Identifiers and Description

Gene Model Identifier

TTHERM_00486790

Standard Name

DRP1 (Dynamin Related Protein 1)

Aliases

PreTt19610 | 59.m00248 | 3680.m00105

Description

DRP1 dynamin central region family protein; Dynamin-related protein (DRP); localized to endocytic sites; essential for growth; DRP1 expression required for clathrin-mediated endocytosis; one of 8 DRP genes in Tetrahymena

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• ciliary basal body (IDA) | GO:0036064
• clathrin-coated pit (IDA) | GO:0005905

Molecular Function

• GTP binding (IEA) | GO:0005525
• GTPase activity (IEA) | GO:0003924

Biological Process

• clathrin-dependent endocytosis (IMP) | GO:0072583

Domains

• ( PF00350 ) Dynamin family
• ( PF01031 ) Dynamin central region
• ( PF01926 ) 50S ribosome-binding GTPase
• ( PF02212 ) Dynamin GTPase effector domain
• ( PF03789 ) ELK domain
• ( PF08256 ) Aurein-like antibiotic peptide

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_5951	0
	Description: None
Tetrahymena borealis	EI9_12179.1	9.997093137033517e-262
	Description: dynamin central region family protein (643 aa)
Oxytricha	Contig22482.0.g88	9.997093137033517e-262
	Description: Dynamin central region
Tetrahymena borealis	EI9_12246.1	9.997093137033517e-262
	Description: hypothetical protein (244 aa)
SGD	YKR001C	9.999242092827953e-100
	Description: VPS1 Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
DictyBase	DDB_G0277849	3.9985196551577655e-99
	Description: dymA on chromosome: 3 position 252381 to 255025
WormBase	WBGene00001093	7.998415523157811e-91
	Description: locus:drp-1 status:Confirmed UniProt:Q8WQC9 protein_id:CCD70526.1
Tetrahymena borealis	EI9_20593.1	7.998415523157811e-91
	Description: hypothetical protein (733 aa)

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16276403: Elde NC, Morgan G, Winey M, Sperling L, Turkewitz AP (2005) Elucidation of clathrin-mediated endocytosis in tetrahymena reveals an evolutionarily convergent recruitment of dynamin. PLoS genetics 1(5):e52

Sequences

>TTHERM_00486790(coding)
ATGGCTGAGCAAGAAAGTTCATTTTAGGGATCAGGTCTTTTTGATAACCTTAGAAAGTTA
ATTAACGTCATCGATGAATTAAGAGATGTCGGTTTACAACAATATATTAGATTGCCTAGA
ATCGCAGTTATTGGTTCTTAATCATCTGGTAAATCATCTCTTCTCGAAAGTATCGTTGGT
ATCGATTTCTTGCCAAGAGGTTCTGGTGTAGTTACTCGTAGACCTTTAGAACTCAGATTA
GTTCATGTGCCTCCCAATGAAAGATAAATCAAGCCATATGCTATTTTCGATGTTGATAAA
TCAAAGAAGTGGGAAAACTTTGATTAGGTTAGATAACAAATCGATTTCTTAACTGACCAA
GTTGCAGGTAAGAGAAAGAAAATTATCAATGACCCTATCGTATTGACTATTTACTCAAAT
GATGTTATCGATTTGACAATTATTGATTTGCCTGGTATTACAAGAATTCCCTTAAAAGAT
TCAGACCAATAAGAAGATATCGAAAAAGTTACTAAAGATATGGCTTACTCATACATAAAA
GATGAAAGAACAATTATTTTGTGTGTTGTTCCTGGTAACTAGGATATTTCTAACTCCGAT
GGTCTCTAATTAGCTAGAGAAGTAGACAGAGAAGGCAATAGAACAATTGGTGTTGTTACA
AAACTTGATATCATGGATGCTGATACTGATGCAAGAAAAATGATCATGGGTCTTGAAATT
CCTTTGAAATTAGGATATGTTGGTGTCAAGGGTAGATCTCAAAAGGATATTAATGACAAT
AAGAGAGTTTCTAAAGCTCTTGACGAAGAAAGACTTTTCTTTGCTTAGCATAAAGTATAC
TCAACTATGGATCCTAAGTTCTTAGGTACTAAAGCTTTGACTAATAAGTTATCAAGTGTG
CTTTTCTATCACATTAGAAATATTTTACCTGCTATCGTCAAGGAAATTAAAGATAAATTG
AAAGAATGTGAAGATAGACTTAAAGACTTGGGTCCCTCTCTTCCAAGAGAACAAAAAGAT
AAAATGCAACTTATCTGGACCATGATTACTGATTTTACTGAAAACTTTAAAAATACAATT
AAGGGTAAATACGATCAAAGACGTTCTAATATTAATACAGAATTATCTGGTGGTGCAGTT
ATTAAGATGATGTTCAATGAGCTTTATGAAGATTTCATTTAAAAAACCTTTAGAGCAACT
AGAGAATATAGCGATAAAGATATTTAAACAGCTATTTAATTGCATTAAGGTGATTCTATT
CCAGGTTTCCCCTCAATAGATGCTTTCTTATATTTAATTAATCCTCAATTAGAAAAGCTA
AAAGACCCTGCCTTTGAATGCTTAACTTAATGCTACAATTATTTGGAAGGTTTAGCTAAT
AAGATTTTGAAGAAAATATTCTCAAGATTCCCCACTGTTATGGACGAAATTGCAGATATT
ACAAGCAGAGTGCTTCAAGCTTAAAGAGATTAAGCAAAAGAAGTTGTTAACAATATTATT
GAATCTGAATAAGGTTACCTTTTCACTAATGATTTAGGCTATCTTGCTCACAGAACTCAT
TTGATTCCAGCTCAAGAATCTGGTAAAGAAGGTTAACAATAGATAGATGCTGAAAAAGCT
TTTATTAATGAATTGAGATCTAGAGTAGACGTTTACTTCAATATCGTTGTCAGAAATGTA
AGAGACTCTATTCCTAAGGCTATTGGTTTCTTCTTAGTTAAGGCTGCTTAAGAATAATTG
TAATATTAATTATATAATGAAATTATGAGAAGTGAAGATTCTCTTGGTAGCATTGCAGAA
CCTGCCAACATCGCAGAAGAAAGAGATACACTCAATAAAACTATCGAAGTTCTTCAAAAG
GCTCATAGAGTTATTAAGAGAGATCCTGATCTTCAACCCAGATATGATGGATAGAATCCT
TAAAAGCAAGTTGTTTGA

