Identifiers and Description

Gene Model Identifier

TTHERM_00284020

Standard Name

TTLL6A (Tubulin Tyrosine Ligase-Like )

Aliases

PreTt04940 | 25.m00404 | 3694.m00187

Description

TTLL6A tubulin-tyrosine ligase family protein; Beta-tubulin polyglutamylase; Tubulin-tyrosine ligase/Tubulin polyglutamylase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (IEA) | GO:0008413
• acid-amino acid ligase activity (IMP) | GO:0016881
• axon guidance receptor activity (IEA) | GO:0008046
• glucan 1,4-alpha-maltotetraohydrolase activity (IEA) | GO:0033910
• L-ribulose-5-phosphate 3-epimerase activity (IEA) | GO:0034015
• obsolete sodium-transporting two-sector ATPase activity (IEA) | GO:0015443
• phosphatidylserine decarboxylase activity (IEA) | GO:0004609
• R-linalool synthase activity (IEA) | GO:0034008
• sphingomyelin phosphodiesterase activity (IEA) | GO:0004767
• titin binding (IEA) | GO:0031432

Biological Process

• 3-keto-sphinganine metabolic process (IEA) | GO:0006666
• cell wall modification involved in fruit ripening (IEA) | GO:0009829
• negative regulation of complement-dependent cytotoxicity (IEA) | GO:1903660
• negative regulation of epithelial cell-cell adhesion involved in epithelium migration (IEA) | GO:1903682
• negative regulation of fractalkine production (IEA) | GO:0032684
• negative regulation of hepatocyte growth factor production (IEA) | GO:0032686
• neutral lipid metabolic process (IEA) | GO:0006638
• photosynthesis, light harvesting in photosystem I (IEA) | GO:0009768
• plant-type cell wall modification (IEA) | GO:0009827
• positive regulation of peroxisome proliferator activated receptor signaling pathway (IEA) | GO:0035360
• positive regulation of response to water deprivation (IEA) | GO:1902584
• positive regulation of wound healing, spreading of epidermal cells (IEA) | GO:1903691
• priming of cellular response to stress (IEA) | GO:0080136
• protein polyglutamylation (ISS) | GO:0018095
• regulation of complement-dependent cytotoxicity (IEA) | GO:1903659
• regulation of L-arginine import into cell (IEA) | GO:1902826
• regulation of TRAIL production (IEA) | GO:0032679

Domains

• ( PF03133 ) Tubulin-tyrosine ligase family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15890843: Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B (2005) Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science (New York, N.Y.) 308(5729):1758-62

