Identifiers and Description

Gene Model Identifier

TTHERM_00379000

Standard Name

EPC1 (EPiplasmin C 1 )

Aliases

EpiC | PreTt10354 | 40.m00239

Description

EPC1 hypothetical protein; Epiplasmin C; the major protein component of the membrane skeleton (epiplasm); influences cell shape and the fidelity of cortical development

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• cornified envelope (IEA) | GO:0001533
• cortical cytoskeleton (IDA) | GO:0030863

Molecular Function

• structural constituent of cytoskeleton (IMP) | GO:0005200

Biological Process

• cortical cytoskeleton organization (IMP) | GO:0030865
• keratinocyte differentiation (IEA) | GO:0030216
• viral process (IEA) | GO:0016032

Domains

• ( PF00038 ) Intermediate filament protein
• ( PF00261 ) Tropomyosin
• ( PF00769 ) Ezrin/radixin/moesin family
• ( PF01239 ) Protein prenyltransferase alpha subunit repeat
• ( PF01576 ) Myosin tail
• ( PF01920 ) Prefoldin subunit
• ( PF02344 ) Myc leucine zipper domain
• ( PF02524 ) KID repeat
• ( PF02996 ) Prefoldin subunit
• ( PF04044 ) Nup133 nucleoporin
• ( PF04394 ) Protein of unknown function, DUF536
• ( PF04508 ) Viral A-type inclusion protein repeat
• ( PF04576 ) Protein of unknown function, DUF593
• ( PF04899 ) MbeD/MobD like
• ( PF05911 ) Plant protein of unknown function
• ( PF06696 ) Streptococcal surface antigen repeat
• ( PF06994 ) Involucrin
• ( PF07544 ) RNA polymerase II transcription mediator
• ( PF08385 ) Dynein heavy chain, N-terminal region
• ( PF08614 ) Autophagy protein 16 (ATG16)
• ( PF08946 ) Osmosensory transporter coiled coil
• ( PF09006 ) Lung surfactant protein D coiled-coil
• ( TIGR00020 ) peptide chain release factor 2
• ( TIGR00158 ) ribosomal protein L9
• ( TIGR02681 ) phage regulatory protein, Rha family
• ( TIGR03185 ) DNA sulfur modification protein DndD

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_00075.1	9.997093137033517e-262
	Description: hypothetical protein (808 aa)
Oxytricha	Contig16911.0.1.g92	0.0005997485943342685
	Description: hypothetical protein

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15134256: Williams NE (2004) The epiplasm gene EPC1 influences cell shape and cortical pattern in Tetrahymena thermophila. The Journal of eukaryotic microbiology 51(2):201-6
2. Ref:12674474: Honts JE, Williams NE (2003) Novel cytoskeletal proteins in the cortex of Tetrahymena. The Journal of eukaryotic microbiology 50(1):9-14
3. Ref:12674475: Huttenlauch I, Stick R (2003) Occurrence of articulins and epiplasmins in protists. The Journal of eukaryotic microbiology 50(1):15-8
4. Ref:11112694: Bouchard P, Chomilier J, Ravet V, Mornon JP, Viguès B (2001) Molecular characterization of the major membrane skeletal protein in the ciliate Tetrahymena pyriformis suggests n-plication of an early evolutionary intermediate filament protein subdomain. Journal of cell science 114(Pt 1):101-110
5. Ref:10571109: Bouchard P, Ravet V, Meiniel R, Creveaux I, Meiniel A, Vellet A, Vigues B (1999) Use of a heterologous monoclonal antibody for cloning and detection of glial fibrillary acidic protein in the bovine ventricular ependyma. Cell and tissue research 298(2):207-16
6. Ref:9788878: Huttenlauch I, Peck RK, Stick R (1998) Articulins and epiplasmins: two distinct classes of cytoskeletal proteins of the membrane skeleton in protists. Journal of cell science 111 ( Pt 22)( ):3367-78
7. Ref:7620468: Williams NE, Honts JE, Dress VM, Nelsen EM, Frankel J (1995) Monoclonal antibodies reveal complex structure in the membrane skeleton of Tetrahymena. The Journal of eukaryotic microbiology 42(4):422-7

