Identifiers and Description

Gene Model Identifier

TTHERM_00508970

Standard Name

TPA5 (Tetrahymena P-type ATPase)

Aliases

PreTt10682 | 64.m00162 | 3723.m00025

Description

TPA5 Na-H/K antiporter P-type ATPase alpha subunit family protein; P-type ATPase; putative Na(+)/K(+) or H(+)/K(+) ATPase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039
• membrane (IEA) | GO:0016020

Molecular Function

• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824
• hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (IEA) | GO:0016820
• P-type ion transporter activity (ISS) | GO:0015662
• P-type ion transporter activity (IEA) | GO:0015662

Biological Process

• ATP biosynthetic process (IEA) | GO:0006754
• metabolic process (IEA) | GO:0008152
• monoatomic cation transport (IEA) | GO:0006812

Domains

• ( PF00122 ) E1-E2 ATPase
• ( PF00689 ) Cation transporting ATPase, C-terminus
• ( PF00690 ) Cation transporter/ATPase, N-terminus
• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( PF03720 ) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
• ( PF03742 ) PetN
• ( PF08282 ) haloacid dehalogenase-like hydrolase
• ( TIGR00099 ) Cof-like hydrolase
• ( TIGR01106 ) Na,H/K antiporter P-type ATPase, alpha
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01487 ) SPP-like hydrolase, Archaeal
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( TIGR01497 ) K+-transporting ATPase, B subunit
• ( TIGR01511 ) copper-translocating P-type ATPase
• ( TIGR01512 ) cadmium-translocating P-type ATPase
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
• ( TIGR01523 ) potassium/sodium efflux P-type ATPase, fungal-type
• ( TIGR01524 ) magnesium-translocating P-type ATPase
• ( TIGR01525 ) heavy metal translocating P-type ATPase
• ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
• ( TIGR01657 ) P-type ATPase of unknown pump

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_24478	0
	Description: None
WormBase	WBGene00001137	9.997093137033517e-262
	Description: locus:eat-6 status:Confirmed UniProt:P90735 protein_id:CAB02694.1
Tetrahymena borealis	EI9_15482.1	9.997093137033517e-262
	Description: Na,H/K antiporter P-type ATPase, alpha subunit protein (1215 aa)
DictyBase	DDB_G0277269	9.997093137033517e-262
	Description: ionA on chromosome: 2 position 7864423 to 7868216
Oxytricha	Contig21999.0.g128	9.997093137033517e-262
	Description: E1-E2 ATPase
SGD	YGL167C	3.0009992673984943e-111
	Description: PMR1 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease

General Information

No Data fetched for General Information

Associated Literature

1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
3. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60
4. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28

