Identifiers and Description

Gene Model Identifier

TTHERM_00456750

Standard Name

TOP2B (TOPoisomerase 2B )

Aliases

PreTt20305 | 53.m00207 | 3712.m00067

Description

TOP2B DNA topoisomerase IV; DNA topoisomerase type 2; DNA Topoisomerase II Enzyme

Genome Browser (Macronucleus)

Full Screen View


Genome Browser (Micronucleus)

Full Screen View

External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( PF00204 ) DNA gyrase B
  • ( PF00521 ) DNA gyrase/topoisomerase IV, subunit A
  • ( PF01751 ) Toprim domain
  • ( PF02518 ) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
  • ( PF16898 ) C-terminal associated domain of TOPRIM

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:28621664: Akematsu T, Fukuda Y, Garg J, Fillingham JS, Pearlman RE, Loidl J (2017) Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11. eLife 6( ):
  2. Ref:17821280: Harrison JA, Fowler EH (1945) AN ANTIGEN-ANTIBODY REACTION WITH TETRAHYMENA WHICH RESULTS IN DYSTOMY. Science (New York, N.Y.) 102(2638):65-6

Sequences 

>TTHERM_00456750(coding)
ATGTCAGTCGAAACAACTTATCAAAAAAAGACACAACTTGAACATATTTTATTGAGACCA
GATACTTACGTAGGTTCCAATGAATACCAAGATGAATAAATGTGGGTTCTAGCAGATGAC
GGATCATCTTTTGAAAACAGACAAATAAAGTATGTCCCAGCTCTTTATAAAATCTTTGAT
GAAATTCTTGTCAACGCAGCTGATAACTATTAGAGAGATAAGAGAATGAAAAGATTAGAT
GTAATTATTGATCAAAAGAACAATTGTATTTCAATCCTAAACGACGGAAAAGGAATTCCT
GTTTAGATTCATAAAGAATATAATATTTATGTTCCAGAACTTATTTTTGGACATCTTTTG
ACTTCTTCAAATTATAATGACGAAGAAAAAAAAGTTGTAGGAGGTAGAAATGGTTTTGGT
GCAAAGCTTACCAATATATTTTCAACTAAGTTTATTGTAGAATCAGCAGACTCTAAAAAC
AAAAAGAAATTTTAAATGACTTGGACAAAAAACATGTCTGAATAATCTGAACCACAAATA
TCAAGTTATACCGAAAGCGACTACACAAAAATCACTTTTTACCCTGACTTAAAGAAATTC
CACATGAAAGAACTAGAAAAGGATATTGTTGACTTGATGAAAAAAAGAGTATATGATATG
GCTGGTGTCATTGGCGGCTCTGTTAAAGTATCATTAAATGGAGAAAGAATTTCAATAAGT
TCATTCTCTGATTATTGCGATTTTTATTTAAAGAACCAAGGTGCAGAAGTAATTAAGGTA
TCAGATAATAAAGGTACCAATAATTAAAGATGGGAAGTTATAGCAAGTTTATCAGAGGGC
TAATTCTAATAAGTTTCATTTGTTAATTCAATTTGCACCTCAAAGGGAGGTACTCATGTT
AACTACATAACTGACTAAATCACTGAAAAATTGATGGAAACTTTGAAAAAAAAGGAGAAA