Sequences

>TTHERM_00379000(coding)
ATGTCTTATCAATACAGTCAAAACCTCGTTCAAAGCACCAACGTCCCACCTGGTAGCATT
CAATACTCCTAAAACAATATCCAAACTGCTGGACGTACCTTGATTGACTCTAGCTCCCCG
GAACATCCCATTCAATTGGCATCCAGCAACTAAGTCGTCAGCTAGATCCTCACCACCACT
TAAGGTTCTCCCACCAGACAATCCAAGACCTTCGTCTACAGATCTGAATCTCCTATTAGA
TCTTCTCAATACGGTAAGCACGTAGTCAATGTTTCTCACATTGAAAAGGGTCAAGCTCCC
ATTTACGTCTCCCAATCTACTGTCTAAAACCCTATCTACGTTGAAAAGATTGTTAAGGTC
GAAAGCAGTAACACTTCTGAACTCAACCTTCTCAGATAACGTATTTCAGCTTTGGAACTC
TAAAACAAGACCTTGACTGAAGAACTCATCACCTTAAGAAACAACACTCCTCAAGAAGTT
GAATAGATTGTTTACATTGAAAACAACGAAGAAATCAACAAATTGAGATATGAATTGAAC
AACATCAAGGCTCTCTCTGACGCTGAAAATGAAAACGTCAAGAGATCAAAGAAGAACTTG
GAAGACTAATTCAACTCAGTCTTACAAGAAAGAGACAGAATGATCATCTAACTTAAGGAA
TTAACTGTTAAGATCACTGAATTCTAATCCTTGATTGCCTCTAGAGATATCCAAATCAAC
AACTTAAAGATCTAAAACGAAAACCTTGCCACCAGACTCGTCCTCACTACTGCTGAATTA
GAAAAGATCACTCAAGTTAAGGTTGAAGCTGAACCTTTGAGAAGAAAGGTTACTGAACTC
GAATAATACTTGATTCAATAAGAAAAGATTATCGAGGACTTGAGAAATAGACTTGGCCAA
CAAGATCAAGTTATTTCTCAATTAAGAATGTTCGAAATCAGATGTTCCTAATACGAATAA
GAAATCAATGCTTTGAGAGCCAAGTTACAAGAATCTGAAAACAACTCTCTCCTCCTTATC
AAGAAGATTGAAGAATTACAAAACTTACTCAATGATGAAAACGTCAAGAGATCTAAGAAG
GATGGTGAACTCGCCATTTCTCTCAGAGACAAGCAAGCTCTTGAAGAAAAGCTTGTTCAC
TTGACTCAACAAGTCGAATTCTTAACAAGAAAGGTTGCTGCTCAAGAACAAGATATCAAT
GCCCAAAGAACTAGAATCATTGAGTTAGAAGGTATTGCTGCTAAGGTAGGATCTTACGAA
CAACAAATCTAATACCTCAGCCAACAAATCGAAAGATTGAACTAGGTTATTAGAGAAAAG
GACCAAACCATCACTCAACTTAACATTGAACTCAACCAACTCAGATTATCTAACTCTCAA
ATCGCTTAACTCTAAGAATAAGTCGTTACCTTATAACAAAACCTTGTTACTAGAACTGCT
GAAGTTGAATCTCTTAGAAAGAGAGTCTCTGAATAAGAACTCCTCATTAACTAACTCAGA
ATGTTTGAATAAAGAGTTGGTGAATATGAACAAATCATTAATGCTCTCAGATAGAGAATT
GCTGAACTTGAAGCTCAACTCAACGACGAAAACGTCAAGAGAAGCAAGAAGGACGGTGAA
CTCGCCATCTCCCTCAGAGACAAGCAAGCTCTTGAAGAAAAGCTCGTCCACATGACCCAA
