Identifiers and Description

Gene Model Identifier

TTHERM_00621280

Standard Name

NHX2 (Sodium Hydrogen Exchanger 2)

Aliases

PreTt05125 | 86.m00157

Description

NHX2 transporter monovalent cation:proton antiporter-2 (CPA2) family protein; Sodium/hydrogen exchanger family protein

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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Gene Ontology Annotations

Cellular Component

Molecular Function

  • inorganic anion transmembrane transporter activity (IEA) | GO:0015103

Biological Process

Domains

  • ( PF00999 ) transporter, monovalent cation:proton antiporter-2 (CPA2)
  • ( PF02322 ) cytochrome oxidase subunit II
  • ( PF03647 ) Transmembrane proteins 14C
  • ( PF07690 ) transporter, major facilitator family
  • ( TIGR00831 ) Na+/H+ antiporter
  • ( TIGR00840 ) sodium/hydrogen exchanger 3
  • ( TIGR02831 ) stage II sporulation protein M
  • ( TIGR03173 ) xanthine permease

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_03058.1 9.997093137033517e-262
Description: Ulp1 protease family, C-terminal catalytic domain-containing protein (597 aa)
Oxytricha Contig14635.0.g92 3.999498296699862e-96
Description: Sodium/hydrogen exchanger family
WormBase WBGene00003735 2.999661265281073e-47
Description: locus:nhx-8 Sodium/hydrogen exchanger status:Confirmed UniProt:G5EFN1 protein_id:CAD36499.1
SGD YDR456W 5.997418848378574e-45
Description: NHX1 Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
DictyBase DDB_G0275711 5.998886722426197e-42
Description: nhe1 on chromosome: 2 position 6042281 to 6044641
Stentor Coeruleus SteCoe_33846 1.3336148155022614e-34
Description: None

General Information

No. Gene Name(s) Paragraph Text
26 NHX2 NHX2 belongs in the family of sodium-hydrogen exchangers that act as antiporrters that maintain the pH of actively metabolizing cells by controlling the balance of sodium. THe antiporters have 10-12 regions on the N-terminus and a large cytoplasmic region on the C-terminus. The 10-12 transmembrane regions contain 2 highly conserved regions and most of the regions share identities within the family , while the large cytoplasmic region is noted to have little similarity with other members in the family. Paragraph by: Chris Fang and Deanna Liou (undergraduates) Keck Science Department, The Claremont Colleges

