Identifiers and Description

Gene Model Identifier

TTHERM_00575350

Standard Name

TBP1 (TATA-Binding Protein )

Aliases

TATA-binding protein | PreTt28925 | 77.m00137 | 3812.m02620

Description

TBP1 TATA box-binding protein (TBP): present in archaea and protein; TATA-binding protein; component of the basal transcription apparatus; found in macronuclei throughout life cycle- but only found in micronuclei early in conjugation

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039
• micronucleus (IDA) | GO:0031040

Molecular Function

• DNA binding (IEA) | GO:0003677
• obsolete RNA polymerase II transcription factor activity (IEA) | GO:0003702

Biological Process

• DNA-templated transcription (IEP) | GO:0006351
• regulation of DNA-templated transcription (IEA) | GO:0006355
• transcription initiation at RNA polymerase II promoter (IEA) | GO:0006367

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

• ( SD02729 ) Macronucleus: Partial Neo KO of TBP1

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_04002.1	8.000194140818961e-170
	Description: TATA-box binding protein (246 aa)
WormBase	WBGene00015186	8.000194140818961e-170
	Description: locus:misc-1 status:Confirmed UniProt:P90992 protein_id:CCD61938.1
SGD	YER148W	5.0002513615276457e-88
	Description: SPT15 TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
DictyBase	DDB_G0275617	5.998372506255629e-88
	Description: tbpA on chromosome: 2 position 6092208 to 6093026
WormBase	WBGene00006542	2.0000012618802033e-84
	Description: locus:tbp-1 TATA-box-binding protein status:Confirmed UniProt:P32085 protein_id:CCD69071.1
Tetrahymena borealis	EI9_15201.1	2.0000012618802033e-84
	Description: hypothetical protein (496 aa)
Oxytricha	Contig262.1.g32	6.999281070199524e-80
	Description: Transcription factor TFIID (or TATA-binding protein, TBP)
Stentor Coeruleus	SteCoe_11068	8.985825944049381e-37
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:9115421: Tsukiyama T, Wu C (1997) Chromatin remodeling and transcription. Current opinion in genetics & development 7(2):182-91
2. Ref:8756729: Shen X, Gorovsky MA (1996) Linker histone H1 regulates specific gene expression but not global transcription in vivo. Cell 86(3):475-83
3. Ref:7579709: Lu MJ, Mpoke SS, Dadd CA, Allis CD (1995) Phosphorylated and dephosphorylated linker histone H1 reside in distinct chromatin domains in Tetrahymena macronuclei. Molecular biology of the cell 6(8):1077-87
4. Ref:8264641: Stargell LA, Gorovsky MA (1994) TATA-binding protein and nuclear differentiation in Tetrahymena thermophila. Molecular and cellular biology 14(1):723-34
5. Ref:8177745: Liu X, Gorovsky MA (1993) Mapping the 5' and 3' ends of Tetrahymena thermophila mRNAs using RNA ligase mediated amplification of cDNA ends (RLM-RACE). Nucleic acids research 21(21):4954-60

Sequences

>TTHERM_00575350(coding)
ATGAGCAGCGATAAAACATCTCAGCAGACTTTTAAGTTAGCACCAAACAATAGCGTCGCT
TAGAGCAATAGCATAGACCAAAATAAAAATAAAAACAATATCCTTAGCACTATAGAAACG
ATGGATAAGAGCATAAGTGAAGATTTATACCCAAAATTGTAGAATATTGTTTCCACTGTA
AATCTTAGTACAAAATTAGATTTAAAGCAAATAGCTCTTAGAGCCAGAAATGCTGAATAC
AATCCTAAAAGATTTGCTGCAGTAATTATGAGATTGAGAGATCCTAAAACTACAGCTCTG
ATTTTTGCTTCTGGTAAAATGGTGTGTACGGGTGCAAAAACAGAAGAAGATTCTAATAGA
GCTGCAAGAAAGTATGCTAAGATTATCTAAAAAATAGGTTTCCCCGTACAGTTCAAAGAT
TTTAAAATATAAAATATAGTAGGATCGACTGATGTAAAATTCCCCATCAATCTTGACCAT
CTTGAATAAGACCATAAAAAGTTCGTTTAGTATGAACCTGAAATTTTCCCTGGCTTGATT
TATCGTGAATTTAATACAAAAATAGTTCTCTTAATCTTCGTATCAGGTAAAATTGTACTG
ACAGGTGCAAAAACTAGAGAAAATATTAACAAAGCTTTCTAAAAAATATATTGGGTTTTG
TACAATTACTAGAAAAAAGACTATAGAGGTGCAAATCTTCATAATTAAAATTTAAATATT
AAACCTAGTATAAAAAATTGA

>TTHERM_00575350(gene)
ATGAGCAGCGATAAAACATCTCAGCAGACTTTTAAGTTAGCACCAAACAATAGCGTCGCT
TAGAGCAATAGCATAGACCAAAATAAAAATAAAAACAATATCCTTAGCACTATAGAAACG
ATGGATAAGAGCATAAGTGAAGATTTATACCCAAAATTGTAGAATATTGTTTCCACTGTA
AATCTTAGTACAAAATTAGATTTAAAGCAAATAGCTCTTAGAGCCAGAAATGCTGAATAC
AATCCTAAAAGATTTGCTGCAGTAATTATGAGATTGAGAGATCCTAAAACTACAGCTCTG
ATTTTTGCTTCTGGTAAAATGGTGTGTACGGGTGCAAAAACAGAAGAAGATTCTAATAGA
GCTGCAAGAAAGTATGCTAAGATTATCTAAAAAATAGGTTTCCCCGTACAGTTCAAAGAT
TTTAAAATATAAAATATAGTAGGATCGACTGATGTAAAATTCCCCATCAATCTTGACCAT
CTTGAATAAGACCATAAAAAGTTCGTTTAGTATGAACCTGAAATTTTCCCTGGCTTGATT
TATCGTGAATTTAATACAAAAATAGTTCTCTTAATCTTCGTATCAGGTAAAATTGTACTG
ACAGGTGCAAAAACTAGAGAAAATATTAACAAAGCTTTCTAAAAAATATATTGGGTTTTG
TACAATTACTAGAAAAAAGACTATAGAGGTGCAAATCTTCATAATTAAAATTTAAATATT
AAACCTAGTATAAAAAATTGA

>TTHERM_00575350(protein)
MSSDKTSQQTFKLAPNNSVAQSNSIDQNKNKNNILSTIETMDKSISEDLYPKLQNIVSTV
NLSTKLDLKQIALRARNAEYNPKRFAAVIMRLRDPKTTALIFASGKMVCTGAKTEEDSNR
AARKYAKIIQKIGFPVQFKDFKIQNIVGSTDVKFPINLDHLEQDHKKFVQYEPEIFPGLI
YREFNTKIVLLIFVSGKIVLTGAKTRENINKAFQKIYWVLYNYQKKDYRGANLHNQNLNI
KPSIKN