTTTTGATAACCTGAAAAAAACTGTAGTTTATCTTCTTACTTCTAATATGACTGAA
ATCGTTCCTTTCTTGGCCTTCATTATTCTTTAAATTCCTTTACCTCTCTCAAGTATTTAT
ATGCTCGTCATTTGTGTTGGTACTGATGTTTGGCCAGCTATCTCTCTCGCTTACGAAGAA
GCTGAGCTCGATGTAATGACTAGAAGACCTCGTACTAAGTAGGAGCATTTAGTTTCTAAC
AAATTAATTACTATAGCTTATCTTTAAACAGGTCAAATAGCTAGTGGTGCTGGATTTTTA
GGTTATTACATAGCATTTAACTATTTTGGATTCCCAGTACTTTCTTTGTTCGGTCTAGCT
TCTGCTACTGGTTATAGACCAAGTAAAAATGATTTTGGTACCTATTATAACCCTTTACTT
TAAAGAGACGACCCTTACTATAACTCCAGGTTATATAATATTACATAATTCAAAAATTGT
AAGGATATTGATGTAGAAAGCATCTCGTATACCATAGATTGGTTTACACTAGATGAAGGT
AATTATGATATGAGAAAATCTTTGGTTAAATGTGATCCTGTAACTGGAGCTTTTATTCCT
TGGATTCATTGGAGTGATTGTGATATAAATAAATAATAAAACTGGTCAAAACTAACATCC
TAAACAGCTTGCTACTCGGTAGAAGCTATTAACTATGCTCAGAGTGTTTATTTCTTAACC
GTAGTTTTACTTTAATGGACTAACGTCTTTGCATGTAAAAGTAGATCTACAAGCTTTACA
ACAACAGCATTTAATCCGATTATGATTCACGGTATTATTTTTGAAACATTACTTACCATT
TTCTTATAATATTGTCCGGGAGTTTAAGATGTGTTTGGTGGTAGGCCTATGTTCTTCTGG
TTATGGACAAGTTGCTTAGCATATACTATATTGTTACTTGTCTATGATGAACTAAGAAAG
TTTATGTGTAGAAGATTTAAATGGTATTATAAGTATTGTTATTGGTGA

>TTHERM_00245100(gene)
ATGAGTTAGACTAATATTCGTTAGTCAATGAATGGTGTTCGATAGTCAACGTCGAATATA
GCAAGAAAATTTGAAGAAATGAGACAGTCTATATAGCTTAAGAACTCCCAATAAGAAGTT
AGATAGAGCTAGTAAATGCGTAGATATGAAGGTGATTAAGATGATGGAAACAAAGTGGCA
CATTACAATCGCGAGTTAATGGAAGACCATCAACCTATACATACTGAAACAATTATGCTT
TAAGGTACTTCTTCTTAACATGATACTCACTAAAAACCATCAGCTCCAGCAGATAAAAAG
GAGGTTTCTAAAGAAGATTAATCAAAGCAAGCTCTTGTAGAAAAAGTTGATCACAAAATT
TCGTTAGAAGAGCTTAAGGAGAAGTATCAGACAGATTATTAAAAAGGTTTAACTGATTAG
TAAGCTGAACATTTACTTAGAGTCAATGGAGAAAACAAACTTTCAGCTAAAGCAGGTGTC
CCTTTATGGTTAAAGCTTTTGAGAGAAATGACCAATGGATTTTCTATTATGCTTTGGGTA
AGTGCAGGTCTTTGCTTTCTTGCTGAAGGTTTACAGCCTAATCCTTCAAATATCTATTTA
GCTGTTGTGTTAATTATTGTCATTCTAATTACTACAGCAATTACATTTTAATAGAATGCT
AAAAGTGAGGCTTTGATGAACTCCTTCAAGAATTTTATTCCTGCAAAAACTGTAGTTATT
AGAGGGGGCGATACTAAATCAATTGATGCAGCTCATCTTGTTGTTGGTGATATAGTCGTA
ATAAGACTGGGTGAAAAAATTCCTGCTGATATTCGTATTCTTGAATCTAACGAAATGAAA
GTTGACAATTCTCCCTTGACAGGTGAAAGTGAACCCTTACTACGTACGATTGAATGCTCT