AGTCTTAACATTAAGTAATTTTAGGTTAAGAGTCATTTATGGATTTTCGTTAATTGCTTG
ATTGAGAATCCCTCTTTCGATACTTAAACTAAAGAAACACTAACTTTAAGATAATAAAGC
TTCGGTTCAACCTGTGAAGTTTCTGAAAAGTTTATCAAAGAACTCTTAAAATCAAATATT
ATTAATCATATCCTCCTTTAAGCTAGAGCTAAAGAGTAAGCAAAGATGGCTAAAACTTTG
TCTGCTAAAAAGCAAAGTAGATTATTAGGAGTTCCTAAGCTGGAAGATGCAAACGATGCA
GGTACAAGAAACGCTGAAAGCTGTACACTAATTATAACAGAAGGTGATTCTGCCAAAGCT
TTAGCTATGAGTGGTATTGAAGTTGTTGGAAGAGATAAATTTGGTGTCTTCCCATTAAAG
GGTAAAATGTTAAATGTAAGAGATTCTACAAGCAAGCAAATTACAGAAAATTTAGAAATC
TAAAATATCATCAAGGTAATGGGTATGAAGCTAAATACAAACTATGATAATGTTAAAAGT
TTGAGATATGGATCAATTATGATTATGGCTGATTAAGATCACGATGGTTCCCATATCAAA
GGTTTATTCATTAACTTTATATAGAATTTTTGGCCCAGCTTGTTCTAAATGGATGGTTTT
CTTAAAGAATTTATTACACCAATCGTGAAAGTTAGAAAAGGTAATTAATCAATAAGCTTC
TTTAGTATTCAAGACTTTAAAAGATGGAAAAGCACATGCCCAAACTAGCATTTATGGAAA
ATTAAGTATTACAAAGGTCTTGGTACTTCAACCGATTAAGAAGCCTAAGAATATTTTGGA
AATATAAACAAGCATGTCATTAGTTTTAAATACAATGGTAAGGATGATGAAGATGCTATT
GATTTGGCTTTTAATAAGAAGAGAGCTGAAGACCGTAAAAAATGGTTAGTTAAATATGAC
CCAGAAGAAAATGTTGACCACTCATAAAAACATTTGACATACAAAGATTTTGTTAATAAG
GAGCTAATTAATTTTTCTAATTCTGATAATGCAAGATCTATTCCCAGCCTTTGTGATGGT
TTAAAGCCTGGTTAAAGAAAAATTCTTTTTGCATGCTTTAAGAGAAACTTGAAGAATGAA
ATTAAAGTAGCTTAGTTATCTGGTTATGTAGCTGAACACTCCGCTTATCACCATGGTGAA
TAATCTTTAGAATCTACCATTGTAGGTATGGCTTAGAGTTTCGTTGGTACAAATAACATC
AATTACCTCATGCCTATAGGTCAATTCGGTTCTCGTAACATGGGAGGAAAGGAAGCTGCA
TCTGCAAGATATATCCATACTTGCTTAAATAAAATTACTCGTTGTGTTTTCCCTGAGCCA
GACGATCATATTCTCTACTACCTTGAAGATGAAGGATAATAGGTAGAACCTATTTATTAC
CTTCCTATCATCCCTACAGCTCTTTTAAATGGTGCTGATGGTATCGGTACAGGTTGGTCT
ACTAGTATTCCTTGCTATAACCCAAGAGAATTAGTTGATTCAATTGAAAAAAGAATGATG
GGAGTTCCCTTTACTGATTTATTGCCATGGTACAAAGGTTTCACTGGTGAAATTTCTAAT
AACGAAAAATCTTAAATTACTGTTAGTGGAAAGTACCATTTAGTAAATGAAACAACAATA
GAAATTACTGAATTACCTATTAAGAAATGGATTAGAGATTATAAGAACTTTTTAGAAGAG
AAATTAGAATCTACTAAAGATAAGGATCCCGAAATTGAAGATATTAAGGAATATCATGCT
GGTAATAGAGTGCATTTTGTAGTTAAAATGAGCGAAAAGCAAATGGAAAAAGTATAAAGG
GAAGGTATTGACAAATACTTCAAATTATAATCAACTATTCCTACTACAAACATGGTTTTA
TTCAATCATGAAGGAAAACTTACTAGATATGCTAATATTTGCGAAATTATGGAAGAGTTT
TATGAAGTTAGATTAAATGCATATAAAAGGAGAAAGGAATATTTGGTCTCTAAAATCGAA
