Identifiers and Description

Gene Model Identifier

TTHERM_00310640

Standard Name

DES7 (C-7(8) sterol DESaturase 7)

Aliases

PreTt21365 | 29.m00326 | 3696.m00144

Description

DES7 Rieske-like [2Fe-2S] domain protein; Sterol-C7 desaturase- a Rieske-type oxygenase; catalyzes the introduction of a C-7(8) double bond into cholesterol and other sterols

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• 2 iron, 2 sulfur cluster binding (IEA) | GO:0051537
• electron transfer activity (IEA) | GO:0009055
• oxidoreductase activity (IEA) | GO:0016491

Biological Process

• obsolete oxidation-reduction process (IEA) | GO:0055114

Domains

• ( PF00355 ) Rieske [2Fe-2S] domain
• ( TIGR02377 ) Rieske [2Fe-2S] domain protein, MocE
• ( TIGR02378 ) nitrite reductase [NAD(P)H], small subunit

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_18551.1	9.997093137033517e-262
	Description: hypothetical protein (454 aa)
WormBase	WBGene00007536	5.001531130907917e-44
	Description: locus:daf-36 Cholesterol desaturase daf-36 status:Partially_confirmed UniProt:Q17938 protein_id:CAA98235.2
Stentor Coeruleus	SteCoe_36177	3.0144087850653746e-40
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:25681633: Poklepovich TJ, Urtasun N, Miranda MV, Nusblat AD, Nudel CB (2015) Expression and functional characterization of a C-7 cholesterol desaturase from Tetrahymena thermophila in an insect cell line. Steroids 96( ):132-9

Sequences

>TTHERM_00310640(coding)
ATGATTGAGTTCAACAAAGAATGTCTTATGGACATCCTTAAAAATCAAGATTACCATTTT
TATATGGTCATTCCTTTGATTTTCATAGGTCTCTACGCACTTTATATTAAAAAATTCAAA
TACTACAATCCTATTGAAAAGCAAGAATGGGATGATAGACGCTCTAACGTCAAGAGAGGT
AACCCACCTCCAAGCTATCCTAATGGTTGGTTCAGAGTTTGTCACAAAAATGAACTCTAA
ATTGGTCAATCTAAGTTCTTCAAGCTTAATGGTCGTCACATCACTGTTTTCCGCGGTGAA
GATGGTATCCCTTATGCTTTACATGCTTACTGCTCTCATATGGGTGCAAATCTCGGTATT
GGAGGTAAAGTTAAATGGAACTCTTGTATTGAATGTCCTTTCCATGGATGGTCTTTCGAC
GGTAAATCAGGTAAATGTGTTAACTCTGAACATTTAGATGAGAAGTAATGTACCCACCAC
ACCTATCACGACATCAAGAAAATGACCAAGGGTTCTGACAACAGATACATTAAAACATGC
GAATCTGGTTCTCCTTCCTAAATCTAAAAATTCCATGTCCGTCAATAAAACAATTTAATT
TATGTCTGGTTCCATGCTAAAAACGTCGACCCTTACTATGAACCTTTTGAAATTAATGAA
ATTCCTTATCTTGAAGATAGAGGTGAAACTGCCGACTATGTTAATTGCTAAATCCAAGAA
ATCCCTGAAAACGGAGCTGATTTCAAGCACTTTGAATACGTTCACTACGCTTGGATCGAA
ATACTTTTCCCATGGATTAAATTCAAGTGGGTTCCTAAGGATCGTAAACCAACTGATAAG
GACTTCGATGAAGTAATGAGAACTCACCCCAACAAAAAGGTTCAAGCCTTTTCAAACAAG
CTCTTCGACAAGTACACTAACGAATAAAATAAAACTCACATCAATAACCTCGTCTTGGAT
GCCTATCTTGTCTTCTTTGATAAATTTGAATTCTACATCTAAACTGCAACAGTCTTCTAA
TTAGGTTCCGGTACTGTATTTTTATTCTTGAAATTCCCCTTATGGGAAGCTGTTGTTGTC
TAGAGTGTTACTCCTGTTGGAAAGTTCAATTAACTTGTTCACCACAAGATGTACACTTCC
TGGTGGTTACCTTACTGGGTCTCTGCTTATCTCCTAGCTGGTTTTAGAAAGTAATTCATT
TCTGACAAAATTGTCTGGAATAACAAAATTTTTGCTGACAAGCTTACATACAATCCTAAA
GCTGTATTTGATGAGAGACTCCTCAACTGGAGAGAATGGTATTCTCAGTACTACGAAGGC
TGCGATGAATTCGAAAAGAACCAAGAAGCTTTTGACTGGTGA

