Identifiers and Description

Gene Model Identifier

TTHERM_00481220

Standard Name

KIN1 (KINesin)

Aliases

PreTt06254 | 58.m00226 | 3719.m00082

Description

KIN1 kinesin motor catalytic domain protein; Kinesin II heavy chain homolog; implicated in intraciliary transport; shares essential functions with KIN2 in ciliary assembly and maintenance, rotokinesis and phagocytosis; localizes to locomotory and oral cilia undergoing active assembly; Kinesin-like protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• cilium (IGI) | GO:0005929
• kinesin II complex (ISS) | GO:0016939

Biological Process

• cilium assembly (IMP) | GO:0042384
• obsolete movement of cell or subcellular component (IMP) | GO:0006928
• phagocytosis (IGI) | GO:0006909
• septum digestion after cytokinesis (IGI) | GO:0000920

Domains

• ( PF00225 ) Kinesin motor domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:14983519: Awan A, Bernstein M, Hamasaki T, Satir P (2004) Cloning and characterization of Kin5, a novel Tetrahymena ciliary kinesin II. Cell motility and the cytoskeleton 58(1):1-9
2. Ref:12925756: Brown JM, Fine NA, Pandiyan G, Thazhath R, Gaertig J (2003) Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport subunit gene. Molecular biology of the cell 14(8):3192-207
3. Ref:10512852: Brown JM, Marsala C, Kosoy R, Gaertig J (1999) Kinesin-II is preferentially targeted to assembling cilia and is required for ciliogenesis and normal cytokinesis in Tetrahymena. Molecular biology of the cell 10(10):3081-96
4. Ref:11212349: Cole DG (1999) Kinesin-II, the heteromeric kinesin. Cell Mol Life Sci 56(3-4):217-26
5. Ref:10772758: Brown JM, Hardin C, Gaertig J (1999) Rotokinesis, a novel phenomenon of cell locomotion-assisted cytokinesis in the ciliate Tetrahymena thermophila. Cell biology international 23(12):841-8

Sequences

>TTHERM_00481220(coding)
ATGAGCAAATAAGAAAAAAATAGTAAAAATGATGAGTGTGTTAAGGTCGTCGTTAGATGT
AGACCTTTGAACTCAAAGGAAAAAGAAGATGGAAGAACATAAGTAGTATTTGTAAATTAA
TCAAGAGGTGAAATTTCAGTCACAAACCCAAAAGGTGATTCAGCTGAAGCACCTAAAGTA
TTTACTTTTGATTCCACATTTGAACCTGAAGTTGAATAAGAAACTGTTTACAAAAATACT
GCATATCCAATTGTTGAAAGTGTTCTTGAGGGTTATAATGGAACTATTTTTGCATATGGT
CAAACTGGTACAGGTAAAACCCATACTATGGAAGGTAAAGATGAACCTAAACATTTAAGA
GGTATCATTCCTAGAACTTTCGACCATATTTTCCGTTCAATTAAGGGAACTCCAAACGTA
CAGTTTTTAGTTAGAGTTAGTTTTCTTGAATTGTACAATGAAGAAATTAGAGATCTACTT
TAGAAGAATATCAAAAAGTTAGAATTGAGAGAAAAACCAGGCAGTGGTGTTTATGTAAAA
GATTTGTCTACTTTTATGATTTAAGATTAAGAAGAATTGAGAGAAAAATTATTACATGGT
CGTGAAAATCGTGCTGTAGGAGCTACTTAAATGAATCAAGATTCTTCACGTTCTCACTCT
ATTTTTGCAATTACTATTGAAAGATGCGATATTGTTAATGGTGAAAGCCACATTAGAGTC
GGTAAGTTAAATCTTGTCGATCTTGCTGGTTCTGAACGTTAGAGTAAAACTCAAGCTACT
GGTTCTAGACTAAAAGAAGCCATTAATATTAACTAAAGTTTAACAACTCTAGGTAACGTT
ATCTCCTCTCTTATCGATCCTAAAGCTACCCACGTTCCTTATAGAGATTCTAAATTAACA
AGACTTCTTTAAGATTCACTTGGTGGTAACACTAAAACTGTTATGGTTGCTAACGTTGGT
CCTGCCGACTTTAACTATGATGAAACTATTTCAACTTTGAGATATGCCCACAGAGCTAAA
TCCATTTAGAATCATGCTAAAATTAATGAAGATCCTAAAGATGCTATGATTAGATAGTTT
TAAGAAGAAATTGCTAAGTTGAAATAACAATTAGCCAGTTCAGTTGATAAAGATGGAAAT
ATTGTCATGATGGAAGCAGAAGTCATCTAGGTTGAAAAAGTCATTACTATTAATGATGAT
GAAAAGGTCAAGCTTTTATAGCAAAAGTTAGAGCAAGAAAAGTCTGAAGTTGAGAAGAAG
TATTAGAATGAAGTAAAGAAGATTGAAGAAGATAAAAAACTTTAAGAAAAAGAAAAGCAA
CAACTTCTCTAACAACTTATGGATAAAGAAGAAAGAGAATAGAAGTAGAGAGAACAACAA
GAAAAATTGCTTAAAAAATTATAAAAAATGTAAGAAAAAGTTATTTAAGGAGATGAAATT
ATGTAAAAGGCTCTTGAAAAAGAAAGAGAATTAAATAAAGCCCAGCAAGAATTGCAACAA
AGAAAGGAAAGAGACCGTTAAATAGCTGAATAAATTAAAAGAAATGAAGATTTGGCTTTA
GAAATTAATTAAAAATATAGAAGTTAAGCAGAAGAAGCTTAGGATAAAACAAAAAGAATA
AAAGCATTGGTTGGTAGACTTAAATAAATTGAAAGTGAAAACAGAGAACTCGATGATTTC
TATGGTTCTGAAATAGAATAACTCTAAGAAAGACGTAGAGATTTGTAAAAAGAACTCAAG
TTAAAGAATTTAATACTTGAATATTTCATTCCTGAAAAAGAGTTAGAAAGATTATAATTA
AGAGCAATGTATAATGAAGAGCTAGATGAATGGATGTATCCTTACTTACACCTGGCTGGA
AATTTAGTTAGAAATTCAGAAGAAAGAAAATAATAAGAATAAGAGATTAAATTTTAAGAA
GATGTTGAAGAAATTCTTAAACTAGAAGAAGAAGGTCATCCAAATGTATTCTTTGTATAC
ACTGAAGAAGGACCAGTTCGTGAAGATGACATAGACCCAGAGCAAAGAAAAAAGAAAGCA
GTTGCACAAGCTAGAAAATAAAGTGCCAAAAAACGTCCAACTTCAAAGCCAGGGTAATCA
GCTACATCAAAAAGACCATAAAGCGGTGTTAAAAATTCAAATAACAGCTCTTCTGTTACA
GCTGACTCTGATAATTACCCCAAAGCAAAAGGATTATAACCTAAAAAGTGA