CGTGATTTAGAAATTCTTTCTAATAAAAAAAGATTCATTTTAGCTGTCATAAATGAATCT
ATTAGAGTAAGAAACGCTAAGAGAAAAGACTTGATCAAAGAACTAAGCGTCTAAGGTTAC
GTCTAAATGAAAGATATGCCAAAAATTAAATCAAGTAAGCTTACAAGCTAACTTGAATAA
GAATAAAATTAAGATAGTAATGAAGAAAATTTTGAAACTAATCCTAATGAGATTAATGCT
AAAGAGTATAACTATCTCCTTAGTTTGCCTATGTGGAGCTTGACTTATGAAAAAGTTGAA
GAGATAAAGTAAGAATAAAAAAATAAGTAGGACGAGTTAGACAAGCTTGTTGCTACTGAA
GTTATTGATATTTGGAAAGAAGATCTTAAAAACTTCATTGAATGCCTTGATTAAATTGAG
GAAGAAGAAGATGAAGAAATGCGTAAAAGAATGAAGAAACAAAGCAACTCTAAAGTTAAA
TAAGGCAGTACAGCTAGTTCTAAGTTAAAGAAAAAACCAACCAAGAAGAAATAAGATAGT
GACGATGATGACGATGATGCCATGGATATAGAGGAAGATGGAGATGGATCAGATTTTGAT
ACAGGCAAGAAAAAATAGAAGAAAAAACCTTCATCAGCTCCTTCTTCATAAGCAGGACCT
AAGGGAAAGATCGGTGATTATAAACCTAATTTGTCTTAAGATACAGGAATAAGCAGTAAA
ACAAATAAAAATAATTAAAATACTCTCGGGTTTATCAAATAGTAAGCTCCAATTACTACT
TAAGTTAAGACTCAACCAGAAGTCAAAAAACCAGTAGATCCTTTGCTTGAAACTTTAGAA
AAATATACTTTCAAGAAAGAAAATACTTAAACATAAAAAGAAGAAAATAATACATAAAAT
TCAGTTATATCTTAAATACTTTCATAAAACTATTCTCTATCACTTGAAGAGAGACTTAAA
TTGAGGGCAGGGGAAAACTCATAAAATTTGACTCAATAAACAAATGGATTTTCCTAATAA
GTAAATACATAATAAGACTATAATAACTTGGGCAATAAAGATGAAGAAGAAGAAGATGAC
CTTCTCTTTAACTTCAAAAAAGAAAAGAAAGAGAAATAATCAACTGATATTTTTGATGAA
TTAGATGATCTTGATGCACTTTTTAATGAAAAACGCTAAGGAGCAGACCTCGAAAATGAA
GAAGAGTAGCTGACCAAAAAAAGAGTTCTGAATGAAGGAGAACCAAAAAGTATAGCTTAA
AATAAAAAATAAACAAAAGAAATAAATGATGAAGATCTTGAATATAATTTGTTTAAGGAT
GAAAAGCCAAAGTAAAAAAAGCCTCCTGCTACTGCTGCTTCAAAATCAAAGAAAGTGATA
AATAAAAATGAAGATGATGATGAAGACTTTAATGATGATTTATCAGAAGATGAAAAACCA
AAGAAGAAAAGGTCCAATTAAACTTAATCAAAAACCAAAAAATAGAAAAATGAAAGTGAA
GATGAAGATTTTAATAGCAAAGAATCTGATGAAAAACCTAAATAAAGAAAATCTAATTCT
AACTCATAAAAAGCAAGGAAACCTAAGAAAATGAGTGATGATGAGGGAGAAGAAGATGAT
GATTTTATCATACCTGATGAGGATTCTGATGAAGAAAAACCTAAGAAGAGAAAGAGTAAT
GCAACAAAACCTAAAAATAATAAAGAAGATAAAGATAATCAAAAGTCTAAAAAAAATAGA
ACCGATTCACCAAAACTTAAAATAACAAATTCAGAAGATGAAGATGTTGCTGAATTAAAG
CAAAATGAAGTTTTATAAACCAGAACAAGAGGTAAAAGAAACCCAATTCCTCGTAAAATG
ATCATTGATAATTCTGATGAAGATTTCAGTGAAGAGGAAGAATTTGGAAATAGCAAAAAG
AAATCAGTAAATAGTAAAAGCCAAAAAAAATAAAAAGACGATGAATCATCGGATGAATGC
TATTTCTGA



