Identifiers and Description

Gene Model Identifier

TTHERM_00335780

Standard Name

EZL1 (Enhancer of Zeste-Like 1)

Aliases

PreTt06023 | 34.m00260 | 3689.m00057

Description

EZL1 SET domain protein; Conjugation-specific H3K27 HKMT; responsible for H3K27 methylation associated with developmentally regulated heterochromatin formation and DNA elimination; Ezl1p-catalyzed H3K27 methylation occurs in an RNAi-dependent manner; Histone-lysine N-methyltransferase EZH1/2-like

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (EXP) | GO:0031039

Biological Process

• heterochromatin assembly involved in chromatin silencing by small RNA (EXP) | GO:0070924
• obsolete histone H3-K27 methylation (EXP) | GO:0070734
• obsolete histone H3-K9 methylation (EXP) | GO:0051567
• programmed DNA elimination (IMP) | GO:0031049

Domains

• ( PF00856 ) SET domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:30808657: Zhao X, Xiong J, Mao F, Sheng Y, Chen X, Feng L, Dui W, Yang W, Kapusta A, Feschotte C, Coyne RS, Miao W, Gao S, Liu Y (2019) RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena. Genes & development 33(5-6):348-364
2. Ref:29021213: Noto T, Mochizuki K (2017) Whats, hows and whys of programmed DNA elimination in Tetrahymena. Open biology 7(10):
3. Ref:25161194: Papazyan R, Voronina E, Chapman JR, Luperchio TR, Gilbert TM, Meier E, Mackintosh SG, Shabanowitz J, Tackett AJ, Reddy KL, Coyne RS, Hunt DF, Liu Y, Taverna SD (2014) Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis. eLife 3( ):e02996
4. Ref:22427430: Chung PH, Yao MC (2012) Tetrahymena thermophila JMJD3 homolog regulates H3K27 methylation and nuclear differentiation. Eukaryotic cell 11(5):601-14
5. Ref:17575054: Liu Y, Taverna SD, Muratore TL, Shabanowitz J, Hunt DF, Allis CD (2007) RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes & development 21(12):1530-45

Sequences

>TTHERM_00335780(coding)
ATGGATCCAAAATTTGAAATATAGCTCAGAGCTTAAGAGTAAGATTTATAGGAATAAAAT
TTCTTCAATTTGGATATAAATGATCAATAGAAAATTAAGGAAGGGATGGTAAAGGTTATT
GCTTCTGCATATATTAGGTTTAAAATGGCTTTTAGAGCTTGTTGCTGGAAAGGGTACAGC
GATAATGATATCTATATTTAATAGAATTTACAAAAAGGCATCGCTGAACACTAAAATAAA
GTAAAAAGAATAAAAAAAAAGGTATAGAATTTTTTTCAGTCTGAGATGTCTATTGAGCCT
CACTAATTTGTGGTTTAAATACTTAAAAACAGAGATTAAGTTTATTCAGGTGGTATTTTC
TAACATGTAAACTCATATGTGCAAATAAACGAATCTATAAAAGATGAAAAAACAAAATAT
CTCTACAGAGATGTTGAAAATATAGGTTTGAAAAAATCTGACCAAGTAAATCACTAAGAG
AGTTAGCAAGCTAAGCAATTAAAAGAAAATTAGAAAAAAATTCTTTAATCAATAAGTTCT
ACTTACATTACTAAATACACAGAATTACTTCTCAAATGCATAATTAAAGACATCCAGTAT
TATTATGGGTATAATTTTCGGGTTCTCAAAATTTTTTAAATCGAATTTGCTAAAAACTCT
GACTTCAGAATTCCTCATATTTGGTGGAGCGCATTTTAAGATAGATATAGGATGCTAATT
GAATTTAAGAGAAATGAACATGAAAAAAAAAAAAAATTTAAACTAAATGTTTTTAAGAAC
AATTATTTTCTCTGTCCTATTTGCATTCAGTATAACTGTATGATCCACAAAAGCTGTAAC
GATATCCACTATCTTAAAAATGATAATTGGACACCACTCTTTGATAAAAACATTCCAAAA
CACTAATTGCATATTGATAAAATCAAAGATTTTTTAACAATGTATAATGGAACTAATTAT
GCACATAAATTTATGTGTAAAGATCATGAATTTTGTTTTAGGAATCAACTGAATAAAAAT
AAATAAGATTTGATTTCAGTATAATAGCATAAATTTAATTGCCTGAATAAAAGGTGGATA
AACATGCTTCTTTACTTTGCAGATTGCTTTACATTTTAAAATCCTTGCTTTTTGACTATC
ATCATTAACATGAGCACTTCTAATGATGATCTCAAATTTTAGTGTAAGGATATTTATCAG
TACTTAAAAAGTGTTAGACCTCAATATTACAGCTTAGAAAGAATACAAAATGAGATAAAT
GCCTTTATTTAATCTAGAGAAAAGGAGTATTTAAAATTGTTAAGCAAAGACTCAGAAAAT
ATTTTGGATGACAAATATATTTAAAAACACTTCTATCATATCCCTGACTAGAAATAAGAA
ATATTGAATTAATTGAAAGAGTTAAGCGAGATGCTCAAATGCAATTACACTCCTTGCTTT
CATACAGGTGTGTGTGATGGAGAAAATGGATGCCGTTGCTATAGAAATAGAGATCTTATT
GAAAAAATGTAAAAGAGAATTGATAAGTTAAAACATATTTAAAAGAAAGAAAAAAAGCAC
ACAAAGAAGGTATTAGAGCTTTCTTTTGACAATAATTCTATAGATAGTAATGAAGAAGAT
GATGATGAGGAATCTAGTGATCTTTAATATATGACTTATTAAGAGATTATTAGCAAATTT
TTGCATGAATGTGAAAGATTTTGTGGATGCCCTAATTACTGTAGATCAAAAAATAAGAAA
TTAGGTTGTAATTGCTTAAATGATATGACATGCCAAACTGATAAAAATTGCTAATGCAGA
AGTAAATTGAGAGAGTGCGACCCAGAAGTTTGTAGATGCTTCTGTAATAGGAATGCAAGA
ACAATATAAAAATTTGGACTCAATATTGATTACTGCACTAATTCTTAAGCCCTTTATAAC
TGTAAACCGCGAGTGCTTCTTGGTAAAAGTCTTGTTTGTGAAGGTCTGGGTCTTTTTGCT
GGATAGGATTTTAAAAAGAACTAGTATATTGGATGCTATATAGGAGAGATCATAAATGAA
AAATAAGGAACAGAAAGACAAGAAGTCTAACAGCCTTAAGGGATTAGTTATTTATTTATG
CTTAATAAGGAGACAGATGTGGACAGTTTTAGATATGGAAATAAAATGAGATATGTAAAT
CATAATTGTGGTAGTATGGCGAATTGCAAAGTTGATGTCATTTATAACAGAGGCATCAAT
ATAGTTAGATTCAGTGCTAAGGAAGATATTTAAAAAGGACAAGAAATATATTTCGATTAT
AATAGAAATTATCAAATTGAATGGATGAAATATTTTAACGAGTACTATGATAAGTTTGAA
TAAGAAGAAAAGAAATAGCAAGTCTAAAAAAAAATAATATCTAAATTTATAAAGAACTGA

