Identifiers and Description

Gene Model Identifier

TTHERM_00439250

Standard Name

GIP1 (Granule-biosynthesis Induced Protease 1)

Aliases

PreTt05482 | 49.m00254 | 3708.m00103

Description

GIP1 papain family cysteine protease; Granule-biosynthesis induced protease; putative cysteine protease; transcription induced following exocytosis; putative cargo protein of dense core secretory granules; Peptidase C1A

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• dense core granule (IDA) | GO:0031045
• obsolete integral component of mitochondrial membrane (IEA) | GO:0032592
• THO complex (IEA) | GO:0000347

Molecular Function

• 11-deoxycorticosterone binding (IEA) | GO:1903878
• 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (IEA) | GO:0008413
• cytoskeletal anchor activity (IEA) | GO:0008093
• interleukin-10 receptor binding (IEA) | GO:0005141
• obsolete sodium-transporting two-sector ATPase activity (IEA) | GO:0015443
• phosphatidylserine decarboxylase activity (IEA) | GO:0004609
• sphingomyelin phosphodiesterase activity (IEA) | GO:0004767
• tumor necrosis factor receptor binding (IEA) | GO:0005164

Biological Process

• auditory receptor cell fate commitment (IEA) | GO:0009912
• cell wall modification involved in fruit ripening (IEA) | GO:0009829
• heme A biosynthetic process (IEA) | GO:0006784
• heme biosynthetic process (IEA) | GO:0006783
• macrophage derived foam cell differentiation (IEA) | GO:0010742
• muscle contraction (IEA) | GO:0006936
• negative regulation of complement-dependent cytotoxicity (IEA) | GO:1903660
• negative regulation of epithelial cell-cell adhesion involved in epithelium migration (IEA) | GO:1903682
• negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
• obsolete induction by virus of host cell-cell fusion (IEA) | GO:0006948
• ommochrome biosynthetic process (IEA) | GO:0006727
• phagocytosis (IEA) | GO:0006909
• plant-type cell wall modification (IEA) | GO:0009827
• positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction (IEA) | GO:0052330
• positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
• positive regulation of cap-independent translational initiation (IEA) | GO:1903679
• positive regulation of flower development (IEA) | GO:0009911
• positive regulation of peroxisome proliferator activated receptor signaling pathway (IEA) | GO:0035360
• positive regulation of response to water deprivation (IEA) | GO:1902584
• positive regulation of stress response to copper ion (IEA) | GO:1903855
• positive regulation of wound healing, spreading of epidermal cells (IEA) | GO:1903691
• propan-2-ol biosynthetic process (IEA) | GO:1902640
• protein localization to old growing cell tip (IEA) | GO:1903858
• pteridine biosynthetic process (IEA) | GO:0006728
• regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902641
• regulation of complement-dependent cytotoxicity (IEA) | GO:1903659
• regulation of macrophage derived foam cell differentiation (IEA) | GO:0010743
• regulation of sprouting angiogenesis (IEA) | GO:1903670
• regulation of wound healing, spreading of epidermal cells (IEA) | GO:1903689
• tertiary alcohol biosynthetic process (IEA) | GO:1902645
• vesicle organization (IEP) | GO:0016050
• vitamin A metabolic process (IEA) | GO:0006776

Domains

• ( PF00112 ) Papain family cysteine protease
• ( PF08246 ) Cathepsin propeptide inhibitor domain (I29)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:12456006: Haddad A, Bowman GR, Turkewitz AP (2002) New class of cargo protein in Tetrahymena thermophila dense core secretory granules. Eukaryotic cell 1(4):583-93

Sequences

>TTHERM_00439250(coding)
ATGATACTCAAACATATCATCAATTAAATAAAATATTTACTAGAACGAACGGTAAGCTTT
AAATCTTGGATATTTTAGTCATAAAATTTATAAAAATTATAAAACAAAAAAACTAATAAA
TAAAAAATGAATAAGCTACTTATCTCTGCTTTAATTTGCTTAATGATTGCTACTCCTAGT
GTGTTTTGCTAGGATGTTGAAAATAACATTTCTGAAGACATTAAAGTCTAAGACTTATTA
GCATACAATAAATGGAGATTCAACTATAAGAGAGTCTATCTTAATGAAGAAGAGCAGATC
TACAGATAGATTGTTTTCTTTGAAAATCTTGCTAGTGTTAACAAACACCCTTCTCATAAA
TCCTACAGTAAGGGTTTGAACCAGTTCTCTGATATGACTAAAGAAGAATTCAAACAAAGA
GTTTTGAATAAGAAGATTTCTAAAAAGGCTAGCAGTAATAAGGGTGGTAGAAATTTAGCT
GCTGATCCAGCTGTTTCCAACTTAGTCTTTCCCACCAATAATCTTCCTCTATCTGTTGAT
TGGAGAAAAAGAGGTGTCCTCAATCCTGTAAAAAATTAAGGTACTTGTGGTTCATGCTGG
ACTTTTGCAACTGCTGGCATCCTTGAGTCATTCAACTAAATTAAAAATAAATAGCTTCTT
AAGTTCTCTGAGCAACAACTTGTTGATTGTGTCAGCCTAGCTGGATATGATTCTGATGGT
TGTGATGGTGGTTTTTAAGAAGATGGTGTTAGATATGCAATTGAGTATGGTATTGTTTAA
TCTTACAAATACCCTTATGTTGGATATCAAGGTAGATGCAAAGTCACATCTCCCACTTCT
CGTTCTGTAGGTTTTTACCCTTAAAAGTTCCAACTTGTCAATAAAACTGAAGCTGACTTG
AAAGCTGCTTTAGTTTTCTCCCCTGTTTCAATCTCCGTCAATGCTGATACCTGGAAAGAA
TACTATGGTGGTGTTTTTGATGAATGTGGATATACTACCGAAGAAGATCTCAATCATGCT
GTCATCGCTGTAGGTTATGACCAAGAAGGTAACTGGATTGTTAGAAACAGTTGGTCTGCA
GCTTGGGGTGAAGATGGTTACATAAGATTAGCTCCTGGTAACACTTGTGGTATTTTGCTT
GATGGATTAATAGTTACTTAATGA

