Identifiers and Description

Gene Model Identifier

TTHERM_00448570

Standard Name

MCM6 (DNA replication licensing factor MCM6)

Aliases

PreTt15376 | 52.m00154 | 3811.m00917

Description

MCM6 DNA replication licensing factor MCM4; Component of the Mcm2-7 complex involved in DNA replication

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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Gene Ontology Annotations

Molecular Function

Biological Process

Domains

No Data fetched for Domains

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
WormBase WBGene00003158 9.997093137033517e-262
Description: locus:mcm-6 DNA replication licensing factor mcm-6 status:Confirmed UniProt:P34647 protein_id:CAA80191.1
Tetrahymena borealis EI9_14945.1 9.997093137033517e-262
Description: MCM2/3/5 family protein (825 aa)
DictyBase DDB_G0272760 9.997093137033517e-262
Description: mcm6 on chromosome: 2 position 2111171 to 2113956
Oxytricha Contig21040.0.g23 9.997093137033517e-262
Description: MCM2/3/5 family
SGD YGL201C 9.997093137033517e-262
Description: MCM6 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
Stentor Coeruleus SteCoe_4188 5.0345753587649823e-45
Description: None

General Information

No. Gene Name(s) Paragraph Text
72 MCM6 Gene Information: MCM6 is a gene coding for a protein product associated with replicative origins in G1 phase during pre-replicative complex assembly. ORC recruits MCM6p on non-rDNA chromosomes. Mcm6p ChIP analysis was performed with affinity-purified rabbit antibodies directed against amino acids 34–51 (GKKIKYYREKALLLKIYE) of the T. thermophila MCM6 protein (Tetrahymena Genome Database gene prediction: TTHERM-00448570, e value versus human MCM6 (NP_005906.2): 1.0e-172. Human MCM6 (NP_005906.2) versus TGD TTHERM-0048570 e value : 1.0e-178.
73 MCM6 Nucleic Acid Interactions: Non-rDNA and rDNA origin in cells synchronized at the G1/S border.
74 MCM6 Protein Interaction Partners: Not assessed
75 MCM6 Biochemical Activities: Predicted helicase activity for dsDNA as a component of MCM2-7 complex

Associated Literature

  1. Ref:19153611: Donti TR, Datta S, Sandoval PY, Kapler GM (2009) Differential targeting of Tetrahymena ORC to ribosomal DNA and non-rDNA replication origins. The EMBO journal 28(3):223-33

