Identifiers and Description

Gene Model Identifier

TTHERM_00433420

Standard Name

TPK1  (Takashi's Protein Kinase )

Aliases

PreTt26485 | 48.m00248 | 3831.m01586

Description

CAMP-dependent kinase catalytic subunit; cAMP-dependent protein kinase catalytic subunit

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein kinase activity (IEA) | GO:0004672
• protein tyrosine kinase activity (IEA) | GO:0004713

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_19441	0
	Description: None
Tetrahymena borealis	EI9_04173.1	9.997093137033517e-262
	Description: protein kinase domain-containing protein (320 aa)
Oxytricha	Contig6812.0.g72	5.0009905108069856e-172
	Description: Protein kinase domain
WormBase	WBGene00002189	3.000328303707556e-126
	Description: locus:kin-1 cAMP-dependent protein kinase catalytic subunit status:Confirmed UniProt:P21137 protein_id:CAD45618.1
SGD	YJL164C	2.9997543900496206e-112
	Description: TPK1 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
DictyBase	DDB_G0283907	7.000246217316476e-111
	Description: pkaC on chromosome: 4 position 1394958 to 1397005

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences

>TTHERM_00433420(coding)
ATGGAAAAAGCTAAGAAGATGAAGCTCTCGGACTACGAGATATTTTAGACTTTGGGAACA
GGTTCATTTGGTAGAGTCAAGCTCGCTAAAAAGAAGAATACTACTCAATACGTCGCACTT
AAAGTATTGAAAAAAGCTGAAATTATTAGACTTAAACAGGTTGACCATATCATCAATGAA
AACACCATCTTGTCAAACTTAAATCACCCTTTCATTGTTAAGATGGACGGTTTCTGCTAA
GATAGTCGCTACCTTTATCTTGTCTTAGAATTCGTATCAGGTGGTGAATTGTTTACATAT
TTAAGAAGTGTTGGCCGTTTAGAAACCAATCATGCATGCTTTTATGCAGCTCAAGTTACT
TTGATGTTTGAATATTTACACACAAAGAACATTATATATCGTGATCTTAAGCCTGAAAAT
TTACTTATCGCAGATGATGGTTATCTTAAATTGACTGATTTTGGTTTTGCAAAAGTTGTC
GAAGGTCGTACATACACTCTTTGTGGTACTCCTGAATATCTTGCTCCTGAAATCCTTCTT
AACAAGGGTCACGGTAAAGCAGTTGACTGGTGGACATTAGGTATTCTTATCTATGAAATG
AATGCTGGTATTGATCCCTTCACTGATGAAGATCCTATGGCTATCTATCAAAAAATCTTA
AAGGGTAAAGTTAAATTCCCCAGAAACTTTGATAAAAATGCAAAATCTCTTGTAAAGCAT
TTACTCGTAGCTGATCTCTCTAAGAGATACGGTAACTTGAAAAATGGTGCAAATGATATT
AAGAATCATAGATGGTTCAGTAGCATTGACTGGGCATAGCTTCTTTCTAAAAAGCTTCCA
GTTCCTTATAAGCCAGTTGTTAAAGCTCCAAATGATACTTCTAACTTCTCTAGTTATCCT
GAAAGTGATACTCATTCACCAGCACTAAAACCTGCTGACGATCCTTTCCTTGACTGGTGA