Sequences

>TTHERM_00284020(coding)
ATGTTCATGAAAAAGTTGTAGATAATAATTAAAAATTAAACATTCAGTAAAATAATATTA
ACGATTATTAAGAGGACATTAAAAAGGACTAATCAAATAATTTAGTTGATATACAATAAA
ATAATGAAATTATTAAAGAAGTTAATAGTGAGGATTAATAATAAAAAAATGAGATGGATA
ATAAATAAAGTGATATAGTACTAGCTTAAGAGGAGAGCAAGCAAAGTGAATAGGTTGAAG
CTCCTATCGTAAAATAAAAAAAAATAGAATTGCGTCCTAAGGTTATTTATGATCCTAAAA
ATGATGTTGATTAATATACAGGAGACTATTCTGATTCAGGAGAAAGTGATGAAGAAGCAA
ACAACGAAGATGATGACGAAGATGAAGATGATGAATCAGAAAATGAATCTAGAAGCAGAA
AAAATAAAGCCTAGTTGTTAAAAAAAAAGAATAATAAGAAAGAATACAAAATATCCTGTT
GTGAAATTTGTGGGTAAAAAAATATTTAAATGGAAATTAGCCTATGACATGGAATCTATG
GATTTTGATATCTTTTGGACTGATAATGCTGTTTAACCAGAATAGCTAGGACGTATGCAG
CCATATTAAAAAATCAATCACTTTCCTGGTATGTTTTCTTTAGCAAGAAAAAATCACTTA
GCTAGAAATCTTATGAAAATGCGTAAGTAATTTCCTGATTAGTATAAATTTTTCCCGTAA
ACTTGGCTTCTTCCTGCTGAATACAATGATTTTAAAAACTAATTTGAAAAGAGCAGATCC
TAATAAAAAATATTTATAGTTAAACCTGAAGCTAGTTGTTAAGGCAGAGGTATTTTCCTA
ACTCGAAGTCTAGATGACTTAAATCCTTCAGATCATTATGTTGTATAAAGGTATTTAAAT
AAGCCATATTTAATTGATGGTTTGAAGTTCGATTTCAGACTATACGTCTTACTAGCTGGG
TGTGATCCTCTTAGAATTTATTTATATTACGAGGGTTTAACTCGTTTTGCTACTGAAAAA
TATTAAGAAGTAAATAGAGATAATATAGAAGATATGTGTATGCATTTAACAAACTATGCT
ATCAATAAAGATAATCCTAATTTCAAATTCAATAAAGACAAAGAAAAAATGGATGTTGGA
CACAAAAGATCTCTCACTTCTGTTTTACAGCTTCTTGAAGACTAGGGTCATGATGTTAAC
AAGCTGTGGAAAGATATTAAGAGGGTTTTAATTAAAACAATTATTAGTGCTTAGCCAACA
TTAGCTCATCATTACAAAAGCTGCTAGCCTGATAATTTTATGAATAATATGTGTTTCGAA
ATATTAGGATTTGATATTATATTGGATAGCCATTTGAAGCCATGGGTTTTAGAAGTTAAT
CACACGCCAAGCTTTTCCACTGATACTCCACTTGATAGTTACATCAAAAAGAACACAATT
AGGGACTCATTAAAATTGATGAATTGTACTTGTAAAGCAAAAAATGAGATTATAAATTAA
AGAAAGGAAATAATGTAAAAAAGAGTTTTGACTGGTAAAAAAGTGAAGTACACACCTGAA
GAAAAGCTAGAAGAAATAAAAAAAGCATAATAAAAAAGAGATGAATATGAAGATAAACAT
TTAGGGGGATTTGAAAGAATTTTTCCTATGGAAGATGATGAAGATGATAATTTTACTGAG
TATATGTAATATGCATTAAAGTGTTATGAAGAACAAACTGGAGCAAATATTAGAAGAAAT
ACAAAAAAGGTCACTGAAGATCCTAAAAAAATAACAAATTAACCAAAAAAGCTAAATCAA
CCAAAAGATTTAGAAAAAATTTATAATACAAAAATAGGAGCTAAACTACCTCCTCGTAAG
CCTAATTCTTAGACTACTATTAATAAAGGAATACCCGGTTAAAATGGATAGCGTCCAAGC
TCTTCTTAATTAAACGAAGAAGGTGAAACTATTCAATGCGAAGACCAAGAATAAAATAAA
GATGAAGCTATTGAAAACGCTATCACAAGATCAGCTAGTGGAAGAATGCATGATTTTAGG
ATTAAAAAATAAAATTCTCCATATAATATACACCAAAAATTCAAAAATAAAATATAAAAC
AGAGTAGCAATAGGAGTCAAAGAATTGAAGCTAGCAGAAGAACCTTTCCAATTTGAAGAA
AATATAAATGGCAAACCATCTAATCCAAATGTCAAAAAGATCTAAGCGTATATCACCTCA
GAAAAGGAGCAATTAGAAATAAAAAACATGAATATTCTTTAAGATTAAAATTATAATTCC
TCTAGAGCAGTTTAAGCTAAAAAGCCATAAATAGAGCCATAAGTATTATTTGTATAAGAA
CCTCAAACTAAAAAGCTTTAAATTCTCAATTAAGCAAAACCACCCTAACAAAAATTATAA
TTTTAATTAATTGATAATACAGCTGCTTAAATGGAAGAAGAAAGGAGATAATGGCTTATA
CAAGCTTAAAGAAATTTATAATATCAGCTATCTTAACAATAATACTAACCTTAATAAAAG
CTGACATTACTTCCAAAAGGACCACCTATACATCCTTAAACAAATGTAATGCAATCTATT
GCAGATATTCCTAATAGTTCTAATAGTAAGGAAATACTAGCAGCTGTTGGAGGAGCTATT
TCTGGATAATATAAAACTGATAAACGAGTGACAATAAAATAAAAGGGGTAGATATAGAAT
TAAAGTATAAATTAACTCAAGGATAATAATGGCTTGTTTTTACAACCAAAACTTTTTGAA
ATTCAAAGCTTTTAATCTAGTTAGCAGTAATAAGCATAATAAGCTATACAAAGCAGCCTG
GATTAAAATTTAATTGGAATAAATTAGAATATGGTTGGGCTAAATGATCTTTTTGTCTCA
GGTAAAAGCCATAAAGTATAACCTCATTATTAAGCATAATAAGATTCATATAGTTACCAA
AAGCATAATAGCTATAGTAATTACTATCAAAAATGA

