Identifiers and Description

Gene Model Identifier

TTHERM_00277550

Standard Name

MCM4 (DNA replication licensing factor MCM4)

Aliases

PreTt04796 | 25.m00260 | 3694.m00047

Description

MCM4 DNA replication licensing factor MCM4 putative; Component of the Mcm2-7 complex involved in DNA replication

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• DNA binding (IEA) | GO:0003677

Biological Process

• DNA replication (IEA) | GO:0006260

Domains

• ( PF00493 ) MCM P-loop domain
• ( PF01078 ) Magnesium chelatase, subunit ChlI
• ( PF06835 ) Lipopolysaccharide-assembly, LptC-related
• ( PF07724 ) AAA domain (Cdc48 subfamily)
• ( PF07726 ) ATPase family associated with various cellular activities (AAA)
• ( PF07728 ) AAA domain (dynein-related subfamily)
• ( PF07946 ) PAT complex subunit CCDC47
• ( PF08792 ) A2L zinc ribbon domain
• ( TIGR00368 ) Mg chelatase homolog

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_1656	0
	Description: None
WormBase	WBGene00003156	9.997093137033517e-262
	Description: locus:mcm-4 status:Confirmed UniProt:Q95XQ8 protein_id:CCD69913.1
Tetrahymena borealis	EI9_08908.1	9.997093137033517e-262
	Description: MCM2/3/5 family protein (806 aa)
DictyBase	DDB_G0275623	9.997093137033517e-262
	Description: mcm4 on chromosome: 2 position 5936245 to 5938905
Oxytricha	Contig21940.0.g54	9.997093137033517e-262
	Description: MCM2/3/5 family
SGD	YPR019W	9.997093137033517e-262
	Description: MCM4 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
WormBase	WBGene00006820	9.997093137033517e-262
	Description: locus:unc-89 Muscle M-line assembly protein unc-89 status:Partially_confirmed UniProt:O01761 protein_id:CCD63864.1
WormBase	WBGene00012925	9.997093137033517e-262
	Description: locus:wht-8 status:Partially_confirmed UniProt:Q9U2D0 protein_id:CAB57891.2