>TTHERM_00433420(gene)
ATGGAAAAAGCTAAGAAGATGAAGCTCTCGGACTACGAGATATTTTAGACTTTGGGAACA
GGCAATCATTTTTTTAAAATAATTATTTACTTATCATTCATTCAGCATCAAATTTACTTT
ATTTTCAATATTATACTGATATCGTCTTTCAACTACCAAGATTCTCATTTTCATAATCTT
ATTTAAATCCAACCATTGAAGATTATAAACAAAAATACGCTCAATTTAATTTTTTGTTAT
TGTAAATTCTATCTTTTTTTTCTTTCTCTCTCTCTCTAACGCCCTTTGCTAAACAACCAG
CTGCTAGACTTTTACATGAAACTGCTTTTTTAAAAATCACAGCTAATTTTTAAAAAATAA
ACTCGGCAGTTTTTTTCTTATAAGTTATGATTCTTTGTCATATAAAAAATGAGCCCAATA
ATCATTTGATTTTAACTTGAGTTTAAAGAAGCGATTCCTGAACATCATGTATAGTTATTT
TGGAAAACTTAGAATCAAATCAAAAGCAAAAGAGAAATGAGGCTAACAATTCATGAAATT
TTAGAATTTAAATTAACTTGCTCATAACAGTAGAGATAAGTAGAAGGAGAGAATCATAGT
TGCCTTTATTTATTATTGTTTGTTAATTTGCTTGCCCACTTCATAGCAGAAAGGCAAAAT
ACTTATTAGCAAGCAGTTAAAGCAAAGCAAATGATTAATAAAAAGGCAAATAATAACAAG
CCATTTCTAACTTTAAAAGGAGCTTGTTCAGCATTCCTTTTATAAACTGAACTAATAAAT
AAACAAAAAATAAAAAAAGAAACATTTTGCAGTTAAAAGAAATATAAAAGTAGGTAGCTC
ATTAGCTATTACCAGGTTAGGAGAGAGAAAGAATGAAATGGATTAAAGTTGTTATTGAGT
GAAAGATCACCCTTTAATTTTTATTAGGATGAATGAATAAAATGCCTTTTATTATTTTTA
TATAATGTTTTTTTTTACTTTTATAGGTTCATTTGGTAGAGTCAAGCTCGCTAAAAAGAA
GAATACTACTCAATACGTCGCACTTAAAGTATTGAAAAAAGCTGAAATTATTAGACTTAA
ACAGGTTGACCATATCATCAATGAAAACACCATCTTGTCAAACTTAAATCACCCTTTCAT
TGTAATGCTTACATTCATTTGTTATTTATCTGATCAAAAAAGCTGCCTCATTTTTACTTA
GGAGATTATAAATAAAATTTGAACTTTTACTAAAGCAACAATTAACTAAATAAACCAAAC
CAAATCACAGTGCAGTTTTTTATTATAAGCTTTAGACAACTTTTGCTATAGTAATGGACT
AATTACCTTTTAAATAAATAGGTTAAGATGGACGGTTTCTGCTAAGATAGTCGCTACCTT
TATCTTGTCTTAGAATTCGTATCAGGTGGTGAATTGTTTACATATTTAAGAAGTGTTGGC
CGTTTAGAAACCAATCATGCATGGTAATTCATTAAATTAATATTTTTTGTATAAGAAAAT
GCAACTAAATTTTGTTAAAGAATGGCATTTTATACCACTCATTAAGTTGTTTACTCAATT
TGATAATAGATAAAACAAAGGATTAATTTTTGTCAAATCAAACATTAGTTTGAGTTTTAT
ATTCCATGACTATTCAAGCAATAAAGCATTCAGTTTAAATAAAACTTATCGCAGACTAAA
ATAAATTGATAACAAATAACAAAATAAATAAATTCCAAGAGCCACTGCGAATGTTATAAA
TTTTAGAGATAGTTTTATTTTCGTTTTAAACATAGTCAAATAGGTAAAGAGGAAATTTAA
GATTTTAACAATTTAGTTATGTTTGCAATAAAATTAGTCATAAAGTAATATAATCAGTTA
TTCTCGCCATTTATCATCATAAAATAAAAATGTATTTAAAATTCAAATATGTAAGCAAAA
GGTAATGATAATAGAAAGCAAAATAGCATCAATATAAAAATAAAAACATCGCATTAATAT
TAAACTTATTTGGCCAGTTTCAAATATGCTTATAAAAATATATTCTAATACAAAATGATG
