Identifiers and Description

Gene Model Identifier

TTHERM_00499470

Standard Name

TPA10 (Tetrahymena P-type ATPase )

Aliases

PreTt07990 | 63.m00168 | 3716.m00022

Description

TPA10 E1-E2 ATPase family protein; Novel P-type ATPase with undefined ion specificity; shares certain homology to Plasmodium ATPase-1; constitutively expressed; expression upregulated at 37C and downregulated by starvation

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• membrane (IEA) | GO:0016020

Molecular Function

• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824
• hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (IEA) | GO:0016820

Biological Process

• ATP biosynthetic process (IEA) | GO:0006754
• metabolic process (IEA) | GO:0008152
• monoatomic ion transport (ISS) | GO:0006811

Domains

• ( PF00122 ) E1-E2 ATPase
• ( PF00690 ) Cation transporter/ATPase, N-terminus
• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( PF07112 ) Protein of unknown function (DUF1368)
• ( PF08282 ) haloacid dehalogenase-like hydrolase
• ( TIGR00099 ) Cof-like hydrolase
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( TIGR01497 ) K+-transporting ATPase, B subunit
• ( TIGR01512 ) cadmium-translocating P-type ATPase
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
• ( TIGR01523 ) potassium/sodium efflux P-type ATPase, fungal-type
• ( TIGR01524 ) magnesium-translocating P-type ATPase
• ( TIGR01525 ) heavy metal translocating P-type ATPase
• ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
• ( TIGR01657 ) P-type ATPase of unknown pump

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_09686.1	9.997093137033517e-262
	Description: E1-E2 ATPase (1193 aa)
Oxytricha	Contig21988.0.g64	4.000089512234839e-180
	Description: E1-E2 ATPase
DictyBase	DDB_G0284849	1.999126889527329e-167
	Description: DDB_G0284849 on chromosome: 4 position 2557758 to 2561551
WormBase	WBGene00022010	6.997264088033092e-153
	Description: locus:catp-7 status:Partially_confirmed UniProt:Q86FP2 protein_id:CCD71143.1
Tetrahymena borealis	EI9_41328.1	6.997264088033092e-153
	Description: hypothetical protein (373 aa)
SGD	YOR291W	1.99972299831384e-147
	Description: YPK9 Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
Stentor Coeruleus	SteCoe_35057	7.362997122252211e-76
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
3. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28
4. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60

