Identifiers and Description

Gene Model Identifier

TTHERM_00429890

Standard Name

CNPL1 (Conserved nucleoplasmin like 1)

Aliases

PreTt26429 | 48.m00192 | 3831.m01535 | GTE3

Description

CNPL1 nucleoplasmin protein; Interacts with histone H2A and localizes to MAC; Homolog of human nucleoplasmin 1 (NPM1) (Kanwal Ashraf et al., 2019); Nucleoplasmin-like domain

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Domains

  • ( PF17800 ) Nucleoplasmin-like domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2337 CNPL1 NPM-family proteins are H2A/H2B chaperones with important roles in various cellular processes. Vertebrates have three NPM proteins (NPM 1-3) whereas invertebrates contain only a single Npm-like protein. Human NPM1 functions in many processes, including histone chaperoning, chromatin remodeling, transcription regulation, genome stability, apoptosis, and embryogenesis. Tetrahymena CNPL1 shares conserved domain architecture with NPM-family members and is an ortholog of NPM1 protein. CNPL1 co-purified with histone H2A as a high-confidence interacting partner. CNPL1 localizes to MAC during vegetative growth (Ashraf et al. 2019).

Associated Literature

  1. Ref:30796450: Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J (2019) Proteomic analysis of histones H2A/H2B and variant Hv1 in Tetrahymena thermophila reveals an ancient network of chaperones. Molecular biology and evolution ( ):

Sequences 

>TTHERM_00429890(coding)
ATGTTCTGGGGTTGCACTGTTAAGAAAGGTAACGATCACAAGTTCGAATCTGAAGACCAC
GCTATTTTGCATCTTTCCAATGTTGCTTTGGGTTTAAATACTAAGGCCGGAGCTCAAGCT
TCCGTCTTTGCCAAAGTTGATGGAAAGGAATTCGTCATTACTCACTTGACCTAGGGTAAA
GTTGAACACACTACTCTCGATCTCTATTTTAGAAACGACCAAGAAGTCACTTTCGGTGTT
AAAGGAGAAGCTGAAGTTCACTTGAGTGGTTATTTCGAACCTGATCATGATGAAGAAGAT
CTTTATGATGATTATCCTTATGGCGAAGAAGAATTCGACGACGAAGAAGATGAAGAACTC
GAAGGAGAAGATGATGAAGATGACGATGAAGAGGAAGAAGAAGAAAAGCCTAAGCAACAA
CTCCAAAAGGAAGCTGCTAAGAAGCCAGCTGCCTAACAATAAGCTGCTGCTGCCACTAAA
AAGCCAGCTGAAGTTCAAAAGAAGGCTGAACCTGCTGCCAAGGCTGCTGAAGCAAAGAAG
CAACCTTCCCTTCAAGAAACTTTAGCCTTAAAGGCTGCTGCTGCTGCCAAGGCTAAGGAA
GCTTTGTAAAGTGATGAAGATGATGAAGACGATGATGATATGGATATTGATATGGAAGAT
GATGATGAAGAAGACGATGACGAAGAAGATTTCGATGATGAAGAAGAAGGTAATGATATC
GATGACGATGTTTCTGACTCTGACAATGAAAATGGAACTTTATCTTAAATGTTAAAGAGA
ACTGGTGCTGAATAACACTAAGACTTGAATAAGAAGGCCAAGGCCAACAACAACTAAGCT
GTTAACAAGCCTTAAAACTAAAACTAAAAGCCTTAATAATAAAACTAAAACCAAAAGCAA
AACAACCAACAATAAGGAAAGCCCCAACAATAACAATAAAACCAAAACAAGCAACAACAC
AATAACTAAAACAAGCAAAATCACTAATAACATCAAAACAAGCAAAACTAACATCAAAAC
AAGCAACACAACAACAACTAATAACATCACAACAAGAATTAACACCATCAAAATAAAAAT
CAACACAACAAAAATGCTCACAAAAAGAACTGA



