Identifiers and Description

Gene Model Identifier

TTHERM_00516370

Standard Name

EFR1 (Elongation Factor 2 Related 1)

Aliases

PreTt10729 | 64.m00209 | 3723.m00065

Description

EFR1 translation elongation factor EF-2 subunit; Elongation factor 2 related protein; expressed only during conjugation- significant amino acid identity to EF-2 from other eukaryotes but with differences at some residues that are typically post-translational regulation sites

Genome Browser (Macronucleus)

Full Screen View


Genome Browser (Micronucleus)

Full Screen View

External Links

Gene Ontology Annotations

Molecular Function

Biological Process

Domains

  • ( PF00009 ) Elongation factor Tu GTP binding
  • ( PF00679 ) Elongation factor G C-terminus
  • ( PF01926 ) GTPase of unknown function
  • ( PF03144 ) Elongation factor Tu domain 2
  • ( PF03764 ) Elongation factor G, domain IV
  • ( PF08477 ) Miro-like protein
  • ( TIGR00231 ) small GTP-binding protein domain
  • ( TIGR00475 ) selenocysteine-specific translation elongation factor
  • ( TIGR00483 ) translation elongation factor EF-1, subunit
  • ( TIGR00484 ) translation elongation factor G
  • ( TIGR00485 ) translation elongation factor Tu
  • ( TIGR00490 ) translation elongation factor aEF-2
  • ( TIGR00503 ) peptide chain release factor 3
  • ( TIGR01393 ) GTP-binding protein LepA
  • ( TIGR01394 ) GTP-binding protein TypA/BipA
  • ( TIGR02034 ) sulfate adenylyltransferase, large subunit

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Stentor Coeruleus SteCoe_7852 0
Description: None
WormBase WBGene00001167 9.997093137033517e-262
Description: locus:eef-2 Elongation factor 2 status:Confirmed UniProt:P29691 protein_id:CAB02985.1
Tetrahymena borealis EI9_08465.1 9.997093137033517e-262
Description: elongation factor G, domain IV family protein (842 aa)
DictyBase DDB_G0287685 9.997093137033517e-262
Description: cinC on chromosome: 5 position 689907 to 692602
Oxytricha Contig22552.0.g51 9.997093137033517e-262
Description: Elongation factor Tu GTP binding domain
SGD YOR133W 9.997093137033517e-262
Description: EFT1 Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:14729267: Malavé TM, Forney JD (2004) Identification of a developmentally regulated translation elongation factor 2 in Tetrahymena thermophila. Gene 326( ):97-105
  2. Ref:12673598: Ueno H, Gonda K, Takeda T, Numata O (2003) Identification of elongation factor-1alpha as a Ca2+/calmodulin-binding protein in Tetrahymena cilia. Cell motility and the cytoskeleton 55(1):51-60
  3. Ref:11129794: Gonda K, Komatsu M, Numata O (2000) Calmodulin and Ca2+/calmodulin-binding proteins are involved in Tetrahymena thermophila phagocytosis. Cell structure and function 25(4):243-51
  4. Ref:10731666: Numata O, Kurasawa Y, Gonda K, Watanabe Y (2000) Tetrahymena elongation factor-1 alpha is localized with calmodulin in the division furrow. Journal of biochemistry 127(1):51-6
  5. Ref:10816251: Numata O, Gonda K, Watanabe A, Kurasawa Y (2000) Cytokinesis in Tetrahymena: determination of division plane and organization of contractile ring. Microscopy research and technique 49(2):127-35
  6. Ref:8743583: Kurasawa Y, Hanyu K, Watanabe Y, Numata O (1996) F-actin bundling activity of Tetrahymena elongation factor 1 alpha is regulated by Ca2+/calmodulin. Journal of biochemistry 119(4):791-8
  7. Ref:8575889: Numata O (1996) Multifunctional proteins in Tetrahymena: 14-nm filament protein/citrate synthase and translation elongation factor-1 alpha. International review of cytology 164( ):1-35
  8. Ref:9019273: Kurasawa Y, Watanabe Y, Numata O (1996) Characterization of F-actin bundling activity of Tetrahymena elongation factor 1 alpha investigated with rabbit skeletal muscle actin. Zoological science 13(3):371-5