>TTHERM_00456750(gene)
AAAATCAAAATCAAATTATTAATAGGATTTAATTATCTTAAAAATAGGAAAAATAAAGCA
TAAGTATAAAGCTTATAAATAAAAGAAACAGCTCTTATATAAATCTAGCTTTAAATCTAT
TATAAATAAAAAAGTCAAACAGGATGTCAGTCGAAACAACTTATCAAAAAAAGACACAAC
TTGAACATATTTTATTGAGACCAGATACTTACGTAGGTTCCAATGAATACCAAGATGAAT
AAATGTGGGTTCTAGCAGATGACGGATCATCTTTTGAAAACAGACAAATAAAGTATGTCC
CAGCTCTTTATAAAATCTTTGATGAAATTCTTGTCAACGCAGCTGATAACTATTAGAGAG
ATAAGAGAATGAAAAGATTAGATGTAATTATTGATCAAAAGAACAATTGTATTTCAATCC
TAAACGACGGAAAAGGAATTCCTGTTTAGATTCATAAAGAATATAATATTTATGTTCCAG
AACTTATTTTTGGACATCTTTTGACTTCTTCAAATTATAATGACGAAGAAAAAAAAGTTG
TAGGAGGTAGAAATGGTTTTGGTGCAAAGCTTACCAATATATTTTCAACTAAGTTTATTG
TAGAATCAGCAGACTCTAAAAACAAAAAGAAATTTTAAATGACTTGGACAAAAAACATGT
CTGAATAATCTGAACCACAAATATCAAGTTATACCGAAAGCGACTACACAAAAATCACTT
TTTACCCTGACTTAAAGAAATTCCACATGAAAGAACTAGAAAAGGATATTGTTGACTTGA
TGAAAAAAAGAGTATATGATATGGCTGGTGTCATTGGCGGCTCTGTTAAAGTATCATTAA
ATGGAGAAAGAATTTCAATAAGTTCATTCTCTGATTATTGCGATTTTTATTTAAAGAACC
AAGGTGCAGAAGTAATTAAGGTATCAGATAATAAAGGTACCAATAATTAAAGATGGGAAG
TTATAGCAAGTTTATCAGAGGGCTAATTCTAATAAGTTTCATTTGTTAATTCAATTTGCA
CCTCAAAGGGAGGTACTCATGTTAACTACATAACTGACTAAATCACTGAAAAATTGATGG
AAACTTTGAAAAAAAAGGAGAAAAGTCTTAACATTAAGTAATTTTAGGTTAAGAGTCATT
TATGGATTTTCGTTAATTGCTTGATTGAGAATCCCTCTTTCGATACTTAAACTAAAGAAA
CACTAACTTTAAGATAATAAAGCTTCGGTTCAACCTGTGAAGTTTCTGAAAAGTTTATCA
AAGAACTCTTAAAATCAAATATTATTAATCATATCCTCCTTTAAGCTAGAGCTAAAGAGT
AAGCAAAGATGGCTAAAACTTTGTCTGCTAAAAAGCAAAGTAGATTATTAGGAGTTCCTA
AGCTGGAAGATGCAAACGATGCAGGTACAAGAAACGCTGAAAGCTGTACACTAATTATAA
CAGAAGGTGATTCTGCCAAAGCTTTAGCTATGAGTGGTATTGAAGTTGTTGGAAGAGATA
AATTTGGTGTCTTCCCATTAAAGGGTAAAATGTTAAATGTAAGAGATTCTACAAGCAAGC
AAATTACAGAAAATTTAGAAATCTAAAATATCATCAAGGTAATGGGTATGAAGCTAAATA
CAAACTATGATAATGTTAAAAGTTTGAGATATGGATCAATTATGATTATGGCTGATTAAG
ATCACGATGGTTCCCATATCAAAGGTTTATTCATTAACTTTATATAGAATTTTTGGCCCA
