Identifiers and Description

Gene Model Identifier

TTHERM_00248390

Standard Name

HAT2 (Histone AcetylTransferase 2)

Aliases

GCN5 | PreTt02535 | 21.m00382

Description

HATA histone acetyltransferase GCN5; Member of the SAGA complex; Histone acetyltransferase; homolog of Saccharomyces cerevisiae GCN5; contains bromodomain; hypothetical protein

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

Biological Process

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:29523178: Saettone A, Garg J, Lambert JP, Nabeel-Shah S, Ponce M, Burtch A, Thuppu Mudalige C, Gingras AC, Pearlman RE, Fillingham J (2018) The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila. Epigenetics & chromatin 11(1):10
  2. Ref:17189264: Morris SA, Rao B, Garcia BA, Hake SB, Diaz RL, Shabanowitz J, Hunt DF, Allis CD, Lieb JD, Strahl BD (2007) Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. The Journal of biological chemistry 282(10):7632-40
  3. Ref:17070031: Couture JF, Trievel RC (2006) Histone-modifying enzymes: encrypting an enigmatic epigenetic code. Current opinion in structural biology 16(6):753-60
  4. Ref:16060659: Zheng Y, Mamdani F, Toptygin D, Brand L, Stivers JT, Cole PA (2005) Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase. Biochemistry 44(31):10501-9
  5. Ref:14536085: Clements A, Poux AN, Lo WS, Pillus L, Berger SL, Marmorstein R (2003) Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Molecular cell 12(2):461-73
  6. Ref:14661947: Poux AN, Marmorstein R (2003) Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates. Biochemistry 42(49):14366-74
  7. Ref:11994311: Langer MR, Fry CJ, Peterson CL, Denu JM (2002) Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases. The Journal of biological chemistry 277(30):27337-44
  8. Ref:11135657: Tan S (2001) One HAT size fits all? Nature structural biology 8(1):8-10
  9. Ref:11112280: Trievel RC, Li FY, Marmorstein R (2000) Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor. Analytical biochemistry 287(2):319-28
  10. Ref:10022893: Ohba R, Steger DJ, Brownell JE, Mizzen CA, Cook RG, Côté J, Workman JL, Allis CD (1999) A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila. Molecular and cellular biology 19(3):2061-8
  11. Ref:10536141: Hettmann C, Soldati D (1999) Cloning and analysis of a Toxoplasma gondii histone acetyltransferase: a novel chromatin remodelling factor in Apicomplexan parasites. Nucleic acids research 27(22):4344-52
  12. Ref:10485713: Rojas JR, Trievel RC, Zhou J, Mo Y, Li X, Berger SL, Allis CD, Marmorstein R (1999) Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide. Nature 401(6748):93-8
  13. Ref:10403255: Lin Y, Fletcher CM, Zhou J, Allis CD, Wagner G (1999) Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A. Nature 400(6739):86-9
  14. Ref:9697775: Utley RT, Ikeda K, Grant PA, Côté J, Steger DJ, Eberharter A, John S, Workman JL (1998) Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature 394(6692):498-502
  15. Ref:9115421: Tsukiyama T, Wu C (1997) Chromatin remodeling and transcription. Current opinion in genetics & development 7(2):182-91
  16. Ref:8601308: Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CD (1996) Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84(6):843-51
  17. Ref:15157517: Roth SY, Allis CD (1996) The subunit-exchange model of histone acetylation. Trends in cell biology 6(10):371-5
  18. Ref:8805705: Kuo MH, Brownell JE, Sobel RE, Ranalli TA, Cook RG, Edmondson DG, Roth SY, Allis CD (1996) Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature 383(6597):269-72
  19. Ref:7603997: Brownell JE, Allis CD (1995) An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei. Proceedings of the National Academy of Sciences of the United States of America 92(14):6364-8
  20. Ref:8034606: Sobel RE, Cook RG, Allis CD (1994) Non-random acetylation of histone H4 by a cytoplasmic histone acetyltransferase as determined by novel methodology. The Journal of biological chemistry 269(28):18576-82

Sequences 

>TTHERM_00248390(coding)
ATGGCTGATTAAGAAAAATCTGCTTAAGATGCATAGAATGCAGCACCATAAGAGACTGCA
TTTGTAGGAATGAATGGTGAAGAAACTGGACTTGGATTTGCAACTCGTGATTAAGGAGCG
AAGGTTGAAGAAGATTAGGGTCTTTTAGATTTTGACATTTTGACTAATGATGGTACTCAT
AGAAACATGAAACTGCTTATAGATTTAAAGAATATTTTCTCTCGTTAGTTGCCAAAAATG
CCTAAAGAATATATTGTTAAATTAGTATTTGATAGACATCATGAATCGATGGTGATATTA
AAGAATAAATAAAAAGTTATTGGTGGTATCTGCTTTCGTTAATATAAGCCTTAAAGATTT
GCAGAAGTAGCTTTCCTTGCTGTCACTGCAAATGAATAGGTTAGAGGGTATGGCACAAGA
TTGATGAATAAATTTAAAGATCATATGTAAAAATAGAATATTGAATATCTTCTCACTTAT
GCTGATAACTTTGCTATTGGATACTTTAAGAAATAAGGTTTTACAAAAGAACATAGAATG
CCATAAGAAAAATGGAAGGGATATATTAAAGATTATGATGGCGGTACTCTTATGGAGTGC
TACATTCACCCATATGTTGATTACGGAAATATATCTCAGATCATCAAAAGATAAAAAGAG
CTTTTGATAGAAAGAATCAAGAAATTATCATTAAATGAAAAAGTATTCTCTGGTAAAGAG
TATGCTGCATTAATATAAAATTCTATGGATAATGAGGATCCTGAAAACCCTAAAGTGAAT
CCTTCAGATATTCCTGGAGTTGCATTTAGTGGTTGGGAGTGGAAAGACTACCATGAACTC
AAGAAATCAAAAGAGAGATCATTCAATCTTTAGTGTGCTAATGTTATTGAAAATATGAAG
AGACACAAACAATCTTGGCCCTTCTTAGATCCTGTTAATAAAGATGATGTTCCAGATTAT
TATGATGTGATTACTGATCCTATAGATATTAAAGCAATAGAAAAGAAGTTATAAAATAAT
CAATATGTTGACAAAGACTAATTTATCAAAGACGTCAAAAGAATTTTTACTAATGCTAAA
ATTTATAACTAGCCCGATACTATATATTATAAAGCTGCTAAAGAATTAGAAGATTTTGTT
GAACCTTATCTTACTAAACTTAAAGATACTAAAGAAAGTAATACTCCATCTAATAATAAT
TCTGCACATGGAAGTAAGAAACCACTTCCTGTTAGAAAAAGTATAAAAAAGAAATGA