>TTHERM_00481220(gene)
AAAGCAACAATATTTGAGTTGTTTAATTAGAAAATCAAATAAATAGGGAGTAATTTGACA
AAAGATAATAGATTCATTCATAGACAACATATCAATTAAGTATAATGAGCAAATAAGAAA
AAAATAGTAAAAATGATGAGTGTGTTAAGGTCGTCGTTAGATGTAGACCTTTGAACTCAA
AGGAAAAAGAAGATGGAAGAACATAAGTAGTATTTGTAAATTAATCAAGAGGTGAAATTT
CAGTCACAAACCCAAAAGGTGATTCAGCTGAAGCACCTAAAGTATTTACTTTTGATTCCA
CATTTGAACCTGAAGTTGAATAAGAAACTGTTTACAAAAATACTGCATATCCAATTGTTG
AAAGTGTTCTTGAGGGTTATAATGGAACTATTTTTGCATATGGTCAAACTGGTACAGGTA
AAACCCATACTATGGAAGGTAAAGATGAACCTAAACATTTAAGAGGTATCATTCCTAGAA
CTTTCGACCATATTTTCCGTTCAATTAAGGGAACTCCAAACGTACAGTTTTTAGTTAGAG
TTAGTTTTCTTGAATTGTACAATGAAGAAATTAGAGATCTACTTTAGAAGAATATCAAAA
AGTTAGAATTGAGAGAAAAACCAGGCAGTGGTGTTTATGTAAAAGATTTGTCTACTTTTA
TGATTTAAGATTAAGAAGAATTGAGAGAAAAATTATTACATGGTCGTGAAAATCGTGCTG
TAGGAGCTACTTAAATGAATCAAGATTCTTCACGTTCTCACTCTATTTTTGCAATTACTA
TTGAAAGATGCGATATTGTTAATGGTGAAAGCCACATTAGAGTCGGTAAGTTAAATCTTG
TCGATCTTGCTGGTTCTGAACGTTAGAGTAAAACTCAAGCTACTGGTTCTAGACTAAAAG
AAGCCATTAATATTAACTAAAGTTTAACAACTCTAGGTAACGTTATCTCCTCTCTTATCG
ATCCTAAAGCTACCCACGTTCCTTATAGAGATTCTAAATTAACAAGACTTCTTTAAGATT
CACTTGGTGGTAACACTAAAACTGTTATGGTTGCTAACGTTGGTCCTGCCGACTTTAACT
ATGATGAAACTATTTCAACTTTGAGATATGCCCACAGAGCTAAATCCATTTAGAATCATG
CTAAAATTAATGAAGATCCTAAAGATGCTATGATTAGATAGTTTTAAGAAGAAATTGCTA
AGTTGAAATAACAATTAGCCAGTTCAGTTGATAAAGATGGAAATATTGTCATGATGGAAG
CAGAAGTCATCTAGGTTGAAAAAGTCATTACTATTAATGATGATGAAAAGGTCAAGCTTT
TATAGCAAAAGTTAGAGCAAGAAAAGTCTGAAGTTGAGAAGAAGTATTAGAATGAAGTAA
AGAAGATTGAAGAAGATAAAAAACTTTAAGAAAAAGAAAAGCAACAACTTCTCTAACAAC
TTATGGATAAAGAAGAAAGAGAATAGAAGTAGAGAGAACAACAAGAAAAATTGCTTAAAA
AATTATAAAAAATGTAAGAAAAAGTTATTTAAGGAGATGAAATTATGTAAAAGGCTCTTG
AAAAAGAAAGAGAATTAAATAAAGCCCAGCAAGAATTGCAACAAAGAAAGGAAAGAGACC
GTTAAATAGCTGAATAAATTAAAAGAAATGAAGATTTGGCTTTAGAAATTAATTAAAAAT
ATAGAAGTTAAGCAGAAGAAGCTTAGGATAAAACAAAAAGAATAAAAGCATTGGTTGGTA
GACTTAAATAAATTGAAAGTGAAAACAGAGAACTCGATGATTTCTATGGTTCTGAAATAG
AATAACTCTAAGAAAGACGTAGAGATTTGTAAAAAGAACTCAAGTTAAAGAATTTAATAC
TTGAATATTTCATTCCTGAAAAAGAGTTAGAAAGATTATAATTAAGAGCAATGTATAATG
AAGAGCTAGATGAATGGATGTATCCTTACTTACACCTGGCTGGAAATTTAGTTAGAAATT
CAGAAGAAAGAAAATAATAAGAATAAGAGATTAAATTTTAAGAAGATGTTGAAGAAATTC
TTAAACTAGAAGAAGAAGGTCATCCAAATGTATTCTTTGTATACACTGAAGAAGGACCAG
TTCGTGAAGATGACATAGACCCAGAGCAAAGAAAAAAGAAAGCAGTTGCACAAGCTAGAA
AATAAAGTGCCAAAAAACGTCCAACTTCAAAGCCAGGGTAATCAGCTACATCAAAAAGAC
CATAAAGCGGTGTTAAAAATTCAAATAACAGCTCTTCTGTTACAGCTGACTCTGATAATT
ACCCCAAAGCAAAAGGATTATAACCTAAAAAGTGATTTAAATATTTAAATAATTAATTTA
AGTATTTTCATAAAATAATTAAAATCTTATTTGTATTGTTTATGTAATCAAATTAGTTTA
AAAAACTTTACAAATTTT