GCTTGTTCTAAATGGATGGTTTTCTTAAAGAATTTATTACACCAATCGTGAAAGTTAGAA
AAGGTAATTAATCAATAAGCTTCTTTAGTATTCAAGACTTTAAAAGATGGAAAAGCACAT
GCCCAAACTAGCATTTATGGAAAATTAAGTATTACAAAGGTCTTGGTACTTCAACCGATT
AAGAAGCCTAAGAATATTTTGGAAATATAAACAAGCATGTCATTAGTTTTAAATACAATG
GTAAGGATGATGAAGATGCTATTGATTTGGCTTTTAATAAGAAGAGAGCTGAAGACCGTA
AAAAATGGTTAGTTAAATATGACCCAGAAGAAAATGTTGACCACTCATAAAAACATTTGA
CATACAAAGATTTTGTTAATAAGGAGCTAATTAATTTTTCTAATTCTGATAATGCAAGAT
CTATTCCCAGCCTTTGTGATGGTTTAAAGCCTGGTTAAAGAAAAATTCTTTTTGCATGCT
TTAAGAGAAACTTGAAGAATGAAATTAAAGTAGCTTAGTTATCTGGTTATGTAGCTGAAC
ACTCCGCTTATCACCATGGTGAATAATCTTTAGAATCTACCATTGTAGGTATGGCTTAGA
GTTTCGTTGGTACAAATAACATCAATTACCTCATGCCTATAGGTCAATTCGGTTCTCGTA
ACATGGGAGGAAAGGAAGCTGCATCTGCAAGATATATCCATACTTGCTTAAATAAAATTA
CTCGTTGTGTTTTCCCTGAGCCAGACGATCATATTCTCTACTACCTTGAAGATGAAGGAT
AATAGGTAGAACCTATTTATTACCTTCCTATCATCCCTACAGCTCTTTTAAATGGTGCTG
ATGGTATCGGTACAGGTTGGTCTACTAGTATTCCTTGCTATAACCCAAGAGAATTAGTTG
ATTCAATTGAAAAAAGAATGATGGGAGTTCCCTTTACTGATTTATTGCCATGGTACAAAG
GTTTCACTGGTGAAATTTCTAATAACGAAAAATCTTAAATTACTGTTAGTGGAAAGTACC
ATTTAGTAAATGAAACAACAATAGAAATTACTGAATTACCTATTAAGAAATGGATTAGAG
ATTATAAGAACTTTTTAGAAGAGAAATTAGAATCTACTAAAGATAAGGATCCCGAAATTG
AAGATATTAAGGAATATCATGCTGGTAATAGAGTGCATTTTGTAGTTAAAATGAGCGAAA
AGCAAATGGAAAAAGTATAAAGGGAAGGTATTGACAAATACTTCAAATTATAATCAACTA
TTCCTACTACAAACATGGTTTTATTCAATCATGAAGGAAAACTTACTAGATATGCTAATA
TTTGCGAAATTATGGAAGAGTTTTATGAAGTTAGATTAAATGCATATAAAAGGAGAAAGG
AATATTTGGTCTCTAAAATCGAACGTGATTTAGAAATTCTTTCTAATAAAAAAAGATTCA
TTTTAGCTGTCATAAATGAATCTATTAGAGTAAGAAACGCTAAGAGAAAAGACTTGATCA
AAGAACTAAGCGTCTAAGGTTACGTCTAAATGAAAGATATGCCAAAAATTAAATCAAGTA
AGCTTACAAGCTAACTTGAATAAGAATAAAATTAAGATAGTAATGAAGAAAATTTTGAAA
CTAATCCTAATGAGATTAATGCTAAAGAGTATAACTATCTCCTTAGTTTGCCTATGTGGA
GCTTGACTTATGAAAAAGTTGAAGAGATAAAGTAAGAATAAAAAAATAAGTAGGACGAGT