>TTHERM_00439250(gene)
AACAAATAAACCAATAAATAAAAAATGAAAAAGCTACTTATCTCTGCTTTAATTTGCTTA
ATGATTACTACTCCTAGTGTGTTTTGCTAGGATGTTGAAAATAACATTTACATTTATTTT
AGATATTAATCAAGTAGATTTATTATCAAATGAACTTAATAAATTAATTTATTAGAAAAT
TCAGTATTCAATCTGTCTGATTAAGTATGATGGTTTCTACTTTAAATGATACTCAAACAT
ATCATCAATTAAATAAAATATTTACTAGAACGAACGGTAAGCTTTAAATCTTGGATATTT
TAGTCATAAAATTTATAAAAATTATAAAACAAAAAAACTAATAAATAAAAAATGAATAAG
CTACTTATCTCTGCTTTAATTTGCTTAATGATTGCTACTCCTAGTGTGTTTTGCTAGGAT
GTTGAAAATAACATTTCTGAAGACATTAAAGTCTAAGACTTATTAGCATACAATAAATGG
AGATTCAACTATAAGAGAGTCTATCTTAATGAAGAAGAGCAGATCTACAGATAGATTGTT
TTCTTTGAAAATCTTGCTAGTGTTAACAAACACCCTTCTCATAAATCCTACAGTAAGGGT
TTGAACCAGTTCTCTGATATGACTAAAGAAGAATTCAAACAAAGAGTTTTGAATAAGAAG
ATTTCTAAAAAGGCTAGCAGTAATAAGGGTGGTAGAAATTTAGCTGCTGATCCAGCTGTT
TCCAACTTAGTCTTTCCCACCAATAATCTTCCTCTATCTGTTGATTGGAGAAAAAGAGGT
GTCCTCAATCCTGTAAAAAATTAAGGTACTTGTGGTTCATGCTGGACTTTTGCAACTGCT
GGCATCCTTGAGTCATTCAACTAAATTAAAAATAAATAGCTTCTTAAGTTCTCTGAGCAA
CAACTTGTTGATTGTGTCAGCCTAGCTGGATATGATTCTGATGGTTGTGATGGTGGTTTT
TAAGAAGATGGTGTTAGATATGCAATTGAGTATGGTATTGTTTAATCTTACAAATACCCT
TATGTTGGATATCAAGGTAGATGCAAAGTCACATCTCCCACTTCTCGTTCTGTAGGTTTT
TACCCTTAAAAGTTCCAACTTGTCAATAAAACTGAAGCTGACTTGAAAGCTGCTTTAGTT
TTCTCCCCTGTTTCAATCTCCGTCAATGCTGATACCTGGAAAGAATACTATGGTGGTGTT
TTTGATGAATGTGGATATACTACCGAAGAAGATCTCAATCATGCTGTCATCGCTGTAGGT
TATGACCAAGAAGGTAACTGGATTGTTAGAAACAGTTGGTCTGCAGCTTGGGGTGAAGAT
GGTTACATAAGATTAGCTCCTGGTAACACTTGTGGTATTTTGCTTGATGGATTAATAGTT
ACTTAATGAAAATAAAAATAAATATAAATTAGTACATTTACAATAATATTAATTATATAC
ATTATGTTTTTTTCTTTTTGCTTAAAGCTTAAAATATTTTTAAAATTAAAATAAAT

>TTHERM_00439250(protein)
MILKHIINQIKYLLERTVSFKSWIFQSQNLQKLQNKKTNKQKMNKLLISALICLMIATPS
VFCQDVENNISEDIKVQDLLAYNKWRFNYKRVYLNEEEQIYRQIVFFENLASVNKHPSHK
SYSKGLNQFSDMTKEEFKQRVLNKKISKKASSNKGGRNLAADPAVSNLVFPTNNLPLSVD
WRKRGVLNPVKNQGTCGSCWTFATAGILESFNQIKNKQLLKFSEQQLVDCVSLAGYDSDG
CDGGFQEDGVRYAIEYGIVQSYKYPYVGYQGRCKVTSPTSRSVGFYPQKFQLVNKTEADL
KAALVFSPVSISVNADTWKEYYGGVFDECGYTTEEDLNHAVIAVGYDQEGNWIVRNSWSA
AWGEDGYIRLAPGNTCGILLDGLIVTQ