Sequences

>TTHERM_00499470(coding)
ATGAATACAGAAAATCAACAATAGATATAGATTGAAGAAAAAAAGTATAATTCTTTAAAA
ACTATTCCTCAGTAGGGTCTATAATGTAAATAGTATTACAAAGCTTAAGAAGAGTGCTTG
ATTGAAAAGGTCTATCCTGTATAAAAACCTTTAAGCTTACTTATACTAGAAATAACTCTT
TACATATTATCTGGAGGTTTACTTTTTATATTATTTTCTTGGAATAATGAATGGAAATTT
AAAATATTCTTTAAACTTGTTAATATTAATTAAGCTACTTAAATTGTAGTTTATGGACCA
GATAAGGATGTCTAGATAGAAAAAATTGTGAATTTAGAAAACAAATGTATTTTTCAATAT
AGATTTTAAAAATTTGTTTATGATGAATAGTCCTTAATTTTCGTGCCATTTGGCGATAGT
ATAATCGAAAGAAACCATAAAGAAATTATTGAGTCAGCTAAAACGGGTTTAAATGACTCT
TAGATTAATTCCTCTATTACTAAAAACGGAGTTAATTCTACTGATATACCAGATTAAGGC
GTTTTGGTTCTAGCATTTCATGAATTCTTTTCTCCTTTCTTCTTGTTTCAAGTTGCAAGT
TGTCTTTTATGGTATTTTGATACTTATGAAATCTATGCTACAGTTATTATTACCACATCA
ACTTTTAGTTTGCTTTTTAAGTTATACGAAGAAAGAACAAATATAAATCGTATAAAAAAA
TTAAGCTATTTTAGGGGTTAAACAACAGTAGTTAGAAATGGACAAACCAAAGTTATCTCT
TCAAACGAGTTAGCATATGGCGATGTTGTTATTTTAAAAGAGGGTGAGACAGCTCCATGT
GATATGGTGATAGTAGAAGGTAGTGTCATAGTAAACGAATCTATGCTTACTGGAGAATCC
GTTCCTATTATCAAATCTGCTCTAGCAGATTTAGACTGCTAATTTAGCGAAAATCGTTAA
AATATTATTTATGGTGGAAGTTAGGTTATGATGGTTTCAAATTCCAAGTTAGTAGTTATT
AGAATAGGTTTTGAAACTCTTAAAGGGAACTTGATCCGTTCCATCCTTTATCCAAAGCAA
CATAATCAAATTTCATTTTAGAATGATTCTGTTAAATTCTTATCTATCCTTCTATTTGTT
ACATTGATATAATTCTTTATTGCATTACCAACTTTCATTGATAACTTAGATCGAGGTACT
ATGGATTCATCAGATTTAATTAAAAAATTTTTTGATTTAATCACCATCAGTGTTCCTCCT
GCTTTGCCAACATGCCTTTCCTTTGGTGTCTCCTTCTCGTTAAATAGAATGCGTAGAAAA
CAAATTTTTTGTATCAATAATGAAAAAATTAATATTTGCGGTATTGTAAAAAGTGTGTGT
TTTGATAAGACTGGTACTTTGACTGAAGAGCTCCTATCCTTTAAACTTATTTCTTCATTT
TTAAGTAGCTCAAACAAATTTGAAGATTAGTTTTCTGAAGAAGCTGCTAAAAAAAACAAA
CACATATTTCCTACCTTCTCCAAAATTTAAAGATAAATTATAGCATCGTGCCACAGTATC
ATGGTTTATAATAACGAATTTATTGGAGATCCTTTGGACATTGAAATGTTTAAAAATTCA
TCATATTGCTTAGTTGAAAATGAAAATTCAAAAAGCGATAACTAGGCAGATTAAAATGAT
AAATTATTTTATTAAGGTTATGAAGTTTTGCAAGAACTTACTTGCAACAAAAGTTTAGGA