TAGACAAGCTTGTTGCTACTGAAGTTATTGATATTTGGAAAGAAGATCTTAAAAACTTCA
TTGAATGCCTTGATTAAATTGAGGAAGAAGAAGATGAAGAAATGCGTAAAAGAATGAAGA
AACAAAGCAACTCTAAAGTTAAATAAGGCAGTACAGCTAGTTCTAAGTTAAAGAAAAAAC
CAACCAAGAAGAAATAAGATAGTGACGATGATGACGATGATGCCATGGATATAGAGGAAG
ATGGAGATGGATCAGATTTTGATACAGGCAAGAAAAAATAGAAGAAAAAACCTTCATCAG
CTCCTTCTTCATAAGCAGGACCTAAGGGAAAGATCGGTGATTATAAACCTAATTTGTCTT
AAGATACAGGAATAAGCAGTAAAACAAATAAAAATAATTAAAATACTCTCGGGTTTATCA
AATAGTAAGCTCCAATTACTACTTAAGTTAAGACTCAACCAGAAGTCAAAAAACCAGTAG
ATCCTTTGCTTGAAACTTTAGAAAAATATACTTTCAAGAAAGAAAATACTTAAACATAAA
AAGAAGAAAATAATACATAAAATTCAGTTATATCTTAAATACTTTCATAAAACTATTCTC
TATCACTTGAAGAGAGACTTAAATTGAGGGCAGGGGAAAACTCATAAAATTTGACTCAAT
AAACAAATGGATTTTCCTAATAAGTAAATACATAATAAGACTATAATAACTTGGGCAATA
AAGATGAAGAAGAAGAAGATGACCTTCTCTTTAACTTCAAAAAAGAAAAGAAAGAGAAAT
AATCAACTGATATTTTTGATGAATTAGATGATCTTGATGCACTTTTTAATGAAAAACGCT
AAGGAGCAGACCTCGAAAATGAAGAAGAGTAGCTGACCAAAAAAAGAGTTCTGAATGAAG
GAGAACCAAAAAGTATAGCTTAAAATAAAAAATAAACAAAAGAAATAAATGATGAAGATC
TTGAATATAATTTGTTTAAGGATGAAAAGCCAAAGTAAAAAAAGCCTCCTGCTACTGCTG
CTTCAAAATCAAAGAAAGTGATAAATAAAAATGAAGATGATGATGAAGACTTTAATGATG
ATTTATCAGAAGATGAAAAACCAAAGAAGAAAAGGTCCAATTAAACTTAATCAAAAACCA
AAAAATAGAAAAATGAAAGTGAAGATGAAGATTTTAATAGCAAAGAATCTGATGAAAAAC
CTAAATAAAGAAAATCTAATTCTAACTCATAAAAAGCAAGGAAACCTAAGAAAATGAGTG
ATGATGAGGGAGAAGAAGATGATGATTTTATCATACCTGATGAGGATTCTGATGAAGAAA
AACCTAAGAAGAGAAAGAGTAATGCAACAAAACCTAAAAATAATAAAGAAGATAAAGATA
ATCAAAAGTCTAAAAAAAATAGAACCGATTCACCAAAACTTAAAATAACAAATTCAGAAG
ATGAAGATGTTGCTGAATTAAAGCAAAATGAAGTTTTATAAACCAGAACAAGAGGTAAAA
GAAACCCAATTCCTCGTAAAATGATCATTGATAATTCTGATGAAGATTTCAGTGAAGAGG
AAGAATTTGGAAATAGCAAAAAGAAATCAGTAAATAGTAAAAGCCAAAAAAAATAAAAAG
ACGATGAATCATCGGATGAATGCTATTTCTGACAAAAAATATTATAATTTAAAAAACAGT
TGTATCTTTATATTAAATTTTAAATATTTGTGTGTATCTAACTCTTTAAAATTTATTGTG
TCA