CACCCTGAGAGTTATCTTGAAACCTCAAATATAGCCTTCTTCGGAACTCTGTGCAAAGAA
GGTACTGGAAAAGGTATTGTAATTGCCACTGGTGATCGTACTATGCTTGGACAAATTGCT
GATTTATCTTCTGGCGAAAAGAAAACTAAAACTCCTCTTCGTGTTGAACTCGATCGTTTT
GTTATTTTGATTACAGTAATTGCAATCTTCCTTGGTGTCCTCTTTTTCTTACTCGCTTTA
TTGTATATGAAGTATAAATTTAATGATTGCTTAGTCTTCGGTATAGGTATCCTTGTTGCG
AATGTACCTGAAGGTTTGCTAGGTTGCATTACTATCTCTCTCGCTATCACAGCAAAGAAC
CTATCTGCTAAAAGTGTCTTAGTTAAAAACTTAGAAGCCGTTGAAACTCTAGGTTCTACT
TCCTGTATTTGCTCTGACAAAACAGGTACTCTCACATAAAATGTTATGTCAGTCAAAAAC
TTGTGGTACAAAGATAGAATTTACCTATCTAAGAATAAAGTCTAACTTAAGTAAGGAGAA
TTACCTGAATATGACACTGAAGATGTTGATTTTAAAATTCTTTAAAAGGCAGCTATGCTC
AGCAGTGAGGCTCGTTTCGATACCTCTACTGTTAAGGACTAATAAAATATTGACTATTTG
ACCTGTCCTGTATTAGGTGATGCGACTGAAACAGGTATTATTAGATTCTATTAGTATATT
GAAGATGTTAACACCTTCCGTAATAGATATTAAATTGCTAAAAATCCAGATGGTACATTT
GGTAAAATGCCTTTCAATTCTTAGGTTAAGTTTGCTTTAACAATTATTGAAGAACAAACA
TAGGACAGCTTTTATACAGTTTACATAAAAGGTGCTCCAGAAAAAATTTGGACTTACTGC
TCATCAGTTATTGTTAATGGAAGGCCATAGAATTTAGATCAAACTTGGTAGAAAAAATTC
AAAGCTGTTAATCTTACTTTTGGTAAAGGAGGAGAAAGAGTGCTTGGTTTTGCTAAATTA
CATTTACCAGCTACTAAATATCCTCATGGATTTACATTCAATGTATCATCATTACAAAAA
TTCCCTTTTAAACTCGCTGACTTTTAATTTTGCGGTTTAGTCTCCTTGATGGATCCTCCT
AAGACAAGAGTTCCTTATGCTATCTTAGAATGTAGATCTGCTGGTGTGAAAGTTGTCATG
GTAACTGGTGATTAACCTCCTACAGCCGCTGCAATTGCCAAAGAAGTCAATATTATTCCT
AGGGACATTTTAACTAACGAAGATCTTATGGAAAGAGACCCTACCCTTAGCTGGTGGGAT
GCAAGCAAACAGTGTGAAGCTATTATTGTTCACGGCGATAGAATTACAGAATCCTATGAA
AAATCTTTAGGAGAATAAAAGGAAGAACAATTTTATTTAAGAAGCTGGGTTGTAAAGCCT
TATTGTGTTTTTGCAAGAACTACTCCTGCTTAAAAACTATAAATTGTTGATGCCTGTTAA
AAAGAAGGATTTATTGTTGCTGCTACTGGTGATGGTGTTAACGACTCCCCTGCAATCAAG
AAAGCAGATATTGGTATTTCTATGAATCTGTCTGGATCTGATGTAACCAAAGATGCTGCA
GACATGGTTTTAATTGATGACGATTTTGCTTCAATTGTTAACGGTGTTGAAGAAGGAAGA
AAAATTTTTGATAACCTGAAAAAAACTGTAGTTTATCTTCTTACTTCTAATATGACTGAA
ATCGTTCCTTTCTTGGCCTTCATTATTCTTTAAATTCCTTTACCTCTCTCAAGTATTTAT
ATGCTCGTCATTTGTGTTGGTACTGATGTTTGGCCAGCTATCTCTCTCGCTTACGAAGAA
GCTGAGCTCGATGTAATGACTAGAAGACCTCGTACTAAGTAGGAGCATTTAGTTTCTAAC
AAATTAATTACTATAGCTTATCTTTAAACAGGTCAAATAGCTAGTGGTGCTGGATTTTTA
