Identifiers and Description

Gene Model Identifier

TTHERM_00292170

Standard Name

ERF1 (Eukaryotic Release Factor 1)

Aliases

PreTt26050 | 26.m00402 | 3688.m00193

Description

ERF1 eukaryotic peptide chain release factor subunit 1; Eukaryotic release factor; believed to recognize the stop codon of mRNA and terminate translation; gene has 4 introns; deduced protein sequence 57% similar to human eRF1; domain 1 proposed to be the codon recognition site; Peptide chain release factor eRF1/aRF1

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

  • translation release factor activity, codon specific (IGI) | GO:0016149

Biological Process

Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:16382136: Salas-Marco J, Fan-Minogue H, Kallmeyer AK, Klobutcher LA, Farabaugh PJ, Bedwell DM (2006) Distinct paths to stop codon reassignment by the variant-code organisms Tetrahymena and Euplotes. Molecular and cellular biology 26(2):438-47
  2. Ref:12084909: Ito K, Frolova L, Seit-Nebi A, Karamyshev A, Kisselev L, Nakamura Y (2002) Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within domain 1. Proceedings of the National Academy of Sciences of the United States of America 99(13):8494-9
  3. Ref:11788716: Inagaki Y, et al. (2002) Convergence and constraint in eukaryotic release factor 1 (eRF1) domain 1: the evolution of stop codon specificity. Nucleic Acids Res 30(2):532-44
  4. Ref:11163755: Muramatsu T, Heckmann K, Kitanaka C, Kuchino Y (2001) Molecular mechanism of stop codon recognition by eRF1: a wobble hypothesis for peptide anticodons. FEBS letters 488(3):105-9
  5. Ref:11762076: Muramatsu T (2001) [Molecular mechanism of stop codon recognition by eRF1: a wobble hypothesis for peptide anticodons]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 46(15):2163-70
  6. Ref:11231122: Lozupone CA, Knight RD, Landweber LF (2001) The molecular basis of nuclear genetic code change in ciliates. Current biology : CB 11(2):65-74
  7. Ref:11179680: Liang A, Brünen-Nieweler C, Muramatsu T, Kuchino Y, Beier H, Heckmann K (2001) The ciliate Euplotes octocarinatus expresses two polypeptide release factors of the type eRF1. Gene 262(1-2):161-8
  8. Ref:11160924: Inagaki Y, Doolittle WF (2001) Class I release factors in ciliates with variant genetic codes. Nucleic acids research 29(4):921-7
  9. Ref:10648963: Karamyshev AL, Karamysheva ZN, Ito K, Matsufuji S, Nakamura Y (1999) Overexpression and purification of recombinant eRF1 proteins of rabbit and Tetrahymena thermophila. Biochemistry. Biokhimiia 64(12):1391-400
  10. Ref:10471834: Karamyshev AL, Ito K, Nakamura Y (1999) Polypeptide release factor eRF1 from Tetrahymena thermophila: cDNA cloning, purification and complex formation with yeast eRF3. FEBS letters 457(3):483-8
  11. Ref:1160924: Urbanek R, et al. (1975) [Hypophosphataemia as early sign of septicaemia in childhood (author's transl)] Monatsschr Kinderheilkd 123(8):593-7

Sequences 

>TTHERM_00292170(coding)
ATGGAAGAGAAAGATCAACGTTAAAGAAATATTGAACATTTTAAGATCAAGAAATTGATG
ACAAGACTTAGAAACACTAGAGGTTCTGGTACTTCTATGGTTTCTTTGATTATTCCTCCT
AAGAAGTAAATTAACGATTCCACAAAGTTAATCAGTGATGAATTCAGTAAGGCCACTAAT
ATTAAAGACAGAGTCAACCGTTAATCTGTACAAGATGCAATGGTTTCCGCCTTACAAAGA
TTAAAATTATATCAAAGAACTCCCAATAATGGTTTGATTCTTTATTGCGGTAAGGTTCTT
AACGAAGAAGGAAAAGAAATTAAGCTTTTGATCGATTTCGAACCCTACAAGCCCATCAAC
ACCTCTCTTTATTTCTGTGACAGTAAGTTCCACGTTGATGAATTGGGTTCACTTCTTGAA
ACCGACCCTCCTTTTGGTTTCATCGTTATGGATGGTCAAGGTGCTCTCTATGCCAATCTC
CAAGGAAATACAAAGACAGTTTTAAATAAATTCTCAGTCGAATTGCCCAAGAAGCACGGT
AGAGGTGGTCAATCATCAGTTCGTTTTGCACGTCTTAGAGTTGAAAAGAGACACAACTAT
CTTAGAAAGGTTTGTGAAGTCGCCACTTAAACTTTCATTTCCCAAGATAAAATTAATGTT
TAAGGTTTAGTCTTAGCTGGTTCTGGTGATTTCAAGAATGAATTGAGTACTACATAGATG
TTCGACCCTCGTCTTGCTTGCAAGATTATCAAGATTGTTGATGTTTCTTATGGTGGTGAA
AATGGTCTTAACCAAGCTATTGAACTCGCTTAAGAATCTTTAACTAACGTCAAGTTCGTT
TAAGAAAAGAACGTTATCTCCAAATTCTTCGATTGCATCGCTATTGACTCCGGTACCGTT
GTCTATGGTGTTCAAGATACTATGTAACTCTTATTAGATGGTGTTATTGAAAACATTCTT
TGTTTCGAAGAACTCACTACCTTGAGAGTCACTCGTAAAAATAAAGTCACAGAATAAATC
ACTCATATATTCATTCCTCCTAATGAATTAAATAATCCTAAGCATTTCAAGGATGGTGAA
CATGAACTTGAAAAGATTGAAGTTGAAAACTTAACTGAATGGTTAGCTGAACACTACAGT
GAATTCGGTGCTGAACTTTACTTTATTACTGATAAATCTGCTGAAGGTTGCCAATTTGTC
AAAGGTTTCTCTGGTATTGGTGGTTTCTTAAGATATAAGGTCGATTTAGAACATATTGTT
AACCCTAATGACGAATACAACTACGAAGAAGAAGAAGGCTTCATATGA



