Identifiers and Description

Gene Model Identifier

TTHERM_00499420

Standard Name

TGP1 (Tetrahymena G-DNA binding Protein )

Aliases

PreTt07985 | 63.m00163 | 3716.m00017

Description

TGP1 G-quartet DNA-binding protein TGP1; G-quartet DNA binding protein; shows preference for binding parallel G-DNAs; activity localized predominantly in the nuclear fraction; knockout strain shows increased occurrence of extra micronuclei; not essential for growth; Nucleic acid-binding, OB-fold

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• nucleus (IDA) | GO:0005634

Molecular Function

• G-quadruplex DNA binding (IDA) | GO:0051880

Biological Process

• nuclear division (IMP) | GO:0000280

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:10908364: Lu Q, Henderson E (2000) Two Tetrahymena G-DNA-binding proteins, TGP1 and TGP3, share novel motifs and may play a role in micronuclear division. Nucleic acids research 28(15):2993-3001
2. Ref:9512530: Lu Q, Schierer T, Kang SG, Henderson E (1998) Purification, characterization and molecular cloning of TGP1, a novel G-DNA binding protein from Tetrahymena thermophila. Nucleic acids research 26(7):1613-20
3. Ref:7509637: Schierer T, Henderson E (1994) A protein from Tetrahymena thermophila that specifically binds parallel-stranded G4-DNA. Biochemistry 33(8):2240-6

Sequences

>TTHERM_00499420(coding)
ATGACTGATCAAGGTGTCGCTAAAGAACAATACATTACCGTCGGTAGTTTGAAGGAAATT
GCAGATCCCGTCAAGAAATTCCTTAGAAAGGGAAACAGAAAGGGTAGAAATTAGAAGGAA
TTAAAGTTCAGAGCTAAGGTTGTTAACCAATAACTTGCTGACGAAACTGGCTCTATCAAC
TTCACTACTGAAGGTGTTGCCGTAAATAACAACCAAACTTATGAATTCACTGGTTCCTTG
AAGGTTGTCGACTATAAGCTCAACTTAGCTGTTACCTCTGCTACTCCTGCTAAAGATTAA
ATTGCTAATCTTGGTTCTGAATAACTCAGCAAAGCTGATATTGATCAACACTCAGGAAAG
CATATCGTTTTGATCAAGGATCTCATTAATCTTAGAATCGGTCAATCTTTCTTCGCTAGA
CCTAGAGATATTGTTCACAATAACGAATAAAGAAGAATGACAGCTACCTTAGCCGATAAC
ACTGCTGCTATCCAAGCTGAAATTAGTGTTAACAAGAAATCAATCACTTAAGAAGTACTT
GAATCCTTAAACTCTGATAAGGTCTACCTTTTCAGTGATGTTGTTCTCAACTTCAATGAA
AGTAACAAGTTAGTTGCCAGATTCAACTACAGATCAAACATTGTTGAAGCTAATGACCGT
TAGATCTAACAATTATCAAATAACAACTTGAGCGCCAAAGAATACTCAGATGAAACTGAA
AAGAAGGCTCTTACTGATGTCCTCTAAATCCATGAAAAGAAGGAAAGAGTTCACAAATAG
TAAAATAAGAATAAAAATACAAGAAATGCTCACAAGAATCACAACAGATAAAGACCAAAT
TTATAAGAAACTGAACCCGTAAAAATTAGCGGTCTCTAATAATGGAACAATAACTAGACA
GTTATTGGCAAGATTGTCTCTCTCCGCACTGAAGATAAGTCTTTACCAGCTAAGCAAGAC
GGTACCTCAACTACCATGGTCTACCTTAAGGGAACTATTGGTGACGAAACAGGTGTAATT
GATTTCGATATGGCTGAAAAAAGAGATTGCCCTCGTTTCAAAGAAAATGATGTCGTTAAA
TTCACCTCTGTAATGAACAAAGGTAGATAAAGCGCTGAAGGAAAAGTCGGTGGTCACTAC
ATCGAAGTTAAGAAATTCGGTCAATATATTATCCTTTCAGATCATAATATTAACAATGTA
AATTTAAACAATAACTTGTCTAATTTAGAACTCACCGCTCGTCCCAAGAATCCCAACCCA
AGATTCATCAAGGGAGAATTTGTTGGTGTAAAGGAAGAAGAAAAAGATGGAAACATCTAA
TATACTTACACTGTCAGAAGTAAAGAAGGTGAAGAACAATCTATCACTATTAGAAACAAA
ATTACTACACTTAAAGTTGGTGAAATTCACAAAATCGATAGAGAAAGAAAAAGATCAAGT
AGCAGACCTAATCATCAAGGTGGTTAAAGGGGAAATAGATCTCATTCTTAAAATAACAGA
AACCAAAGAAATAGAGATAAGCACCACAATAGCTAAAACAATTAACCCAATAAATACAAC
AAAAACACTTCCGTCTAAAACAATAACAACAACAAAAACTAATAAAGATCTTAATCACAA
AACCAAAGACCTCCTAGAAACTATGATAACAGACAAGGAGGTGAAAATAGAAATAATAGA
TAAAGAAATGAAAATAATAGAAATAATTTCAATGGCAATGGTCATAGAGTCAATAACCAA
AACAATCAAAGAAATAGAAATAGCTCATATCCTAGAAATAATAACTATGATCATCATCAT
AATTAATAAACCGATATTTCTGGCTTAGAACCTGGTAAGAGAGGTCAAAATGTAACTGGT
TAGGTAAAGATAAATTTAAAATTAAATAAAAAAATGATATATCTAAATAACTATAATTAG
GTGATTGAAGTTTCTGAATTCTCCAAGTAGATCAATGATAAAACTTTACACTTTGTCAAG
GGTAGAATTGCTGATGAAAATGCTAATATTAGATTTGATATCAAGAAACCTTAAAACTTA
GAAATTAAGGTTGGTGAAGTCTATAATTTCAAGGACGTTAACAACAAAGTTGATGATAAT
GGTTACCACTATATTGACCTCAATAGATTTGGCAGAGTTTTCCCTTCTCATAAAAAATTC
TAAAGCATTAATGATAAAAGAAATTGTGATGCTGATCGTTCATCAATTGAATACGTCAAA
AAAACTGTCCCTAACTGA

