Identifiers and Description

Gene Model Identifier

TTHERM_00295920

Standard Name

MSH2 (mismatch repair gene )

Aliases

PreTt15702 | 27.m00362 | 3692.m00165

Description

MSH2 DNA mismatch repair MutS family DNA-binding domain protein putative; MutS domain III family protein; homolog to human MSH2

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• mismatched DNA binding (IEA) | GO:0030983

Biological Process

• mismatch repair (IEA) | GO:0006298

Domains

• ( PF00488 ) MutS domain V
• ( PF03904 ) Domain of unknown function (DUF334)
• ( PF05188 ) MutS domain II
• ( PF05190 ) MutS family domain IV
• ( PF05192 ) MutS domain III
• ( PF08011 ) PD-(D/E)XK nuclease superfamily
• ( PF08385 ) Dynein heavy chain, N-terminal region 1
• ( TIGR01069 ) MutS2 family protein
• ( TIGR01070 ) DNA mismatch repair protein MutS

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_08853.1	9.997093137033517e-262
	Description: MutS domain III family protein (815 aa)
Oxytricha	Contig22029.0.g67	9.997093137033517e-262
	Description: MutS domain V
WormBase	WBGene00018426	9.997093137033517e-262
	Description: status:Partially_confirmed UniProt:Q6A598 protein_id:CCD67863.1
SGD	YOL090W	8.995855300591991e-150
	Description: MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
DictyBase	DDB_G0275809	7.000020090806431e-140
	Description: msh2 on chromosome: 2 position 5513128 to 5516287
WormBase	WBGene00003418	1.0000732791548452e-89
	Description: locus:msh-2 status:Confirmed UniProt:Q9TXR4 protein_id:CCD68358.1
Stentor Coeruleus	SteCoe_34271	1.368539471173853e-44
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00295920(coding)
ATGGAAGAGGAAATTGAATTAGTTAATGATAAGAACTTGATGGTTCTTGCTGTTTATTTT
ACTTACCCAAACAATACTCGTTAAGTAAATGCTGCTATTTTAGACAGTGATTAAAGAAAA
TTCTAAGTTACAGAATTCTAAGACACAGAATATTACTCAAATTTTGAGTCCCTCATTCTC
TAGACCAACCCTTAAAATTAGCATACCCAATTTTTGTTGTTAATCCAGTATCCAGATTTG
ACAACAGAAAAAGAAAAAGTCAATGATATTGTTTAACAATGCGACATTAATGTGAAAGAA
AAGGATAAGAAAAGTTTTTTAGAAAAGGGTTATGAAGATGACCTTAATAAATTATTAAAA
AAACCTTTAGCCTAATATATTTAAGAAAGTTAACTTACTCATGCTTTGAGTAGTTTGGCT
TGTATTGTAGGTGATTTATAACTGTCTAAAGAACCTACTAATTAAAATTAATTCACTGTT
GAGACATTGATCTTGAATAATTTTATGAAATTGGATCTCGCTGCTATTAATGCCCTTTTA
ATTTTCCCAAAAGAAAAAGATATCTAGAGAAGAAACTTAATGGGTGGTCAAGAAAATAAT
TTTAGTACATTAGTTGACTTATTAGACAAGTGCAAAACTCAAATTGGCAGTAGAACCTTA
AAGCGCTGGATAAAGCAACCTCTTAAAAATGAGGCTGAAATCAATAGAAGACTTGATATT
GTTGAATATTTTGTCAACAATTAAGATTTGAGAAACTACATTCAAAATGAATTTTTAAGA
AAAATAGCTGACTTAGATAAGCTATATGCTAAATTCTATAAAGTCGCTAGTAAGAAAAAG
CATAACGCTAGTTTAGCTGATTGTATCAAAGTCTATCAACTTGTTACTAATCTAAGTACT
TTAGCACAATATATTGAAAATAACCACTCAGCTGATGAATTAGCATAGAGGGAATTTTTA
ATACCTTTAGGGGAAATACTTGAAAATTTTGAAAAGCTTTCTAGTATGATTGATTAATCA
ATAGATATGGAAAAGGCGAGACGTGATAATGAATACTAAGTTAGTTCTAAATTCTCTCCA
ACTTTAGCAGAACTTGCAAAACAAATGAAATAAATCATGAAGTAAATTGAATCATTAAGA
AATGAATATGCATAAGAATTAGGAGTTGAGCCTAAATTAGTGGAATCTACTACTCACACT
TATTTGTTTGAAAGTAAAAAGAAAGAGACAGATGAAGCCTTCCGTCGTCTCCATAGTCGT
AAGTATAAATCTATTTCAGTTAAGAAAGGCTGTATTTCCTTTACAACTGATGAATTATAA
GCTTGTGTAGCTGAGTATAACAGCTTAAAAGATAACTATTAAGAAGAGTAGAAGTCTGTA
GTTTAGAAAATATTAGACGTCGTTTCTACATACTACCCTGCTATGGAACGTGCAAGTTTC
GTTATTTCTGAATTGGATGTTCTTGCTAACTTTGCTTCTTTAGTTAACTCAGCCACTCGT
CCATATGTCAAACCCAATATTCATGCATCAAATAAGCAAATTAACTTAGTAGAATCTCGT
CATCCCTGCTTAGAAGTAATGGACAATAATTGTGTAGCAAATGACTGCTTTATGGATAAT
GACAAGTCTCGTTTCCATATCATTACTGGGCCAAATATGGGTGGTAAAAGTACTTTTATT
AGATAAGTTGCCATATGCGTTCTATTAGCTCATATTGGTTGCTTTATACCCTGCAAGAGT
GGTGAAATGCCTATCATTGATGCAATCATTACAAGAGTAGGTGCAAGTGATATGCAACTT
CGTGGTATTAGTACTTTCATGAGTGAAATGTTAGAAGCTTCTAACATGTTAATGACAGCA
ACTGAAAATTCTTTAATTATAATCGATGAACTTGGTCGTGGTACTTCTACAAGTGAAGGA
TTTGGTATCGCATGGGCTATTTCAGAACATATTGCTAATAAAATCAAATGTTATTGCTTA
TTTGCAACTCATTTCCATGAAATGACCAAAATGGAACAAGAAGTTAAAGGAGTAATTAAC
TATTATGTAAGCTGTGTAACAATAGACAATAAATTGACTATGCAATATAAATTAAAGAGA
GGTTTTGCTGAGCGTAGTTATGGTTTGTTTGTTGCAGAAACTTTAGATTTCCCTAGAGAA
ATTCTTGAGCATGCCTCAAATAAGCTTTTAGAACTGGAAAGTTATTCAAAGGGAATTTCT
GAAAACCAGAGCTCGGATTAAAATTTTGAGAATTTCAATAAAAATAGCTAAACAGACGAC
ATATTTTTACTTAGTAAGAACTCAACAATTGCTCAAAAAGAAGCTGTTGTTGATCTTGCT
TCTTCCTATAATGAAAAAATAAGAAATGCTGCTTCTAAAGAATAAAAGAAGTAACTACTT
AATGAATTAAAATAAAAAATTATTTCTGCTTTAAAATCTTGA