TCACCAATTTTTATTCTGAAAAGATTTTAATTTGATGCTGATGTTTAAAGAATGTCGGTT
ATAGTAGCTATTACAAAAGAAAATCAAAATTATATCTATACAAAAGGCTCACCTGAAAGC
ATTCAGAAAATTTGTAAATAATAAACTATTCCCAATGACTTTTCAAATAAATTATAAGAA
TTTACAAATGAAGGATATCGTGTTCTTGCATTAGCTTATAGTTAGATTAATGAAGTTGAT
TTTGAAAAAGACAGAAACCAATACGAAGCAAACCTAACTTTTGCAGGTTTTTTGGTATTT
GAAAACAAATTAAAACCAGAAACAACAGAACATATCAAACTACTTAAAAATAATGACGTT
TAAGTCCGTATGGTAACTGGTGACAATCCTGAAACTTCCTTGAATATTGCTAAACAATGT
GGAATTTTAAGTTTAAATTAGTAAATTAATCTCCTTGATTATAGTAATAATTAATTTACA
ATGAATGGAAAAAAATCTGATTTAGATTAATTTATAAATTCAGCTTCATTTGTTTAAGGA
TAGGAATAGTTAGTTATTACTGGTAATTTTTTTGAAGAATTCCTCCAAAACAAAACAAAT
CAGAATTCATAATAAAACCAATGCGACATTGAAAGCAATACTTGCTCAAAGAGAACTAGC
TTATTCTTTACTCTTATTTTATAGTACGGAAAAGTTTTTGCGAGAATGAAGCCAGATTAG
AAGTAAAGCTTAATACATCTATTGCAAAAGTATTAAAATCCAGAGTAAGGATACTCATTT
GTTGGAATGTGTGGTGATGGTGCAAATGACTGCTAAGCTCTGAAAGATGCTGATATGGGT
ATTTCATTAGGTGAAGCAGAGGCTTCCGTTGCAGCTGCTTTCACAAGCAAGGTTATTAAT
ATAAGTGTTATTGAATACATTTTACGTGAAGGTAGATGCTGCTTAACAACTTCATTTTAA
TGCTTTAAGTACATGGCCCTTTACTCTCTTATATAAGGTTTCACTTAAACTTTGACTTAT
TTTCGTGGTACACAACCAGCTGATATGTAGATTCTGTATTGGGATCTTTTTATTATCATT
CCTCTAACATTTTTCTTAGGCTTAACTGAAGCTAGTGATAAACTTACACCTGATATTCCA
GCACATCGGCTTTTCTCATACAAAAATATACTCTCTGTTGCTGGCTAAGGTGTTATTTAA
CTCTTGTTTTTAATCATAACAGTAGCTACTACATGTAATCAAAGCTGGTATCTTAACCCA
TAATAATTATCTAAAGCTTAAGAATTTGAAGACGAAGAATTAGCACCAACTACATATGAC
ACAACTGTTCTATTCTGGGTTTCTAACTTCTAATACATTTTCACTGTAATAGCTTTTTCT
ATTGGTTCTGTTCATAAAAAACCATTCTATACAAACATTCTATTCACTTTCTTCCTTGTT
TCAATCACAGGCTTGAGTTTACTAATTATTTTCTCAGAACAATAACCCATACTTGATTTC
TTTACTCTTTTTATCAAAGCTACTAATTAAAATGATGAAATCGTTTCATAAATGGATTAT
AGCTGGAAATTCGTAATTTTAGCTATTATTTTAGCAAATGCTATAGTAACAATATTGTAC
GAAAAGTATTTCTTAGCATTTTTAAATAATTTACTTGATAAAAAATATAGAAAGGCTTAT
TAAAATGTTGAAAGTACAACTGTAACTTAAGAAATCTAAAAAGTATGCACTTCAACTTCT
CCGAAGTGA

