Identifiers and Description

Gene Model Identifier

TTHERM_00348170

Standard Name

LIG1 (DNA ligase I )

Aliases

PreTt05229 | 36.m00193 | 3703.m00026

Description

LIG1 DNA ligase I ATP-dependent protein; homolog to human LIG1

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• DNA binding (IEA) | GO:0003677
• DNA ligase (ATP) activity (IEA) | GO:0003910

Biological Process

• DNA recombination (IEA) | GO:0006310
• DNA repair (IEA) | GO:0006281
• DNA replication (IEA) | GO:0006260

Domains

• ( PF01068 ) ATP dependent DNA ligase domain
• ( PF01331 ) mRNA capping enzyme, catalytic domain
• ( PF04675 ) DNA ligase N terminus
• ( PF04679 ) ATP dependent DNA ligase C terminal region
• ( TIGR00574 ) DNA ligase I, ATP-dependent (dnl1)
• ( TIGR01725 ) phage protein, HK97 gp10 family
• ( TIGR02776 ) DNA ligase D
• ( TIGR02779 ) DNA polymerase LigD, ligase domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_09734.1	9.997093137033517e-262
	Description: DNA ligase I (816 aa)
Oxytricha	Contig887.1.g61	9.997093137033517e-262
	Description: ATP dependent DNA ligase domain
WormBase	WBGene00018376	9.997093137033517e-262
	Description: status:Confirmed UniProt:Q20358 protein_id:CCD67083.1
DictyBase	DDB_G0274493	1.9999565133760522e-166
	Description: lig1 on chromosome: 2 position 4400712 to 4404415
SGD	YDL164C	1.0002534232488231e-144
	Description: CDC9 DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
WormBase	WBGene00002985	2.0002124324463154e-144
	Description: locus:lig-1 DNA ligase 1 status:Partially_confirmed UniProt:Q27474 protein_id:CAA98242.2
WormBase	WBGene00000500	2.0002124324463154e-144
	Description: locus:chn-1 status:Confirmed UniProt:G5ECY6 protein_id:CCD71994.1
Stentor Coeruleus	SteCoe_12774	0.00000000027894680928689246
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00348170(coding)
ATGAAGCAAGGTACCATTAAAAACTTCTTTGGAAATAGCCAAAAGAAAAAGGAAGAATTA
GGTGAAAGCAATTTAGGTTCTGACAAAAAATGTGCTACTCAGTCTCAAAAAGGTGCTGAG
ACAAATGGTTAAAACTCAAAGGAATCCCAATAAAAGCCTGATGAATCAAAATCATAGCAA
GAAGAATCTTAATTAAAAGAAAAACCAAAAGCATAAAAAAGAAGATAAATAATAGATAGC
AGTGATGATGAAGAAGTTCCTTCATTGGCTACGATGTCTATAAGTAATAAGTAAATAAAA