>TTHERM_00486790(gene)
ATGGCTGAGCAAGAAAGTTCATTTTAGGGATCAGGTCTTTTTGATAACCTTAGAAAGTTA
ATTAACGTCATCGATGAATTAAGAGATGTCGGTTTACAACAATATATTAGATTGCCTAGA
ATCGCAGTTATTGGTTCTTAATCATCTGGTAAATCATCTCTTCTCGAAAGTATCGTTGGT
ATCGATTTCTTGCCAAGAGGTTCTGTAAGCTTTAAAATTAAAATACTCTTAATAAGTTAT
TTAAATTTAATCTACCTATAACAAAATAGGGTGTAGTTACTCGTAGACCTTTAGAACTCA
GATTAGTTCATGTGCCTCCCAGTAATAAAAAAGCATTTTTGTTTTTACATATTTTTATGA
ATATTTGAAAACAGTGAACATAAAACAATCTTTTTCTAACTTAAATGAAAAAAAATTTAC
TGATTAGATAGAATTTGATTGCGCTAGAATAGAATATCAAAATAAATTGAATCTAAAATA
TGAAACATTTTATTAATTTCAAACTATAAAAATTAGATGAAAGATAAATCAAGCCATATG
CTATTTTCGATGTTGATAAATCAAAGAAGTGGGAAAACTTTGATTAGGTTAGATAACAAA
TCGATTTCTTAACTGACCAAGTTGCAGGTAAGAGAAAGAAAATTATCAATGACCCTATCG
TATTGACTATTTACTCAAATGATGTTATCGATTTGACAATTATTGATTTGCCTGGTATTA
CAAGAATTCCCTTAAAAGATTCAGACCAATAAGAAGATATCGAAAAAGTTACTAAAGATA
TGGCTTACTCGTAACTTATTTTTTATATAATTACAAATGTTTTAATAGTAAATTATAGCC
AAAAGCTTCCATCAAAGCAACCTTCTTTGAAAAAAATTAAAGGAGTTTTTTAACTTAAGT
TATGAGGCGATTTTGTTAAAATTATCCAAATTAAAAGCAATACATCAATAAAAAATACTT
AATCATGCACACATTTTAAACAAAAATTATTATAAAAATAGATACATAAAAGATGAAAGA
ACAATTATTTTGTGTGTTGTTCCTGGTAACTAGGATATTTCTAACTCCGATGGTCTCTAA
TTAGCTAGAGAAGTAGACAGAGAAGGCAATAGAACAATTGGTGTTGTTACAAAAGTATGC
AGCATTTATTTCTTAAATATAAAAAATAAATAAATATTTTAGAGGCTATTTATTCTAAAT
TTGCTTTATTTAATTAAAAAAGCTTGATATCATGGATGCTGATACTGATGCAAGAAAAAT
GATCATGGGTCTTGAAATTCCTTTGAAATTAGGATATGTTGGTGTCAAGGGTAGATCTCA
AAAGGATATTAATGACAATAAGAGAGTTTCTAAAGCTCTTGACGAAGAAAGACTTTTCTT
TGCTTAGCATAAAGTATACTCAACTATGGATCCTAAGTTCTTAGGTACTAAAGCTTTGAC
TAATAAGTTATCAAGTGTGCTTTTCTATCACATTAGAAATATTTTACCTGCTATCGTCAA
GGAAATTAAAGATAAATTGAAAGAATGTGAAGATAGACTTAAAGACTTGGGTCCCTCTCT
TCCAAGAGAACAAAAAGATAAAATGCAACTTATCTGGACCATGATTACTGATTTTACTGA
AAACTTTAAAAATACAATTAAGGGTAAATACGATCAAAGACGTTCTAATATTAATACAGA
ATTATCTGGTGGTGCAGTTATTAAGATGATGGTAAATAAATTTACCTTATCATTAATTAT
TAATCATACATTTTTATATAATTAATTAAATAGTTCAATGAGCTTTATGAAGATTTCATT
TAAAAAACCTTTAGAGCAACTAGAGAATATAGCGATAAAGATATTTAAACAGCTATTTAA
TTGCATTAAGGTGATTCTATTCCAGGTTTCCCCTCAATAGATGCTTTCTTATATTTAATT
AATCCTCAATTAGAAAAGCTAAAAGACCCTGCCTTTGAATGCTTAACTTAATGCTACAAT
TATTTGGAAGGTTTAGCTAATAAGATTTTGAAGAAAATATTCTCAAGATTCCCCACTGTT
ATGGACGAAATTGCAGATATTACAAGCAGAGTGCTTCAAGCTGTAAATTTACTTTAATTT
TTATTTAAAAAGATATTTAGCTCAATATTTAAAATTAAAATAGTAAAGAGATTAAGCAAA
AGAAGTTGTTAACAATATTATTGAATCTGAATAAGGTTACCTTTTCACTAATGATTTAGG
CTATCTTGCTCACAGAACTCATTTGATTCCAGTATATTTTAATATTCTCAAACTTTTTAT
AAATAATTTTAATTAAAAAAAAAGGCTCAAGAATCTGGTAAAGAAGGTTAACAATAGATA
GATGCTGAAAAAGCTTTTATTAATGAATTGAGATCTAGAGTAGACGTTTACTTCAATATC
GTTGTCAGAAATGTAAGAGACTCTATTCCTAAGGCTATTGGTTTCTTCTTAGTTAAGGCT
GCTTAAGAATAATTGTAATATTAATTATATAATGAAATTATGAGAAGTGAAGATTCTCTT
GGTAGCATTGCAGAAGTATGTTTTTTTTTTCAAATAGTTAAAACCAAATTTAATCTTATT
TTTTTCTTCAATCTAGCCTGCCAACATCGCAGAAGAAAGAGATACACTCAATAAAACTAT
CGAAGTTCTTCAAAAGGCTCATAGAGTTATTAAGAGAGATCCTGAGTAATTTTATTTCAA
AAATGTAATTGTTTAAATAAATATTTTTTTTTAAATAGTCTTCAACCCAGATATGATGGA
TAGAATCCTTAAAAGCAAGTTGTTTGA