Sequences 

>TTHERM_00448570(coding)
ATGAGCTAGATGAACTTTTCCTAAACAATCTAACTTAAGATTGAAACAGTAAAGACCTAA
TTCCTTAACTTCTTAAACAACTTTGAAGTAGTTGAAAATGGAAAAAAAATCAAGTATTAC
AGAGAAAAGGCACTTTTGTTGAAGATTTATGAAAAGAATACACTTTTTATTGACTTTAAT
CACTTATTAGATTTTATTGATGACAACGATATTTCAGATGTCATTTTAAACGACTACTAC
AAAATTGAACCTCACTTAAGAAAAATTGTTTCAAATTTCATCTTTAGTCTAACCAACACA
AACGATAGCCAGGAAAGTTACTACCTTAGCTTTTACAACTTACCAACTGAAAAGAAAATT
AGAGAATTGGGAACTTAAGAAATAGGTAAATTGAATAGTATTAAGGGTTTAGTTACTAGA
TCAAGTGAAGTACGTCCTGAATTACTTTATGGTACATTTATTTGCCAATTGTGTAATAGT
GAAGTGCGTGATATTGAGTAGCAATTTAAATACACTGAACCTAAAATATGTTCAAACCCT
GGCTGTAACAACCATACTAAGTGGATGTTAAAACCCTAATCATCAGTATTTTCTGATTTT
TAGAAACTTAGAGTTCAAGAAGAATCTACTGACATTCCTGCAGGAGGTATGCCTCGTTCT
ATTGATATTGTTTGTAGAGGTGAAGTTGTTGACACCGCTAAGCCTGGTGATAAATGTATT
TTCACTGGTTATTTAATTGTTGTTCCTGATATAGCAGCTCTTACTAAACCAGGTGAAAAA
ACTGAAATGGGTATTAAATCTGATGCCGTTAGAGTCAAAGGAGAAGGAAATAATGATGGT
ATTACTGGTCTCTCTCAACTAGGTCAAAGAGATTTGAACTACAGACTTGTTTTCTTAGCT
ATTAACATTGAAGCAAAAAAGAGTAGATTCAACTTATGGAATTAAGATGAAGAAGAAAAT
CAGGATTTAACTGAAGAAGAAGAAAGACAAAAAATTATGGAAAATTTCTCTGAAAGAGAA
CTTGAAGACATTTTTAAAATAAGCAGAAGTTCTAATGTTTATGAAAGATTAGCATCTAGT
TTGTGTCCTACTGTACATGGTCACTTGGAAGTTAAAAAGGGTATTTTACTCATGCTTTTT
GGTGGTGTCAACAAAAAAACAGAAGAAGGTATTAACTTGAGAGGTGATATCAACATTTGC
ATGGTAGGTGATCCATCTACTGCTAAGTCTCAATTCCTTAAATATGTTAATAAGCTTATT
CCTCGTTCAGTCTATACTTCTGGTAAAGCATCAACATCTGCTGGTTTGACTGCAAGTGTT
TCTAAAGATCCTGAAACTGGAGAAAATTGCATTGAAGCTGGTGCTTTGATGCTTTCTGAC
TAAGGTATTTGCTGTATCGATGAATTTGATAAGATGGATAAAAGAGATTAAGTCGCCATC
CACGAAGCTATGGAACAATAAACAATTTCTATTTCAAAGGCAGGTATTCAAGCTACCTTG
AATTCAAGAGCCAGTATTTTAGCTGCTGCAAACCCTGTTTTTGGTAGATACGATAAATCC
AAGGGTTTAAAATACAACTTAGATATAAGCGCTCCCATTCTTTCTCGTTTCGATTTATTC
TTTGTCATTTTGGATGAGTGCAACGAATAATCAGATAGAATGATTGCATAACATATTGTT
AATATTCATTAAAGCTGTGGAAGAAATATCAATCCTGAAATCAGTACTGAAGATTTGTCT
AAGTATATACGTTTTGCTAGAACTATAAAGCCAATTTTCACTCGTGAAGCTGCCCTCGAA
TTGCAAAAATGCTATGTAAAACTTAGATAAAATGATTCAAGCTCTTAAAATACTTCATAC
AGAATTACAGTCAGACAGCTTGAATCTCTTATTAGATTAAGTGAAGCTTTGGCTAGAGTT
CACATTCAATCAGAAGTTACTGCTGAATTTGTATAGGAAGCCGCAAGATTACTCAGCAAT
TCTATTCTTAAAATAGAAAAGGGATAATTGGACATCTAAGATGAAGAAGAGCAAAAGATA
GACCTCAACTAATAAAAAGAATAAGGCTAAAACATTATTTAAGAAGATATTGAAAAAAAA
CAACAATAATAAAGAAAGAAGGAAGGTAAAATCTCAATTACTTATGAGGAATACTTAAAC
ATGAGAAAGATAATCATTCAAACAGTCAAAGATTTAGAAATAGAAGATAGTCTTAGAGTT
TCCACAGAAGGAGAAGACGGAATGGAAGTTGAAAGACAAAATGGTTTCGAATAAAGAGTT
ATTATAGAATAAATTCTTAAGCAATTATTAGAAAATGACCTTATCCAAACAGAAGAAGAT
GCTACTAAATTAAAAAAAATATATTCTCAAATTATTAAAAAGTTAGTAGATGTAGACTAA
GTTTTAATTGTTGTCGAAGAGGCCTCAAATTTAGACGAACGTAGATTATAACTTCATGCT
AACTACTGCGAACCTAGTTGA


