Identifiers and Description

Gene Model Identifier

TTHERM_00633360

Standard Name

HTB1 (Histone h Two B )

Aliases

histone H2B-1 | PreTt28005 | 90.m00169

Description

HTB1 histone H2B.1; Histone H2B; one of the four histones (H2A, H2B, H3 and H4) that comprise the protein core of the eukaryotic nucleosome; differs from Htb2p by three amino acids; Histone H2B

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Biological Process

  • heme A biosynthetic process (IEA) | GO:0006784
  • heme biosynthetic process (IEA) | GO:0006783
  • negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902642
  • negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
  • obsolete extracellular carbohydrate transport (IEA) | GO:0006859
  • ommochrome biosynthetic process (IEA) | GO:0006727
  • positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
  • propan-2-ol biosynthetic process (IEA) | GO:1902640
  • protein localization to old growing cell tip (IEA) | GO:1903858
  • regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (IEA) | GO:1902646
  • regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902641
  • regulation of phosphorus utilization (IEA) | GO:0006795
  • tertiary alcohol biosynthetic process (IEA) | GO:1902645

Domains

  • ( PF00125 ) Core histone H2A/H2B/H3/H4

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

  • ( SD01882 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1
  • ( SD01883 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1 with A8C mutation
  • ( SD01884 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1 with A8C, K4R mutation
  • ( SD01885 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1 with A8C, K4R mutation
  • ( SD01999 )
  • ( SD02031 ) Micronucleus: neo2 KO of HTB1 Macronucleus: KO of HTB1 with neo2
  • ( SD02061 ) Micronucleus: neo2 replaces coding of HTB1,HTB2
  • ( SD02062 ) Micronucleus: neo2 replaces coding of HTB1,HTB2
  • ( SD02063 ) Micronucleus: neo2 replaces coding of HTB1,HTB2
  • ( SD02078 ) Micronucleus: Neo2 into HTB1 replacing coding
  • ( SD02079 ) Micronucleus: Neo2 into HTB1 replacing coding
  • ( SD02080 ) Micronucleus: Neo2 into HTB1 replacing coding
  • ( SD02081 ) Micronucleus: Neo2 into HTB1 replacing coding
  • ( SD02082 ) Micronucleus: neo2 KO of HTB1 Macronucleus: KO of HTB1 with neo2
  • ( SD02083 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with A1G
  • ( SD02084 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with A1G
  • ( SD02085 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with A1G
  • ( SD02086 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with A1G
  • ( SD02087 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: HTB1
  • ( SD02088 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: HTB1
  • ( SD02089 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with K4Q
  • ( SD02090 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with K4Q
  • ( SD02091 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with K4Q
  • ( SD02093 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with K4R
  • ( SD02094 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with K4R
  • ( SD02095 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with S29A
  • ( SD02096 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with S29A
  • ( SD02097 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with S29A
  • ( SD02098 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with T19A,T20A
  • ( SD02099 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with T19A,T20A
  • ( SD02100 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with T19A,T20A
  • ( SD02101 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with T31A
  • ( SD02102 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with T31A
  • ( SD02103 ) Micronucleus: neo2 KO of HTB1 and HTB2 coding Macronucleus: Mutated HTB1 with T31A
  • ( SD02104 ) Micronucleus: Neo2 into HTB2 replacing coding Macronucleus: HTB2 coding replaced by neo2 but assorted to pm-s
  • ( SD02105 ) Micronucleus: Neo2 into HTB2 replacing coding Macronucleus: HTB2 coding replaced by neo2 but assorted to pm-s
  • ( SD02466 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1
  • ( SD02467 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1
  • ( SD02468 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1
  • ( SD02469 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1 with K115R, HTB2 KO with neo2
  • ( SD02470 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1 with K115R, HTB2 KO with neo2
  • ( SD02471 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1 with K115R, HTB2 KO with neo2
  • ( SD02472 ) Micronucleus: neo2 into coding of HTB1 and HTB2 Macronucleus: HTB1 with K115R, HTB2 KO with neo2

