Identifiers and Description

Gene Model Identifier

TTHERM_00390060

Standard Name

NRK22 (NIMA-Related Kinase)

Aliases

PreTt24902 | 41.m00309

Description

NRK22 Serine/Threonine kinase domain protein; Protein kinase domain containing protein. Sequence similarity to the NEK protein kinase family (Eisen et al.- 2006).;NIMA-Related Kinase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein kinase activity (IEA) | GO:0004672
• protein tyrosine kinase activity (IEA) | GO:0004713

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) Protein kinase domain
• ( PF01636 ) Phosphotransferase enzyme family
• ( PF06519 ) TolA C-terminal
• ( PF07714 ) Protein tyrosine and serine/threonine kinase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_04541.1	9.997093137033517e-262
	Description: protein kinase domain-containing protein (878 aa)
Oxytricha	Contig19374.0.g85	2.9995308115992368e-117
	Description: Protein kinase domain
DictyBase	DDB_G0289277	1.000296925633081e-74
	Description: nek4 on chromosome: 5 position 2561379 to 2563106
Stentor Coeruleus	SteCoe_37998	9.710436457780846e-67
	Description: None
WormBase	WBGene00021461	2.0008958828286524e-54
	Description: locus:nekl-1 status:Partially_confirmed UniProt:Q6AW07 protein_id:CCD69902.1
Tetrahymena borealis	EI9_08059.1	2.0008958828286524e-54
	Description: hypothetical protein (211 aa)
SGD	YAR018C	4.000139296874041e-45
	Description: KIN3 Nonessential serine/threonine protein kinase; possible role in DNA damage response

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16611747: Wloga D, Camba A, Rogowski K, Manning G, Jerka-Dziadosz M, Gaertig J (2006) Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Molecular biology of the cell 17(6):2799-810