Sequences

>TTHERM_00508970(coding)
ATGATAGAAAGAAATTAGACGGAGGTGTAGAAAAGTGTTAATTCACTTAATAAGTCTATT
AACTCTGCTTATGCCCGTAAATACGAAGAAATCAGATAATCTATTAACATTCATAATTCT
TAGAGTGTCTACAGAAATTAGAAGCATGATATCCAAGGAGCTTTTTATGTCTAAGAACCT
AATAATAGGTAGACTCATATTAATTCCTTAATAGAATTAGAAATATAGTCTTCTGTTGCC
ACTGAGTAAGATGCAATGCATTAGAATTAACAATAAGGACAGACAGATAATCTACAAATT
GAAGATAAAACTGAGAAAAAGAAGTTAGAATTTGCTCAAAAAGAAGATCATAAAATTCCT
CTTTCTGAACTCAAAGAAAAATACAAAACTGATTATAAAGTTGGTTTAACTGAACCTTAA
GCTCAATAAAATCTTATCGATTACGGTGAAAACAAACTCACCGATAAAGTTAGAATCCCT
GCTTGGGTTATTTTACTAAAAGAACTTACTAATGGTTTTGCATTAATGCTTTGGGTTAGT
GCTGGACTTTGTTTCTTGGCTTATGGTCTTACTCCTGATGATCCCTCTAACATGTATCTC
GCTATTGTTCTTTTAATCGTTATTTTTGTCACTGCTTTCATTACATTCTAATAAAATGCT
AAGAGCGAAGCTCTAATGAAATCTTTTAAAAATTTTCTCCCTTAGAAGTGCACAGTTATT
AGAGATGGTGAACCCAAACACCTTGACGCATTAAAGATTGTTGTTGGAGATATTGTTCTT
ATCAAAGCTGGTGAAAAGATCCCTGCTGATATCCGTATCTTAGAGTCTTCTGAAATGAAA
GTAGATAATTCACCTCTTACAGGTGAGAGTGAACCATAGCTTAGAACTGCAGAATGTTCT
CACCCAGAAAATTATTTAGAAACAGCCAACATGGCATTTTTCGGTACATTATGCAAAGAG
GGTACTGGTAAAGGTATTGTAGTTAGTACTGGTGATAGAACTACTCTCGGTTAAATTGCA
GATTTATCTTCAGGTGAAAAAAAGGCTAAAACTCCTTTACGTGCAGAATTAGATAGATTT
GTTTACATGGTTACTATACTAGGTATATTTTTATGCATTTTATTCTTCCTTTTAGCTTAC
TTAGTTATTGGTTTCCCTGTTATGTCTTGCATTGTCTTCGGTATTGGTATTCTAGTCGCA
AATGTTCCAGAAGGTTTGTTAGGCTGTATCACTATTTGTCTTGCAATTACTGCTAAGAAT
CTCGCAAAAAAGTAGGTGCTTGTCAAAAACTTAGAAGCTGTCGAAACTCTTGGTTCTACT
TCTTGTATCTGTACTGACAAAACAGGTACCTTGACTTAAAATGTCATGACTGTTAAGCAT
ATTTGGATTAATGACTCTGTATTTGAAACTCCTAATCTTTTACATCTTTAAAAAGGTTAA
GAACCTCCTTATGATACAAAGGATATAGGCTTCAAAACTCTTTAATAAGCTGCCATGATT
TCTAGTGAAGCAGTTTTTGACTTGTCTGGTTTATAAGATAAAAATAATGTTGATTATCTT
AAATGTCCAGTTATCGGTGATGCTACTGAAACAGGTTTGATTAGATTCTATTAATCTATT
GATGATGTCAACTCTTTTAGAAGCAAATTTAAAATTGTCAAAAATCCTGATGAAACACTC
AGTAGAATGCCTTTTAGTTCCTAATACAAATTTGCTCTCACTGTTGTTGAAGAAGAATCA
GAAAATAGCCATTACGCTGTTTATATGAAAGGTGCTCCTGAAAAAATTTGGAGTTACTGC