>TTHERM_00335780(gene)
TTAAATATTAAATCAAAATAAATAGATTATTGAAAATAAAATGGATCCAAAATTTGAAAT
ATAGCTCAGAGCTTAAGAGTAAGATTTATAGGAATAAAATTTCTTCAATTTGGATATAAA
TGATCAATAGAAAATTAAGGAAGGGATGGTAAAGGTTATTGCTTCTGCATATATTAGGTT
TAAAATGGCTTTTAGAGCTTGTTGCTGGAAAGGGTACAGCGATAATGATATCTATATTTA
ATAGAATTTACAAAAAGGCATCGCTGAACACTAAAATAAAGTAAAAAGAATAAAAAAAAA
GGTATAGAATTTTTTTCAGTCTGAGATGTCTATTGAGCCTCACTAATTTGTGGTTTAAAT
ACTTAAAAACAGAGATTAAGTTTATTCAGGTGGTATTTTCTAACATGTAAACTCATATGT
GCAAATAAACGAATCTATAAAAGATGAAAAAACAAAATATCTCTACAGAGATGTTGAAAA
TATAGGTTTGAAAAAATCTGACCAAGTAAATCACTAAGAGAGTTAGCAAGCTAAGCAATT
AAAAGAAAATTAGAAAAAAATTCTTTAATCAATAAGTTCTACTTACATTACTAAATACAC
AGAATTACTTCTCAAATGCATAATTAAAGACATCCAGTATTATTATGGGTATAATTTTCG
GGTTCTCAAAATTTTTTAAATCGAATTTGCTAAAAACTCTGACTTCAGAATTCCTCATAT
TTGGTGGAGCGCATTTTAAGATAGATATAGGATGCTAATTGAATTTAAGAGAAATGAACA
TGAAAAAAAAAAAAAATTTAAACTAAATGTTTTTAAGAACAATTATTTTCTCTGTCCTAT
TTGCATTCAGTATAACTGTATGATCCACAAAAGCTGTAACGATATCCACTATCTTAAAAA
TGATAATTGGACACCACTCTTTGATAAAAACATTCCAAAACACTAATTGCATATTGATAA
AATCAAAGATTTTTTAACAATGTATAATGGAACTAATTATGCACATAAATTTATGTGTAA
AGATCATGAATTTTGTTTTAGGAATCAACTGAATAAAAATAAATAAGATTTGATTTCAGT
ATAATAGCATAAATTTAATTGCCTGAATAAAAGGTGGATAAACATGCTTCTTTACTTTGC
AGATTGCTTTACATTTTAAAATCCTTGCTTTTTGACTATCATCATTAACATGAGCACTTC
TAATGATGATCTCAAATTTTAGTGTAAGGATATTTATCAGTACTTAAAAAGTGTTAGACC
TCAATATTACAGCTTAGAAAGAATACAAAATGAGATAAATGCCTTTATTTAATCTAGAGA
AAAGGAGTATTTAAAATTGTTAAGCAAAGACTCAGAAAATATTTTGGATGACAAATATAT
TTAAAAACACTTCTATCATATCCCTGACTAGAAATAAGAAATATTGAATTAATTGAAAGA
GTTAAGCGAGATGCTCAAATGCAATTACACTCCTTGCTTTCATACAGGTGTGTGTGATGG
AGAAAATGGATGCCGTTGCTATAGAAATAGAGATCTTATTGAAAAAATGTAAAAGAGAAT
TGATAAGTTAAAACATATTTAAAAGAAAGAAAAAAAGCACACAAAGAAGGTATTAGAGCT
TTCTTTTGACAATAATTCTATAGATAGTAATGAAGAAGATGATGATGAGGAATCTAGTGA
TCTTTAATATATGACTTATTAAGAGATTATTAGCAAATTTTTGCATGAATGTGAAAGATT
TTGTGGATGCCCTAATTACTGTAGATCAAAAAATAAGAAATTAGGTTGTAATTGCTTAAA
TGATATGACATGCCAAACTGATAAAAATTGCTAATGCAGAAGTAAATTGAGAGAGTGCGA
CCCAGAAGTTTGTAGATGCTTCTGTAATAGGAATGCAAGAACAATATAAAAATTTGGACT
CAATATTGATTACTGCACTAATTCTTAAGCCCTTTATAACTGTAAACCGCGAGTGCTTCT
TGGTAAAAGTCTTGTTTGTGAAGGTCTGGGTCTTTTTGCTGGATAGGATTTTAAAAAGAA
CTAGTATATTGGATGCTATATAGGAGAGATCATAAATGAAAAATAAGGAACAGAAAGACA
AGAAGTCTAACAGCCTTAAGGGATTAGTTATTTATTTATGCTTAATAAGGAGACAGATGT
GGACAGTTTTAGATATGGAAATAAAATGAGATATGTAAATCATAATTGTGGTAGTATGGC
GAATTGCAAAGTTGATGTCATTTATAACAGAGGCATCAATATAGTTAGATTCAGTGCTAA
GGAAGATATTTAAAAAGGACAAGAAATATATTTCGATTATAATAGAAATTATCAAATTGA
ATGGATGAAATATTTTAACGAGTACTATGATAAGTTTGAATAAGAAGAAAAGAAATAGCA
AGTCTAAAAAAAAATAATATCTAAATTTATAAAGAACTGAGTGACTGATAGACTGACAAG
TATTAGGAATTCAATTAATCAAAACACAGAAAAAACAAGAAAAAAATAGCTATTACGATT
TTTAAAAACTATAAAAAATAATCAATCTAATAATTTATAAACCAAATTAGAATTTATCAA
AATGTAACCATAAAAAAATAAAAAATTTTATGTAAAAAAAATTATTATTTTATAAAAAAT
AAATTTAAACAGAGCATATATTTGTTAAAAATAATTATTTTATAAAAACTTAATTTGAAC
A