CAAATTGAATTCTTATCTCAAAAGGTTAACTAATTAACTGGTCAAGTTGCTGAAAGAGAC
TAAATCATCAGCTAACTCAGAGTTTACGAAATCAGAGTTAAGGAATACGAAAATGTCATC
AACGCTCTTAGATAGAGAGTTGCTGAACTTGAAGCTCAACTCAACGACGAAAACGTCAAG
AGAAGCAAGAAGGACGGTGAACTCGCCATCTCCCTCAGAGACAAGCAAGCTCTTGAAGAA
AAGCTCGTTCACATGACCCAACAAATTGAATTCTTAAGCCAAAAGGTTGCTCAATACGAA
AAGATTCTTGGTGAACAATAATAATAACTCGCTGAAAGAGATAACATTATTAACTAACTC
AGAGTCTTCGAAATTAGAGTTAAGGAATACGAAAACGTCATCAACGCTCTTAGATAGAGA
GTTGCTGAACTTGAAGCTCAACTCAACGACGAAAACGTCAAGAGAAGCAAGAAGGACGGT
GAACTCGCCATCTCCCTCAGAGACAAGCAAGCTCTTGAAGAAAAGCTCGTTCACATGACC
TAGTAGATCGAATTCTTAAGCCAAAAGGTTGCCCAATACGAAAAGATCCTTGGTGAATAA
TAATAATAACTCGCTGAAAGAGACAACATCATTAACTAACTCAGAGTTTATGAAATCAGA
GTTAAGGAATACGAAAATGTCATCAACGCTCTTAGATAGAGAGTTTCTGAACTTGAAGCT
CAACTCAACGACGAAAACGTCAAGAGAAGCAAGAAGGACGGTGAACTCGCCATCTCCCTC
AGAGACAAGCAAGCCCTCGAAGAAAAGCTCGTCCACATGACCCAACAAATTGAATTCTTA
TCTCAAAAGGTTAACTAATTAACTGGTCAAGTTGCTGAAAGAGACAACATCATTAACTAA
CTCAGAGTTTATGAAATCAGAGTTAAGGAATACGAAAATGTTATCAACGCTCTTAGATAG
AGAGTTGCTGAACTTGAAGCTCAACTCAACGACGAAAACGTCAAGAGAAGCAAGAAGGAC
GGTGAACTCGCCATCTCCCTCAGAGACAAGCAAGCCCTCGAAGAAAAGCTCGTCCACATG
ACCTAATAGATTGAATTCTTGAACATGAAGGTCACTTCTTACGAAAAGTAAATCTAAGAA
AAGGATGGTCAAATTAACTAACTCAGAATCGAAATCTCTCAACTCCAAATCAACCTTCAA
TAATTGTAGAACGCTTCTGAAGAAGTCAGAAGACTCACTGAACTCCTCGTCGTTAAGACC
ACTGAAATCGACTAACTCAGAAAGAGATTAGCCGAATTAGAAATCGCCCTCTAGGAATTC
AACCTCGTCCAAGCTAAGCTCCAAGAATGTGAAAAGAATAACTAATTACTCAGATAGAGA
ATTGCTGAATTAGAAGCTCTCCTCAATGATGAAGCTGTTAAGAGATCTAGAAACCAAGGA
GATTTGGAAATTTCTTTGAGAGACAAGTAAGCCTTAGAAGAAAAGCTCGTCCACATGACT
CAACAAATCGAATTCTTAAGCAGAAAGGTTACCTAACTCACCGAAGAAAACTCCAACCTC
AGAGTTATCGTTTCTTCTTACTAACAAATCATCGATGAATGGTAATCCATCAGTGTCAGA
CACGCCAGCTTCTCCTAATTATTAGAAAACCTCAAGGTTAGAGTCCAACAAATCTCTTTC
TCTTCCTCTTCATCTTCCTAAGTTATTTCCCAATCTTCTTACGTCAGAAGCTCTGGTGTT
GCTCACAAGTGA