>TTHERM_00248390(gene)
AATTTTATCTTTGTTGGATTATAAAATTTAAAATTTTTTGCTACATTAATTTAGTGCGGA
AAATGCGAATACTTTTTAGTATTCAAATCAAAAGCTAAGTAATTACATAAATAGAAATAT
ATTTAATATTATATAGATATATAGATAGATACATAGATTGATTAGTTAATTGATTAAAAG
GATTGTGAATTGCGCCTTAGCTATTTAATAAAAAAGAAATTAAGAATATAGGAGAAGACT
TTTATTATTAGAGTTTTAAATATAATAATAGTTAGTTAAAGCATAAATAGATTAAATTAT
AGGTATATTTAAGCGATAGTTAAAACATAAAAAGTATGGCTGATTAAGAAAAATCTGCTT
AAGATGCATAGAATGCAGCACCATAAGAGACTGCATTTGTAGGAATGAATGGTGAAGAAA
CTGGACTTGGATTTGCAACTCGTGATTAAGGAGCGAAGGTTGAAGAAGATTAGGGTCTTT
TAGATTTTGACATTTTGACTAATGATGGTACTCATAGAAACATGAAACTGCTTATAGATT
TAAAGAATATTTTCTCTCGTTAGTTGCCAAAAATGCCTAAAGAATATATTGTTAAATTAG
TATTTGATAGACATCATGAATCGATGGTGATATTAAAGAATAAATAAAAAGTTATTGGTG
GTATCTGCTTTCGTTAATATAAGCCTTAAAGATTTGCAGAAGTAGCTTTCCTTGCTGTCA
CTGCAAATGAATAGGTTAGAGGGTATGGCACAAGATTGATGAATAAATTTAAAGATCATA
TGTAAAAATAGAATATTGAATATCTTCTCACTTATGCTGATAACTTTGCTATTGGATACT
TTAAGAAATAAGGTTTTACAAAAGAACATAGAATGCCATAAGAAAAATGGAAGGGATATA
TTAAAGATTATGATGGCGGTACTCTTATGGAGTGCTACATTCACCCATATGTTGATTACG
GAAATATATCTCAGATCATCAAAAGATAAAAAGAGCTTTTGATAGAAAGAATCAAGAAAT
TATCATTAAATGAAAAAGTATTCTCTGGTAAAGAGTATGCTGCATTAATATAAAATTCTA
TGGATAATGAGGATCCTGAAAACCCTAAAGTGAATCCTTCAGATATTCCTGGAGTTGCAT
TTAGTGGTTGGGAGTGGAAAGACTACCATGAACTCAAGAAATCAAAAGAGAGATCATTCA
ATCTTTAGTGTGCTAATGTTATTGAAAATATGAAGAGACACAAACAATCTTGGCCCTTCT
TAGATCCTGTTAATAAAGATGATGTTCCAGATTATTATGATGTGATTACTGATCCTATAG
ATATTAAAGCAATAGAAAAGAAGTTATAAAATAATCAATATGTTGACAAAGACTAATTTA
TCAAAGACGTCAAAAGAATTTTTACTAATGCTAAAATTTATAACTAGCCCGATACTATAT
ATTATAAAGCTGCTAAAGAATTAGAAGATTTTGTTGAACCTTATCTTACTAAACTTAAAG
ATACTAAAGAAAGTAATACTCCATCTAATAATAATTCTGCACATGGAAGTAAGAAACCAC
TTCCTGTTAGAAAAAGTATAAAAAAGAAATGAACCATAAAGAAATATTATATTTTATTAT
CATTATTTCTGTAAATATTTATTACTCTTGTAAATTAATTATTATTTTTATAGGAACTTT
CCCTAAACC



>TTHERM_00248390(protein)
MADQEKSAQDAQNAAPQETAFVGMNGEETGLGFATRDQGAKVEEDQGLLDFDILTNDGTH
RNMKLLIDLKNIFSRQLPKMPKEYIVKLVFDRHHESMVILKNKQKVIGGICFRQYKPQRF
AEVAFLAVTANEQVRGYGTRLMNKFKDHMQKQNIEYLLTYADNFAIGYFKKQGFTKEHRM
PQEKWKGYIKDYDGGTLMECYIHPYVDYGNISQIIKRQKELLIERIKKLSLNEKVFSGKE
YAALIQNSMDNEDPENPKVNPSDIPGVAFSGWEWKDYHELKKSKERSFNLQCANVIENMK
RHKQSWPFLDPVNKDDVPDYYDVITDPIDIKAIEKKLQNNQYVDKDQFIKDVKRIFTNAK
IYNQPDTIYYKAAKELEDFVEPYLTKLKDTKESNTPSNNNSAHGSKKPLPVRKSIKKK