>TTHERM_00284020(gene)
TTTTTACAATTATTTATAAATCAATCACTACTTATTTTACAAGAATCTCATGATTTGAGA
TATCAACTTAAATTTAAGCAAAAAATCTACCCTTAATAAAGAAAGCTATCTATAACTACA
AATAACAATTATTTATTACTTTCAATCATAATTTTTCAAACTTATTATTTTTAAAAATTT
TACACTGCATTAAAAATAGGCAAAAAAGATGTCATAGAAAGATATATATAATAAATATTC
AAATTAAAGCGCAGACGACCAATAAGAGGAAGATGATGATGAGAATTAAGAATCATCATG
CCAATTAAGTCCAGAAAAAGATTTAGGAGAATCATTATAAGGCGAAGACTTGGATGAAGA
TTAAGGAGTTATAGGCGAAGATGATGAAGAATAAGAAGAATCTTATGATGAGGAAGACGA
AGAAGAAGATGATGAAGAAAATAATTAAGATTAATAAAATAATTCAGAATCCAATTTATA
GTATGACAAAACAAACCAGAAGAATTAGTAAACTGAGATGACTGACAACTAAAATGAATT
TTTAGCAGAAGACTATTTAAGTTAAATAAAAACAAATGAAAAAAGCGAATTAAAATATCA
ACTTGACATTTAAAGTAACTTGTCTGGTGAAAATGTATAAGATATGGATGAAAAACTTAA
ACAATATATAGAATTAAATGGAAAAAATGAAAATTAATAAGCTGCAGAAAGTAAAAAAAT
TGAAAATGATGAAATTATGAAGAAATCAGAGGAAAATGTTCATGAAAAAGTTGTAGATAA
TAATTAAAAATTAAACATTCAGTAAAATAATATTAACGATTATTAAGAGGACATTAAAAA
GGACTAATCAAATAATTTAGTTGATATACAATAAAATAATGAAATTATTAAAGAAGTTAA
TAGTGAGGATTAATAATAAAAAAATGAGATGGATAATAAATAAAGTGATATAGTACTAGC
TTAAGAGGAGAGCAAGCAAAGTGAATAGGTTGAAGCTCCTATCGTAAAATAAAAAAAAAT
AGAATTGCGTCCTAAGGTTATTTATGATCCTAAAAATGATGTTGATTAATATACAGGAGA
CTATTCTGATTCAGGAGAAAGTGATGAAGAAGCAAACAACGAAGATGATGACGAAGATGA
AGATGATGAATCAGAAAATGAATCTAGAAGCAGAAAAAATAAAGCCTAGTTGTTAAAAAA
AAAGAATAATAAGAAAGAATACAAAATATCCTGTTGTGAAATTTGTGGGTAAAAAAATAT
TTAAATGGAAATTAGCCTATGACATGGAATCTATGGATTTTGATATCTTTTGGACTGATA
ATGCTGTTTAACCAGAATAGCTAGGACGTATGCAGCCATATTAAAAAATCAATCACTTTC
CTGGTATGTTTTCTTTAGCAAGAAAAAATCACTTAGCTAGAAATCTTATGAAAATGCGTA
AGTAATTTCCTGATTAGTATAAATTTTTCCCGTAAACTTGGCTTCTTCCTGCTGAATACA
ATGATTTTAAAAACTAATTTGAAAAGAGCAGATCCTAATAAAAAATATTTATAGTTAAAC
CTGAAGCTAGTTGTTAAGGCAGAGGTATTTTCCTAACTCGAAGTCTAGATGACTTAAATC
CTTCAGATCATTATGTTGTATAAAGGTATTTAAATAAGCCATATTTAATTGATGGTTTGA
AGTTCGATTTCAGACTATACGTCTTACTAGCTGGGTGTGATCCTCTTAGAATTTATTTAT
ATTACGAGGGTTTAACTCGTTTTGCTACTGAAAAATATTAAGAAGTAAATAGAGATAATA
TAGAAGATATGTGTATGCATTTAACAAACTATGCTATCAATAAAGATAATCCTAATTTCA
AATTCAATAAAGACAAAGAAAAAATGGATGTTGGACACAAAAGATCTCTCACTTCTGTTT