>TTHERM_00379000(gene)
ATGTCTTATCAATACAGTCAAAACCTCGTTCAAAGCACCAACGTCCCACCTGGTAGCATT
CAATACTCCTAAAACAATATCCAAACTGCTGGACGTACCTTGATTGACTCTAGCTCCCCG
GAACATCCCATTCAATTGGCATCCAGCAACTAAGTCGTCAGCTAGATCCTCACCACCACT
TAAGGTTCTCCCACCAGACAATCCAAGACCTTCGTCTACAGATCTGAATCTCCTATTAGA
TCTTCTCAATACGGTAAGCACGTAGTCAATGTTTCTCACATTGAAAAGGGTCAAGCTCCC
ATTTACGTCTCCCAATCTACTGTCTAAAACCCTATCTACGTTGAAAAGATTGTTAAGGTC
GAAAGCAGTAACACTTCTGAACTCAACCTTCTCAGATAACGTATTTCAGCGTAATATTTT
ACATCTTTTTACAGTATTTAGTCTCAATCTCTTCTTACTTCTATCTCCCTTTTCAGCATT
TTCTTTTTGATTTTTCTTTCCACACCCTATCATACCAAATCTGCTCTTTTCATACTCCAA
TCACTTTTTAAAACTCCTTAAATTGACTCTTCAGTAGCTCTTTAGCAGCTAGCTTTATGG
TTCTTATTAAGCAAAAAGGACTCAGTACTCAAAGGTGTAGAAAAGAGATAGATAAATACA
TATCAAAGAAAATAACAGCCTTCTAGTTAGTATTTTTAACAAAAATGCTACTTTTAGGTT
AAATTTTCTAAGAAATTGTAGTGTTTTTCTATCTTAATTCTATAGTCATTGATTGATCTA
AAGAGTGAAGGAAGTAGTCGTTTACTCAAACTTTTCTACCCTCAAGCAAATAGTAGGTAA
AAGGTATGAAAAGTTTTGAGTAACAGTCATTCAAAAGCTTCTCTTTTAAAGTACAAAGCC
AAAAAATGAATGAATATAATCTGATCGTACATACCTTCATTTACTGAAGCAGTCGACTAT
TGGGAGAAAAAGGATAAGGAGAAGTAGCAGTGTTAAAATAAAAGATTTAAACTAATATTA
CCCTACTGATAAAACTAATAAAAATAAAAAATTTAATTCATCTAATGATGTAATAGAATT
ACAAATTGGTTGACTGATTAATTGATTGATTCATTCATTCTTTTATTCATTCATTAATTC
GCCATTACATTTATACATACAAAAAAAGAAAGATTGATAGGAAAAAGTAAAATCAATAGG
TGGTAGACCAGAAGATATAAAATAATAAAAAAAATAAATAAAGAAAATAAAAATTAATTA
AAATTTTAATTAGTTGACCAGTAGCAATTTATTTAATTAATTTATAAAGAGAAGAAAGTG
GAAAGAAATAAAAACCATAGAAAAAATTAAAAAGAAGGATAGAAAAAGACAATAGAAAAT
AATTAATAAATAAATCCTACTTTTTAGAGACTAACTAATTAACTATTCATCATATCTAAA
TAAATAAATTTTAACTAACTAATTATTTTATTAACTTATAGTTTGGAACTCTAAAACAAG
ACCTTGACTGAAGAACTCATCACCTTAAGAAACAACACTCCTCAAGAAGTTGAATAGATT
GTTTACATTGAAAACAACGAAGAAATCAACAAATTGAGATATGAATTGAACAACATCAAG
GCTCTCTCTGACGCTGAAAATGAAAACGTCAAGAGATCAAAGAAGAACTTGGAAGACTAA
TTCAACTCAGTCTTACAAGAAAGAGACAGAATGATCATCTAACTTAAGGAATTAACTGTT
AAGATCACTGAATTCTAATCCTTGATTGCCTCTAGAGATATCCAAATCAACAACTTAAAG
ATCTAAAACGAAAACCTTGCCACCAGACTCGTCCTCACTACTGCTGAATTAGAAAAGATC
ACTCAAGTTAAGGTTGAAGCTGAACCTTTGAGAAGAAAGGTTACTGAACTCGAATAATAC
TTGATTCAATAAGAAAAGATTATCGAGGACTTGAGAAATAGACTTGGCCAACAAGATCAA
GTTATTTCTCAATTAAGAATGTTCGAAATCAGATGTTCCTAATACGAATAAGAAATCAAT
GCTTTGAGAGCCAAGTTACAAGAATCTGAAAACAACTCTCTCCTCCTTATCAAGAAGATT
GAAGAATTACAAAACTTACTCAATGATGAAAACGTCAAGAGATCTAAGAAGGATGGTGAA
CTCGCCATTTCTCTCAGAGACAAGCAAGCTCTTGAAGAAAAGCTTGTTCACTTGACTCAA