>TTHERM_00486790(protein)
MAEQESSFQGSGLFDNLRKLINVIDELRDVGLQQYIRLPRIAVIGSQSSGKSSLLESIVG
IDFLPRGSGVVTRRPLELRLVHVPPNERQIKPYAIFDVDKSKKWENFDQVRQQIDFLTDQ
VAGKRKKIINDPIVLTIYSNDVIDLTIIDLPGITRIPLKDSDQQEDIEKVTKDMAYSYIK
DERTIILCVVPGNQDISNSDGLQLAREVDREGNRTIGVVTKLDIMDADTDARKMIMGLEI
PLKLGYVGVKGRSQKDINDNKRVSKALDEERLFFAQHKVYSTMDPKFLGTKALTNKLSSV
LFYHIRNILPAIVKEIKDKLKECEDRLKDLGPSLPREQKDKMQLIWTMITDFTENFKNTI
KGKYDQRRSNINTELSGGAVIKMMFNELYEDFIQKTFRATREYSDKDIQTAIQLHQGDSI
PGFPSIDAFLYLINPQLEKLKDPAFECLTQCYNYLEGLANKILKKIFSRFPTVMDEIADI
TSRVLQAQRDQAKEVVNNIIESEQGYLFTNDLGYLAHRTHLIPAQESGKEGQQQIDAEKA
FINELRSRVDVYFNIVVRNVRDSIPKAIGFFLVKAAQEQLQYQLYNEIMRSEDSLGSIAE
PANIAEERDTLNKTIEVLQKAHRVIKRDPDLQPRYDGQNPQKQVV