Sequences 

>TTHERM_00516370(coding)
ATGAAGACTCTCTAAATTGAGAAGATAAGAGAACTCATGATGAACCCTAACCAAATCAGA
AATATGTCTGTCATAGCCCACGTTGATCATGGTAAGACTACTTTAACTGATTCCTTATTA
GCTAGAGCTGGTATCATATCTGAAAACAACGCTGGTAAAGCATGTTTGATGGATACTGAC
CCTAAGGAGTAAGAAATGGGCATCACCATTAAGTCTACTGGAGTTTCCTTATACTATCAA
AATACTGTGACCAAGTAGGAGAGTATCATTAATTTGATTGATTCTCCTGGTCATATTGAC
TTTTCTGGTGAAGTCACTGCTGCTTTAAGAGTTACTGATGGAGCTCTTGTAGTAGTGGAT
GCTGTTGAAGGTGTTGCTGTTCAGACAGAAACAGTTCTAAGGCAGGCTTGCCAAGAGCGA
ATACGACCCGTTCTTGTAATTAATAAGCTAGACAGGCTTTTTAGTGAACTTAAGGATGAT
TATGAAAATATTTATCAAAGACTTGTTAAGATTATAGCAAAAGTTAATTCCATCTTAGAG
ATGCATGAAAACGATTCTATCAGAGGTTACACTTTAGATCCTTCACTAGGTAACGTTGCC
TTCTCTTCTGGTAAGTAGTGTTGGGGATTCACCTTAAAAACTTTTGCAAGAATTTACAGC
CAAAAATTCTCAACCAAGGAGGAAACCTTAATGGCTAAGTTATGGGGAGATAACTACTTT
AACTCTCAAACCAAATCATTCACCTCAGAAATAACCAAAATTAATAACTAAAACAAGAAA
GCTTTGCGCTCTTTCATTGAATTCGTTTTAGTTCCTTTAGATAAGTACTACTCTGCTTCT
TCAAGCGCAGATGTAGAAGTTCTATCTAAGATGGTTGAAAAGCTCAACCTCTCTACTATT
TTAACTACAGCTGAATTAGAAAGACTCAAACAAGTTGATGTTCAAGAGAGAATCAAAAGA
ACTATGAGAGCTTGGTTACCTTTAGCAGATGCTATACTTGAAATGGTCTAAGATCACCTT
CCTTCGCCTAAAGAAGCTATGAAGTATCGTAGTTTGTATCTCTACGAAGGGCCTGCAGAT
GATGAGGCTTGCACAGCCATGAGAGAATGTAATTCTGAGGGACCTCTTATGCTTTATGTT
TCAAAAATGGTCCCAACTGCAGATCTCAGCAGATTTTATGCTTTCGGTAGAGTATTCAGT
GGTACAATTTCTCAAGGAATGAAAGTTAGAGTTCAAGGCCCTGATTACAAGCCAGGAAGT
AAGGAAGGTCTCTTTATCAAAACTATCTAGAGAACCTTTTTGATGATGGGTAAATAACAC
GAACCTATCGAATCAGTACCAGCTGGAGGTACTGTCCTCATTTTAGGTGTTGATAATGCA
CTTACTAAGACAGGCACTCTTACAACTTCTGAAACAGCACATAATATCAGAAACATGAAA
TATACGATTTCACCTATATTGAGAGTTGCTGTTAATACTCCCAACTAGCAAGATCTTCCA
CGTCTTCTTGAAGGTCTTAAGATGCTTCAAAAGTATGACCCTCTTGTTTAAGTAGAAGTT
GATGAAAATACAGGTTCTTATGTTGTTGCTGGTGGTGGAGAGCTACACGTCCAAATTTGT
CTAGAAAAGCTCAATGATTTCACCCACAATTCTATCAATATCGTCGCTTCTCAGCCCACT
GTATCGTATAGAGAAACCATAGGTGATAAGAGTTCTTAAATGTGCCTTGCTAAGACTGCA
AATAAGTTGAATCGTTTATATGGTACTTGCGAACCTCTAGATGAAGAATTAGGATCAGCT
ATTGTAAGCAACAAAATAAATATACAGGAAATCAATAGTTAAGAAACAATCAACAGTTTG
GTGAATGATTACTCATGGGAAAGAGAAGATGCAAAGCGTATATGGTGCTTCGGTCCTCTA
GAAAAGGAATCAACTAATTGCATCGTAAACCAAACAGTTGGTATATAAGGTATGCCTGCC
ATTCAGCCTTCAATCATAACAGCTTTCGAATGGTGTACAAAGGAAGGTCTTTTATGTGAT
GAACCCCTAAGAAATATTCGTTTTAACATTATGGATGCAGTAATACATGTAGATCCAGCT
CACCATCGTAGCAATTAAATAACACCAGCTGCTAGAAGATTATTTAAGGCTTGCCAATAT
GTGAGTGAACCTAAAATTCTGGAGCCATTTTACTTATGCGACATTAGAATTCCAGACGAA
AGCAAAGGCCCTATATATGCAGTCTTAAACAAGAGAAGAGGTATAGTTGTTGGAGAAGAA
TATGAAGATACACTCTCTGTGATATAAGCCCACATCCCTGTATCTGAAAGCTTTGGACTA
GACTAAGCCCTGAAGTCAGCCACTCAAGGTAAGGCTATACCTGCTCTCTCATTCAGTCAC
TGGCAAGTAGTTTAAGGCAATCCACTTGACCCAGAATCAAAATCAGGTAAGATCGTCAAT
GAAATAAGAATTAGAAAAGGTTTGAATGCTAAAATACCAGAACTCAACAACTATCTTGAT
AAACTTTGA