>TTHERM_00499420(gene)
AGAAAAAGATATTTTTCACATTCAAAATAAAATAAAAAAAACTCCACTTAAAAAAAAAAC
AACAACAACAAAAATTAAAAAAATGACTGATCAAGGTGTCGCTAAAGAACAATACATTAC
CGTCGGTAGTTTGAAGGAAATTGCAGATCCCGTCAAGAAATTCCTTAGAAAGGGAAACAG
AAAGGGTAGAAATTAGAAGGAATTAAAGTTCAGAGCTAAGGTTGTTAACCAATAACTTGC
TGACGAAACTGGCTCTATCAACTTCACTACTGAAGGTGTTGCCGTAAATAACAACCAAAC
TTATGAATTCACTGGTTCCTTGAAGGTTGTCGACTATAAGCTCAACTTAGCTGTTACCTC
TGCTACTCCTGCTAAAGATTAAATTGCTAATCTTGGTTCTGAATAACTCAGCAAAGCTGA
TATTGATCAACACTCAGGAAAGCATATCGTTTTGATCAAGGATCTCATTAATCTTAGAAT
CGGTCAATCTTTCTTCGCTAGACCTAGAGATATTGTTCACAATAACGAATAAAGAAGAAT
GACAGCTACCTTAGCCGATAACACTGCTGCTATCCAAGCTGAAATTAGTGTTAACAAGAA
ATCAATCACTTAAGAAGTACTTGAATCCTTAAACTCTGATAAGGTCTACCTTTTCAGTGA
TGTTGTTCTCAACTTCAATGAAAGTAACAAGTTAGTTGCCAGATTCAACTACAGATCAAA
CATTGTTGAAGCTAATGACCGTTAGATCTAACAATTATCAAATAACAACTTGAGCGCCAA
AGAATACTCAGATGAAACTGAAAAGAAGGCTCTTACTGATGTCCTCTAAATCCATGAAAA
GAAGGAAAGAGTTCACAAATAGTAAAATAAGAATAAAAATACAAGAAATGCTCACAAGAA
TCACAACAGATAAAGACCAAATTTATAAGAAACTGAACCCGTAAAAATTAGCGGTCTCTA
ATAATGGAACAATAACTAGACAGTTATTGGCAAGATTGTCTCTCTCCGCACTGAAGATAA
GTCTTTACCAGCTAAGCAAGACGGTACCTCAACTACCATGGTCTACCTTAAGGGAACTAT
TGGTGACGAAACAGGTGTAATTGATTTCGATATGGCTGAAAAAAGAGATTGCCCTCGTTT
CAAAGAAAATGATGTCGTTAAATTCACCTCTGTAATGAACAAAGGTAGATAAAGCGCTGA
AGGAAAAGTCGGTGGTCACTACATCGAAGTTAAGAAATTCGGTCAATATATTATCCTTTC
AGATCATAATATTAACAATGTAAATTTAAACAATAACTTGTCTAATTTAGAACTCACCGC
TCGTCCCAAGAATCCCAACCCAAGATTCATCAAGGGAGAATTTGTTGGTGTAAAGGAAGA
AGAAAAAGATGGAAACATCTAATATACTTACACTGTCAGAAGTAAAGAAGGTGAAGAACA
ATCTATCACTATTAGAAACAAAATTACTACACTTAAAGTTGGTGAAATTCACAAAATCGA
TAGAGAAAGAAAAAGATCAAGTAGCAGACCTAATCATCAAGGTGGTTAAAGGGGAAATAG
ATCTCATTCTTAAAATAACAGAAACCAAAGAAATAGAGATAAGCACCACAATAGCTAAAA
CAATTAACCCAATAAATACAACAAAAACACTTCCGTCTAAAACAATAACAACAACAAAAA
CTAATAAAGATCTTAATCACAAAACCAAAGACCTCCTAGAAACTATGATAACAGACAAGG
AGGTGAAAATAGAAATAATAGATAAAGAAATGAAAATAATAGAAATAATTTCAATGGCAA
TGGTCATAGAGTCAATAACCAAAACAATCAAAGAAATAGAAATAGCTCATATCCTAGAAA
TAATAACTATGATCATCATCATAATTAATAAACCGATATTTCTGGCTTAGAACCTGGTAA
GAGAGGTCAAAATGTAACTGGTTAGGTAAAGATAAATTTAAAATTAAATAAAAAAATGAT
ATATCTAAATAACTATAATTAGGTGATTGAAGTTTCTGAATTCTCCAAGTAGATCAATGA
TAAAACTTTACACTTTGTCAAGGGTAGAATTGCTGATGAAAATGCTAATATTAGATTTGA
TATCAAGAAACCTTAAAACTTAGAAATTAAGGTTGGTGAAGTCTATAATTTCAAGGACGT
TAACAACAAAGTTGATGATAATGGTTACCACTATATTGACCTCAATAGATTTGGCAGAGT
TTTCCCTTCTCATAAAAAATTCTAAAGCATTAATGATAAAAGAAATTGTGATGCTGATCG
TTCATCAATTGAATACGTCAAAAAAACTGTCCCTAACTGAGAGGAAAGAAAGAGCCATAT
AAAAAATGCTATCAACTTGAGGAATTAGCAAATAAATAAAATTAAATAGCTTCATGAATA
AATAAATTGACCATCATTATCAATCAATGATTAATTTACATCAAGATTAGAATATTATTT
AAAATATTTCTTAATGGTTAATAAATCAATCTATCTTTACATATTTTATATTTTGATCGT
T