>TTHERM_00295920(gene)
ATGGAAGAGGAAATTGAATTAGTTAATGATAAGAACTTGATGGTTCTTGCTGTTTATTTT
ACTTACCCAAACAATACTCGTTAAGTAAATGCTGCTATTTTAGACAGTGATTAAAGAAAA
TTCTAAGTTACAGAATTCTAAGACACAGAATATTACTCAAATTTTGAGTCCCTCATTCTC
TAGACCAACCCTTAAAATTAGCATACCCAATTTTTGTTGTTAATCCAGTATCCAGATTTG
ACAACAGAAAAAGAAAAAGTCAATGATATTGTTTAACAATGCGACATTAATGTGAAAGAA
AAGTAATTTTTATTGAATAAAATTGAAATTTCATTTTAAAAATCTTATTTAAATGTAAAA
ATTATAGGGATAAGAAAAGTTTTTTAGAAAAGGGTTATGAAGATGACCTTAATAAATTAT
TAAAAAAACCTTTAGCCTAATATATTTAAGAAAGTTAACTTACTCATGCTTTGAGTAGTT
TGGCTTGTATTGTAGGTGATTTATAACTGTCTAAAGAACCTACTAATTAAAATTAATTCA
CTGTTGAGACATTGATCTTGAATAATTTTATGAAATTGGATCTCGCTGCTATTAATGCCC
TTTTAATTTTCCCAAAAGAAAAAGATATCTAGAGAAGAAACTTAATGGGTGGTCAAGAAA
ATAATTTTAGTACATTAGTTGACTTATTAGACAAGTGCAAAACTCAAATTGGCAGTAGAA
CCTTAAAGCGCTGGATAAAGCAACCTCTTAAAAATGAGGCTGAAATCAATAGAAGACTTG
ATATTGTTGAATATTTTGTCAACAATTAAGATTTGAGAAACTACATTCAAAATGAATTTT
TAAGAAAAATAGCTGACTTAGATAAGCTATATGCTAAATTCTATAAAGTCGCTAGTAAGA
AAAAGCATAACGCTAGTTTAGCTGATTGTATCAAAGTCTATCAACTTGTTACTAATCTAA
GTACTTTAGCACAATATATTGAAAATAACCACTCGTAAATTCTATTTGCATGTTATTAAT
AATATTTTATTGATTAAATTATAAAAAAAAAGAGCTGATGAATTAGCATAGAGGGAATTT
TTAATACCTTTAGGGGAAATACTTGAAAATTTTGAAAAGCTTTCTAGTATGATTGATTAA
TCAATAGATATGGAAAAGGCGAGACGTGATAATGAATACTAAGTTAGTTCTAAATTCTCT
CCAACTTTAGCAGAACTTGCAAAACAAATGAAATAAATCATGAAGTAAATTGAATCATTA
AGAAATGAATATGCATAAGAATTAGGAGTTGAGCCTAAATTAGTGGAATCTACTACTCAC
ACTTATTTGTTTGAAAGTAAAAAGAAAGAGACAGATGAAGCCTTCCGTCGTCTCCATAGT
CGTAAGTATAAATCTATTTCAGTTAAGAAAGGCTGTATTTCCTTTACAACTGATGAATTA
TAAGCTTGTGTAGCTGAGTATAACAGCTTAAAAGATAACTATTAAGAAGAGTAGAAGTCT
GTAGTTTAGAAAATATTAGACGTCGTTTCTACATACTACCCTGCTATGGAACGTGCAAGT
TTCGTTATTTCTGAATTGGATGTTCTTGCTAACTTTGCTTCTTTAGTTAACTCAGCCACT
CGTCCATATGTCAAACCCAATATTCATGCATCAAATAAGCAAATTAACTTAGTAGAATCT
CGTCATCCCTGCTTAGAAGTAATGGACAATAATTGTGTAGCAAATGACTGCTTTATGGAT
AATGACAAGTCTCGTTTCCATATCATTACTGGGCCAAATATGGGTGGTAAAAGTACTTTT
ATTAGATAAGTTGCCATATGCGTTCTATTAGCTCATATTGGTTGCTTTATACCCTGCAAG
AGTGGTGAAATGCCTATCATTGATGCAATCATTACAAGAGTAGGTGCAAGTGATATGCAA
CTTCGTGGTATTAGTACTTTCATGAGTGAAATGTTAGAAGCTTCTAACATGTTAATGACA
GCAACTGAAAATTCTTTAATTATAATCGATGAACTTGGTCGTGGTACTTCTACAAGTGAA
GGATTTGGTATCGCATGGGCTATTTCAGGTAATTTAAAACCTTATTATAAATTAATTTAT
TATAATTATAATTATTTAATTACTAGAACATATTGCTAATAAAATCAAATGTTATTGCTT
ATTTGCAACTCATTTCCATGAAATGACCAAAATGGAACAAGAAGTTAAAGGAGTAATTAA
CTATTATGTAAGCTGTGTAACAATAGACAATAAATTGACTATGCAATATAAATTAAAGAG
AGGTTTTGCTGAGCGTAGTTATGGTTTGTTTGTTGCAGAAACTTTAGATTTCCCTAGAGA
AATTCTTGAGCATGCCTCAAATAAGCTTTTAGAACTGGAAAGTTATTCAAAGGGAATTTC
TGAAAACCAGAGCTCGGATTAAAATTTTGAGAATTTCAATAAAAATAGCTAAACAGACGA
CATATTTTTACTTAGTAAGAACTCAACAATTGCTCAAAAAGAAGCTGTTGTTGATCTTGC
TTCTTCCTATAATGAAAAAATAAGAAATGCTGCTTCTAAAGAATAAAAGAAGTAACTACT
TAATGAATTAAAATAAAAAATTATTTCTGCTTTAAAATCTTGA

