Identifiers and Description

Gene Model Identifier

TTHERM_00633170

Standard Name

GPR37 (Gene Protein coupled Receptor 37)

Aliases

PreTt27986 | 90.m00150 | GPCR37

Description

GPR37 7 transmembrane receptor (secretin family) protein; G protein coupled receptor; demonstrates chemorepellent receptor activity in the presence of conditioned supernatant factor; GCR1-cAMP receptor

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• alpha6-beta1 integrin-CD151 complex (IEA) | GO:0071059
• CD19-Vav-PIK3R1 complex (IEA) | GO:0070024
• ionotropic glutamate receptor complex (IEA) | GO:0008328
• myosin II complex (IEA) | GO:0016460
• obsolete chromosome segregation-directing complex (IEA) | GO:0043913
• obsolete ectoplasm (IEA) | GO:0043265
• obsolete intrinsic component of synaptic vesicle membrane (IEA) | GO:0098563

Molecular Function

• 11-deoxycorticosterone binding (IEA) | GO:1903878
• 17alpha-hydroxyprogesterone binding (IEA) | GO:1903880
• 2-octaprenyl-6-methoxyphenol hydroxylase activity (IEA) | GO:0008681
• 3-hydroxybutyrate dehydrogenase activity (IEA) | GO:0003858
• 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (IEA) | GO:0008413
• ABC-type amino acid transporter activity (IEA) | GO:0015424
• ABC-type D-xylose transporter activity (IEA) | GO:0015614
• ABC-type maltose transporter activity (IEA) | GO:0015423
• ABC-type oligosaccharide transporter activity (IEA) | GO:0015422
• amino acid transmembrane transporter activity (IEA) | GO:0015171
• aminotriazole transporter activity (IEA) | GO:0015241
• arginine transmembrane transporter activity (IEA) | GO:0015181
• arsenate reductase (glutaredoxin) activity (IEA) | GO:0008794
• cadmium ion transmembrane transporter activity (IEA) | GO:0015086
• carboxylic ester hydrolase activity (IEA) | GO:0052689
• carboxymethylenebutenolidase activity (IEA) | GO:0008806
• cobalamin transporter activity (IEA) | GO:0015235
• Cys-tRNA(Pro) hydrolase activity (IEA) | GO:0043907
• cytochrome o ubiquinol oxidase activity (IEA) | GO:0008827
• cytosine-purine permease activity (IEA) | GO:0015392
• drug transmembrane transporter activity (IEA) | GO:0015238
• endochitinase activity (IEA) | GO:0008843
• G protein-coupled serotonin receptor binding (IEA) | GO:0031821
• galactoside 2-alpha-L-fucosyltransferase activity (IEA) | GO:0008107
• glycine transmembrane transporter activity (IEA) | GO:0015187
• high-affinity copper ion transmembrane transporter activity (IEA) | GO:0015089
• high-affinity sodium:dicarboxylate symporter activity (IEA) | GO:0015362
• iron-chelate-transporting ATPase activity (IEA) | GO:0015623
• L-aspartate transmembrane transporter activity (IEA) | GO:0015183
• L-cystine transmembrane transporter activity (IEA) | GO:0015184
• L-isoleucine transmembrane transporter activity (IEA) | GO:0015188
• lipopolysaccharide heptosyltransferase activity (IEA) | GO:0008920
• mercury (II) reductase (NADP+) activity (IEA) | GO:0016152
• monoatomic anion:monoatomic cation symporter activity (IEA) | GO:0015296
• obsolete cation:cation antiporter activity (IEA) | GO:0015491
• obsolete D-lysine oxidase activity (IEA) | GO:0043912
• obsolete negative transcription elongation factor activity (IEA) | GO:0008148
• obsolete phosphatidylinositol 3-kinase, class I, catalyst activity (IEA) | GO:0015072
• obsolete sodium-transporting two-sector ATPase activity (IEA) | GO:0015443
• obsolete zinc, iron permease activity (IEA) | GO:0015342
• orexigenic neuropeptide QRFP receptor binding (IEA) | GO:0031854
• pantothenate transmembrane transporter activity (IEA) | GO:0015233
• phosphatidylserine decarboxylase activity (IEA) | GO:0004609
• polyamine transmembrane transporter activity (IEA) | GO:0015203
• pristanoyl-CoA oxidase activity (IEA) | GO:0016402
• purinergic nucleotide receptor activity (IEA) | GO:0001614
• pyrimidine nucleotide-sugar transmembrane transporter activity (IEA) | GO:0015165
• Ser(Gly)-tRNA(Ala) hydrolase activity (IEA) | GO:0043908
• sodium ion transmembrane transporter activity (IEA) | GO:0015081
• type 1B serotonin receptor binding (IEA) | GO:0031822
• uridine:proton symporter activity (IEA) | GO:0015394