CAAGTCGAATTCTTAACAAGAAAGGTTGCTGCTCAAGAACAAGATATCAATGCCCAAAGA
ACTAGAATCATTGAGTTAGAAGGTATTGCTGCTAAGGTAGGATCTTACGAACAACAAATC
TAATACCTCAGCCAACAAATCGAAAGATTGAACTAGGTTATTAGAGAAAAGGACCAAACC
ATCACTCAACTTAACATTGAACTCAACCAACTCAGATTATCTAACTCTCAAATCGCTTAA
CTCTAAGAATAAGTCGTTACCTTATAACAAAACCTTGTTACTAGAACTGCTGAAGTTGAA
TCTCTTAGAAAGAGAGTCTCTGAATAAGAACTCCTCATTAACTAACTCAGAATGTTTGAA
TAAAGAGTTGGTGAATATGAACAAATCATTAATGCTCTCAGATAGAGAATTGCTGAACTT
GAAGCTCAACTCAACGACGAAAACGTCAAGAGAAGCAAGAAGGACGGTGAACTCGCCATC
TCCCTCAGAGACAAGCAAGCTCTTGAAGAAAAGCTCGTCCACATGACCCAACAAATTGAA
TTCTTATCTCAAAAGGTTAACTAATTAACTGGTCAAGTTGCTGAAAGAGACTAAATCATC
AGCTAACTCAGAGTTTACGAAATCAGAGTTAAGGAATACGAAAATGTCATCAACGCTCTT
AGATAGAGAGTTGCTGAACTTGAAGCTCAACTCAACGACGAAAACGTCAAGAGAAGCAAG
AAGGACGGTGAACTCGCCATCTCCCTCAGAGACAAGCAAGCTCTTGAAGAAAAGCTCGTT
CACATGACCCAACAAATTGAATTCTTAAGCCAAAAGGTTGCTCAATACGAAAAGATTCTT
GGTGAACAATAATAATAACTCGCTGAAAGAGATAACATTATTAACTAACTCAGAGTCTTC
GAAATTAGAGTTAAGGAATACGAAAACGTCATCAACGCTCTTAGATAGAGAGTTGCTGAA
CTTGAAGCTCAACTCAACGACGAAAACGTCAAGAGAAGCAAGAAGGACGGTGAACTCGCC
ATCTCCCTCAGAGACAAGCAAGCTCTTGAAGAAAAGCTCGTTCACATGACCTAGTAGATC
GAATTCTTAAGCCAAAAGGTTGCCCAATACGAAAAGATCCTTGGTGAATAATAATAATAA
CTCGCTGAAAGAGACAACATCATTAACTAACTCAGAGTTTATGAAATCAGAGTTAAGGAA
TACGAAAATGTCATCAACGCTCTTAGATAGAGAGTTTCTGAACTTGAAGCTCAACTCAAC
GACGAAAACGTCAAGAGAAGCAAGAAGGACGGTGAACTCGCCATCTCCCTCAGAGACAAG
CAAGCCCTCGAAGAAAAGCTCGTCCACATGACCCAACAAATTGAATTCTTATCTCAAAAG
GTTAACTAATTAACTGGTCAAGTTGCTGAAAGAGACAACATCATTAACTAACTCAGAGTT
TATGAAATCAGAGTTAAGGAATACGAAAATGTTATCAACGCTCTTAGATAGAGAGTTGCT
GAACTTGAAGCTCAACTCAACGACGAAAACGTCAAGAGAAGCAAGAAGGACGGTGAACTC
GCCATCTCCCTCAGAGACAAGCAAGCCCTCGAAGAAAAGCTCGTCCACATGACCTAATAG
ATTGAATTCTTGAACATGAAGGTCACTTCTTACGAAAAGTAAATCTAAGAAAAGGATGGT
CAAATTAACTAACTCAGAATCGAAATCTCTCAACTCCAAATCAACCTTCAATAATTGTAG
AACGCTTCTGAAGAAGTCAGAAGACTCACTGAACTCCTCGTCGTTAAGACCACTGAAATC
GACTAACTCAGAAAGAGATTAGCCGAATTAGAAATCGCCCTCTAGGAATTCAACCTCGTC
CAAGCTAAGCTCCAAGAATGTGAAAAGAATAACTAATTACTCAGATAGAGAATTGCTGAA
TTAGAAGCTCTCCTCAATGATGAAGCTGTTAAGAGATCTAGAAACCAAGGAGATTTGGAA
ATTTCTTTGAGAGACAAGTAAGCCTTAGAAGAAAAGCTCGTCCACATGACTCAACAAATC
GAATTCTTAAGCAGAAAGGTTACCTAACTCACCGAAGAAAACTCCAACCTCAGAGTTATC
GTTTCTTCTTACTAACAAATCATCGATGAATGGTAATCCATCAGTGTCAGACACGCCAGC
TTCTCCTAATTATTAGAAAACCTCAAGGTTAGAGTCCAACAAATCTCTTTCTCTTCCTCT
TCATCTTCCTAAGTTATTTCCCAATCTTCTTACGTCAGAAGCTCTGGTGTTGCTCACAAG
TGA