>TTHERM_00516370(gene)
ATGAAGACTCTCTAAATTGAGAAGATAAGAGAACTCATGATGAACCCTAACCAAATCAGA
AATATGTCTGTCATAGCCCACGTTGATCATGGTAAGACTACTTTAACTGATTCCTTATTA
GCTAGAGCTGGTATCATATCTGAAAACAACGCTGGTAAAGCATGTTTGATGGATACTGAC
CCTAAGGAGTAAGAAATGGGCATCACCATTAAGTCTACTGGAGTTTCCTTATACTATCAA
AATACTGTGACCAAGTAGGAGAGTATCATTAATTTGATTGATTCTCCTGGTCATATTGAC
TTTTCTGGTGAAGTCACTGCTGCTTTAAGAGTTACTGATGGAGCTCTTGTAGTAGTGGAT
GCTGTTGAAGGTGTTGCTGTTCAGACAGAAACAGTTCTAAGGCAGGCTTGCCAAGAGCGA
ATACGACCCGTTCTTGTAATTAATAAGCTAGACAGGCTTTTTAGTGAACTTAAGGATGAT
TATGAAAATATTTATCAAAGACTTGTTAAGATTATAGCAAAAGTTAATTCCATCTTAGAG
ATGCATGAAAACGATTCTATCAGAGGTTACACTTTAGATCCTTCACTAGGTAACGTTGCC
TTCTCTTCTGGTAAGTAGTGTTGGGGATTCACCTTAAAAACTTTTGCAAGAATTTACAGC
CAAAAATTCTCAACCAAGGAGGAAACCTTAATGGCTAAGTTATGGGGAGATAACTACTTT
AACTCTCAAACCAAATCATTCACCTCAGAAATAACCAAAATTAATAACTAAAACAAGAAA
GCTTTGCGCTCTTTCATTGAATTCGTTTTAGTTCCTTTAGATAAGTACTACTCTGCTTCT
TCAAGCGCAGATGTAGAAGTTCTATCTAAGATGGTTGAAAAGCTCAACCTCTCTACTATT
TTAACTACAGCTGAATTAGAAAGACTCAAACAAGTTGATGTTCAAGAGAGAATCAAAAGA
ACTATGAGAGCTTGGTTACCTTTAGCAGATGCTATACTTGAAATGGTCTAAGATCACCTT
CCTTCGCCTAAAGAAGCTATGAAGTATCGTAGTTTGTATCTCTACGAAGGGCCTGCAGAT
GATGAGGCTTGCACAGCCATGAGAGAATGTAATTCTGAGGGACCTCTTATGCTTTATGTT
TCAAAAATGGTCCCAACTGCAGATCTCAGCAGATTTTATGCTTTCGGTAGAGTATTCAGT
GGTACAATTTCTCAAGGAATGAAAGTTAGAGTTCAAGGCCCTGATTACAAGCCAGGAAGT
AAGGAAGGTCTCTTTATCAAAACTATCTAGAGAACCTTTTTGATGATGGGTAAATAACAC
GAACCTATCGAATCAGTACCAGCTGGAGGTACTGTCCTCATTTTAGGTGTTGATAATGCA
CTTACTAAGACAGGCACTCTTACAACTTCTGAAACAGCACATAATATCAGAAACATGAAA
TATACGATTTCACCTATATTGAGAGTTGCTGTTAATACTCCCAACTAGCAAGATCTTCCA
CGTCTTCTTGAAGGTCTTAAGATGCTTCAAAAGTATGACCCTCTTGTTTAAGTAGAAGTT
GATGAAAATACAGGTTCTTATGTTGTTGCTGGTGGTGGAGAGCTACACGTCCAAATTTGT
CTAGAAAAGCTCAATGATTTCACCCACAATTCTATCAATATCGTCGCTTCTCAGCCCACT
GTATCGTATAGAGAAACCATAGGTGATAAGAGTTCTTAAATGTGCCTTGCTAAGACTGCA
AATAAGTTGAATCGTTTATATGGTACTTGCGAACCTCTAGATGAAGAATTAGGATCAGCT
ATTGTAAGCAACAAAATAAATATACAGGAAATCAATAGTTAAGAAACAATCAACAGTTTG
GTGAATGATTACTCATGGGAAAGAGAAGATGCAAAGCGTATATGGTGCTTCGGTCCTCTA
GAAAAGGAATCAACTAATTGCATCGTAAACCAAACAGTTGGTATATAAGGTATGCCTGCC
ATTCAGCCTTCAATCATAACAGCTTTCGAATGGTGTACAAAGGAAGGTCTTTTATGTGAT
GAACCCCTAAGAAATATTCGTTTTAACATTATGGATGCAGTAATACATGTAGATCCAGCT
CACCATCGTAGCAATTAAATAACACCAGCTGCTAGAAGATTATTTAAGGCTTGCCAATAT
GTGAGTGAACCTAAAATTCTGGAGCCATTTTACTTATGCGACATTAGAATTCCAGACGAA
AGCAAAGGCCCTATATATGCAGTCTTAAACAAGAGAAGAGGTATAGTTGTTGGAGAAGAA
TATGAAGATACACTCTCTGTGATATAAGCCCACATCCCTGTATCTGAAAGCTTTGGACTA
GACTAAGCCCTGAAGTCAGCCACTCAAGGTAAGGCTATACCTGCTCTCTCATTCAGTCAC
TGGCAAGTAGTTTAAGGCAATCCACTTGACCCAGAATCAAAATCAGGTAAGATCGTCAAT
GAAATAAGAATTAGAAAAGGTTTGAATGCTAAAATACCAGAACTCAACAACTATCTTGAT
AAACTTTGA