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:30796450: Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J (2019) Proteomic analysis of histones H2A/H2B and variant Hv1 in Tetrahymena thermophila reveals an ancient network of chaperones. Molecular biology and evolution ( ):
  2. Ref:19822522: Wang Z, Cui B, Gorovsky MA (2009) Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena. The Journal of biological chemistry 284(50):34870-9
  3. Ref:15199121: Medzihradszky KF, Zhang X, Chalkley RJ, Guan S, McFarland MA, Chalmers MJ, Marshall AG, Diaz RL, Allis CD, Burlingame AL (2004) Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS). Molecular & cellular proteomics : MCP 3(9):872-86
  4. Ref:8760889: Liu X, Gorovsky MA (1996) Cloning and characterization of the major histone H2A genes completes the cloning and sequencing of known histone genes of Tetrahymena thermophila. Nucleic acids research 24(15):3023-30
  5. Ref:2713375: Nickel BE, Allis CD, Davie JR (1989) Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatin. Biochemistry 28(3):958-63
  6. Ref:3039463: Nomoto M, Imai N, Saiga H, Matsui T, Mita T (1987) Characterization of two types of histone H2B genes from macronuclei of Tetrahymena thermophila. Nucleic acids research 15(14):5681-97
  7. Ref:6818230: Nomoto M, Kyogoku Y, Iwai K (1982) N-Trimethylalanine, a novel blocked N-terminal residue of Tetrahymena histone H2B. Journal of biochemistry 92(5):1675-8
  8. Ref:6804458: Nomoto M, Hayashi H, Iwai K (1982) Tetrahymena histone H2B. Complete amino acid sequence. Journal of biochemistry 91(3):897-904

Sequences 

>TTHERM_00633360(coding)
ATGGCTCCCAAGAAAGCTCCCGCTGCCGCTGCTGAAAAGAAGGTCAAGAAGGCCCCCACA
ACCGAAAAGAAGAACAAGAAGAAGAGATCAGAAACCTTCGCCATCTACATCTTCAAGGTC
TTAAAGCAAGTCCACCCTGATGTCGGTATTTCCAAGAAGGCTATGAACATTATGAACTCC
TTCATTAACGACTCCTTCGAAAGAATCGCCTTAGAATCCTCTAAGTTGGTCAGATTCAAC
AAGAGAAGAACCCTCTCATCCAGGGAAGTCTAAACCGCTGTCAAGCTCTTATTACCCGGT
GAACTCGCTAGACACGCCATCTCCGAAGGTACCAAGGCCGTCACCAAGTTCTCTTCTTCT
ACCAACTGA



>TTHERM_00633360(gene)
AAAAAATATAAATTAAAAAGAAAAAAAGTAAAAAATCCATTTAAATGGCTCCCAAGAAAG
CTCCCGCTGCCGCTGCTGAAAAGAAGGTCAAGAAGGCCCCCACAACCGAAAAGAAGAACA
AGAAGAAGAGATCAGAAACCTTCGCCATCTACATCTTCAAGGTCTTAAAGCAAGTCCACC
CTGATGTCGGTATTTCCAAGAAGGCTATGAACATTATGAACTCCTTCATTAACGACTCCT
TCGAAAGAATCGCCTTAGAATCCTCTAAGTTGGTCAGATTCAACAAGAGAAGAACCCTCT
CATCCAGGGAAGTCTAAACCGCTGTCAAGCTCTTATTACCCGGTGAACTCGCTAGACACG
CCATCTCCGAAGGTACCAAGGCCGTCACCAAGTTCTCTTCTTCTACCAACTGAGAAAATT
TATTGATACATACTTGCAAACAATTATTAATCATAATTTAATCCAATAAATACATATAAA
CAAAATATACATCAACCTTTTACCATATAAAATACTCTGTTTTATAAAATAACTTATTAT
TAAAACTGTTTTATATATTTTTTATGGTGTACTAATCAGTTTTCATCGAGTTTAAGTCGT
CTCAAT



>TTHERM_00633360(protein)
MAPKKAPAAAAEKKVKKAPTTEKKNKKKRSETFAIYIFKVLKQVHPDVGISKKAMNIMNS
FINDSFERIALESSKLVRFNKRRTLSSREVQTAVKLLLPGELARHAISEGTKAVTKFSSS
TN