TTCTTTTCCTATATAATTTTATTAAATATAAAGAAAGAACAAAAAGCCAAAGGAAAGTTT
TTTTCTTAATATTAATTGCTCTTTTTTATAACTATTCAAACCACAAGTCTCTATCTATCT
TGTAATAAAAATATAGTTTGCAAATAAATTAAAGTTATTCAAGCAATAAATTATTTATTT
TATTTCACTGCAATAATTCGTTTTTTAATTTTTGCAAACTCACATAAATAAATAATTGAA
TTTTCTCCTCTTTCTTATCTTATTAATAAATTATATTCTTCAGCATTAAATTTTATTACC
TGATTAATTAATAAATTAAACATCTTCAATTTAAATATCTATCAATCAAATTATCAAACA
AAAACAAAAGAGCATTTAGACTAACTAATAAATAATTAATTGCCTTTTACAGTTATTTAT
TTTCTTTTTATTTTTTATTGATATGATTAAAAATAAATAAGTACCGTCCCCCTTTTATTT
TCAAATTTTATTTCTTTTTTATTTTTTCATTCTATTGAATTGATTTATCAAACAAACAAA
AACATATTTCTCAATCTTTCTTTTAATTTTTTGAATAAATAAATAAATCAATCAATCAAT
TGTCTTTTCTTTATACATATCAATAAAGGAAGAAATAAAATTAAATGCTATGAGTGAGTT
AAAATATCATTTTTTCATTAAGAAATAGAGAATTTATATAAATATCTATTTTTAAAAATT
TAAATATTCGTTAAAATACTTACCTTTATCAGATATATTCTAATAACTGAACTTCTAACA
ACTTTAATTAATTTTAATAACCCAGACTAATATTTAAATCATTTTATTTTACTATTCTAG
CTTTTATGCAGCTCAAGTTACTTTGATGTTTGAATATTTACACACAAAGAACATTATATA
TCGTGATCTTAAGCCTGAAAATTTACTTATCGCAGATGATGGTTATCTTAAATTGACTGA
TTTTGGTTTTGCAAAAGTTGTCGAAGGTCGTACATACACTCTTTGTGGTACTCCTGAATA
TCTTGCTCCTGAAATCCTTCTTAACAAGGGTAAATTAATTAAATTAATAAATTGATCAAC
TTGAATTTATAATTAAAATTAACTAATCTAGGTCACGGTAAAGCAGTTGACTGGTGGACA
TTAGGTATTCTTATCTATGAAATGAATGCTGGTATTGATCCCTTCACTGATGAAGATCCT
ATGGCTATCTATCAAAAAATCTTAAAGGGTAAAGTTAAATTCCCCAGAAACTTTGATAAG
TAAGCATTTTTACATGAATAATGATAGCAATATTAAAATTTTATTTTATAAAATAGAAAT
GCAAAATCTCTTGTAAAGCATTTACTCGTAGCTGATCTCTCTAAGAGATACGGTAACTTG
AAAAATGGTAACATATCGCTATATCTATTAATAAAAATTTTATCATAAACAATAATACTG
ATTCATTTAATAATACAACATTTTCTATATAGGTGCAAATGATATTAAGAATCATAGATG
GTTCAGTAGCATTGACTGGGCATAGCTTCTTTCTAAAAAGCTTCCAGTTCCTTATAAGCC
AGTTGTTAAGTAAAAATTTAATTGATCCTTAACATTTAAAAATGATATTTATTTTTAATA
ACAGAGCTCCAAATGATACTTCTAACTTCTCTAGTTATCCTGAAAGTGATACTCATTCAC
CAGCACTAAAACCTGCTGACGATCCTTTCCTTGACTGGTGA

>TTHERM_00433420(protein)
MEKAKKMKLSDYEIFQTLGTGSFGRVKLAKKKNTTQYVALKVLKKAEIIRLKQVDHIINE
NTILSNLNHPFIVKMDGFCQDSRYLYLVLEFVSGGELFTYLRSVGRLETNHACFYAAQVT
LMFEYLHTKNIIYRDLKPENLLIADDGYLKLTDFGFAKVVEGRTYTLCGTPEYLAPEILL
NKGHGKAVDWWTLGILIYEMNAGIDPFTDEDPMAIYQKILKGKVKFPRNFDKNAKSLVKH
LLVADLSKRYGNLKNGANDIKNHRWFSSIDWAQLLSKKLPVPYKPVVKAPNDTSNFSSYP
ESDTHSPALKPADDPFLDW