Identifiers and Description

Gene Model Identifier

TTHERM_00312120

Standard Name

DTS1 (Dihydrofolate reductase-Thymidylate Synthase 1)

Aliases

PreTt03400 | 30.m00209 | 3810.m01825

Description

DTS1 dihydrofolate reductase-thymidylate synthase; Bifunctional dihydrofolate reductase-thymidylate synthase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• dihydrofolate reductase activity (IEA) | GO:0004146
• thymidylate synthase activity (IEA) | GO:0004799

Biological Process

• dTMP biosynthetic process (IEA) | GO:0006231
• glycine biosynthetic process (IEA) | GO:0006545
• nucleotide biosynthetic process (IEA) | GO:0009165

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_03227.1	9.997093137033517e-262
	Description: bifunctional dihydrofolate reductase-thymidylate synthase (486 aa)
WormBase	WBGene00004055	9.997093137033517e-262
	Description: locus:pmk-1 Mitogen-activated protein kinase pmk-1 status:Partially_confirmed UniProt:Q17446 protein_id:CCD61386.1
Oxytricha	Contig20294.0.g9	6.000727524697947e-169
	Description: Thymidylate synthase
WormBase	WBGene00022455	9.998919090800975e-129
	Description: Thymidylate synthase status:Confirmed UniProt:Q9N588 protein_id:CCD66193.1
WormBase	WBGene00016277	9.998919090800975e-129
	Description: Uncharacterized protein C30G12.6 status:Partially_confirmed UniProt:Q09259 protein_id:CCD66260.1
SGD	YOR074C	2.9990837046884738e-127
	Description: CDC21 Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
Stentor Coeruleus	SteCoe_17804	3.665820411179563e-77
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00312120(coding)
ATGAAAACAAGACATTTTGATATAGTTTTAGCTTAGACTTTAAAAAAATAGGGTATAGGT
TATAAGAACAGTTTACCATGGAGACTACCTAATGAGCTTAAAAACTTTAAAAAAATAACT
ACAGAAACTAAGAACAAAGGCCTATAAAACGCTGTTATCATGGGTAAAAATACTTGGGAA
GCACTACCTAAAAAGCAATAACCATTGAAAGATCGCTTAAATATTGTTATTTCCACTACT
ATGCAAGAGGGGTAAATTGCAGATCATTCCTACGCCTGTAAAAGCTTAGATTCTGCTTTA
AACTTTTTAGAATAGTAAAATTAAATATAAGATGCCCTTGTAATTGGAGGAGCTAAACTT
TGCCAATAAGCATTAAGCGATCAGAGACTTAGATAGATTCATCTAACAAGAGTAGGTGTC
GAAGTTGAGTGCGATGTTTTTATGCAAAAGGACTACTTAAAAAACTTTGATATGATTGAG
GTGTCTGAAACTTAAAGCGAAAATAATTTAAATTATGATTTTACTAGGTATTTTAATAAG
AATTATAAAGGATAAGTTGACCCTTCTCTCTTTAAGAAAATGTACAAGCCTCATCAAGAA
TATTAATACTTAGAACTTATCGATGAAATTATAAAGAATGGACATGTTAAAACAGACAGA
ACTGGAACTGGTACAATTTCTCAGTTTGGCAAGTTGATGAGATTTGACTTATCAAAGAGT
TTTCCTCTGCTTACTACCAAAAATGTTTTTTGGAGAGGTGTAGTAGAAGAACTTATTTGG
TTTATCAAAGGCAGTACAAACAGCAAAATACTTTCAGAAAAAGGAGTTAAAATATGGGAC
GGTAATGGCAGCAGAGAATTTTTAGATTAATTAGGCTTTAAAAACAGAGAAGAAGGAGAT
TTAGGTCCTGTTTATGGTTTCTAATGGAGACACTTCGGTGCTGAATATAAAGATATGCAT
ACAAATTATAAAGGTAAAGGTGTCGACCAGCTTCAAGATTTAATTAACACAATAAAGAAA
AATCCTGACAGCAGAAGGATGATTATGAATGCCTGGAATGTTAAAGATCTACCATTGATG
GCTTTACCTCCTTGTCATGTCATGAGCTAGTTTTATGTAAATGATAATAAACTAAGCTGT
ATGATGTACTAAAGATCTTGTGATATGGGTTTAGGAATACCATTTAATATAGCCAGTTAT
GCTTTATTGACTCATATGATAGCTTAAGTCACTAATATGTAAGTTGGAGAGTTTATACAT
GTTCTAGGTGATGCTCATGTTTACTCTAATCACGTAGATTAACTAAAAATTTAATTAGAA
AGAGCTCCATACCCCTTCCCTCTTTTAAAAATTAATAACAACAAGTAATATAACTCTATT
GAAGACTTCACTCTTGAAGATTTCGAATTAATTGGATACAACTATCACCCTAAAATATAA
ATGAAAATGGCTGTCTGA