TCAACAATATATTGTAATAATCAAATAAGTGTAATTGAAAACTCATGGTAGACAAAATTC
AAGTAAGTAAATTTATAATTTGGTAAAGGAGGAGAAAGAGTTTTAGGTTTTGCTAAGCTT
GCTCTTCCAGCAGCTTAATATCCTAAAGGTTCTCATTTCTATGTACAAAATCCATCTAAA
TTTACATTTCACCTTGCTTAATTTTAATTTTGCGGTTTAGTTTCTCTCATGGACCCTCCT
AAACCAAGAGTTCCTTATGCTATCCTTGAGTGCAGATCTGCAGGTATTAAGGTTATTATG
GTTACTGGTGATTAACCTCCAACTGCTGCTGCAATTGCAAAAGAAGTCAATATAGTTCCT
CAAGAGATTATTACTAATGAAGACTTGATGGAAAGAAACCCCACACTTGACTGGTTTACT
GCCAGTGAATAGTGTGAAGCTATTGTAGTTCATGGTGATAGAATTCTCGAATCATTTGAA
AAATCAATCGAAGAAAAGAGAGAATCTCCTGACTTTTATCTTCGTCAATGGGTAAAAAAA
CCTTTTTGCGTTTTCGCTAGAACCACCCCAGCCTAAAAACTCTAAATTGTAGAGGCTTGC
TAAAAGGAAGGCTTTATTGTTGCAGCAACTGGTGATGGTGTGAATGATTCTCCTGCTATA
AAAAAAGCTGATATCGGTGTTTCAATGAATCTATCTGGTAGTGATGTAACAAAAGATGCA
GCAGATATGATTCTCCTTGATGATGATTTTGCTTCGATTGTACTTGGTGTTGAAGAAGGT
AGAAAAATTTTTGATAATCTTAAAAAATCATGTGTTTATCTTCTTACTTCTAATATGACT
GAAATTATTCCATTTTTGGCCTTTATTATATTGCTTCTTCCTGTGCCGCTTTCTAGTATT
TACATGTTAATTTTATAAGTCGGCACAGATATATGGCCTGCTATTTCTTTAGCATATGAG
GACGCAGAGCTTGATGTAATGACCAGAAGACCTCGTAGAAAAAGTGATCACTTATGTTCA
CTTAAATTGGTTACAATAGCTTATTTCTAAATGGGTTAATTAGAAAGTGCAGCTGGTTTT
ATAGGTTATTATATGATGTTTAACTATTTTGGTTTCCCAGTTAGAGAACTATTTGGACTT
GCTAATGTTTCTGGATATACTCCATAGAAAGATGATTTTGATAGTCACTTTAATCCTTAT
ACAGGCAAATTTGATCCTTATTTCAATAGCGAACTATTTAAAGCAGCAGGAAACTAATAC
GATTGCAGAGTAAATAGAAAGGGTGCAGATTCAATTAAGAATGATATTGATTGGTAGAAA
TTAACAGATGGTAACTATGACTTAAGAAAATCTCTTTTGAAATGCAATGAAAGTACAGGT
GAATGGGTCCCTAAAGTTAAATGGAGCGATTGCGATACTACTTCTCATAAAACTTGGTCT
GACATTACAAGTCAAACAGCCTGCTACAGTACTGAAGCAGTAAAGTGGGCATAAACAGCT
TTCTTTTCTTCTGTTGTCACAAACTAATGGTCAAATGTATTTGCTTGCAAGAGTAGAAAA
ATGAGTTTTGCAACTTCTAATTTAAATACTGTCATGCTTTAAGGTATTATTTTCGAAACA
GCTTTATTATGCTTCTTGCTCTATGTACCTGGTGTTCAAGAAGTTTTTGGTGGTAGACCC
TATTCATTCTGGATGTTCTGTCATGGATTATTTTTCAGTATATGCTTATTACTATGGGAA
GAAACAAGAAAGTATACTACTAGAACTTTTAAATGGTTCTTCAAATACGCTTATTGGTGA