Sequences

>TTHERM_00390060(coding)
ATGGAAGTCTATGAGACTGTAAAATTGATTGGATCGGGTGCATTCGGTCAAGTCTATTTA
GTGAAGCATAAGCGTGAAGACAAAATGTATGTCAATAAAAAGATTAAAACAAGAGATATG
AGTCAAAAAGATAGGGAGAACACAGAGAATGAAGTACGCTTGTTGTAAAAATTAAGACAT
GCTAACATTGTAGCATATAAAGATAGTTATATGGATAGAGAGCAGTATTTAAATATTGTT
ATGATTCATTGTGAAGGAGGAGATATGCATAATAGAATTAAAAATTAAAAAGGAAAAAAT
TTTCCCGAAGATTAGATTTAGGATTGGTTAGCATAAATGGCATTAGCGCTTTTTTATTTG
CATGAAAAGAAAATATTACATAGAGATCTTAAAACCCAAAATATTTTTTTAAAGAGCGGC
AGAGTAAGACTAGGTGATTTTGGTATAGCAAAAGTACTTGATTCAACTAGAGACTTCGCA
AATACATGCATTGGTACTCCTTATTATATGTCTCCAGAGTTATTTAAGTACAAACCTTAT
AGTTACAAAAGTGATATTTGGGCATTTGGTTGTGTGCTTTATGAAATGTGTAATCTAAGA
CATGCATTTGATGCTTAAAGTTTAAATGGATTAGCAGTCAAGATTATGAATGGTACATAC
CCGCCTATAAATTCTACTTATTCCAAGTCTTTAAGAGATTTAATTGGCAAAATGCTTTAA
CTTAATCCTAAAAGTAGACCTTCTATTTTAGATATTATAAACACGTCCTTTGTTAAACGT
AGGATCATATCTTACATCACAGATCTATTAAGTGGAAACTTGACAGATCCTAATATTATT
AATGATGTTGATGATCTCTATTTTGATAGTCTAAGGGATTAAGCTTAAAAACTTGGTATT
CTTTAAATTATTAATTAAAATCTTTCTAAAAATGGCCCAGCTTTACCAATTAGTGATGAG
TAGCTTAGACCTCCATAGAGGGTTGGTTAAAGATAGCAAGGGACTGATAGAAAAGTGATT
GAACAAAAGCAAAAAGCTAAAAAGGAATTGTAGAAATAGATTAATGAAAAAAATAGAATT
GAATAGGAAATTAAAAGGTTAGAAAAGAAAAAAATGGTTAGAAGCTCTAGCACAAATATC
AAACAGCCATAGCAGTAAAGTCAATAAAGTGATTCCAGATAAAATATTAAAAAGACAGAA
AATGATCGTCGTGACAAAAAAGAAAGGGATCGTAGCTATTCCTTGGAAAGGGAAAGCTCT
GTCAAATAGCGTAAACCTTTATAAAATTAACAGCAGTAATCTGTAAATCAATCAAAATCT
TCAGTTAATTCCATAAGAAATGAAGTGAAGAGAGTTAGATAATAGATAGATTCATCATCA
TCAACAAGTGCTGAATCTGATGTAGTCTCAACCAAAGTAACCCCTTCAGTTAGGCAGAGT
GCTGAGTAAAGTTATAATGAATAAAAAAATGTGGATCGTAGAGAATAAATTAGACAAGAG
TAGGAGAGAAAAAAGAAATAAGAACAGGAAGAAATGGAATAATAGAGGAAATAAATTATT
TAAGAAAATATTTAAGCAAGGTAAAAAGCTGTTTAATTATAATAAGCCTAATACAGGCCA
TCTAAAGACAATATGGTTTTTATGAATGATGAGGAGGAAAAGCAATAGCAGCAGTAATAA
AACTAAATGTAAGGATTTGTCAAAAGAGGTAGTCTTTAGTCATTTGAATATTCAAAAAAG
TAAAATGGTAACCCTGTTGACGACTTCTCCATAGATATTAATGAGCGTGAAAGCTTCGAT
TATAAATCTAGTATAGATTAAAATTCAAATATTTATAACTCTGAGAGATATGCACCTCCA
ATGTAAAATAACAGCTAAGTAAATAACAATTATTAAGATGAGAGATATACTTAGCAACAA
CAGTAGCAAAGACCTTAATAATAGTATCCTTACAAAATTTAAGAAGAAGAGGATTAAATT
ATAGATATAAATGAAATCATAGGAGAAAATAATGAAGAAAATGATGATGATGCATTATAA
TCAGTAATCCATGAAGAAGAAAATGAAGAATCAGATGATGAAGTAGAAGAGGACCCAAAT
AAAATAGAAGAAAAATTAGAATTAATGAAAACAAAGCTTAAGGAAAAAACGATTAAAATC
AATACAATCACTAATTTCCTCAATTAATCTAGGAAGCAAGCAACTCTTTAAAAGAACCAA
ATCAGTCAGTAAATGCAAAATTAAGATTAAGAAGAAGGGCATATCATCCCAGAAGATCAA
TAAAGTGAAGAAGATGATAATAATTACTATGATGATGAGGATTTAGATGATGATGATAAT
TATGATGAAAACGAAGGAGAAGTTATTTAAGAGTTTTAACAAAACAATAACCCATAATAT
TTCAAAATTTAAGATAAAATAAAACTATTTAGACACAGATGTGAAGCCAGTTTAGGAATA
GTAATGTTTGATAAAGCTTATGATTATCTCAAAGTAAATAGTAATAAATGTTCGACCGAT
GAATTAAGAAAGTAGCTAGTAGAAATTTTATCAGAGGAAAATATTGGCTTTTGGCATTTA
ATCGACTAAATATTATTTTTAGAAGAAGTTTTGTAGACTATCCCATCATAAATATAAAAA
TGA