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00277550(coding)
ATGAATCAATCTGTTTCTGGCGAGTAAGGAAAGCAAACTCCTAACACTTCTTTTCAACGT
AGACATTTGTCTCAAAGCATCGGAGGAAACTAATCTTAAAGAATCCTCACCTAACCCTCA
TCTTTCATGCAATCTCCTATGTAGGATGGAACTGCAACTCTTTCTGGTGAAACTGGATAC
ATAAACTGGGGAACAAATATTAATACATAAGAATGTAGTAACAAATTCGAAAAGTTCTTG
TTAGAATTCAAGGCTATTCCTTCTGATGATCATGACATGTTAGATGAAAACGCTAGTGAA
GTTAACATTTATGTTGAAAAATTCAATTAAATGGCTGCTCTTGAATAATACATATTGACA
TTTGATGGCTAACATCTATTGCAGTTTGATAAGATTCTCTACTACCAACTTATTTTCTTC
CCTGCTGAAGTTATTCAAATATTCGATAAAGTAGCACAATCCATTTTTAGAGAACGTTTT
GCTTAGAATGAAACTCAAGTTGAAAAGTCAAACTCAGTCTTAGTTGCTGTAGTCAATATT
AATAAAAGTACCTAACTTAGAGATTTGCGTCATAAGGATATCAACCGTTTAGTTTCCATC
AAGTGTATTGTAATTAGAGTATCAGATATCTATCCTGAAATGAAGATGGCTGTTTTCAAG
TGCAGTAGATGCAGCCATTCAGTTATTGTACCTCTTGAAAGAGCTCATGTTGATGAACCT
AATGATTGCGAAAGTTGTCACACTAAAAACTCTTTCATGATTCAACATAATTTATCTCAC
TTTACTGATAAGTAGTATATAAAGATCTAAGAATTACCAGAAAAAGTGAGGGAAGGTGAA
ACTCCTCAAACTGCTACTTTGATGGCTTATGACAATAATTTAGTTGATCAAGTTAAACCT
GGTGACAGAGTCGAAGTCGTTGGTGTGTTTAGAGCAGCAGGAGTAAGAAAGAATAAAAAT
ATAAGAACCTTGAGATCCGTCTATAACACTTATATCGATGTCGTCTCATACTCTCTTTTA
AGCAAGCAAAAGTTATAAGAAGAAAAAATCAATTTTTCCGAAGAAACCAAAAGAAAGCTT
TAAGAAATTGCTGACAGTGAAAATGTTTATGATAAACTCATTAAATCAGTAGCACCATCT
ATTTGGGAAAATACTGATGTTAAGAGAGGTCTTCTTTGTCAACTTTTCGGTGGTAGTGTT
AAGACTATTCACGATGCTAAAGACAGCAGAACTAGAGCAGAAATCAATTGCTTATTGGTT
GGTGATCCTTCTGTTGCTAAATCCCAAATGCTTAAATACGTTCACAACTTAGTACCCAGA
GGTATTTACACATCTGGTAAAGGTTCTTCTGCAGTAGGTTTGACTGCATACGTAACCAGA
GATCCTGATACTAAAGAAATAGTTCTTGAAAGTGGTGCACTAGTACTTAGTGATCTAGGT
ATTTGTTGTATTGATGAGTTTGACAAGATGGATGAAAATACAAGAACTATTTTACACGAA
GCTATGGAATAATAATCTATTTCTATTGCAAAGGCAGGTATTGTTGCTACTTTGAACACA
AGAACTGCAATTTTGGCTGGTGCTAATCCAATAGATTCCCGTTATGACCCCAAGAAATCA
GTCATCGATAATATAAATCTCCCTCCTTCTTTACTTTCTAGATTTGATTTGATCTATATT
TTATTAGATAATCATGATGAAAGAAAAGATATTTAATTAGCTTCTCATATCTTAAAGCTT
TTCTCTAATTCAAGCTAGCATAGACTTACTCAAGGATAAAATAGTGGATACTCTGATATT
GATATTATTGATAAAGATACACTTATCAAGTATATTGCATATGCTCGTTAAGAAATTCAT
CCCAAACTTACTTAGGAAGCTGCTGACAGACTAGTTTAAGGATATGTTGACATGAGAAAG
GTTGGTTTAAGCAATAAAGTTATTACTTCAACTACCCGTCAACTTGAATCATTAATTCGT
ATTTCAGAATCTTTGGCAAAAATGAAACTAAGTGATTAGGTTACAGTTGAAAATGTAGAA
GAAGCTATCAGATTAATGAAGGTTGCCACACAAAGTGCTGCTACTGACCCTACAACTGGT
CTAATTGATATGGATATGCTTGCAACTGGTATATCAGCTTAAAAGAAATAGAGAATTTTA
GACTTATCAGATTAAATCCGTGGTTTGGCTAAATCCAATTAAGGTGTATTCAAAAAGGGT
ATTTCAGTCCATGAATTGCGTTAATTGTTAGCAAACAAAGAAAATATATAAATAATCAAG
ATCGATGAATAAGAAGTTATATCAGCAGTAAATATGTTAGTAGAAGAAAATTTACTCCTT
AAGATGGGTAATAATAAGAATCCAATTATAAAATTATAAAGTATCGAAGAGTGA

