Identifiers and Description

Gene Model Identifier

TTHERM_00283180

Standard Name

HTB2 (Histone h Two B )

Aliases

histone H2B-2 | PreTt04857 | 25.m00321 | 3694.m00104

Description

HTB2 histone H2B.1; Histone H2B; one of the four histones (H2A, H2B, H3 and H4) that comprise the protein core of the eukaryotic nucleosome; differs from Htb1p by three amino acids; Histone H2B

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Biological Process

  • heme A biosynthetic process (IEA) | GO:0006784
  • heme biosynthetic process (IEA) | GO:0006783
  • negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902642
  • negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
  • obsolete extracellular carbohydrate transport (IEA) | GO:0006859
  • ommochrome biosynthetic process (IEA) | GO:0006727
  • positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
  • propan-2-ol biosynthetic process (IEA) | GO:1902640
  • protein localization to old growing cell tip (IEA) | GO:1903858
  • regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (IEA) | GO:1902646
  • regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902641
  • regulation of phosphorus utilization (IEA) | GO:0006795
  • tertiary alcohol biosynthetic process (IEA) | GO:1902645

Domains

  • ( PF00125 ) Core histone H2A/H2B/H3/H4

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

  • ( SD02106 ) Micronucleus: neo2 KO of HTB2 Macronucleus: KO of HTB2 with neo2

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:19822522: Wang Z, Cui B, Gorovsky MA (2009) Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena. The Journal of biological chemistry 284(50):34870-9
  2. Ref:15199121: Medzihradszky KF, Zhang X, Chalkley RJ, Guan S, McFarland MA, Chalmers MJ, Marshall AG, Diaz RL, Allis CD, Burlingame AL (2004) Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS). Molecular & cellular proteomics : MCP 3(9):872-86
  3. Ref:8760889: Liu X, Gorovsky MA (1996) Cloning and characterization of the major histone H2A genes completes the cloning and sequencing of known histone genes of Tetrahymena thermophila. Nucleic acids research 24(15):3023-30
  4. Ref:2713375: Nickel BE, Allis CD, Davie JR (1989) Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatin. Biochemistry 28(3):958-63
  5. Ref:3131141: Brandt WF, de Andrade Rodrigues J, von Holt C (1988) The amino acid sequence of wheat histone H2B(2). A core histone with a novel repetitive N-terminal extension. European journal of biochemistry 173(3):547-54
  6. Ref:3039463: Nomoto M, Imai N, Saiga H, Matsui T, Mita T (1987) Characterization of two types of histone H2B genes from macronuclei of Tetrahymena thermophila. Nucleic acids research 15(14):5681-97
  7. Ref:6818230: Nomoto M, Kyogoku Y, Iwai K (1982) N-Trimethylalanine, a novel blocked N-terminal residue of Tetrahymena histone H2B. Journal of biochemistry 92(5):1675-8
  8. Ref:6804458: Nomoto M, Hayashi H, Iwai K (1982) Tetrahymena histone H2B. Complete amino acid sequence. Journal of biochemistry 91(3):897-904

Sequences 

>TTHERM_00283180(coding)
ATGGCTCCCAAGAAAGCTCCCGCTGCTACTACTGAAAAGAAGGTCAAGAAGGCCCCCACC
ACCGAAAAGAAGAACAAGAAGAAGAGATCAGAAACCTTCGCTATTTATATCTTCAAGGTC
TTAAAGCAAGTCCACCCTGATGTCGGTATTTCCAAGAAGGCTATGAACATTATGAACTCT
TTCATTAACGACTCCTTCGAAAGAATCGCCCTCGAATCTTCCAAGTTAGTCAGATTCAAT
AAGAGAAGAACCCTCTCATCCAGGGAAGTCTAAACTGCCGTCAAGCTCTTATTACCTGGT
GAACTCGCTAGACACGCTATCTCCGAAGGTACCAAGGCCGTCACCAAGTTCTCTTCTTCC
TCCAATTGA



>TTHERM_00283180(gene)
AAATTAATAAAAAAGCATTAAAATGGCTCCCAAGAAAGCTCCCGCTGCTACTACTGAAAA
GAAGGTCAAGAAGGCCCCCACCACCGAAAAGAAGAACAAGAAGAAGAGATCAGAAACCTT
CGCTATTTATATCTTCAAGGTCTTAAAGCAAGTCCACCCTGATGTCGGTATTTCCAAGAA
GGCTATGAACATTATGAACTCTTTCATTAACGACTCCTTCGAAAGAATCGCCCTCGAATC
TTCCAAGTTAGTCAGATTCAATAAGAGAAGAACCCTCTCATCCAGGGAAGTCTAAACTGC
CGTCAAGCTCTTATTACCTGGTGAACTCGCTAGACACGCTATCTCCGAAGGTACCAAGGC
CGTCACCAAGTTCTCTTCTTCCTCCAATTGAGAAAACAAACTTAAAGCTAAATATTTTGC
CTTTGCTTCAATTCTTCTCTTTAATCTTGAAGTTTTATGCAGCAATAGGTCAAAATATTC
GTTTTGCAGATCTCTAAATAAACATAAATTAATTAATTTATTAGGAATAGTAAACAATTT
CACATGTTAATTAATGTGTTTATGTCAGCGTATGAAATTTTATTATAATTCGAGTTGGTG
TGTTCAAAAATCTCTCTATATGTCTTTTCAATATTTCTTCTTCTTTTATTATTATATAAA
AATGAGCTCCTAATTTAACCATACAGTTATCTATGCTCATTAAAAATTATTTTAATTTTT
AGTTAATAAACTTGTATAAATTTATAAGTTAAATTAAATTTAAAAAAAGCATAAATCTTA
CTAAACAAACT



>TTHERM_00283180(protein)
MAPKKAPAATTEKKVKKAPTTEKKNKKKRSETFAIYIFKVLKQVHPDVGISKKAMNIMNS
FINDSFERIALESSKLVRFNKRRTLSSREVQTAVKLLLPGELARHAISEGTKAVTKFSSS
SN