>TTHERM_00390060(gene)
ATGGAAGTCTATGAGACTGTAAAATTGATTGGATCGGGTGCATTCGGTCAAGTCTATTTA
GTGAAGCATAAGCGTGAAGACAAAATGTATGTCAATAAAAAGATTAAAACAAGAGATATG
AGTCAAAAAGATAGGGAGAACACAGAGAATGAAGTACGCTTGTTGTAAAAATTAAGACAT
GCTAACATTGTAGCATATAAAGATAGTTATATGGATAGAGAGCAGTATTTAAATATTGTT
ATGATTCATTGTGAAGGAGGAGATATGCATAATAGAATTAAAAATTAAAAAGGAAAAAAT
TTTCCCGAAGATTAGATTTAGGATTGGTTAGCATAAATGGCATTAGCGCTTTTTTATTTG
CATGAAAAGAAAATATTACATAGAGATCTTAAAACCCAAAATATTTTTTTAAAGAGCGGC
AGAGTAAGACTAGGTGATTTTGGTATAGCAAAAGTACTTGATTCAACTAGAGACTTCGCA
AATACATGCATTGGTAATGAGCGATAAACTTTTCTATATTATATACTTTTGAAATTTAAA
ACAAAAGAGTAGAATTTAAATTATAAAAATACCTAAAAATTAATTTTATTGCTTGTTTAA
AAAAGATTAGCTATTTTTAATTCATTTATTATTTTTAAAAAGGTACTCCTTATTATATGT
CTCCAGAGTTATTTAAGTACAAACCTTATAGTTACAAAAGTGATATTTGGGCATTTGGTT
GTGTGCTTTATGAAATGTGTAATCTAAGACATGCATTTGATGCTTAAAGTTTAAATGGAT
TAGCAGTCAAGATTATGAATGGTACATACCCGCCTATAAATTCTACTTATTCCAAGTCTT
TAAGAGATTTAATTGGCAAAATGCTTTAACTTAATCCTAAAAGTAGACCTTCTATTTTAG
ATATTATAAACACGTCCTTTGTTAAACGTAGGATCATATCTTACATCACAGATCTATTAA
GTGGAAACTTGACAGATCCTAATATTATTAATGATGTAAAACTAGATTGATTCACATCTC
TTTTTGCATTTTATTTGCTTATGCCCAAAATTGTATTGAATACATATTATTTTTGTAAAT
TAAAAGGTTGATGATCTCTATTTTGATAGTCTAAGGGATTAAGCTTAAAAACTTGGTATT
CTTTAAATTATTAATTAAAATCTTTCTAAAAATGGCCCAGCTTTACCAATTAGTGATGAG
TAGCTTAGACCTCCATAGAGGGTTGGTTAAAGATAGCAAGGGACTGATAGAAAAGTGATT
GAACAAAAGCAAAAAGCTAAAAAGGAATTGTAGAAATAGATTAATGAAAAAAATAGAATT
GAATAGGAAATTAAAAGGTTAGAAAAGAAAAAAATGGTTAGAAGCTCTAGCACAAATATC
AAACAGCCATAGCAGTAAAGTCAATAAAGTGATTCCAGATAAAATATTAAAAAGACAGAA
AATGATCGTCGTGACAAAAAAGAAAGGGATCGTAGCTATTCCTTGGAAAGGGAAAGCTCT
GTCAAATAGCGTAAACCTTTATAAAATTAACAGCAGTAATCTGTAAATCAATCAAAATCT
TCAGTTAATTCCATAAGAAATGAAGTGAAGAGAGTTAGATAATAGATAGATTCATCGTAA
AATTATTATTTTCTTATGTATAATTTAAAAATTACCTTAAATATTTTATTTAGATCATCA
ACAAGTGCTGAATCTGATGTAGTCTCAACCAAAGTAACCCCTTCAGTTAGGCAGAGTGCT
GAGTAAAGTTATAATGAATAAAAAAATGTGGATCGTAGAGAATAAATTAGACAAGAGTAG
GAGAGAAAAAAGAAATAAGAACAGGAAGAAATGGAATAATAGAGGAAATAAATTATTTAA
GAAAATATTTAAGCAAGGTAAAAAGCTGTTTAATTATAATAAGCCTAATACAGGCCATCT
AAAGACAATATGGTTTTTATGAATGATGAGGAGGAAAAGCAATAGCAGCAGTAATAAAAC
TAAATGTAAGGATTTGTCAAAAGAGGTAGTCTTTAGTCATTTGAATATTCAAAAAAGTAA
AATGGTAACCCTGTTGACGACTTCTCCATAGATATTAATGAGCGTGAAAGCTTCGATTAT
AAATCTAGTATAGATTAAAATTCAAATATTTATAACTCTGAGAGATATGCACCTCCAATG
TAAAATAACAGCTAAGTAAATAACAATTATTAAGATGAGAGATATACTTAGCAACAACAG
TAGCAAAGACCTTAATAATAGTATCCTTACAAAATTTAAGAAGAAGAGGATTAAATTATA
GATATAAATGAAATCATAGGAGAAAATAATGAAGAAAATGATGATGATGTAAAAATAAAA
ACTCACCATATTATTTATTTAATATTTTCATATCTTCTAGGCATTATAATCAGTAATCCA
TGAAGAAGAAAATGAAGAATCAGATGATGAAGTAGAAGAGGACCCAAATAAAATAGAAGA
AAAATTAGAATTAATGAAAACAAAGCTTAAGGAAAAAACGATTAAAATCAATACAATCAC
TAATTTCCTCAATTAATCTAGGAAGCAAGCAACTCTTTAAAAGAACCAAATCAGTCAGTA
AATGCAAAATTAAGATTAAGAAGAAGGGCATATCATCCCAGAAGATCAATAAAGTGAAGA
AGATGATAATAATTACTATGATGATGAGGATTTAGATGATGATGATAATTATGATGAAAA
CGAAGGAGAAGTTATTTAAGAGTTTTAACAAAACAATAACCCATAATATTTCAAAATTTA
AGATAAAATAAAACTATTTAGACACAGATGTGAAGCCAGTTTAGGAATAGTAATGTTTGA
TAAAGCTTATGATTATCTCAAAGTAAATAGTAATAAATGTTCGACCGATGAATTAAGAAA
GTAGCTAGTAGAAATTTTATCAGAGGAAAATATTGGCTTTTGGCATTTAATCGACTAAAT
ATTATTTTTAGAAGAAGTTTTGTAGACTATCCCATCATAAATATAAAAATGA