Associated Literature

No Data fetched for Associated Literature

Sequences 

>TTHERM_00621280(coding)
ATGTTTGGAGTAATCTTTTTAATTGTAGTTGTGCTAATCTTGTTCTATTTGATTGGAGGT
GGGCTCCTTGAGCACTATAAGATACACGTTATTCATGAAACAGGATTAGGTATCATTATG
GGTATGATTGTAGGATTTATTTTCTATCAAGCCGATTACGAATTCTACTCAAGTAGTATG
ATATTTGAAGGTGAGCTCTTCTTTTACTTTATCCTTCCACCCATTATTTTTGCAGGCGGT
TACAACTTGAAAAAGCGTCGTTTTTTCCAAAATTTCTTCTACATTAATATATATGGATTA
CTTGGTACTATAGTCAATTTCATAGTAGTATGGCTCTTAACTTATGCTGTTAACGAAGCA
GGTTTGATTCGTAGATATAGTGATTTTTCTCAGTCTGTAACATTATCAACAAGAGATATC
CTTCTGTTTTCTGCTACTATATGCGCTACAGATAGTGTAGCTGCCTTAGCTATGATTAAA
TCAGAGAAATATCCAAAATTATTTAGTGTTATTTTTGGTGAAGGCATGGTAAATGATTCT
GTATCAATTATTCTATATAAGGCTGTCTTGGATTTAGTTGGCGACTCATCTGAACCTCAG
CCTATAACTTTCACTTTCCTTAACTTCTTAAAGATGATTGGTGAATTCCTTAAAAACTCA
GTATGCAGTTTAGCTATTGGTCTTGGTTGGGGTCTCTTAGCTACTTTAGTCATGAAAAAA
TTTAGGTTTTTGACACATAATCCAGTAGTTGAAACAGTTGTTGTTTTACTATTTGGTTTT
GGTGCTTTCGCTTCTTCAGAAAACCTAGATATGTCTGGTGTCATTTCAATTTTAGTATGT
GGTATTATCATGTCTCATTACCTTTTCTATAACATATCATCAACTGGTAAAGTAACAACA
GGTGTCACTTTTTCAAGTATCTCTATTATTGCAGAATCAGCTCTTTATATCTATTTGGGT
ATCGTCTTCTGGTAAACAAAGGGAGATCCTCACAATCCAAGCTCTTATGCATGGTCATGG
ACTTTCTTACTCATTGAATTGGCTATTGCCTTTTTCGCTCGTTTTGTGAGTGTTTTTGTA
GTTTCTTGGATTTTCATGCTAATTAAGGGCAAATAAAAATGGAGATTAAATAGATATGAA
ATGGGTATTATTTGGTTTGCAGGTATTATTAGAGGAGCTATTGCTTTTGCATTGATTTAG
AATGTACCTTAAGATGATTCAAATCCTTAGGCAACACAAGTTATTTAGAGTACAACTCTC
TTTATTGTTATAATCACAACTATTGTCTTAGGAGGTCTAATGCCTTTTTATATAAATGTC
ATGCTGAAACAAATTTCAAAGAATCCTAAGTATCATGAAAATCATCCTTCTATTCGTGAT
AGTTTGGTTGGAGAATCAAAAGAAAGTAGAGAATTCAAAAGCAAGAGTCAGACAAAGTGG
AAATTATTTGATGAAAACTTTATCAAACCTTTGTTCATTTTCGACTATGAAAATAGAAAA
GAGCAAATTAAGATGGAAAAACAAAAGCTTAAAATGAACAGCTCACAGTTTGATGCTGGA
TATATAAAAGAATAGGAATAGGAAATGGGTCACCAAGAAAACGAAAATGAAGAAAATCAT
CAAGATTAACAAGATCAACAGCAACAAGAATTGCAAATTGGAAATGATAATGGCTAAGAA
GAAAATTTCAAATAAATATCCAGAGCAAACATGAATAAGCAAGCAGTTTAATCAATCAAT
TAAGATCCAGAAAATCATAGTAGTAATGAACATATTTGA