>TTHERM_00448570(gene)
ATGAGCTAGATGAACTTTTCCTAAACAATCTAACTTAAGATTGAAACAGTAAAGACCTAA
TTCCTTAACTTCTTAAACAAGTATATTGCAATTATTGATTAACAAATAATTTTAATAATA
ATTTATTTCTAATAGCTTTGAAGTAGTTGAAAATGGAAAAAAAATCAAGTATTACAGAGA
AAAGGCACTTTTGTTGAAGATTTATGAAAAGAATACACTTTTTATTGACTTTAATCACTT
ATTAGATTTTATTGATGACAACGATATTTCAGATGTCATTTTAAACGACTACTACAAAAT
TGAACCTCACTTAAGAAAAATTGTTTCAAATTTCATCTTTAGTCTAACCAACACAAACGA
TAGCCAGTAATAAATAAATAATTTAATATTTTTTAATGATAAATTACTTTTGTAATGATA
AATAAAGATGCATGCTCTCTCAACAATGAGCTAGTTTATGATTTAGATATTTGATAAATG
AATGAATTACTATTATGATATTTTAATCTATTTTTTTATAATCAATTAGGGAAAGTTACT
ACCTTAGCTTTTACAACTTACCAACTGAAAAGAAAATTAGAGAATTGGGAACTTAAGAAA
TAGGTAAATTGAATAGTATTAAGGGTTTAGTTACTAGATCAAGTGAAGTACGTCCTGAAT
TACTTTATGGTACATTTATTTGCCAATTGTGTAATAGTGAAGTGCGTGATATTGAGTAGC
AATTTAAATACACTGAACCTAAAATATGTTCAAACCCTGGCTGTAACAACCATACTAAGT
GGATGTTAAAACCCTAATCATCAGTATTTTCTGATTTTTAGAAACTTAGAGTTCAAGAAG
AATCTACTGACATTCCTGCAGGAGGTATGCCTCGTTCTATTGATATTGTTTGTAGAGGTG
AAGTTGTTGACACCGCTAAGCCTGGTGATAAATGTATTTTCACTGGTTATTTAATTGTTG
TTCCTGATATAGCAGCTCTTACTAAACCAGGTGAAAAAACTGAAATGGGTATTAAATCTG
ATGCCGTTAGAGTCAAAGGAGAAGGAAATAATGATGGTATTACTGGTCTCTCTCAACTAG
GTCAAAGAGATTTGAACTACAGACTTGTTTTCTTAGCTATTAACATTGAAGCAAAAAAGA
GTAGATTCAACTTATGGAATTAAGATGAAGAAGAAAATCAGGTAATTAATCAAAATTTAA
CATTATTTATATTCATTTTAATAGAAAGAAAAGCAGCAATATAGATAGGGTTTTATTATA
GCAAAAATTAGAAAAGATTTAAAGTCTTTACTTTACTTTAGTTTTTTTGTTTGTCTGAGA
TAAGAAAAAAAATTAAAAACAAAAAATATTTGCAATAAATTTTCAAATTATTAAATAAAA
TTTTTATTTTTTAGTGAAATTTTGTTATTAATAAATAATTTATAATATTTGTAATAGGAT
TTAACTGAAGAAGAAGAAAGACAAAAAATTATGGAAAATTTCTCTGAAAGAGAACTTGAA
GACATTTTTAAAATAAGCAGAAGTTCTAATGTTTATGAAAGATTAGCATCTAGTTTGTGT
CCTACTGTACATGGTCACTTGGAAGTTAAAAAGGGTATTTTACTCATGCTTTTTGGTGGT
GTCAACAAAAAAACAGAAGAAGGTATTAACTTGAGAGGTGATATCAACATTTGCATGGTA
GGTGATCCATCTACTGCTAAGTCTCAATTCCTTAAATATGTTAATAAGCTTATTCCTCGT
TCAGTCTATACTTCTGGTAAAGCATCAACATCTGCTGGTTTGACTGCAAGTGTTTCTAAA
GATCCTGAAACTGGAGAAAATTGCATTGAAGCTGGTGCTTTGATGCTTTCTGACTAAGGT
ATTTGCTGTATCGATGAATTTGATAAGATGGATAAAAGAGATTAAGTCGCCATCCACGAA
GCTATGGAACAATAAACAATTTCTATTTCAAAGGCAGGTATTCAAGCTACCTTGAATTCA
AGAGCCAGTATTTTAGCTGCTGCAAACCCTGTTTTTGGTAGATACGATAAATCCAAGGGT
TTAAAATACAACTTAGATATAAGCGCTCCCATTCTTTCTCGTTTCGATTTATTCTTTGTC
ATTTTGGATGAGTGCAACGAATAATCAGATAGAATGATTGCATAACATATTGTTAATATT
CATTAAAGCTGTGGAAGAAATATCAATCCTGAAATCAGTACTGAAGATTTGTCTAAGTAT
ATACGTTTTGCTAGAACTATAAAGCCAATTTTCACTCGTGAAGCTGCCCTCGAATTGCAA
AAATGCTATGTAAAACTTAGATAAAATGATTCAAGCTCTTAAAATACTTCATACAGAATT
ACAGTCAGACAGCTTGAATCTCTTATTAGATTAAGTGAAGCTTTGGCTAGAGTTCACATT
CAATCAGAAGTTACTGCTGAATTTGTATAGGAAGCCGCAAGATTACTCAGCAATTCTATT
CTTAAAATAGAAAAGGGATAATTGGACATCTAAGATGAAGAAGAGCAAAAGATAGACCTC
AACTAATAAAAAGAATAAGGCTAAAACATTATTGTAAAAACAATTAATTAAATTTTTATA
CCTTATTTACTAATTAATCATTTTAATTTTAAAAAAAATAGTAAGAAGATATTGAAAAAA
AACAACAATAATAAAGAAAGAAGGAAGGTAAAATCTCAATTACTTATGAGGAATACTTAA
ACATGAGAAAGATAATCATTCAAACAGTCAAAGATTTAGAAATAGAAGATAGTCTTAGAG
TTTCCACAGAAGGAGAAGACGGAATGGAAGTTGAAAGACAAAGTAAATTAATTTTATTTA
TTTATTACCTCCAAATACTAAATTGAATTTTATTAATAAATTAGATGGTTTCGAATAAAG
AGTTATTATAGAATAAATTCTTAAGCAATTATTAGAAAATGACCTTATCCAAACAGAAGA
AGATGCTACTAAATTAAAAAAAATATATTCTCAAATTATTAAAAAGTTAGTAGATGTAGA
CTAAGTTTTAATTGTTGTCGAAGAGGCCTCAAATTTAGACGAACGTAGATTATAACTTCA
TGCTAACTACTGCGAACCTAGTTGA