AAAGTGGAAAATGAGAACTAAAAAAATGAGTCTTCTAAATCAGAAACAAAATCATCCACA
GATTCTAGCAATTTGTCGAAATAAATACTTGAAAAACCAAAAAATGAAGATGAAAAATTA
AGCCAATCATCTAAAAAAGCAGCAGAATAATAAGATACAAAAAAGAAACCAACTAATAAT
TTGAGAAAACTTTTGGATAAGCACTTTGACCCTATTGAAGACGCTCCATTCTATAAGGAT
TAAGAAGTCTTGTTTGGTTATTTATGTGATGGATTTGAAAGAGTAAATGAACAGGAAGGT
AAAAATTCAAAGGCTATACAAATTGAAATAATGTCAAAAATTTTCAAGTCGATCATATTA
CTTAATCCTGACTAGGTATATGAAGCTTATATGTTTTGTATTTTAAAGATAGCACCTGAT
TATGAGTCTAATGAGCTTGGTGTGGGTAGGGAAATACTTTAAAAAGCAATTAGTAATTGT
TGTGGTAAATCAGTTACTTAAATCAGAGATAGCCTTAATAAACTTGGTGACTTAGGTAAG
GTTGCGTCCGAAGCCAAATCTACCTAAAAAAACATCACAAATTATTTTTAAAAGCAGGCT
AAAGAAAAGCCTCCTATTACTCTTAATAGAACTTTTAATGATTTGAAAAGTATTGCAGCT
GCTTCAGGAAAGGACTCAACTGCAGAAAGAGAAAGAATTATTATAAAATATATGAATGAA
GCAAAACCAGATGAAGCATGCTATTTTATTAGATTTTTAGAGTAGAATTTGAAAATTGGT
GCTGCTGAAAAAACAATGTAGGCAGCTCTTTCCAAAGCATTCTTTGAAATTGCCCACAAT
ATCAAAAGCAATCACGTTTACACAGAATAATAAAACTAACTTTTAGAAGAATTTAACTTC
AATATCACTAGATGTCTGTGTGAGTTTCCAAACTATTACTAAGTCATTGAGACTTTGAAA
TAAATTGGCAAAGATATTTCTAAATTATTAGATATCTGCAAGATCACGATAGGCGTTCCC
TGCAAGCCTATGCTTGCCAAACCAACAAAATCAATTTAAGTTATTTTGGAAAGATTCAAA
GACATGACTTTTACTTGTGAATACAAGTATGATGGATTGAGAGGTCAAATACACTACGAT
GGAAAAGATGTTACTATTTTTAGCAGAAACCTAGAAAATATGACATAGATGTATCCTGAT
ATTGTAGAATTCATAAAAAAACATGTCAGCTAATCGAAAACTGTTAAAAATTTTATTTTA
GATAGTGAAATTGTAGCTTTTGATAAAAACACCAACAAAATTAGACCTTTCTAATAATTA
GCAACAAGAGGAAGAGTCAATGTCAAATTAGATGAAATTGATATAAAAGTTTGTGTTTTT
ATGTTCGATTTAATATATATCAATGACTAGAGTTTGCTACAAACAACACTTTAAGAAAGA
AGATAAAAAATTTAGGAGTGTTTTGTTCAAGAACCTGGTGAGTTCTGCTTTGCTGAGCAC
ATAAACACTGAAGATGTTGAACAAATTTAAGAATTCTTAGAAAAATCTGTTAAGGTGGGA
TGTGAAGGCTTGATGGTTAAAACTTTAGAAACTAACTCAACTTATGAACCAGCAAAAAGA
TCATTTAAATGGCTTAAACTCAAAAAAGATTATTTAGATAGTGGGTTAGGAGATACACTT
GATTTAGTTCCGATTGCAGCCTTCAAGGGTACAGGTAAAAGAGTTGGATTGTATGGTGCT
TACCTATTAGCTTGCTACAATGAAGATATGGAACGTTATGAAACAATATGTAAAATAGGT
ACAGGATTTTCAGATGAAATCTTAGAAGCATGCTATAAATTCTTCTAAGATAAAATTATA
CCATAGCCATAATCTGATTATTTAACCAAAGATTTTAAAGCAGATGTATGGTTTAAACCT
TCTGTAGTTTGGGAAATTAAGGGAGCAGATTTACAAATATCACCAGTATATACTTGTGCA
ATTAGTGAAACAAATTAAGAAAAAGGTATTGGTCTTAGATTCCCTCGTCTTATCAGAGTT
AGAGATGATAAAGATCCAGTCGATGCTACTTCTCCTTCTTTTATATACGATATATATAAA
CAATAAGCTGTTGTAGCAAATGATTTTGATGATGGTGATGATTTCTATTGA

