Identifiers and Description

Gene Model Identifier

TTHERM_00502610

Standard Name

THD6 (Tetrahymena Histone Deacetylase 6)

Aliases

PreTt08100 | 63.m00278 | 3716.m00130 | THD6 | RPD3

Description

THD6 class I histone deacetylase family protein; Histone deacetylase family protein; suppresses DNA transcription by deacetylation of histones

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• integral component of membrane (IEA) | GO:0016021

Molecular Function

• ATP binding (IEA) | GO:0005524
• ATP hydrolysis activity (IEA) | GO:0016887
• ATPase-coupled transmembrane transporter activity (IEA) | GO:0042626

Biological Process

• transport (IEA) | GO:0006810

Domains

• ( PF00850 ) Histone deacetylase domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_09551.1	9.997093137033517e-262
	Description: histone deacetylase (457 aa)
WormBase	WBGene00011962	9.997093137033517e-262
	Description: CRAL-TRIO domain-containing protein T23G5.2 status:Confirmed UniProt:Q03606 protein_id:CAJ76964.1
WormBase	WBGene00001836	2.0005528695435914e-146
	Description: locus:hda-3 Histone deacetylase status:Confirmed UniProt:G5ECH0 protein_id:CAB03224.1
Tetrahymena borealis	EI9_19567.1	2.0005528695435914e-146
	Description: TPR Domain containing protein (844 aa)
DictyBase	DDB_G0268024	5.002003259710477e-145
	Description: hdaA on chromosome: 1 position 1320084 to 1322172
SGD	YNL330C	1.0004982362389172e-141
	Description: RPD3 Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members
Oxytricha	Contig1866.0.g68	3.001349705199738e-130
	Description: Histone deacetylase domain
Stentor Coeruleus	SteCoe_31554	2.8946403116483003e-63
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00502610(coding)
ATGGAAGATGATATTAGAACAATTTATGAAGGGAAAAGAATTAGTTATTTCTATAATCCT
GAAATAGGAAAGTTTTACTACAGCAAAGATCACCCTATGAAACCAAAAAGAGTTGCTATG
GCACATTCTTTAATTTAAAATTTTGGTCTGTATAAAGACTTAGATGTTTACACTGCTCGT
TAAGCTACTTTTGAAGAAATGATCAAATTTCACGATATAGAATATATTAATTATCTACAA
AATTATGTTAGTAATGGTTGGACATAAGAGCTAAAAAAGCTGAAACAAGATCCCTTAATA
AATTTAGAATCTTCATACCATATAAATAACCCTAAAAAAAGATAAACAAGCAAAGTAGGA
GATACTTCTGATTGCCCAGGTTTTGAAGGTCTTTATAATTTTTGTTAGATTAGTGCTGGT
GGTTCTTTAGATTGCGCATCAATGATTATAAATCAATAATCTGATATTGCTATCAACTGG
GGAGGTGGTTTACATCATGCAAAGAAAAAAGAAGCTAGTGGATTTTGTTATGTTAATGAT
ATTGTTTTGTGTGCATTAGAGTTATTAAAGTATTATCCAAGAGTAATTTATATTGATATT
GATGTTCATCATGGCGATGGTGTAGAAGAAGCTTTTTTCCTTACAAATCGTGTGATGACA
GTTAGTTTTCATGAATATGGTGATGACTTCTTCCCAGGAAGTGGCTCTCTAAATTCTATT
GGCGATGGACCAGGCAAATATCATGCTATTAATGTACCTTTAAGACCAGGAATCAATGAT
GAAACATTTGAACAAGTATTTAAGGATGTTATGAAAAAAGTAATGGAAGTATATAGACCT
AATGTAATATTGCTATAATGCGGAGCTGATTCATTAGCATATGATAAGCTAGGACACTTC
AATTTATCAACAAAAGGGCATGGAAAAGCTGTAGAATATATGAAAAGCTTTGGTATTCCT
CTAATATTAATGGGAGGTGGTGGTTATAATGTACCAAATGTTGCAAGATGCTGGGCTTAT
GAGACATCTATTTGTGTTGGAAATAAAATTGATGGAAATATTCCTATTACTGAGCCGTTT
TATGACTATTTTGGTCCAGATCATAAACTCCATGTTACTCCTAAAAATAATGTGGATAAT
AAAAATACCAAGGATGAGCTCCATTAGAAGGTTTCAACCGTTCATGAATATTTAAGATAA
ATAGAAAGTGCACCTTCTATGGCATTCCATCACACCCCTGATAATAGTAAATTTGCAGAA
GAAGAATAAAATATAGATGAAGAATTTGATTATGATATGGATGATGAAGAGTTAGAAAGA
TATTTTAAATAGAAAGAAAAACCTATTATAATGAATAATAGATATATTTGA