Biological Process

• aminotriazole transport (IEA) | GO:0015899
• cell wall modification involved in fruit ripening (IEA) | GO:0009829
• cytoplasmic actin-based contraction involved in forward cell motility (IEA) | GO:0060328
• D-tagatose 6-phosphate catabolic process (IEA) | GO:2001059
• DNA recombinase mediator complex assembly (IEA) | GO:1903871
• fucose metabolic process (IEA) | GO:0006004
• galactose to glucose-1-phosphate metabolic process (IEA) | GO:0061612
• glycolytic process from glycerol (IEA) | GO:0061613
• glycolytic process through fructose-6-phosphate (IEA) | GO:0061615
• GTP synthesis coupled proton transport (IEA) | GO:0015987
• hair cycle process (IEA) | GO:0022405
• heme A biosynthetic process (IEA) | GO:0006784
• heme biosynthetic process (IEA) | GO:0006783
• internal genitalia morphogenesis (IEA) | GO:0035260
• laminaritriose transport (IEA) | GO:2001097
• lung connective tissue development (IEA) | GO:0060427
• lung saccule development (IEA) | GO:0060430
• malolactic fermentation (IEA) | GO:0043464
• maltoheptaose catabolic process (IEA) | GO:2001123
• maltoheptaose metabolic process (IEA) | GO:2001122
• maltotetraose transport (IEA) | GO:2001099
• meiotic DNA double-strand break formation involved in meiotic gene conversion (IEA) | GO:0010781
• meiotic DNA double-strand break formation involved in reciprocal meiotic recombination (IEA) | GO:0010780
• mercury ion transport (IEA) | GO:0015694
• microtubule cytoskeleton organization involved in mitosis (IEA) | GO:1902850
• mitochondrial RNA surveillance (IEA) | GO:2000827
• mitotic nuclear division (IEA) | GO:0007067
• multicellular organism development (IEA) | GO:0007275
• N-acetylglucosamine catabolic process (IEA) | GO:0006046
• N,N'-diacetylchitobiose import (IEA) | GO:1902815
• negative regulation of cellular glucuronidation (IEA) | GO:2001030
• negative regulation of cellular response to oxidopamine (IEA) | GO:1905847
• negative regulation of complement-dependent cytotoxicity (IEA) | GO:1903660
• negative regulation of double-strand break repair via nonhomologous end joining (IEA) | GO:2001033
• negative regulation of hemopoiesis (IEA) | GO:1903707
• negative regulation of L-glutamine biosynthetic process (IEA) | GO:0062133
• negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
• negative regulation of postsynaptic membrane organization (IEA) | GO:1901627
• negative regulation of sprouting angiogenesis (IEA) | GO:1903671
• nitrite transport (IEA) | GO:0015707
• nurse cell nucleus anchoring (IEA) | GO:0007302
• obsolete carbamate resistance (IEA) | GO:0008161
• obsolete cyclodiene resistance (IEA) | GO:0008162
• obsolete fertilization, exchange of chromosomal proteins (IEA) | GO:0035042
• obsolete histone H4-K20 demethylation (IEA) | GO:0035574
• obsolete induction by virus of host cell-cell fusion (IEA) | GO:0006948
• obsolete negative regulation of transcription during mitotic cell cycle (IEA) | GO:0007068
• obsolete reproduction (IEA) | GO:0000003
• ommochrome biosynthetic process (IEA) | GO:0006727
• phagocytosis (IEA) | GO:0006909
• phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene (IEA) | GO:0018956
• plant-type cell wall modification (IEA) | GO:0009827
• positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
• positive regulation of ATF6-mediated unfolded protein response (IEA) | GO:1903893
• positive regulation of axon guidance (IEA) | GO:1902669
• positive regulation of double-strand break repair via nonhomologous end joining (IEA) | GO:2001034
• positive regulation of macrophage chemotaxis (IEA) | GO:0010759
• positive regulation of macrophage derived foam cell differentiation (IEA) | GO:0010744
• positive regulation of oligopeptide transport (IEA) | GO:2000878
• positive regulation of protein autoubiquitination (IEA) | GO:1902499
• positive regulation of siRNA processing (IEA) | GO:1903705
• positive regulation of tumor necrosis factor biosynthetic process (IEA) | GO:0042535
• primitive palate development (IEA) | GO:0062010
• programmed cell death (IEA) | GO:0012501
• propan-2-ol biosynthetic process (IEA) | GO:1902640
• protein localization to old growing cell tip (IEA) | GO:1903858
• proton motive force-driven ATP synthesis (IEA) | GO:0015986
• regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902641
• regulation of antisense RNA transcription (IEA) | GO:0060194
• regulation of beta-glucan metabolic process (IEA) | GO:0032950
• regulation of cellular glucuronidation (IEA) | GO:2001029
• regulation of chemorepellent activity (IMP) | GO:1903667
• regulation of complement-dependent cytotoxicity (IEA) | GO:1903659
• regulation of cytokinin dehydrogenase activity (IEA) | GO:1903856
• regulation of dendrite extension (IEA) | GO:1903859
• regulation of macrophage chemotaxis (IEA) | GO:0010758
• regulation of phosphatidylcholine biosynthetic process (IEA) | GO:2001245
• regulation of protein insertion into mitochondrial outer membrane (IEA) | GO:1903636
• regulation of response to type II interferon (IEA) | GO:0060330
• regulation of satellite cell activation involved in skeletal muscle regeneration (IEA) | GO:0014717
• release of sequestered calcium ion into cytosol by endoplasmic reticulum (IEA) | GO:1903514
• response to non-ionic osmotic stress (IEA) | GO:0010335
• response to osmotic stress (IEA) | GO:0006970
• response to reactive oxygen species (IEA) | GO:0000302
• sperm aster formation (IEA) | GO:0035044
• sterol metabolic process (IEA) | GO:0016125
• syncytium formation (IEA) | GO:0006949
• tertiary alcohol biosynthetic process (IEA) | GO:1902645
• tetrasaccharide transport (IEA) | GO:2001098
• xanthophyll biosynthetic process (IEA) | GO:0016123
• xanthophyll catabolic process (IEA) | GO:0016124