>TTHERM_00348170(gene)
ATGAAGCAAGGTACCATTAAAAACTTCTTTGGAAATAGCCAAAAGAAAAAGGAAGAATTA
GGTGAAAGCAATTTAGGTTCTGACAAAAAATGTGCTACTCAGTCTCAAAAAGGTGCTGAG
ACAAATGGTTAAAACTCAAAGGAATCCCAATAAAAGCCTGATGAATCAAAATCATAGCAA
GAAGAATCTTAATTAAAAGAAAAACCAAAAGCATAAAAAAGAAGATAAATAATAGATAGC
AGTGATGATGAAGAAGTTCCTTCATTGGCTACGATGTCTATAAGTAATAAGTAAATAAAA
AAAGTGGAAAATGAGAACTAAAAAAATGAGTCTTCTAAATCAGAAACAAAATCATCCACA
GATTCTAGCAATTTGTCGAAATAAATACTTGAAAAACCAAAAAATGAAGATGAAAAATTA
AGCCAATCATCTAAAAAAGCAGCAGAATAATAAGGTATGTGAAATTTAATCAATTTTTAA
ATATGATTTTTTTTATTTATTCTGTAGATACAAAAAAGAAACCAACTAATAATTTGAGAA
AACTTTTGGATAAGCACTTTGACCCTATTGAAGACGCTCCATTCTATAAGGATTAAGAAG
TCTTGTTTGGTTATTTATGTGATGGATTTGAAAGAGTAAATGAACAGGAAGGTAAAAATT
CAAAGGCTATACAAATTGAAATAATGTCAAAAATTTTCAAGTCGATCATATTACTTAATC
CTGACTAGGTATATGAAGCTTATATGTTTTGTATTTTAAAGATAGCACCTGATTATGAGT
CTAATGAGCTTGGTGTGGGTAGGGAAATACTTTAAAAAGCAATTAGTAATTGTTGTGGTA
AATCAGTTACTTAAATCAGAGATAGCCTTAATAAACTTGGTGACTTAGGTAAGGTTGCGT
CCGAAGCCAAATCTACCTAAAAAAACATCACAAATTATTTTTAAAAGCAGGCTAAAGAAA
AGCCTCCTATTACTCTTAATAGAACTTTTAATGATTTGAAAAGTATTGCAGCTGCTTCAG
GAAAGGTAAACAAACATAATTTATTTATTTATTGAACAACTCATAATTAAATGATTTATA
GGACTCAACTGCAGAAAGAGAAAGAATTATTATAAAATATATGAATGAAGCAAAACCAGA
TGAAGCATGCTATTTTATTAGATTTTTAGAGTAGAATTTGAAAATTGGTGCTGCTGAAAA
AACAATGTAGGCAGCTCTTTCCAAAGCATTCTTTGAAATTGCCCACAATATCAAAAGCAA
TCACGTTTACACAGAATAATAAAACTAACTTTTAGAAGAATTTAACTTCAATATCACTAG
ATGTCTGTGTGAGTTTCCAAACTATTACTAAGTCATTGAGACTTTGAAATAAATTGGCAA
AGATATTTCTAAATTATTAGATATCTGCAAGATCACGATAGGCGTTCCCTGCAAGCCTAT
GCTTGCCAAACCAACAAAATCAATTTAAGTAACAATAAATAAATATATAAATTATAAAGT
ATAATAAATTTACAAATACTTAAAGGTTATTTTGGAAAGATTCAAAGACATGACTTTTAC
TTGTGAATACAAGTATGATGGATTGAGAGGTCAAATACACTACGATGGAAAAGATGTTAC
TATTTTTAGCAGAAACCTAGAAAATATGACATAGATGTATCCTGATATTGTAGAATTCAT
AAAAAAACATGTCAGCTAATCGAAAACTGTTAAAAATTTTATTTTAGATAGTGAAATTGT
AGCTTTTGATAAAAACACCAACAAAATTAGACCTTTCTAATAATTAGCAACAAGAGGAAG
AGTCAATGTCAAATTAGATGAAATTGATATAAAAGTTTGTGTTTTTATGTTCGATTTAAT
ATATATCAATGACTAGAGTTTGCTACAAACAACACTTTAAGAAAGAAGATAAAAAATTTA
GGAGTGTTTTGTTCAAGAACCTGGTGAGTTCTGCTTTGCTGAGCACATAAACACTGAAGA
TGTTGAACAAATTTAAGTAAATTGATAACCAATTAATTATTGAAAAATTAACATCTATTT
TTTTTTTAGGAATTCTTAGAAAAATCTGTTAAGGTGGGATGTGAAGGCTTGATGGTTAAA
ACTTTAGAAACTAACTCAACTTATGAACCAGCAAAAAGATCATTTAAATGGCTTAAACTC
AAAAAAGATTATTTAGATAGTGGGTTAGGAGATACACTTGATTTAGTTCCGATTGCAGCC
TTCAAGGGTACAGGTAAAAGAGTTGGATTGTATGGTGCTTACCTATTAGCTTGCTACAAT
GAAGATATGGAACGTTATGAAACAATATGTAAAATAGGTACAGGATTTTCAGATGAAATC
TTAGAAGCATGCTATAAATTCTTCTAAGATAAAATTATACCATAGCCATAATCTGATTAT
TTAACCAAAGATTTTAAAGCAGATGTATGGTTTAAACCTTCTGTAGTTTGGGAAATTAAG
GGAGCAGATTTACAAATATCACCAGTATATACTTGTGCAATTAGTGAAACAAATTAAGAA
AAAGGTATTGGTCTTAGATTCCCTCGTCTTATCAGAGTTAGAGATGATAAAGATCCAGTC
GATGCTACTTCTCCTTCTTTTATATACGATATATATAAACAATAAGCTGTTGTAGCAAAT
GATTTTGATGATGGTGATGATTTCTATTGA