>TTHERM_00379000(protein)
MSYQYSQNLVQSTNVPPGSIQYSQNNIQTAGRTLIDSSSPEHPIQLASSNQVVSQILTTT
QGSPTRQSKTFVYRSESPIRSSQYGKHVVNVSHIEKGQAPIYVSQSTVQNPIYVEKIVKV
ESSNTSELNLLRQRISALELQNKTLTEELITLRNNTPQEVEQIVYIENNEEINKLRYELN
NIKALSDAENENVKRSKKNLEDQFNSVLQERDRMIIQLKELTVKITEFQSLIASRDIQIN
NLKIQNENLATRLVLTTAELEKITQVKVEAEPLRRKVTELEQYLIQQEKIIEDLRNRLGQ
QDQVISQLRMFEIRCSQYEQEINALRAKLQESENNSLLLIKKIEELQNLLNDENVKRSKK
DGELAISLRDKQALEEKLVHLTQQVEFLTRKVAAQEQDINAQRTRIIELEGIAAKVGSYE
QQIQYLSQQIERLNQVIREKDQTITQLNIELNQLRLSNSQIAQLQEQVVTLQQNLVTRTA
EVESLRKRVSEQELLINQLRMFEQRVGEYEQIINALRQRIAELEAQLNDENVKRSKKDGE
LAISLRDKQALEEKLVHMTQQIEFLSQKVNQLTGQVAERDQIISQLRVYEIRVKEYENVI
NALRQRVAELEAQLNDENVKRSKKDGELAISLRDKQALEEKLVHMTQQIEFLSQKVAQYE
KILGEQQQQLAERDNIINQLRVFEIRVKEYENVINALRQRVAELEAQLNDENVKRSKKDG
ELAISLRDKQALEEKLVHMTQQIEFLSQKVAQYEKILGEQQQQLAERDNIINQLRVYEIR
VKEYENVINALRQRVSELEAQLNDENVKRSKKDGELAISLRDKQALEEKLVHMTQQIEFL
SQKVNQLTGQVAERDNIINQLRVYEIRVKEYENVINALRQRVAELEAQLNDENVKRSKKD
GELAISLRDKQALEEKLVHMTQQIEFLNMKVTSYEKQIQEKDGQINQLRIEISQLQINLQ
QLQNASEEVRRLTELLVVKTTEIDQLRKRLAELEIALQEFNLVQAKLQECEKNNQLLRQR
IAELEALLNDEAVKRSRNQGDLEISLRDKQALEEKLVHMTQQIEFLSRKVTQLTEENSNL
RVIVSSYQQIIDEWQSISVRHASFSQLLENLKVRVQQISFSSSSSSQVISQSSYVRSSGV
AHK