>TTHERM_00448570(protein)
MSQMNFSQTIQLKIETVKTQFLNFLNNFEVVENGKKIKYYREKALLLKIYEKNTLFIDFN
HLLDFIDDNDISDVILNDYYKIEPHLRKIVSNFIFSLTNTNDSQESYYLSFYNLPTEKKI
RELGTQEIGKLNSIKGLVTRSSEVRPELLYGTFICQLCNSEVRDIEQQFKYTEPKICSNP
GCNNHTKWMLKPQSSVFSDFQKLRVQEESTDIPAGGMPRSIDIVCRGEVVDTAKPGDKCI
FTGYLIVVPDIAALTKPGEKTEMGIKSDAVRVKGEGNNDGITGLSQLGQRDLNYRLVFLA
INIEAKKSRFNLWNQDEEENQDLTEEEERQKIMENFSERELEDIFKISRSSNVYERLASS
LCPTVHGHLEVKKGILLMLFGGVNKKTEEGINLRGDINICMVGDPSTAKSQFLKYVNKLI
PRSVYTSGKASTSAGLTASVSKDPETGENCIEAGALMLSDQGICCIDEFDKMDKRDQVAI
HEAMEQQTISISKAGIQATLNSRASILAAANPVFGRYDKSKGLKYNLDISAPILSRFDLF
FVILDECNEQSDRMIAQHIVNIHQSCGRNINPEISTEDLSKYIRFARTIKPIFTREAALE
LQKCYVKLRQNDSSSQNTSYRITVRQLESLIRLSEALARVHIQSEVTAEFVQEAARLLSN
SILKIEKGQLDIQDEEEQKIDLNQQKEQGQNIIQEDIEKKQQQQRKKEGKISITYEEYLN
MRKIIIQTVKDLEIEDSLRVSTEGEDGMEVERQNGFEQRVIIEQILKQLLENDLIQTEED
ATKLKKIYSQIIKKLVDVDQVLIVVEEASNLDERRLQLHANYCEPS