>TTHERM_00481220(protein)
MSKQEKNSKNDECVKVVVRCRPLNSKEKEDGRTQVVFVNQSRGEISVTNPKGDSAEAPKV
FTFDSTFEPEVEQETVYKNTAYPIVESVLEGYNGTIFAYGQTGTGKTHTMEGKDEPKHLR
GIIPRTFDHIFRSIKGTPNVQFLVRVSFLELYNEEIRDLLQKNIKKLELREKPGSGVYVK
DLSTFMIQDQEELREKLLHGRENRAVGATQMNQDSSRSHSIFAITIERCDIVNGESHIRV
GKLNLVDLAGSERQSKTQATGSRLKEAININQSLTTLGNVISSLIDPKATHVPYRDSKLT
RLLQDSLGGNTKTVMVANVGPADFNYDETISTLRYAHRAKSIQNHAKINEDPKDAMIRQF
QEEIAKLKQQLASSVDKDGNIVMMEAEVIQVEKVITINDDEKVKLLQQKLEQEKSEVEKK
YQNEVKKIEEDKKLQEKEKQQLLQQLMDKEEREQKQREQQEKLLKKLQKMQEKVIQGDEI
MQKALEKERELNKAQQELQQRKERDRQIAEQIKRNEDLALEINQKYRSQAEEAQDKTKRI
KALVGRLKQIESENRELDDFYGSEIEQLQERRRDLQKELKLKNLILEYFIPEKELERLQL
RAMYNEELDEWMYPYLHLAGNLVRNSEERKQQEQEIKFQEDVEEILKLEEEGHPNVFFVY
TEEGPVREDDIDPEQRKKKAVAQARKQSAKKRPTSKPGQSATSKRPQSGVKNSNNSSSVT
ADSDNYPKAKGLQPKK