Domains

• ( PF05462 ) Slime mold cyclic AMP receptor

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

• ( SD01667 ) Macronucleus: GPCR3::neo3

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:28685161: Zou D, Hennessey TM (2017) Behavioral Effects of a Chemorepellent Receptor Knockout Mutation in Tetrahymena thermophila. mSphere 2(4):

Sequences

>TTHERM_00633170(coding)
ATGACGATTGTTTCTAACCACAATTAGGTCAACATTATATAGATTATAGCTATTGTTGTC
AGCTCTTTTTCTCTTCTAGGAGCTATATTTATTATTGGAATATTTTTGAGTTTCAAAAAG
CTCAGGGTTTTCCCCTTTATATATGTCTTTTGGCTCAGTGTAAGTGACTTAATATCTTCT
ATAGGGTACCTTCTTGTTACTGACTCGATTGGAGACACTCCTGAATAGCTTCAAGAGGCA
AATTTTACTTGTAAAACTTAGGCTTTAATGATTAATTTTGGATAGCTTGCCTCTATTTGT
TGGACTGCAGTTATTGCCTGGACTCTCTACAACTCCACCGTTAAAGTGGTAACAAACTTA
CAACAAAAAACAGAAACAAAAATGGTTGCGATTGCTTTTGGATTTCCCCTAATTATGTCA
TTGATACCTTTAATTTTAAATGAATATGGCCCATAAGGAGGCTGGTGCTGGATAAAAAGT
GAAGGCAGCAATAAAGTATTAACATTTATTTTGGTAGGAATAGAATTTTATATTCCTCTT
TGGATAGCATTCGTATTTAATGGCATAACAATATACAGAGTAATCAAATATGTCAAGAGT
ATAACTCAAGATAAAAATTAGCTGAAACTAATCAATAGACTAACACTATATCCTCTTATT
TTATTGGTTTGCTGGAGTGCTGGTACCGTAGAAAGAGTATTTGATTTCATCGGTATCTCG
TCAGAGATACTTTCATATTTGCACATCTTCTTTGGTGGATTGTAAGGATTTTTTAATGCT
TGTGTTTACGGTCTCAATTCAAATGTCCGTAAAGTTATCAGAGAAAATCTATGCTCAAGC
CTACCATGCTTTGCAAGTGCATATATATATGAAGAATAAAACCTTAATGAAGCTGAAGAT
CATCAGCAAGATAGTAAAAAAACTGCATCCATATCCTCTGGCGAAGGCCAAGTTGAAATG
GAACAACTTAATCAATGA