>TTHERM_00390060(protein)
MEVYETVKLIGSGAFGQVYLVKHKREDKMYVNKKIKTRDMSQKDRENTENEVRLLQKLRH
ANIVAYKDSYMDREQYLNIVMIHCEGGDMHNRIKNQKGKNFPEDQIQDWLAQMALALFYL
HEKKILHRDLKTQNIFLKSGRVRLGDFGIAKVLDSTRDFANTCIGTPYYMSPELFKYKPY
SYKSDIWAFGCVLYEMCNLRHAFDAQSLNGLAVKIMNGTYPPINSTYSKSLRDLIGKMLQ
LNPKSRPSILDIINTSFVKRRIISYITDLLSGNLTDPNIINDVDDLYFDSLRDQAQKLGI
LQIINQNLSKNGPALPISDEQLRPPQRVGQRQQGTDRKVIEQKQKAKKELQKQINEKNRI
EQEIKRLEKKKMVRSSSTNIKQPQQQSQQSDSRQNIKKTENDRRDKKERDRSYSLERESS
VKQRKPLQNQQQQSVNQSKSSVNSIRNEVKRVRQQIDSSSSTSAESDVVSTKVTPSVRQS
AEQSYNEQKNVDRREQIRQEQERKKKQEQEEMEQQRKQIIQENIQARQKAVQLQQAQYRP
SKDNMVFMNDEEEKQQQQQQNQMQGFVKRGSLQSFEYSKKQNGNPVDDFSIDINERESFD
YKSSIDQNSNIYNSERYAPPMQNNSQVNNNYQDERYTQQQQQQRPQQQYPYKIQEEEDQI
IDINEIIGENNEENDDDALQSVIHEEENEESDDEVEEDPNKIEEKLELMKTKLKEKTIKI
NTITNFLNQSRKQATLQKNQISQQMQNQDQEEGHIIPEDQQSEEDDNNYYDDEDLDDDDN
YDENEGEVIQEFQQNNNPQYFKIQDKIKLFRHRCEASLGIVMFDKAYDYLKVNSNKCSTD
ELRKQLVEILSEENIGFWHLIDQILFLEEVLQTIPSQIQK