>TTHERM_00335780(protein)
MDPKFEIQLRAQEQDLQEQNFFNLDINDQQKIKEGMVKVIASAYIRFKMAFRACCWKGYS
DNDIYIQQNLQKGIAEHQNKVKRIKKKVQNFFQSEMSIEPHQFVVQILKNRDQVYSGGIF
QHVNSYVQINESIKDEKTKYLYRDVENIGLKKSDQVNHQESQQAKQLKENQKKILQSISS
TYITKYTELLLKCIIKDIQYYYGYNFRVLKIFQIEFAKNSDFRIPHIWWSAFQDRYRMLI
EFKRNEHEKKKKFKLNVFKNNYFLCPICIQYNCMIHKSCNDIHYLKNDNWTPLFDKNIPK
HQLHIDKIKDFLTMYNGTNYAHKFMCKDHEFCFRNQLNKNKQDLISVQQHKFNCLNKRWI
NMLLYFADCFTFQNPCFLTIIINMSTSNDDLKFQCKDIYQYLKSVRPQYYSLERIQNEIN
AFIQSREKEYLKLLSKDSENILDDKYIQKHFYHIPDQKQEILNQLKELSEMLKCNYTPCF
HTGVCDGENGCRCYRNRDLIEKMQKRIDKLKHIQKKEKKHTKKVLELSFDNNSIDSNEED
DDEESSDLQYMTYQEIISKFLHECERFCGCPNYCRSKNKKLGCNCLNDMTCQTDKNCQCR
SKLRECDPEVCRCFCNRNARTIQKFGLNIDYCTNSQALYNCKPRVLLGKSLVCEGLGLFA
GQDFKKNQYIGCYIGEIINEKQGTERQEVQQPQGISYLFMLNKETDVDSFRYGNKMRYVN
HNCGSMANCKVDVIYNRGINIVRFSAKEDIQKGQEIYFDYNRNYQIEWMKYFNEYYDKFE
QEEKKQQVQKKIISKFIKN