>TTHERM_00508970(gene)
ATGATAGAAAGAAATTAGACGGAGGTGTAGAAAAGTGTTAATTCACTTAATAAGTCTATT
AACTCTGCTTATGCCCGTAAATACGAAGAAATCAGATAATCTATTAACATTCATAATTCT
TAGAGTGTCTACAGAAATTAGAAGCATGATATCCAAGGAGCTTTTTATGTCTAAGAACCT
AATAATAGGTAGACTCATATTAATTCCTTAATAGAATTAGAAATATAGTCTTCTGTTGCC
ACTGAGTAAGATGCAATGCATTAGAATTAACAATAAGGACAGACAGATAATCTACAAATT
GAAGATAAAACTGAGAAAAAGAAGTTAGAATTTGCTCAAAAAGAAGATCATAAAATTCCT
CTTTCTGAACTCAAAGAAAAATACAAAACTGATTATAAAGTTGGTTTAACTGAACCTTAA
GCTCAATAAAATCTTATCGATTACGGTGAAAACAAACTCACCGATAAAGTTAGAATCCCT
GCTTGGGTTATTTTACTAAAAGAACTTACTAATGGTTTTGCATTAATGCTTTGGGTTAGT
GCTGGACTTTGTTTCTTGGCTTATGGTCTTACTCCTGATGATCCCTCTAACATGTATCTC
GCTATTGTTCTTTTAATCGTTATTTTTGTCACTGCTTTCATTACATTCTAATAAAATGCT
AAGAGCGAAGCTCTAATGAAATCTTTTAAAAATTTTCTCCCTTAGAAGTGCACAGTTATT
AGAGATGGTGAACCCAAACACCTTGACGCATTAAAGATTGTTGTTGGAGATATTGTTCTT
ATCAAAGCTGGTGAAAAGATCCCTGCTGATATCCGTATCTTAGAGTCTTCTGAAATGAAA
GTAGATAATTCACCTCTTACAGGTGAGAGTGAACCATAGCTTAGAACTGCAGAATGTTCT
CACCCAGAAAATTATTTAGAAACAGCCAACATGGCATTTTTCGGTACATTATGCAAAGAG
GGTACTGGTAAAGGTATTGTAGTTAGTACTGGTGATAGAACTACTCTCGGTTAAATTGCA
GATTTATCTTCAGGTGAAAAAAAGGCTAAAACTCCTTTACGTGCAGAATTAGATAGATTT
GTTTACATGGTTACTATACTAGGTATATTTTTATGCATTTTATTCTTCCTTTTAGCTTAC
TTAGTTATTGGTTTCCCTGTTATGTCTTGCATTGTCTTCGGTATTGGTATTCTAGTCGCA
AATGTTCCAGAAGGTTTGTTAGGCTGTATCACTATTTGTCTTGCAATTACTGCTAAGAAT
CTCGCAAAAAAGTAGGTGCTTGTCAAAAACTTAGAAGCTGTCGAAACTCTTGGTTCTACT
TCTTGTATCTGTACTGACAAAACAGGTACCTTGACTTAAAATGTCATGACTGTTAAGCAT
ATTTGGATTAATGACTCTGTATTTGAAACTCCTAATCTTTTACATCTTTAAAAAGGTTAA
GAACCTCCTTATGATACAAAGGATATAGGCTTCAAAACTCTTTAATAAGCTGCCATGATT
TCTAGTGAAGCAGTTTTTGACTTGTCTGGTTTATAAGATAAAAATAATGTTGATTATCTT
AAATGTCCAGTTATCGGTGATGCTACTGAAACAGGTTTGATTAGATTCTATTAATCTATT
GATGATGTCAACTCTTTTAGAAGCAAATTTAAAATTGTCAAAAATCCTGATGAAACACTC
AGTAGAATGCCTTTTAGTTCCTAATACAAATTTGCTCTCACTGTTGTTGAAGAAGAATCA
GAAAATAGCCATTACGCTGTTTATATGAAAGGTGCTCCTGAAAAAATTTGGAGTTACTGC
TCAACAATATATTGTAATAATCAAATAAGTGTAATTGAAAACTCATGGTAGACAAAATTC
AAGTAAGTAAATTTATAATTTGGTAAAGGAGGAGAAAGAGTTTTAGGTTTTGCTAAGCTT
GCTCTTCCAGCAGCTTAATATCCTAAAGGTTCTCATTTCTATGTACAAAATCCATCTAAA
TTTACATTTCACCTTGCTTAATTTTAATTTTGCGGTTTAGTTTCTCTCATGGACCCTCCT
AAACCAAGAGTTCCTTATGCTATCCTTGAGTGCAGATCTGCAGGTATTAAGGTTATTATG
GTTACTGGTGATTAACCTCCAACTGCTGCTGCAATTGCAAAAGAAGTCAATATAGTTCCT
CAAGAGATTATTACTAATGAAGACTTGATGGAAAGAAACCCCACACTTGACTGGTTTACT
GCCAGTGAATAGTGTGAAGCTATTGTAGTTCATGGTGATAGAATTCTCGAATCATTTGAA
AAATCAATCGAAGAAAAGAGAGAATCTCCTGACTTTTATCTTCGTCAATGGGTAAAAAAA
CCTTTTTGCGTTTTCGCTAGAACCACCCCAGCCTAAAAACTCTAAATTGTAGAGGCTTGC
TAAAAGGAAGGCTTTATTGTTGCAGCAACTGGTGATGGTGTGAATGATTCTCCTGCTATA
AAAAAAGCTGATATCGGTGTTTCAATGAATCTATCTGGTAGTGATGTAACAAAAGATGCA
GCAGATATGATTCTCCTTGATGATGATTTTGCTTCGATTGTACTTGGTGTTGAAGAAGGT
AGAAAAATTTTTGATAATCTTAAAAAATCATGTGTTTATCTTCTTACTTCTAATATGACT
GAAATTATTCCATTTTTGGCCTTTATTATATTGCTTCTTCCTGTGCCGCTTTCTAGTATT
TACATGTTAATTTTATAAGTCGGCACAGATATATGGCCTGCTATTTCTTTAGCATATGAG
GACGCAGAGCTTGATGTAATGACCAGAAGACCTCGTAGAAAAAGTGATCACTTATGTTCA
CTTAAATTGGTTACAATAGCTTATTTCTAAATGGGTTAATTAGAAAGTGCAGCTGGTTTT
ATAGGTTATTATATGATGTTTAACTATTTTGGTTTCCCAGTTAGAGAACTATTTGGACTT
GCTAATGTTTCTGGATATACTCCATAGAAAGATGATTTTGATAGTCACTTTAATCCTTAT
ACAGGCAAATTTGATCCTTATTTCAATAGCGAACTATTTAAAGCAGCAGGAAACTAATAC
GATTGCAGAGTAAATAGAAAGGGTGCAGATTCAATTAAGAATGATATTGATTGGTAGAAA
TTAACAGATGGTAACTATGACTTAAGAAAATCTCTTTTGAAATGCAATGAAAGTACAGGT
GAATGGGTCCCTAAAGTTAAATGGAGCGATTGCGATACTACTTCTCATAAAACTTGGTCT
GACATTACAAGTCAAACAGCCTGCTACAGTACTGAAGCAGTAAAGTGGGCATAAACAGCT
TTCTTTTCTTCTGTTGTCACAAACTAATGGTCAAATGTATTTGCTTGCAAGAGTAGAAAA
ATGAGTTTTGCAACTTCTAATTTAAATACTGTCATGCTTTAAGGTATTATTTTCGAAACA
GCTTTATTATGCTTCTTGCTCTATGTACCTGGTGTTCAAGAAGTTTTTGGTGGTAGACCC
TATTCATTCTGGATGTTCTGTCATGGATTATTTTTCAGTATATGCTTATTACTATGGGAA
GAAACAAGAAAGTATACTACTAGAACTTTTAAATGGTTCTTCAAATACGCTTATTGGTGA