TACAGCTTCTTGAAGACTAGGGTCATGATGTTAACAAGCTGTGGAAAGATATTAAGAGGG
TTTTAATTAAAACAATTATTAGTGCTTAGCCAACATTAGCTCATCATTACAAAAGCTGCT
AGCCTGATAATTTTATGAATAATATGTGTTTCGAAATATTAGGATTTGATATTATATTGG
ATAGCCATTTGAAGCCATGGGTTTTAGAAGTTAATCACACGCCAAGCTTTTCCACTGATA
CTCCACTTGATAGTTACATCAAAAAGAACACAATTAGGGACTCATTAAAATTGATGAATT
GTACTTGTAAAGCAAAAAATGAGATTATAAATTAAAGAAAGGAAATAATGTAAAAAAGAG
TTTTGACTGGTAAAAAAGTGAAGTACACACCTGAAGAAAAGCTAGAAGAAATAAAAAAAG
CATAATAAAAAAGAGATGAATATGAAGATAAACATTTAGGGGGATTTGAAAGAATTTTTC
CTATGGAAGATGATGAAGATGATAATTTTACTGAGTATATGTAATATGCATTAAAGTGTT
ATGAAGAACAAACTGGAGCAAATATTAGAAGAAATACAAAAAAGGTCACTGAAGATCCTA
AAAAAATAACAAATTAACCAAAAAAGCTAAATCAACCAAAAGATTTAGAAAAAATTTATA
ATACAAAAATAGGAGCTAAACTACCTCCTCGTAAGCCTAATTCTTAGACTACTATTAATA
AAGGAATACCCGGTTAAAATGGATAGCGTCCAAGCTCTTCTTAATTAAACGAAGAAGGTG
AAACTATTCAATGCGAAGACCAAGAATAAAATAAAGATGAAGCTATTGAAAACGCTATCA
CAAGATCAGCTAGTGGAAGAATGCATGATTTTAGGATTAAAAAATAAAATTCTCCATATA
ATATACACCAAAAATTCAAAAATAAAATATAAAACAGAGTAGCAATAGGAGTCAAAGAAT
TGAAGCTAGCAGAAGAACCTTTCCAATTTGAAGAAAATATAAATGGCAAACCATCTAATC
CAAATGTCAAAAAGATCTAAGCGTATATCACCTCAGAAAAGGAGCAATTAGAAATAAAAA
ACATGAATATTCTTTAAGATTAAAATTATAATTCCTCTAGAGCAGTTTAAGCTAAAAAGC
CATAAATAGAGCCATAAGTATTATTTGTATAAGAACCTCAAACTAAAAAGCTTTAAATTC
TCAATTAAGCAAAACCACCCTAACAAAAATTATAATTTTAATTAATTGATAATACAGCTG
CTTAAATGGAAGAAGAAAGGAGATAATGGCTTATACAAGCTTAAAGAAATTTATAATATC
AGCTATCTTAACAATAATACTAACCTTAATAAAAGCTGACATTACTTCCAAAAGGACCAC
CTATACATCCTTAAACAAATGTAATGCAATCTATTGCAGATATTCCTAATAGTTCTAATA
GTAAGGAAATACTAGCAGCTGTTGGAGGAGCTATTTCTGGATAATATAAAACTGATAAAC
GAGTGACAATAAAATAAAAGGGGTAGATATAGAATTAAAGTATAAATTAACTCAAGGATA
ATAATGGCTTGTTTTTACAACCAAAACTTTTTGAAATTCAAAGCTTTTAATCTAGTTAGC
AGTAATAAGCATAATAAGCTATACAAAGCAGCCTGGATTAAAATTTAATTGGAATAAATT
AGAATATGGTTGGGCTAAATGATCTTTTTGTCTCAGGTAAAAGCCATAAAGTATAACCTC
ATTATTAAGCATAATAAGATTCATATAGTTACCAAAAGCATAATAGCTATAGTAATTACT
ATCAAAAATGAATAATATTTAAGTATAATCTATTTATTTATTTATAACCTTAATTTATTA
AAAATCATTTTTATCAAGCTGTTAGTTAACCTCAAAAAACTTTATGATTAAGAAAAAAAT
ATTTTAATCGCTAA