>TTHERM_00499470(gene)
ATGAATACAGAAAATCAACAATAGATATAGATTGAAGAAAAAAAGTATAATTCTTTAAAA
ACTATTCCTCAGTAGGGTCTATAATGTAAATAGTATTACAAAGCTTAAGAAGAGTGCTTG
ATTGAAAAGGTCTATCCTGTATAAAAACCTTTAAGCTTACTTATACTAGAAATAACTCTT
TACATATTATCTGGAGGTTTACTTTTTATATTATTTTCTTGGAATAATGAATGGAAATTT
AAAATATTCTTTAAACTTGTTAATATTAATTAAGCTACTTAAATTGTAGTTTATGGACCA
GATAAGGATGTCTAGATAGAAAAAATTGTGAATTTAGAAAACAAATGTATTTTTCAATAT
AGATTTTAAAAATTTGTTTATGATGAATAGTCCTTAATTTTCGTGCCATTTGGCGATAGT
ATAATCGAAAGAAACCATAAAGAAATTATTGAGTCAGCTAAAACGGGTTTAAATGACTCT
TAGATTAATTCCTCTATTACTAAAAACGGAGTTAATTCTACTGATATACCAGATTAAGGC
GTTTTGGTTCTAGCATTTCATGAATTCTTTTCTCCTTTCTTCTTGTTTCAAGTTGCAAGT
TGTCTTTTATGGTATTTTGATACTTATGAAATCTATGCTACAGTTATTATTACCACATCA
ACTTTTAGTTTGCTTTTTAAGTTATACGAAGAAAGAACAAATATAAATCGTATAAAAAAA
TTAAGCTATTTTAGGGGTTAAACAACAGTAGTTAGAAATGGACAAACCAAAGTTATCTCT
TCAAACGAGTTAGCATATGGCGATGTTGTTATTTTAAAAGAGGGTGAGACAGCTCCATGT
GATATGGTGATAGTAGAAGGTAGTGTCATAGTAAACGAATCTATGCTTACTGGAGAATCC
GTTCCTATTATCAAATCTGCTCTAGCAGATTTAGACTGCTAATTTAGCGAAAATCGTTAA
AATATTATTTATGGTGGAAGTTAGGTTATGATGGTTTCAAATTCCAAGTTAGTAGTTATT
AGAATAGGTTTTGAAACTCTTAAAGGGAACTTGATCCGTTCCATCCTTTATCCAAAGCAA
CATAATCAAATTTCATTTTAGAATGATTCTGTTAAATTCTTATCTATCCTTCTATTTGTT
ACATTGATATAATTCTTTATTGCATTACCAACTTTCATTGATAACTTAGATCGAGGTACT
ATGGATTCATCAGATTTAATTAAAAAATTTTTTGATTTAATCACCATCAGTGTTCCTCCT
GCTTTGCCAACATGCCTTTCCTTTGGTGTCTCCTTCTCGTTAAATAGAATGCGTAGAAAA
CAAATTTTTTGTATCAATAATGAAAAAATTAATATTTGCGGTATTGTAAAAAGTGTGTGT
TTTGATAAGACTGGTACTTTGACTGAAGAGCTCCTATCCTTTAAACTTATTTCTTCATTT
TTAAGTAGCTCAAACAAATTTGAAGATTAGTTTTCTGAAGAAGCTGCTAAAAAAAACAAA
CACATATTTCCTACCTTCTCCAAAATTTAAAGATAAATTATAGCATCGTGCCACAGTATC
ATGGTTTATAATAACGAATTTATTGGAGATCCTTTGGACATTGAAATGTTTAAAAATTCA
TCATATTGCTTAGTTGAAAATGAAAATTCAAAAAGCGATAACTAGGCAGATTAAAATGAT
AAATTATTTTATTAAGGTTATGAAGTTTTGCAAGAACTTACTTGCAACAAAAGTTTAGGA
TCACCAATTTTTATTCTGAAAAGATTTTAATTTGATGCTGATGTTTAAAGAATGTCGGTT
ATAGTAGCTATTACAAAAGAAAATCAAAATTATATCTATACAAAAGGCTCACCTGAAAGC
ATTCAGAAAATTTGTAAATAATAAACTATTCCCAATGACTTTTCAAATAAATTATAAGAA
TTTACAAATGAAGGATATCGTGTTCTTGCATTAGCTTATAGTTAGATTAATGAAGTTGAT
TTTGAAAAAGACAGAAACCAATACGAAGCAAACCTAACTTTTGCAGGTTTTTTGGTATTT
GAAAACAAATTAAAACCAGAAACAACAGAACATATCAAACTACTTAAAAATAATGACGTT
TAAGTCCGTATGGTAACTGGTGACAATCCTGAAACTTCCTTGAATATTGCTAAACAATGT
GGAATTTTAAGTTTAAATTAGTAAATTAATCTCCTTGATTATAGTAATAATTAATTTACA
ATGAATGGAAAAAAATCTGATTTAGATTAATTTATAAATTCAGCTTCATTTGTTTAAGGA
TAGGAATAGTTAGTTATTACTGGTAATTTTTTTGAAGAATTCCTCCAAAACAAAACAAAT
CAGAATTCATAATAAAACCAATGCGACATTGAAAGCAATACTTGCTCAAAGAGAACTAGC
TTATTCTTTACTCTTATTTTATAGTACGGAAAAGTTTTTGCGAGAATGAAGCCAGATTAG
AAGTAAAGCTTAATACATCTATTGCAAAAGTATTAAAATCCAGAGTAAGGATACTCATTT
GTTGGAATGTGTGGTGATGGTGCAAATGACTGCTAAGCTCTGAAAGATGCTGATATGGGT
ATTTCATTAGGTGAAGCAGAGGCTTCCGTTGCAGCTGCTTTCACAAGCAAGGTTATTAAT
ATAAGTGTTATTGAATACATTTTACGTGAAGGTAGATGCTGCTTAACAACTTCATTTTAA
TGCTTTAAGTACATGGCCCTTTACTCTCTTATATAAGGTTTCACTTAAACTTTGACTTAT
TTTCGTGGTACACAACCAGCTGATATGTAGATTCTGTATTGGGATCTTTTTATTATCATT
CCTCTAACATTTTTCTTAGGCTTAACTGAAGCTAGTGATAAACTTACACCTGATATTCCA
GCACATCGGCTTTTCTCATACAAAAATATACTCTCTGTTGCTGGCTAAGGTGTTATTTAA
CTCTTGTTTTTAATCATAACAGTAGCTACTACATGTAATCAAAGCTGGTATCTTAACCCA
TAATAATTATCTAAAGCTTAAGAATTTGAAGACGAAGAATTAGCACCAACTACATATGAC
ACAACTGTTCTATTCTGGGTTTCTAACTTCTAATACATTTTCACTGTAATAGCTTTTTCT
ATTGGTTCTGTTCATAAAAAACCATTCTATACAAACATTCTATTCACTTTCTTCCTTGTT
TCAATCACAGGCTTGAGTTTACTAATTATTTTCTCAGAACAATAACCCATACTTGATTTC
TTTACTCTTTTTATCAAAGCTACTAATTAAAATGATGAAATCGTTTCATAAATGGATTAT
AGCTGGAAATTCGTAATTTTAGCTATTATTTTAGCAAATGCTATAGTAACAATATTGTAC
GAAAAGTATTTCTTAGCATTTTTAAATAATTTACTTGATAAAAAATATAGAAAGGCTTAT
TAAAATGTTGAAAGTACAACTGTAACTTAAGAAATCTAAAAAGTATGCACTTCAACTTCT
CCGAAGTGA

