Identifiers and Description

Gene Model Identifier

TTHERM_00286770

Standard Name

CDK4 (Cyclin Dependent Kinase 4)

Aliases

PreTt25907 | 26.m00259 | 3688.m00054

Description

cyclin-dependent kinase-like Serine/Threonine kinase family protein; Protein kinase domain containing protein. Sequence similarity to the CDC2 subfamily of the protein kinase CDK family

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein kinase activity (IEA) | GO:0004672
• protein tyrosine kinase activity (IEA) | GO:0004713

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) Protein kinase domain
• ( PF07714 ) Protein tyrosine and serine/threonine kinase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_09291.1	9.997093137033517e-262
	Description: protein kinase domain-containing protein (307 aa)
Tetrahymena borealis	EI9_04739.1	9.997093137033517e-262
	Description: tubulin-tyrosine ligase (1106 aa)
Oxytricha	Contig5189.0.g91	3.0006488705143073e-92
	Description: Protein kinase domain
SGD	YBR160W	5.0019535966450705e-92
	Description: CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
DictyBase	DDB_G0288677	1.999022616705709e-90
	Description: cdk5 on chromosome: 5 position 1885785 to 1886770
WormBase	WBGene00000405	8.997107083354175e-87
	Description: locus:cdk-1 Cyclin-dependent kinase 1 status:Confirmed UniProt:P34556 protein_id:CAA81590.1
Stentor Coeruleus	SteCoe_7783	2.031092662734811e-42
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences

>TTHERM_00286770(coding)
ATGCTTACTTATTAAAACTTTTAGACTAGATATGTATAGCTAGAAAAATTAGGTGAAGGA
ACTTATGGAGTTGTATTTAAGGCATAAGATATGTAGACATAATAATTAGTAGCTATAAAA
TAGATTAGAATAGACCCTAATGAAGATGAAGGAGTTCCTTCGACTACATTAAGAGAAATA
TCAATTTTGAAGAAGTTAAAACATAAAAATATTGTAAAACTGCTTGATGTTTATGTTTTC
CCTGAAGCTTAAAAAGTATCTTTAGTTTTTGAATATTATCCATAAGATTTAAGAGGCTAC
TTGAAACAGTTGCAACAAAAAAATTAGAAAGAGATCCCTTTAAGCTTCTATTAAAATTAA
TTTAGATAAATAATAGAAGGTGTTGATTATTGTCACTCTTAAGGTATCTTGCATCGTGAT
TTAAAGCCATAAAATATTCTAGTAAGTTCAACTGGAGAAATTAAAATAGCAGATTTTGGA
TTGGCAAGAGCTTTTAACTACCCACTAAAAGAATTAACTAAAGATATAGTCACACTTTGG
TATCGTTCCACAGAACTGTTATTAGGTGAGTCATAATATGATATAGCTATTGATATGTGG
TCAGTTGGATGCATTTTAGCAGAATTTGTTACTTTCAAACCACTCTTCATGGGTGACTCA
TAAATTGATTAACTATTTAAAATATTCTAATTTTCTGGAACACCTAATGGGGTTATTTGG
CCAAATGTTAAGAAGTATATAGATTTTAAGTAGACATTCCCTAAGTTTTTGCCTTCAAAC
ACTTTAAGAATAGATCCAAGATTCAAAGAGTAAATTAGAAATGAAGGAATCGAACTTATA
GAAAGTTTACTTCAAATAGTACCAGAAAAGCGTTTAAATTCAGATGAAGCTCTCAAAGCG
CCTTTCTTCAAGTTAACTTAATGA

>TTHERM_00286770(gene)
ATGCTTACTTATTAAAACTTTTAGACTAGATATGTATAGCTAGAAAAATTAGGTGAAGGA
ACTTATGGAGTTGTATTTAAGGCATAAGATATGTAGACATAATAATTAGTAGCTATAAAA
TAGATTAGAATAGACCCTAATGAAGATGAAGGAGTTCCTTCGACTACATTAAGAGAAATA
TCAATTTTGAAGAAGTTAAAACATAAAAATATTGTAAAACTGCTTGATGTTTATGTTTTC
CCTGAAGCTTAAAAAGTATCTTTAGTTTTTGAATATTATCCGTAAAATTAGCTTCATTTT
TTGCAGCAATTTTTTTTATTTAAAATCACATTTTTATATCATATTTAAAAAATAGATAAG
ATTTAAGAGGCTACTTGAAACAGTTGCAACAAAAAAATTAGAAAGAGATCCCTTTAAGCT
TCTATTAAAATTAATTTAGATAAATAATAGAAGGTGTTGATTATTGTCACTCTTAAGGTA
TCTTGCATCGTGATTTAAAGCCATAAAATATTCTAGTAAGTTCAACTGGAGAAATTAAAA
TAGCAGATTTTGGATTGGCAAGAGCTTTTAACTACCCACTAAAAGAATTAACTAAAGATA
TAGTCACACTTTGGTATCGTTCCACAGAACTGTTATTAGGTAAAGTTTGTTTTAAATCTT
TTTCAAGTCAAATAAATATGAAAAATATTAAATACAAAGTCTTAAAAATAGCATATTTGA
TTATTAAAATAAAATTAAATGAATGTTCTCATAACAAAATAATTATGAAATAGGTGAGTC
ATAATATGATATAGCTATTGATATGTGGTCAGTTGGATGCATTTTAGCAGAATTTGTTAC
TTTCAAACCACTCTTCATGGGTGACTCATAAATTGATTAACTATTTAAAATATTCTAATT
TTCTGGAACACCTAATGGGGTTATTTGGCCAAATGTTAAGAAGTATATAGATTTTAAGTA
GACATTCCCTAAGTTTTTGCCTTCAAACACTTTAAGAATAGATCCAAGATTCAAAGAGTA
AATTAGAAATGAAGGAATCGAACTTATAGAAAGTTTACTTCAAATAGTACCAGAAAAGCG
TTTAAATTCAGATGAAGCTCTCAAAGCGCCTTTCTTCAAGTTAACTTAATGA

>TTHERM_00286770(protein)
MLTYQNFQTRYVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNEDEGVPSTTLREI
SILKKLKHKNIVKLLDVYVFPEAQKVSLVFEYYPQDLRGYLKQLQQKNQKEIPLSFYQNQ
FRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELTKDIVTLW
YRSTELLLGESQYDIAIDMWSVGCILAEFVTFKPLFMGDSQIDQLFKIFQFSGTPNGVIW
PNVKKYIDFKQTFPKFLPSNTLRIDPRFKEQIRNEGIELIESLLQIVPEKRLNSDEALKA
PFFKLTQ