>TTHERM_00277550(gene)
ATGAATCAATCTGTTTCTGGCGAGTAAGGAAAGCAAACTCCTAACACTTCTTTTCAACGT
AGACATTTGTCTCAAAGCATCGGAGGAAACTAATCTTAAAGAATCCTCACCTAACCCTCA
TCTTTCATGCAATCTCCTATGTAGGATGGAACTGCAACTCTTTCTGGTGAAACTGGATAC
ATAAACTGGGGAACAAATATTAATACATAAGAATGTAGTAACAAATTCGAAAAGTTCTTG
TTAGAATTCAAGGCTATTCCTTCTGATGATCATGACATGTTAGATGAAAACGCTAGTGAA
GTTAACATTTATGTTGAAAAATTCAATTAAATGGCTGCTCTTGAATAATACATATTGACA
TTTGATGGCTAACATCTATTGCAGTTTGATAAGATTCTCTACTACCAACTTATTTTCTTC
CCTGCTGAAGTTATTCAAATATTCGATAAAGTAGCACAATCCATTTTTAGAGAACGTTTT
GCTTAGAATGAAACTCAAGTTGAAAAGTCAAACTCAGTCTTAGTTGCTGTAGTCAATATT
AATAAAAGTACCTAACTTAGAGATTTGCGTCATAAGGATATCAACCGTTTAGTTTCCATC
AAGTGTATTGTAATTAGGTAAAAAAATTAATTTATATTTTCATTTTCTTTTTTTTTTTCA
AAGTGCTCTTTAAAACAAATTTTATAACACTAAAATGTTATTTTGTTATAGGATGTTAAA
TAAGCTAAAAAACATTATGAATTTAAAGAAAAGCATTTAAAGTGATATAATGAATAAATG
ATTGAAATCTATCAACATTTTATTTTTACCTTTTTGAAATGGCAAAAAGATATTTTTTTA
TTTAAAGAAATAAAAAGGATATTTTTTTAAGTTGATAGGAGCGAAAATTTTTTAAAAATT
GCAAAAATAAATATGGCAAAAATATTTGTTAACATTGAACTAAAATATAAAATAGAGTAT
CAGATATCTATCCTGAAATGAAGATGGCTGTTTTCAAGTGCAGTAGATGCAGCCATTCAG
TTATTGTACCTCTTGAAAGAGCTCATGTTGATGAACCTAATGATTGCGAAAGTTGTCACA
CTAAAAACTCTTTCATGATTCAACATAATTTATCTCACTTTACTGATAAGTAGTATATAA
AGATCTAAGAATTACCAGAAAAAGTGAGGGAAGGTGAAACTCCTCAAGTAAAAACATCAT
TTTAATTATTTAGTTTTAATCTAAGTTATTTTAATATTAAACAATTAGACTGCTACTTTG
ATGGCTTATGACAATAATTTAGTTGATCAAGTTAAACCTGGTGACAGAGTCGAAGTCGTT
GGTGTGTTTAGAGCAGCAGGAGTAAGAAAGAATAAAAATATAAGAACCTTGAGATCCGTC
TATAACACTTATATCGATGTCGTCTCATACTCTCTTTTAAGCAAGCAAAAGTTATAAGAA
GAAAAAATCAATTTTTCCGAAGAAACCAAAAGAAAGCTTTAAGAAATTGCTGACAGTGAA
AATGTTTATGATAAACTCATTAAATCAGTAGCACCATCTATTTGGGAAAATACTGATGTT
AAGAGAGGTCTTCTTTGTCAACTTTTCGGTGGTAGTGTTAAGACTATTCACGATGCTAAA
GACAGCAGAACTAGAGCAGAAATCAATTGCTTATTGGTTGGTGATCCTTCTGTTGCTAAA
TCCCAAATGCTTAAATACGTTCACAACTTAGTACCCAGAGGTATTTACACATCTGGTAAA
GGTTCTTCTGCAGTAGGTTTGACTGCATACGTAACCAGAGATCCTGATACTAAAGAAATA
GTTCTTGAAAGTGGTGCACTAGTACTTAGTGATCTAGGTATTTGTTGTATTGATGAGTTT
GACAAGATGGATGAAAATACAAGGTATTGCATTATTTCTTTAAATAATAAAAGGACCAAA
TGACAATTAAATCTTTTAAAGCAAATATTATTTAAAATAAGATATAGCATTTAGCAATTA
AAAAAGCAATAATTAGAAGATTTTTTTCAAGTTTTTATAACACATATTTTTTAATTTAAA
TAGAACTATTTTACACGAAGCTATGGAATAATAATCTATTTCTATTGCAAAGGCAGGTAT
TGTTGCTACTTTGAACACAAGAACTGCAATTTTGGCTGGTGCTAATCCAATAGATTCCCG
TTATGACCCCAAGAAATCAGTCATCGATAATATAAATCTCCCTCCTTCTTTACTTTCTAG
ATTTGATTTGATCTATATTTTATTAGATAATCATGATGAAAGAAAAGATATTTAATTAGC
TTCTCATATCTTAAAGCTTTTCTCTAATTCAAGCTAGCATAGACTTACTCAAGGATAAAA
TAGTGGATACTCTGATATTGATATTATTGATAAAGATACACTTATCAAGTATATTGCATA
TGCTCGTTAAGAAATTCATCCCAAACTTACTTAGGAAGCTGCTGACAGACTAGTTTAAGG
ATATGTTGACATGAGAAAGGTTGGTTTAAGCAATAAAGTTATTACTTCAACTACCCGTCA
ACTTGAATCATTAATTCGTATTTCAGAATCTTTGGCAAAAATGAAACTAAGTGATTAGGT
TACAGTTGAAAATGTAGAAGAAGCTATCAGATTAATGAAGGTTGCCACACAAAGTGCTGC
TACTGACCCTACAACTGGTCTAATTGATATGGATATGCTTGCAACTGGTATATCAGCTTA
AAAGAAATAGAGAATTTTAGACTTATCAGATTAAATCCGTGGTTTGGCTAAATCCAATTA
AGGTGTATTCAAAAAGGGTATTTCAGTCCATGAATTGCGTTAATTGTTAGCAAACAAAGA
AAATATATAAATAATCAAGATCGATGAATAAGAAGTTATATCAGCAGTAAATATGTTAGT
AGAAGAAAATTTACTCCTTAAGATGGGTAATAATAAGAATCCAATTATAAAATTATAAAG
TATCGAAGAGTGA