>TTHERM_00499470(protein)
MNTENQQQIQIEEKKYNSLKTIPQQGLQCKQYYKAQEECLIEKVYPVQKPLSLLILEITL
YILSGGLLFILFSWNNEWKFKIFFKLVNINQATQIVVYGPDKDVQIEKIVNLENKCIFQY
RFQKFVYDEQSLIFVPFGDSIIERNHKEIIESAKTGLNDSQINSSITKNGVNSTDIPDQG
VLVLAFHEFFSPFFLFQVASCLLWYFDTYEIYATVIITTSTFSLLFKLYEERTNINRIKK
LSYFRGQTTVVRNGQTKVISSNELAYGDVVILKEGETAPCDMVIVEGSVIVNESMLTGES
VPIIKSALADLDCQFSENRQNIIYGGSQVMMVSNSKLVVIRIGFETLKGNLIRSILYPKQ
HNQISFQNDSVKFLSILLFVTLIQFFIALPTFIDNLDRGTMDSSDLIKKFFDLITISVPP
ALPTCLSFGVSFSLNRMRRKQIFCINNEKINICGIVKSVCFDKTGTLTEELLSFKLISSF
LSSSNKFEDQFSEEAAKKNKHIFPTFSKIQRQIIASCHSIMVYNNEFIGDPLDIEMFKNS
SYCLVENENSKSDNQADQNDKLFYQGYEVLQELTCNKSLGSPIFILKRFQFDADVQRMSV
IVAITKENQNYIYTKGSPESIQKICKQQTIPNDFSNKLQEFTNEGYRVLALAYSQINEVD
FEKDRNQYEANLTFAGFLVFENKLKPETTEHIKLLKNNDVQVRMVTGDNPETSLNIAKQC
GILSLNQQINLLDYSNNQFTMNGKKSDLDQFINSASFVQGQEQLVITGNFFEEFLQNKTN
QNSQQNQCDIESNTCSKRTSLFFTLILQYGKVFARMKPDQKQSLIHLLQKYQNPEQGYSF
VGMCGDGANDCQALKDADMGISLGEAEASVAAAFTSKVINISVIEYILREGRCCLTTSFQ
CFKYMALYSLIQGFTQTLTYFRGTQPADMQILYWDLFIIIPLTFFLGLTEASDKLTPDIP
AHRLFSYKNILSVAGQGVIQLLFLIITVATTCNQSWYLNPQQLSKAQEFEDEELAPTTYD
TTVLFWVSNFQYIFTVIAFSIGSVHKKPFYTNILFTFFLVSITGLSLLIIFSEQQPILDF
FTLFIKATNQNDEIVSQMDYSWKFVILAIILANAIVTILYEKYFLAFLNNLLDKKYRKAY
QNVESTTVTQEIQKVCTSTSPK