>TTHERM_00312120(gene)
ATGAAAACAAGACATTTTGATATAGTTTTAGCTTAGACTTTAAAAAAATAGGGTATAGGT
TATAAGAACAGTTTACCATGGAGACTACCTAATGAGCTTAAAAACTTTAAAAAAATAACT
ACAGAAACTAAGAACAAAGGCCTATAAAACGCTGTTATCATGGGTAAAAATACTTGGGAA
GCACTACCTAAAAAGCAATAACCATTGAAAGATCGCTTAAATATTGTTATTTCCACTACT
ATGCAAGAGGGGTAAATTGCAGATCATTCCTACGCCTGTAAAAGCTTAGATTCTGCTTTA
AACTTTTTAGAATAGTAAAATTAAATATAAGATGCCCTTGTAATTGGAGGAGCTAAACTT
TGCCAATAAGCATTAAGCGATCAGAGACTTAGATAGATTCATCTAACAAGAGTAGGTCAG
TAGAATTAAATTTATTAAATACTTTCTTTTTATGAACAAAAGAGATAATTAAATAACTTT
TCAAAAATATTTAGGTGTCGAAGTTGAGTGCGATGTTTTTATGCAAAAGGACTACTTAAA
AAACTTTGATATGATTGAGGTGTCTGAAACTTAAAGCGAAAATAATTTAAATTATGATTT
TACTAGGTATTTTAATAAGAATTATAAAGGATAAGTTGACCCTTCTCTCTTTAAGAAAAT
GTACAAGCCTCATCAAGAATATTAATACTTAGAACTTATCGATGAAATTATAAAGAATGG
ACATGTTAAAACAGACAGAACTGGAACTGGTACAATTTCTCAGTTTGGCAAGTTGATGAG
ATTTGACTTATCAAAGAGTTTTCCTCTGCTTACTACCAAAAATGTTTTTTGGAGAGGTGT
AGTAGAAGTAATAAATATATTTATTTATTTATTAATTTATAGTTTGATAGATTTAAAAAT
GAAATTTAGTCTGATTTTTAGTAGAATAAATAAAATAATCTAAATATATAAATTAATAGG
AACTTATTTGGTTTATCAAAGGCAGTACAAACAGCAAAATACTTTCAGAAAAAGGAGTTA
AAATATGGGACGGTAATGGCAGCAGAGAATTTTTAGATTAATTAGGCTTTAAAAACAGAG
AAGAAGGAGATTTAGGTCCTGTTTATGGTTTCTAATGGAGACACTTCGGTGCTGAATATA
AAGATATGCATACAAATTATAAAGGTAAAGGTGTCGACCAGCTTCAAGATTTAATTAACA
CAATAAAGAAAAATCCTGACAGCAGAAGGATGATTATGAATGCCTGGAATGTTAAAGATC
TACCATTGATGGCTTTACCTCCTTGTCATGTCATGAGCTAGTTTTATGTAAATGATAATA
AACTAAGCTGTATGATGTACTAAAGATCTTGTGATATGGGTTTAGGAATACCATTTAATA
TAGCCAGTTATGCTTTATTGACTCATATGATAGCTTAAGTCACTAATATGTAAGTTGGAG
AGTTTATACATGTTCTAGGTGATGCTCATGTTTACTCTAATCACGTAGATTAACTAAAAA
TTTAATTAGAAAGAGCTCCATACCCCTTCCCTCTTTTAAAAATTAATAACAACAAGTAAT
ATAACTCTATTGAAGACTTCACTCTTGAAGATTTCGAATTAATTGGATACAACTATCACC
CTAAAATATAAATGAAAATGGCTGTCTGA

>TTHERM_00312120(protein)
MKTRHFDIVLAQTLKKQGIGYKNSLPWRLPNELKNFKKITTETKNKGLQNAVIMGKNTWE
ALPKKQQPLKDRLNIVISTTMQEGQIADHSYACKSLDSALNFLEQQNQIQDALVIGGAKL
CQQALSDQRLRQIHLTRVGVEVECDVFMQKDYLKNFDMIEVSETQSENNLNYDFTRYFNK
NYKGQVDPSLFKKMYKPHQEYQYLELIDEIIKNGHVKTDRTGTGTISQFGKLMRFDLSKS
FPLLTTKNVFWRGVVEELIWFIKGSTNSKILSEKGVKIWDGNGSREFLDQLGFKNREEGD
LGPVYGFQWRHFGAEYKDMHTNYKGKGVDQLQDLINTIKKNPDSRRMIMNAWNVKDLPLM
ALPPCHVMSQFYVNDNKLSCMMYQRSCDMGLGIPFNIASYALLTHMIAQVTNMQVGEFIH
VLGDAHVYSNHVDQLKIQLERAPYPFPLLKINNNKQYNSIEDFTLEDFELIGYNYHPKIQ
MKMAV