>TTHERM_00277550(protein)
MNQSVSGEQGKQTPNTSFQRRHLSQSIGGNQSQRILTQPSSFMQSPMQDGTATLSGETGY
INWGTNINTQECSNKFEKFLLEFKAIPSDDHDMLDENASEVNIYVEKFNQMAALEQYILT
FDGQHLLQFDKILYYQLIFFPAEVIQIFDKVAQSIFRERFAQNETQVEKSNSVLVAVVNI
NKSTQLRDLRHKDINRLVSIKCIVIRVSDIYPEMKMAVFKCSRCSHSVIVPLERAHVDEP
NDCESCHTKNSFMIQHNLSHFTDKQYIKIQELPEKVREGETPQTATLMAYDNNLVDQVKP
GDRVEVVGVFRAAGVRKNKNIRTLRSVYNTYIDVVSYSLLSKQKLQEEKINFSEETKRKL
QEIADSENVYDKLIKSVAPSIWENTDVKRGLLCQLFGGSVKTIHDAKDSRTRAEINCLLV
GDPSVAKSQMLKYVHNLVPRGIYTSGKGSSAVGLTAYVTRDPDTKEIVLESGALVLSDLG
ICCIDEFDKMDENTRTILHEAMEQQSISIAKAGIVATLNTRTAILAGANPIDSRYDPKKS
VIDNINLPPSLLSRFDLIYILLDNHDERKDIQLASHILKLFSNSSQHRLTQGQNSGYSDI
DIIDKDTLIKYIAYARQEIHPKLTQEAADRLVQGYVDMRKVGLSNKVITSTTRQLESLIR
ISESLAKMKLSDQVTVENVEEAIRLMKVATQSAATDPTTGLIDMDMLATGISAQKKQRIL
DLSDQIRGLAKSNQGVFKKGISVHELRQLLANKENIQIIKIDEQEVISAVNMLVEENLLL
KMGNNKNPIIKLQSIEE