>TTHERM_00295920(protein)
MEEEIELVNDKNLMVLAVYFTYPNNTRQVNAAILDSDQRKFQVTEFQDTEYYSNFESLIL
QTNPQNQHTQFLLLIQYPDLTTEKEKVNDIVQQCDINVKEKDKKSFLEKGYEDDLNKLLK
KPLAQYIQESQLTHALSSLACIVGDLQLSKEPTNQNQFTVETLILNNFMKLDLAAINALL
IFPKEKDIQRRNLMGGQENNFSTLVDLLDKCKTQIGSRTLKRWIKQPLKNEAEINRRLDI
VEYFVNNQDLRNYIQNEFLRKIADLDKLYAKFYKVASKKKHNASLADCIKVYQLVTNLST
LAQYIENNHSADELAQREFLIPLGEILENFEKLSSMIDQSIDMEKARRDNEYQVSSKFSP
TLAELAKQMKQIMKQIESLRNEYAQELGVEPKLVESTTHTYLFESKKKETDEAFRRLHSR
KYKSISVKKGCISFTTDELQACVAEYNSLKDNYQEEQKSVVQKILDVVSTYYPAMERASF
VISELDVLANFASLVNSATRPYVKPNIHASNKQINLVESRHPCLEVMDNNCVANDCFMDN
DKSRFHIITGPNMGGKSTFIRQVAICVLLAHIGCFIPCKSGEMPIIDAIITRVGASDMQL
RGISTFMSEMLEASNMLMTATENSLIIIDELGRGTSTSEGFGIAWAISEHIANKIKCYCL
FATHFHEMTKMEQEVKGVINYYVSCVTIDNKLTMQYKLKRGFAERSYGLFVAETLDFPRE
ILEHASNKLLELESYSKGISENQSSDQNFENFNKNSQTDDIFLLSKNSTIAQKEAVVDLA
SSYNEKIRNAASKEQKKQLLNELKQKIISALKS