>TTHERM_00633170(gene)
TCATTAAGAAGAATTTATTAGTAACTAGGCCAGAAAAAAAAAATTAAAAATTAATTAATT
AATTGATTGTTTATTTATTAAATTATTATTTAGCAAATACTTCTAAGACATATTATTGTT
ATTTATTTTTAGCGCACTTAGTTAGCTACAAATTATAAAGTAAAAAGCTTGAATTAAGCC
ATTAGCATAGAGTTATGACGATTGTTTCTAACCACAATTAGGTCAACATTATATAGATTA
TAGCTATTGTTGTCAGCTCTTTTTCTCTTCTAGGAGCTATATTTATTATTGGAATATTTT
TGAGTTTCAAAAAGCTCAGGGTTTTCCCCTTTATATATGTCTTTTGGCTCAGTGTAAGTG
ACTTAATATCTTCTATAGGGTACCTTCTTGTTACTGACTCGATTGGAGACACTCCTGAAT
AGCTTCAAGAGGCAAATTTTACTTGTAAAACTTAGGCTTTAATGATTAATTTTGGATAGC
TTGCCTCTATTTGTTGGACTGCAGTTATTGCCTGGACTCTCTACAACTCCACCGTTAAAG
TGGTAACAAACTTACAACAAAAAACAGAAACAAAAATGGTTGCGATTGCTTTTGGATTTC
CCCTAATTATGTCATTGATACCTTTAATTTTAAATGAATATGGCCCATAAGGAGGCTGGT
GCTGGATAAAAAGTGAAGGCAGCAATAAAGTATTAACATTTATTTTGGTAGGAATAGAAT
TTTATATTCCTCTTTGGATAGCATTCGTATTTAATGGCATAACAATATACAGAGTAATCA
AATATGTCAAGAGTATAACTCAAGATAAAAATTAGCTGAAACTAATCAATAGACTAACAC
TATATCCTCTTATTTTATTGGTTTGCTGGAGTGCTGGTACCGTAGAAAGAGTATTTGATT
TCATCGGTATCTCGTCAGAGATACTTTCATATTTGCACATCTTCTTTGGTGGATTGTAAG
GATTTTTTAATGCTTGTGTTTACGGTCTCAATTCAAATGTCCGTAAAGTTATCAGAGAAA
ATCTATGCTCAAGCCTACCATGCTTTGCAAGTGCATATATATATGAAGAATAAAACCTTA
ATGAAGCTGAAGATCATCAGCAAGATAGTAAAAAAACTGCATCCATATCCTCTGGCGAAG
GCCAAGTTGAAATGGAACAACTTAATCAATGAACAAAAAATATAAATCAAATCAATAAAT
TGAGATGAAATAAATATAAATATATTTAAATAAATTCTATTAACAAAAAAGAAATGGAAA
AGCTTTTTTAAGAAAGATGAAACAAACAAACAAAATAAAATAAAATAATAATATACATTT
GTTTATACAAATTAAATTATAATAGTTAATTAATGATTTATAAATAATTTAATATTATTT
TTACATTTAATATAATATTGGAATAATGATAACCATTTAAAAGAGATGTCTGACTTGAGA
GAAAGAAAATCAAACCAAATCAGTTATGAAATTTTATAAAGCAAATCATAGATTAACAAA
TAATGCCTTGCTAGCCTTTATCATAATACAAACTTATTTAATCGCTTTACACAAAAATAA
AAATTGCTTGAAGATTATGCATGTAAATCAGACAATTTATGTATCTTCATTCTTTACTTA
ATCTTCAATGAGGAGAACATCTTTTACTTTCATTTTTTAAGGTTCTTGGTCCTTTTAATC
CAAGCCAGCTATTTATAAAGTTTCTTTTTCTTTATATACAAAATTGCCTTCTAAGAACCC
CTACAGATCATCACTGGTATCGTAATTTCTGCTTATTGTTCAAAAATTACTTAATGGTTG
AACATAAATACATACATATATAAATAACTTAATAATAATTAGAAATAAATTCTTTGTGTT
AATTTACCTCATAGGTGAAAATGATGGCAGTCGTTGCTGCTACTACTATCCTTGTGCAGC
ATTTTGGTTAAAAATAGTTTAGCCTGTATTATCTTCTCCATTAATTTCTTTTAAATTTAT
GACAATATTAGCTTAATCTTCCTTTGTACTATTAATAATATTTATATTGTAATTTTTATT
ATCTATTTCCATTTTTAACAAGCAAAAA

>TTHERM_00633170(protein)
MTIVSNHNQVNIIQIIAIVVSSFSLLGAIFIIGIFLSFKKLRVFPFIYVFWLSVSDLISS
IGYLLVTDSIGDTPEQLQEANFTCKTQALMINFGQLASICWTAVIAWTLYNSTVKVVTNL
QQKTETKMVAIAFGFPLIMSLIPLILNEYGPQGGWCWIKSEGSNKVLTFILVGIEFYIPL
WIAFVFNGITIYRVIKYVKSITQDKNQLKLINRLTLYPLILLVCWSAGTVERVFDFIGIS
SEILSYLHIFFGGLQGFFNACVYGLNSNVRKVIRENLCSSLPCFASAYIYEEQNLNEAED
HQQDSKKTASISSGEGQVEMEQLNQ