>TTHERM_00508970(protein)
MIERNQTEVQKSVNSLNKSINSAYARKYEEIRQSINIHNSQSVYRNQKHDIQGAFYVQEP
NNRQTHINSLIELEIQSSVATEQDAMHQNQQQGQTDNLQIEDKTEKKKLEFAQKEDHKIP
LSELKEKYKTDYKVGLTEPQAQQNLIDYGENKLTDKVRIPAWVILLKELTNGFALMLWVS
AGLCFLAYGLTPDDPSNMYLAIVLLIVIFVTAFITFQQNAKSEALMKSFKNFLPQKCTVI
RDGEPKHLDALKIVVGDIVLIKAGEKIPADIRILESSEMKVDNSPLTGESEPQLRTAECS
HPENYLETANMAFFGTLCKEGTGKGIVVSTGDRTTLGQIADLSSGEKKAKTPLRAELDRF
VYMVTILGIFLCILFFLLAYLVIGFPVMSCIVFGIGILVANVPEGLLGCITICLAITAKN
LAKKQVLVKNLEAVETLGSTSCICTDKTGTLTQNVMTVKHIWINDSVFETPNLLHLQKGQ
EPPYDTKDIGFKTLQQAAMISSEAVFDLSGLQDKNNVDYLKCPVIGDATETGLIRFYQSI
DDVNSFRSKFKIVKNPDETLSRMPFSSQYKFALTVVEEESENSHYAVYMKGAPEKIWSYC
STIYCNNQISVIENSWQTKFKQVNLQFGKGGERVLGFAKLALPAAQYPKGSHFYVQNPSK
FTFHLAQFQFCGLVSLMDPPKPRVPYAILECRSAGIKVIMVTGDQPPTAAAIAKEVNIVP
QEIITNEDLMERNPTLDWFTASEQCEAIVVHGDRILESFEKSIEEKRESPDFYLRQWVKK
PFCVFARTTPAQKLQIVEACQKEGFIVAATGDGVNDSPAIKKADIGVSMNLSGSDVTKDA
ADMILLDDDFASIVLGVEEGRKIFDNLKKSCVYLLTSNMTEIIPFLAFIILLLPVPLSSI
YMLILQVGTDIWPAISLAYEDAELDVMTRRPRRKSDHLCSLKLVTIAYFQMGQLESAAGF
IGYYMMFNYFGFPVRELFGLANVSGYTPQKDDFDSHFNPYTGKFDPYFNSELFKAAGNQY
DCRVNRKGADSIKNDIDWQKLTDGNYDLRKSLLKCNESTGEWVPKVKWSDCDTTSHKTWS
DITSQTACYSTEAVKWAQTAFFSSVVTNQWSNVFACKSRKMSFATSNLNTVMLQGIIFET
ALLCFLLYVPGVQEVFGGRPYSFWMFCHGLFFSICLLLWEETRKYTTRTFKWFFKYAYW