>TTHERM_00310640(gene)
ATGATTGAGTTCAACAAAGAATGTCTTATGGACATCCTTAAAAATCAAGATTACCATTTT
TATATGGTCATTCCTTTGATTTTCATAGGTCTCTACGCACTTTATATTAAAAAATTCAAA
TACTACAATCCTATTGAAAAGCAAGAATGGGATGATAGACGCTCTAACGTCAAGAGAGGT
AACCCACCTCCAAGCTATCCTAATGGTTGGTTCAGAGTTTGTCACAAAAATGAACTCTAA
ATTGGTCAATCTAAGTTCTTCAAGCTTAATGGTCGTCACATCACTGTTTTCCGCGGTGAA
GATGGTATCCCTTATGCTTTACATGCTTACTGCTCTCATATGGGTGCAAATCTCGGTATT
GGAGGTAAAGTTAAATGGAACTCTTGTATTGAATGTCCTTTCCATGGATGGTCTTTCGAC
GGTAAATCAGGTAAATGTGTTAACTCTGAACATTTAGATGAGAAGTAATGTACCCACCAC
ACCTATCACGACATCAAGAAAATGACCAAGGGTTCTGACAACAGATACATTAAAACATGC
GAATCTGGTTCTCCTTCCTAAATCTAAAAATTCCATGTCCGTCAATAAAACAATTTAATT
TATGTCTGGTTCCATGCTAAAAACGTCGACCCTTACTATGAACCTTTTGAAATTAATGAA
ATTCCTTATCTTGAAGATAGAGGTGAAACTGCCGACTATGTTAATTGCTAAATCCAAGAA
ATCCCTGAAAACGGAGCTGATTTCAAGCACTTTGAATACGTTCACTACGCTTGGATCGAA
ATACTTTTCCCATGGATTAAATTCAAGTGGGTTCCTAAGGATCGTAAACCAACTGATAAG
GACTTCGATGAAGTAATGAGAACTCACCCCAACAAAAAGGTTCAAGCCTTTTCAAACAAG
CTCTTCGACAAGTACACTAACGAATAAAATAAAACTCACATCAATAACCTCGTCTTGGAT
GCCTATCTTGTCTTCTTTGATAAATTTGAATTCTACATCTAAACTGCAACAGTCTTCTAA
TTAGGTTCCGGTACTGTATTTTTATTCTTGAAATTCCCCTTATGGGAAGCTGTTGTTGTC
TAGAGTGTTACTCCTGTTGGAAAGTTCAATTAACTTGTTCACCACAAGATGTACACTTCC
TGGTGGTTACCTTACTGGGTCTCTGCTTATCTCCTAGCTGGTTTTAGAAAGTAATTCATT
TCTGACAAAATTGTCTGGAATAACAAAATTTTTGCTGACAAGCTTACATACAATCCTAAA
GCTGTATTTGATGAGAGACTCCTCAACTGGAGAGAATGGTATTCTCAGTACTACGAAGGC
TGCGATGAATTCGAAAAGAACCAAGAAGCTTTTGACTGGTGA

>TTHERM_00310640(protein)
MIEFNKECLMDILKNQDYHFYMVIPLIFIGLYALYIKKFKYYNPIEKQEWDDRRSNVKRG
NPPPSYPNGWFRVCHKNELQIGQSKFFKLNGRHITVFRGEDGIPYALHAYCSHMGANLGI
GGKVKWNSCIECPFHGWSFDGKSGKCVNSEHLDEKQCTHHTYHDIKKMTKGSDNRYIKTC
ESGSPSQIQKFHVRQQNNLIYVWFHAKNVDPYYEPFEINEIPYLEDRGETADYVNCQIQE
IPENGADFKHFEYVHYAWIEILFPWIKFKWVPKDRKPTDKDFDEVMRTHPNKKVQAFSNK
LFDKYTNEQNKTHINNLVLDAYLVFFDKFEFYIQTATVFQLGSGTVFLFLKFPLWEAVVV
QSVTPVGKFNQLVHHKMYTSWWLPYWVSAYLLAGFRKQFISDKIVWNNKIFADKLTYNPK
AVFDERLLNWREWYSQYYEGCDEFEKNQEAFDW