GGTTATTACATAGCATTTAACTATTTTGGATTCCCAGTACTTTCTTTGTTCGGTCTAGCT
TCTGCTACTGGTTATAGACCAAGTAAAAATGATTTTGGTACCTATTATAACCCTTTACTT
TAAAGAGACGACCCTTACTATAACTCCAGGTTATATAATATTACATAATTCAAAAATTGT
AAGGATATTGATGTAGAAAGCATCTCGTATACCATAGATTGGTTTACACTAGATGAAGGT
AATTATGATATGAGAAAATCTTTGGTTAAATGTGATCCTGTAACTGGAGCTTTTATTCCT
TGGATTCATTGGAGTGATTGTGATATAAATAAATAATAAAACTGGTCAAAACTAACATCC
TAAACAGCTTGCTACTCGGTAGAAGCTATTAACTATGCTCAGAGTGTTTATTTCTTAACC
GTAGTTTTACTTTAATGGACTAACGTCTTTGCATGTAAAAGTAGATCTACAAGCTTTACA
ACAACAGCATTTAATCCGATTATGATTCACGGTATTATTTTTGAAACATTACTTACCATT
TTCTTATAATATTGTCCGGGAGTTTAAGATGTGTTTGGTGGTAGGCCTATGTTCTTCTGG
TTATGGACAAGTTGCTTAGCATATACTATATTGTTACTTGTCTATGATGAACTAAGAAAG
TTTATGTGTAGAAGATTTAAATGGTATTATAAGTATTGTTATTGGTGA

>TTHERM_00245100(protein)
MSQTNIRQSMNGVRQSTSNIARKFEEMRQSIQLKNSQQEVRQSQQMRRYEGDQDDGNKVA
HYNRELMEDHQPIHTETIMLQGTSSQHDTHQKPSAPADKKEVSKEDQSKQALVEKVDHKI
SLEELKEKYQTDYQKGLTDQQAEHLLRVNGENKLSAKAGVPLWLKLLREMTNGFSIMLWV
SAGLCFLAEGLQPNPSNIYLAVVLIIVILITTAITFQQNAKSEALMNSFKNFIPAKTVVI
RGGDTKSIDAAHLVVGDIVVIRLGEKIPADIRILESNEMKVDNSPLTGESEPLLRTIECS
HPESYLETSNIAFFGTLCKEGTGKGIVIATGDRTMLGQIADLSSGEKKTKTPLRVELDRF
VILITVIAIFLGVLFFLLALLYMKYKFNDCLVFGIGILVANVPEGLLGCITISLAITAKN
LSAKSVLVKNLEAVETLGSTSCICSDKTGTLTQNVMSVKNLWYKDRIYLSKNKVQLKQGE
LPEYDTEDVDFKILQKAAMLSSEARFDTSTVKDQQNIDYLTCPVLGDATETGIIRFYQYI
EDVNTFRNRYQIAKNPDGTFGKMPFNSQVKFALTIIEEQTQDSFYTVYIKGAPEKIWTYC
SSVIVNGRPQNLDQTWQKKFKAVNLTFGKGGERVLGFAKLHLPATKYPHGFTFNVSSLQK
FPFKLADFQFCGLVSLMDPPKTRVPYAILECRSAGVKVVMVTGDQPPTAAAIAKEVNIIP
RDILTNEDLMERDPTLSWWDASKQCEAIIVHGDRITESYEKSLGEQKEEQFYLRSWVVKP
YCVFARTTPAQKLQIVDACQKEGFIVAATGDGVNDSPAIKKADIGISMNLSGSDVTKDAA
DMVLIDDDFASIVNGVEEGRKIFDNLKKTVVYLLTSNMTEIVPFLAFIILQIPLPLSSIY
MLVICVGTDVWPAISLAYEEAELDVMTRRPRTKQEHLVSNKLITIAYLQTGQIASGAGFL
GYYIAFNYFGFPVLSLFGLASATGYRPSKNDFGTYYNPLLQRDDPYYNSRLYNITQFKNC
KDIDVESISYTIDWFTLDEGNYDMRKSLVKCDPVTGAFIPWIHWSDCDINKQQNWSKLTS
QTACYSVEAINYAQSVYFLTVVLLQWTNVFACKSRSTSFTTTAFNPIMIHGIIFETLLTI
FLQYCPGVQDVFGGRPMFFWLWTSCLAYTILLLVYDELRKFMCRRFKWYYKYCYW