>TTHERM_00502610(gene)
ATGGAAGATGATATTAGAACAATTTATGAAGGGAAAAGAATTAGTTATTTCTATAATCCT
GAAATAGGAAAGTATTGCATTTATACTTAGCACATATTAGAGCTTATATTAAACTTTTAT
AATATCATTAAATTTAACAAATCTATAATTAATAATATTTTTAGGTTTTACTACAGCAAA
GATCACCCTATGAAACCAAAAAGAGTTGCTATGGCACATTCTTTAATTTAAAATTTTGGT
CTGTATAAAGACTTAGATGTTTACACTGCTCGTTAAGCTACTTTTGAAGAAATGATCAAA
TTTCACGATATAGAATATATTAATTATCTACAAAATTATGTTAGTAATGGTTGGACATAA
GAGCTAAAAAAGCTGAAACAAGATCCCTTAATAAATTTAGAATCTTCATACCATATAAAT
AACCCTAAAAAAAGATAAACAAGCAAGTATTGCATATTTTTTAATTTATCTAATTACTTT
GCATCTTTACTTTTTATATTGAACTCATCTATATAAAAATATAGAGTAGGAGATACTTCT
GATTGCCCAGGTTTTGAAGGTCTTTATAATTTTTGTTAGATTAGTGCTGGTGGTTCTTTA
GATTGCGCATCAATGATTATAAATCAATAATCTGATATTGCTATCAACTGGGGAGGTGGT
TTACATCATGCAAAGAAAAAAGAAGCTAGTGGATTTTGTTATGTTAATGATATTGTTTTG
TGTGCATTAGAGTTATTAAAGTATTATCCAAGAGTAATTTATATTGATATTGATGTTCAT
CATGGCGATGGTGTAGAAGAAGCTTTTTTCCTTACAAATCGTGTGATGACAGTTAGTTTT
CATGAATATGGTGATGACTTCTTCCCAGGTAACATATTTGTTTATGAATCATATAGCTTT
TTGAAATAGATTTAGAAGTTAATAATAAATCATAAATTAAAAAAAAAATAAATCCAAGCT
TTGAAAATAGAATTATTATAAATCATAATGAGAATTCAATTTTTTAAAAATAAAAATTGT
TTATTTAAATAGGAAGTGGCTCTCTAAATTCTATTGGCGATGGACCAGGCAAATATCATG
CTATTAATGTACCTTTAAGACCAGGAATCAATGATGAAACATTTGAACAAGTATTTAAGG
ATGTTATGAAAAAAGTAATGGAAGTATATAGACCTAATGTAATATTGCTATAATGCGGAG
CTGATTCATTAGCATATGATAAGGTAAAATTAATTATTGTTAGAGTATTTATTTTTAAAT
AATGATTGATTATTGTTAAAAAAGCTAGGACACTTCAATTTATCAACAAAAGGGCATGGA
AAAGCTGTAGAATATATGAAAAGCTTTGGTATTCCTCTAATATTAATGGGAGGTGGTGGT
TATAATGTACCAAATGTTGCAAGATGCTGGGCTTATGAGACATCTATTTGTGTTGGAAAT
AAAATTGATGGAAATATTCCTATTACTGAGCCGTTTTATGACTATTTTGGTCCAGATCAT
AAACTCCATGTTACTCCTAAAAATAATGTGGATAATAAAAATACCAAGGATGAGCTCCAT
TAGAAGGTTTCAACCGTTCATGAATATTTAAGATAAATAGAAAGTGCACCTTCTATGGCA
TTCCATCACACCCCTGATAATAGTAAATTTGCAGAAGAAGAATAAAATATAGATGAAGAA
TTTGATTATGATATGGATGATGAAGAGTTAGAAAGATATTTTAAATAGAAAGAAAAACCT
ATTATAATGAATAATAGATATATTTGA

>TTHERM_00502610(protein)
MEDDIRTIYEGKRISYFYNPEIGKFYYSKDHPMKPKRVAMAHSLIQNFGLYKDLDVYTAR
QATFEEMIKFHDIEYINYLQNYVSNGWTQELKKLKQDPLINLESSYHINNPKKRQTSKVG
DTSDCPGFEGLYNFCQISAGGSLDCASMIINQQSDIAINWGGGLHHAKKKEASGFCYVND
IVLCALELLKYYPRVIYIDIDVHHGDGVEEAFFLTNRVMTVSFHEYGDDFFPGSGSLNSI
GDGPGKYHAINVPLRPGINDETFEQVFKDVMKKVMEVYRPNVILLQCGADSLAYDKLGHF
NLSTKGHGKAVEYMKSFGIPLILMGGGGYNVPNVARCWAYETSICVGNKIDGNIPITEPF
YDYFGPDHKLHVTPKNNVDNKNTKDELHQKVSTVHEYLRQIESAPSMAFHHTPDNSKFAE
EEQNIDEEFDYDMDDEELERYFKQKEKPIIMNNRYI