>TTHERM_00348170(protein)
MKQGTIKNFFGNSQKKKEELGESNLGSDKKCATQSQKGAETNGQNSKESQQKPDESKSQQ
EESQLKEKPKAQKRRQIIDSSDDEEVPSLATMSISNKQIKKVENENQKNESSKSETKSST
DSSNLSKQILEKPKNEDEKLSQSSKKAAEQQDTKKKPTNNLRKLLDKHFDPIEDAPFYKD
QEVLFGYLCDGFERVNEQEGKNSKAIQIEIMSKIFKSIILLNPDQVYEAYMFCILKIAPD
YESNELGVGREILQKAISNCCGKSVTQIRDSLNKLGDLGKVASEAKSTQKNITNYFQKQA
KEKPPITLNRTFNDLKSIAAASGKDSTAERERIIIKYMNEAKPDEACYFIRFLEQNLKIG
AAEKTMQAALSKAFFEIAHNIKSNHVYTEQQNQLLEEFNFNITRCLCEFPNYYQVIETLK
QIGKDISKLLDICKITIGVPCKPMLAKPTKSIQVILERFKDMTFTCEYKYDGLRGQIHYD
GKDVTIFSRNLENMTQMYPDIVEFIKKHVSQSKTVKNFILDSEIVAFDKNTNKIRPFQQL
ATRGRVNVKLDEIDIKVCVFMFDLIYINDQSLLQTTLQERRQKIQECFVQEPGEFCFAEH
INTEDVEQIQEFLEKSVKVGCEGLMVKTLETNSTYEPAKRSFKWLKLKKDYLDSGLGDTL
DLVPIAAFKGTGKRVGLYGAYLLACYNEDMERYETICKIGTGFSDEILEACYKFFQDKII
PQPQSDYLTKDFKADVWFKPSVVWEIKGADLQISPVYTCAISETNQEKGIGLRFPRLIRV
RDDKDPVDATSPSFIYDIYKQQAVVANDFDDGDDFY