>TTHERM_00292170(gene)
AAATAGTAGAATTGCTTTGACAAGTATAGTCAAAAATAGGCTAAATTTCTTTAGAGGTGA
GGGTCTCTTTTTAATATATGAGATGTGAAGAAAATAAATTAATTGAGCATAACAAAATTT
ATATATCCTTTGTTTTGAAAATAATTGTATAAACTTTAAATTAACAAAAAAAAGTTAAAT
AAAAAAGAGCAAAAATAGATTAAATTTAAACCTAAAATAGTTAGCGTAAATGGAAGAGAA
AGATCAACGTTAAAGAAATATTGAACATTTTAAGATCAAGAAATTGATGACAAGACTTAG
AAACACTAGAGGTTCTGGTACTTCTATGGTTTCTTTGATTATTCCTCCTAAGAAGTAAAT
TAACGATTCCACAAAGTTAATCAGTGATGAATTCAGTAAGGCCACTAATATTAAAGACAG
AGTCAACCGTTAATCTGTACAAGATGCAATGGTTTCCGCCTTACAAAGATTAAAATTATA
TCAAAGAACTCCCAATAATGGTTTGATTCTTTATTGCGGTAAGGTTCTTAACGAAGAAGG
AAAAGAAATTAAGCTTTTGATCGATTTCGAACCCTACAAGCCCATCAACACCTCTCTTTA
TTTCTGTGACAGTAAGTTCCACGTTGATGAATTGGGTTCACTTCTTGAAACCGACCCTCC
TTTTGGTTTCATCGTTATGGATGGTCAAGGTGCTCTCTATGCCAATCTCCAAGGAAATAC
AAAGACAGTTTTAAATAAATTCTCAGTCGAATTGCCCAAGAAGCACGGTAGAGGTGGTCA
ATCATCAGTTCGTTTTGCACGTCTTAGAGTTGAAAAGAGACACAACTATCTTAGAAAGGT
TTGTGAAGTCGCCACTTAAACTTTCATTTCCCAAGATAAAATTAATGTTTAAGGTTTAGT
CTTAGCTGGTTCTGGTGATTTCAAGAATGAATTGAGTACTACATAGATGTTCGACCCTCG
TCTTGCTTGCAAGATTATCAAGATTGTTGATGTTTCTTATGGTGGTGAAAATGGTCTTAA
CCAAGCTATTGAACTCGCTTAAGAATCTTTAACTAACGTCAAGTTCGTTTAAGAAAAGAA
CGTTATCTCCAAATTCTTCGATTGCATCGCTATTGACTCCGGTACCGTTGTCTATGGTGT
TCAAGATACTATGTAACTCTTATTAGATGGTGTTATTGAAAACATTCTTTGTTTCGAAGA
ACTCACTACCTTGAGAGTCACTCGTAAAAATAAAGTCACAGAATAAATCACTCATATATT
CATTCCTCCTAATGAATTAAATAATCCTAAGCATTTCAAGGATGGTGAACATGAACTTGA
AAAGATTGAAGTTGAAAACTTAACTGAATGGTTAGCTGAACACTACAGTGAATTCGGTGC
TGAACTTTACTTTATTACTGATAAATCTGCTGAAGGTTGCCAATTTGTCAAAGGTTTCTC
TGGTATTGGTGGTTTCTTAAGATATAAGGTCGATTTAGAACATATTGTTAACCCTAATGA
CGAATACAACTACGAAGAAGAAGAAGGCTTCATATGATCAATATTTTTATTTCTAAATTA
AATTTTACATCTAAAAGATGTTTTAAAACATTCTGCTTAAGCACTCTAAAATATTAAGTT
TATATTAAAGATTTAATATTTTCTGTAATTCATTTCATTATGTACTATAGTATTATTACT
CTTTGTATTTTGAGAGCTTTAAGCTTCCTTAAAAAAATTCATCTTTTTCTTCATGATAAA
TTAATTATTAATTAATTTGTTGTATTCTCTAATTTTAATT



>TTHERM_00292170(protein)
MEEKDQRQRNIEHFKIKKLMTRLRNTRGSGTSMVSLIIPPKKQINDSTKLISDEFSKATN
IKDRVNRQSVQDAMVSALQRLKLYQRTPNNGLILYCGKVLNEEGKEIKLLIDFEPYKPIN
TSLYFCDSKFHVDELGSLLETDPPFGFIVMDGQGALYANLQGNTKTVLNKFSVELPKKHG
RGGQSSVRFARLRVEKRHNYLRKVCEVATQTFISQDKINVQGLVLAGSGDFKNELSTTQM
FDPRLACKIIKIVDVSYGGENGLNQAIELAQESLTNVKFVQEKNVISKFFDCIAIDSGTV
VYGVQDTMQLLLDGVIENILCFEELTTLRVTRKNKVTEQITHIFIPPNELNNPKHFKDGE
HELEKIEVENLTEWLAEHYSEFGAELYFITDKSAEGCQFVKGFSGIGGFLRYKVDLEHIV
NPNDEYNYEEEEGFI