>TTHERM_00429890(gene)
GGAGTTTCTTTGAAATAAGAATTGTTATAAAAAGGGAAGCCAAGTCTCTGAAAGAATAAA
TTAATATATAAATTAACAATAAAATACTAAGGTATTAAAATAAAAATACAAAAATAAATT
AAGAATCTTTAAAGTTATAAAGCAAGTAAAATGTTCTGGGGTTGCACTGTTAAGAAAGGT
AACGATCACAAGTTCGAATCTGAAGACCACGCTATTTTGCATCTTTCCAATGTTGCTTTG
GGTTTAAATACTAAGGCCGGAGCTCAAGCTTCCGTCTTTGCCAAAGTTGATGGAAAGGAA
TTCGTCATTACTCACTTGACCTAGGGTAAAGTTGAACACACTACTCTCGATCTCTATTTT
AGAAACGACCAAGAAGTCACTTTCGGTGTTAAAGGAGAAGCTGAAGTTCACTTGAGTGGT
TATTTCGAACCTGATCATGATGAAGAAGATCTTTATGATGATTATCCTTATGGCGAAGAA
GAATTCGACGACGAAGAAGATGAAGAACTCGAAGGAGAAGATGATGAAGATGACGATGAA
GAGGAAGAAGAAGAAAAGCCTAAGCAACAACTCCAAAAGGAAGCTGCTAAGAAGCCAGCT
GCCTAACAATAAGCTGCTGCTGCCACTAAAAAGCCAGCTGAAGTTCAAAAGAAGGCTGAA
CCTGCTGCCAAGGCTGCTGAAGCAAAGAAGCAACCTTCCCTTCAAGAAACTTTAGCCTTA
AAGGCTGCTGCTGCTGCCAAGGCTAAGGAAGCTTTGTAAAGTGATGAAGATGATGAAGAC
GATGATGATATGGATATTGATATGGAAGATGATGATGAAGAAGACGATGACGAAGAAGAT
TTCGATGATGAAGAAGAAGGTAATGATATCGATGACGATGTTTCTGACTCTGACAATGAA
AATGGAACTTTATCTTAAATGTTAAAGAGAACTGGTGCTGAATAACACTAAGACTTGAAT
AAGAAGGCCAAGGCCAACAACAACTAAGCTGTTAACAAGCCTTAAAACTAAAACTAAAAG
CCTTAATAATAAAACTAAAACCAAAAGCAAAACAACCAACAATAAGGAAAGCCCCAACAA
TAACAATAAAACCAAAACAAGCAACAACACAATAACTAAAACAAGCAAAATCACTAATAA
CATCAAAACAAGCAAAACTAACATCAAAACAAGCAACACAACAACAACTAATAACATCAC
AACAAGAATTAACACCATCAAAATAAAAATCAACACAACAAAAATGCTCACAAAAAGAAC
TGAGTTGAGTTGAGTTGAGTGAAAATACGTGATTAAATCTAATAAGTCTATCAATATTAG
ATTATAATTATTTTTTGTAATAATTATTTTATGTAGCGCACCACATCAAATAAATTGTAT
GCGTATGTATTTTTAGTAATCTAAAATAAATATGCTGAAAGATAAATAAATAAATAAATA
AATAAATAAAAATATTACTATTATTACAAATTAGATTTTTATTACCTTATTTTTTTTAAT
TATTTTATGAAATATATCTTTTAATTTTGATTCTCAATAATAAAAAAAATATACGATTTA
GCAATAAATAAATAAATAATTATTTCTACTAGCAAATGATACGCAATAAGTAAATAAATA
ATTTAATAGATAAAAACTGATTTTATTTGATATATTTCAAATATA



>TTHERM_00429890(protein)
MFWGCTVKKGNDHKFESEDHAILHLSNVALGLNTKAGAQASVFAKVDGKEFVITHLTQGK
VEHTTLDLYFRNDQEVTFGVKGEAEVHLSGYFEPDHDEEDLYDDYPYGEEEFDDEEDEEL
EGEDDEDDDEEEEEEKPKQQLQKEAAKKPAAQQQAAAATKKPAEVQKKAEPAAKAAEAKK
QPSLQETLALKAAAAAKAKEALQSDEDDEDDDDMDIDMEDDDEEDDDEEDFDDEEEGNDI
DDDVSDSDNENGTLSQMLKRTGAEQHQDLNKKAKANNNQAVNKPQNQNQKPQQQNQNQKQ
NNQQQGKPQQQQQNQNKQQHNNQNKQNHQQHQNKQNQHQNKQHNNNQQHHNKNQHHQNKN
QHNKNAHKKN