>TTHERM_00499420(protein)
MTDQGVAKEQYITVGSLKEIADPVKKFLRKGNRKGRNQKELKFRAKVVNQQLADETGSIN
FTTEGVAVNNNQTYEFTGSLKVVDYKLNLAVTSATPAKDQIANLGSEQLSKADIDQHSGK
HIVLIKDLINLRIGQSFFARPRDIVHNNEQRRMTATLADNTAAIQAEISVNKKSITQEVL
ESLNSDKVYLFSDVVLNFNESNKLVARFNYRSNIVEANDRQIQQLSNNNLSAKEYSDETE
KKALTDVLQIHEKKERVHKQQNKNKNTRNAHKNHNRQRPNLQETEPVKISGLQQWNNNQT
VIGKIVSLRTEDKSLPAKQDGTSTTMVYLKGTIGDETGVIDFDMAEKRDCPRFKENDVVK
FTSVMNKGRQSAEGKVGGHYIEVKKFGQYIILSDHNINNVNLNNNLSNLELTARPKNPNP
RFIKGEFVGVKEEEKDGNIQYTYTVRSKEGEEQSITIRNKITTLKVGEIHKIDRERKRSS
SRPNHQGGQRGNRSHSQNNRNQRNRDKHHNSQNNQPNKYNKNTSVQNNNNNKNQQRSQSQ
NQRPPRNYDNRQGGENRNNRQRNENNRNNFNGNGHRVNNQNNQRNRNSSYPRNNNYDHHH
NQQTDISGLEPGKRGQNVTGQVKINLKLNKKMIYLNNYNQVIEVSEFSKQINDKTLHFVK
GRIADENANIRFDIKKPQNLEIKVGEVYNFKDVNNKVDDNGYHYIDLNRFGRVFPSHKKF
QSINDKRNCDADRSSIEYVKKTVPN