>TTHERM_00516370(protein)
MKTLQIEKIRELMMNPNQIRNMSVIAHVDHGKTTLTDSLLARAGIISENNAGKACLMDTD
PKEQEMGITIKSTGVSLYYQNTVTKQESIINLIDSPGHIDFSGEVTAALRVTDGALVVVD
AVEGVAVQTETVLRQACQERIRPVLVINKLDRLFSELKDDYENIYQRLVKIIAKVNSILE
MHENDSIRGYTLDPSLGNVAFSSGKQCWGFTLKTFARIYSQKFSTKEETLMAKLWGDNYF
NSQTKSFTSEITKINNQNKKALRSFIEFVLVPLDKYYSASSSADVEVLSKMVEKLNLSTI
LTTAELERLKQVDVQERIKRTMRAWLPLADAILEMVQDHLPSPKEAMKYRSLYLYEGPAD
DEACTAMRECNSEGPLMLYVSKMVPTADLSRFYAFGRVFSGTISQGMKVRVQGPDYKPGS
KEGLFIKTIQRTFLMMGKQHEPIESVPAGGTVLILGVDNALTKTGTLTTSETAHNIRNMK
YTISPILRVAVNTPNQQDLPRLLEGLKMLQKYDPLVQVEVDENTGSYVVAGGGELHVQIC
LEKLNDFTHNSINIVASQPTVSYRETIGDKSSQMCLAKTANKLNRLYGTCEPLDEELGSA
IVSNKINIQEINSQETINSLVNDYSWEREDAKRIWCFGPLEKESTNCIVNQTVGIQGMPA
IQPSIITAFEWCTKEGLLCDEPLRNIRFNIMDAVIHVDPAHHRSNQITPAARRLFKACQY
VSEPKILEPFYLCDIRIPDESKGPIYAVLNKRRGIVVGEEYEDTLSVIQAHIPVSESFGL
DQALKSATQGKAIPALSFSHWQVVQGNPLDPESKSGKIVNEIRIRKGLNAKIPELNNYLD
KL