>TTHERM_00284020(protein)
MFMKKLQIIIKNQTFSKIILTIIKRTLKRTNQIIQLIYNKIMKLLKKLIVRINNKKMRWI
INKVIQYQLKRRASKVNRLKLLSQNKKKQNCVLRLFMILKMMLINIQETILIQEKVMKKQ
TTKMMTKMKMMNQKMNLEAEKIKPSCQKKRIIRKNTKYPVVKFVGKKIFKWKLAYDMESM
DFDIFWTDNAVQPEQLGRMQPYQKINHFPGMFSLARKNHLARNLMKMRKQFPDQYKFFPQ
TWLLPAEYNDFKNQFEKSRSQQKIFIVKPEASCQGRGIFLTRSLDDLNPSDHYVVQRYLN
KPYLIDGLKFDFRLYVLLAGCDPLRIYLYYEGLTRFATEKYQEVNRDNIEDMCMHLTNYA
INKDNPNFKFNKDKEKMDVGHKRSLTSVLQLLEDQGHDVNKLWKDIKRVLIKTIISAQPT
LAHHYKSCQPDNFMNNMCFEILGFDIILDSHLKPWVLEVNHTPSFSTDTPLDSYIKKNTI
RDSLKLMNCTCKAKNEIINQRKEIMQKRVLTGKKVKYTPEEKLEEIKKAQQKRDEYEDKH
LGGFERIFPMEDDEDDNFTEYMQYALKCYEEQTGANIRRNTKKVTEDPKKITNQPKKLNQ
PKDLEKIYNTKIGAKLPPRKPNSQTTINKGIPGQNGQRPSSSQLNEEGETIQCEDQEQNK
DEAIENAITRSASGRMHDFRIKKQNSPYNIHQKFKNKIQNRVAIGVKELKLAEEPFQFEE
NINGKPSNPNVKKIQAYITSEKEQLEIKNMNILQDQNYNSSRAVQAKKPQIEPQVLFVQE
PQTKKLQILNQAKPPQQKLQFQLIDNTAAQMEEERRQWLIQAQRNLQYQLSQQQYQPQQK
LTLLPKGPPIHPQTNVMQSIADIPNSSNSKEILAAVGGAISGQYKTDKRVTIKQKGQIQN
QSINQLKDNNGLFLQPKLFEIQSFQSSQQQQAQQAIQSSLDQNLIGINQNMVGLNDLFVS
GKSHKVQPHYQAQQDSYSYQKHNSYSNYYQK