>TTHERM_00621280(gene)
ATGTTTGGAGTAATCTTTTTAATTGTAGTTGTGCTAATCTTGTTCTATTTGATTGGAGGT
GGGCTCCTTGAGCACTATAAGGTAATTGATTTTAATTCTCCATATATTTACATCTAAGAC
GAATTGGATAAAACCAGATAAATTTGAATTAATTGTTTACTAATTTAATTTTATAATATA
TTATAGATACACGTTATTCATGAAACAGGATTAGGTATCATTATGGGTATGATTGTAGGA
TTTATTTTCTATCAAGCCGATTACGAATTCTACTCAAGTAGTGTAAACAATAATAAAATT
GATTAAAAATGATTAAATTAGCAATTTAAAAAGAGTAACAACACCAAATTAACTAAAATT
ATTTTTAATTTAAATTAGATGATATTTGAAGGTGAGCTCTTCTTTTACTTTATCCTTCCA
CCCATTATTTTTGCAGGCGGTTACAACTTGAAAAAGCGTCGTTTTTTCCAAAATTTCTTC
TACATTAATATATATGGATTACTTGGTACTATAGTCAATTTCATAGTAGTATGGCTCTTA
ACTTATGCTGTTAACGAAGCAGGTAAAAAATAATTATTATTTAGTAGCATTTTACAGTAG
AAAATCTTAAATAAATTGCACTTAGCAATAAAATTCAATTGAATTATAAATAGCTAGTGG
ATGTTTATTACATTTAAGCATACTTTAAGTACAGAGTAAACAACCTTCAGCAAAGAAAAT
ACAGGCTCAAAAATAAAAATAAAATTTCTATGAATTAAATTTATATTATATTATCAAAAA
CTCAAAAAATGAATTTACAAATTTAATTAACACTATTTTTGTAATAAAAAGGTTTGATTC
GTAGATATAGTGATTTTTCTCAGTCTGTAACATTATCAACAAGAGATATCCTTCTGTTTT
CTGCTACTATATGCGCTACAGATAGTGTAGCTGCCTTAGCTATGATTAAATCAGAGAAAT
ATCCAAAATTATTTAGTGTTATTTTTGGTGAAGGCATGGTAAATGATTCTGTATCAATTA
TTCTATATAAGGCTGTCTTGGATTTAGTTGGCGACTCATCTGAACCTCAGCCTATAACTT
TCACTTTCCTTAACTTCTTAAAGATGATTGGTGAATTCCTTAAAAACTCAGTATGCAGTT
TAGCTATTGGTCTTGGTTGGGGTAAATAAAATTAAATTTAAATGGTTTAATTTACTAACT
ATTTTTTATAATTAAAAATAAATAGGTCTCTTAGCTACTTTAGTCATGAAAAAATTTAGG
TTTTTGACACATAATCCAGTAGTTGAAACAGTTGTTGTTTTACTATTTGGTTTTGGTGCT
TTCGCTTCTTCAGAAAACCTAGATATGTCTGGTGTCATTTCAATTTTAGTATGTGGTATT
ATCATGTCTCATTACCTTTTCTATAACATATCATCAACTGGTAAAGTAACAACAGGGTAA
TTTTTAGAAATTTTATAAAATATTAAGCTTAATTTTTTTGTTACTCTCTAAATTATTTGG
TTATATTCTTTAAAATAAACATAAATTTCTTTATATAAATTAATAGTGTCACTTTTTCAA
GTATCTCTATTATTGCAGAATCAGCTCTTTATATCTATTTGGGTATCGTCTTCTGGTAAA
CAAAGGGAGATCCTCACAATCCAAGCTCTTATGCATGGTCATGGACTTTCTTACTCATTG
AATTGGCTATTGCCTTTTTCGCTCGTTTTGTGAGTGTTTTTGTAGTTTCTTGGATTTTCA
TGCTGTAAAAAATTTTAATATGAATAAAAAAAAATATTTAAAAATTATATATTTTAATAG
AATTAAGGGCAAATAAAAATGGAGATTAAATAGATATGAAATGGGTATTATTTGGTTTGC
AGGTATTATTAGAGGAGCTATTGCTTTTGCATTGATTTAGAATGTACCTTAAGATGATTC
AAATCCTTAGGCAACACAAGTTATTTAGAGTACAACTCTCTTTATTGTTATAATCACAAC
TATTGTCTTAGGAGGTCTAATGCCTTTTTATATAAATGTCATGCTGAAACAAATTTCAAA
GAATCCTAAGTATCATGAAAATCATCCTTCTATTCGTGATAGTTTGGTTGGAGAATCAAA
AGAAAGTAGAGAATTCAAAAGCAAGAGTCAGACAAAGTGGAAATTATTTGATGAAAACTT
TATCAAACCTTTGTTCATTTTCGACTATGAAAATAGAAAAGAGCAAATTAAGATGGAAAA
ACAAAAGCTTAAAATGAACAGCTCACAGTTTGATGCTGGATATATAAAAGAATAGGAATA
GGAAATGGGTCACCAAGAAAACGAAAATGAAGAAAATCATCAAGATTAACAAGATCAACA
GCAACAAGAATTGCAAATTGGAAATGATAATGGCTAAGAAGAAAATTTCAAATAAATATC
CAGAGCAAACATGAATAAGCAAGCAGTTTAATCAATCAATTAAGATCCAGAAAATCATAG
TAGTAATGAACATATTTGA


>TTHERM_00621280(protein)
MFGVIFLIVVVLILFYLIGGGLLEHYKIHVIHETGLGIIMGMIVGFIFYQADYEFYSSSM
IFEGELFFYFILPPIIFAGGYNLKKRRFFQNFFYINIYGLLGTIVNFIVVWLLTYAVNEA
GLIRRYSDFSQSVTLSTRDILLFSATICATDSVAALAMIKSEKYPKLFSVIFGEGMVNDS
VSIILYKAVLDLVGDSSEPQPITFTFLNFLKMIGEFLKNSVCSLAIGLGWGLLATLVMKK
FRFLTHNPVVETVVVLLFGFGAFASSENLDMSGVISILVCGIIMSHYLFYNISSTGKVTT
GVTFSSISIIAESALYIYLGIVFWQTKGDPHNPSSYAWSWTFLLIELAIAFFARFVSVFV
VSWIFMLIKGKQKWRLNRYEMGIIWFAGIIRGAIAFALIQNVPQDDSNPQATQVIQSTTL
FIVIITTIVLGGLMPFYINVMLKQISKNPKYHENHPSIRDSLVGESKESREFKSKSQTKW
KLFDENFIKPLFIFDYENRKEQIKMEKQKLKMNSSQFDAGYIKEQEQEMGHQENENEENH
QDQQDQQQQELQIGNDNGQEENFKQISRANMNKQAVQSINQDPENHSSNEHI