>TTHERM_00456750(protein)
MSVETTYQKKTQLEHILLRPDTYVGSNEYQDEQMWVLADDGSSFENRQIKYVPALYKIFD
EILVNAADNYQRDKRMKRLDVIIDQKNNCISILNDGKGIPVQIHKEYNIYVPELIFGHLL
TSSNYNDEEKKVVGGRNGFGAKLTNIFSTKFIVESADSKNKKKFQMTWTKNMSEQSEPQI
SSYTESDYTKITFYPDLKKFHMKELEKDIVDLMKKRVYDMAGVIGGSVKVSLNGERISIS
SFSDYCDFYLKNQGAEVIKVSDNKGTNNQRWEVIASLSEGQFQQVSFVNSICTSKGGTHV
NYITDQITEKLMETLKKKEKSLNIKQFQVKSHLWIFVNCLIENPSFDTQTKETLTLRQQS
FGSTCEVSEKFIKELLKSNIINHILLQARAKEQAKMAKTLSAKKQSRLLGVPKLEDANDA
GTRNAESCTLIITEGDSAKALAMSGIEVVGRDKFGVFPLKGKMLNVRDSTSKQITENLEI
QNIIKVMGMKLNTNYDNVKSLRYGSIMIMADQDHDGSHIKGLFINFIQNFWPSLFQMDGF
LKEFITPIVKVRKGNQSISFFSIQDFKRWKSTCPNQHLWKIKYYKGLGTSTDQEAQEYFG
NINKHVISFKYNGKDDEDAIDLAFNKKRAEDRKKWLVKYDPEENVDHSQKHLTYKDFVNK
ELINFSNSDNARSIPSLCDGLKPGQRKILFACFKRNLKNEIKVAQLSGYVAEHSAYHHGE
QSLESTIVGMAQSFVGTNNINYLMPIGQFGSRNMGGKEAASARYIHTCLNKITRCVFPEP
DDHILYYLEDEGQQVEPIYYLPIIPTALLNGADGIGTGWSTSIPCYNPRELVDSIEKRMM
GVPFTDLLPWYKGFTGEISNNEKSQITVSGKYHLVNETTIEITELPIKKWIRDYKNFLEE
KLESTKDKDPEIEDIKEYHAGNRVHFVVKMSEKQMEKVQREGIDKYFKLQSTIPTTNMVL
FNHEGKLTRYANICEIMEEFYEVRLNAYKRRKEYLVSKIERDLEILSNKKRFILAVINES
IRVRNAKRKDLIKELSVQGYVQMKDMPKIKSSKLTSQLEQEQNQDSNEENFETNPNEINA
KEYNYLLSLPMWSLTYEKVEEIKQEQKNKQDELDKLVATEVIDIWKEDLKNFIECLDQIE
EEEDEEMRKRMKKQSNSKVKQGSTASSKLKKKPTKKKQDSDDDDDDAMDIEEDGDGSDFD
TGKKKQKKKPSSAPSSQAGPKGKIGDYKPNLSQDTGISSKTNKNNQNTLGFIKQQAPITT
QVKTQPEVKKPVDPLLETLEKYTFKKENTQTQKEENNTQNSVISQILSQNYSLSLEERLK
LRAGENSQNLTQQTNGFSQQVNTQQDYNNLGNKDEEEEDDLLFNFKKEKKEKQSTDIFDE
LDDLDALFNEKRQGADLENEEEQLTKKRVLNEGEPKSIAQNKKQTKEINDEDLEYNLFKD
EKPKQKKPPATAASKSKKVINKNEDDDEDFNDDLSEDEKPKKKRSNQTQSKTKKQKNESE
DEDFNSKESDEKPKQRKSNSNSQKARKPKKMSDDEGEEDDDFIIPDEDSDEEKPKKRKSN
ATKPKNNKEDKDNQKSKKNRTDSPKLKITNSEDEDVAELKQNEVLQTRTRGKRNPIPRKM
IIDNSDEDFSEEEEFGNSKKKSVNSKSQKKQKDDESSDECYF