Identifiers and Description

Gene Model Identifier

TTHERM_00641080

Standard Name

IRE1 (Inositol REquiring)

Aliases

PreTt10577 | 92.m00119

Description

Serine/Threonine kinase domain protein; Homolog of yeast IRE1; Protein kinase domain containing protein. Sequence similarity to the IRE protein kinase family (Eisen et al.- 2006).

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein kinase activity (IEA) | GO:0004672
• protein tyrosine kinase activity (IEA) | GO:0004713
• RNA endonuclease activity, producing 5'-phosphomonoesters (IEA) | GO:0016891

Biological Process

• mRNA processing (IEA) | GO:0006397
• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) protein kinase domain
• ( PF04383 ) KilA-N domain
• ( PF05316 ) Mitochondrial ribosomal protein (VAR1)
• ( PF06479 ) Ribonuclease 2-5A
• ( PF07714 ) protein tyrosine kinase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_05206.1	9.997093137033517e-262
	Description: protein kinase domain-containing protein (920 aa)
WormBase	WBGene00002147	1.9997677415930956e-65
	Description: locus:ire-1 status:Partially_confirmed UniProt:E5QCG0 protein_id:CBY24252.1
DictyBase	DDB_G0267650	6.996751372006089e-64
	Description: ireA on chromosome: 1 position 495110 to 498317
SGD	YHR079C	6.996751372006089e-64
	Description: IRE1 Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
Oxytricha	Contig237.1.g129	3.999925618735366e-62
	Description: Protein kinase domain
Stentor Coeruleus	SteCoe_9478	1.462486227251231e-31
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00641080(coding)
ATGATAATCTATTTCAATAGTTTTTTTAAGAAATTTGTTTAAAATTAAAAGTAAATAAGA
TTTATACTGCCTTATTTCATCATTAAGTTTATATAAATTATTAATACAAAATAAAACATG
AATAACTTTTAAAATTTCTTCAAAAAGTAAAAAAAACTTATTGCCATTTTTATATTACTT
TTATTAATAAATGGCACTTTAGCTTAGCATAGCAATAAAAAAAGCTAGACTCAGAATAAT
AGTTCTGAGACGGCTTTAACTCATTCTAAAGTAGACAAAGATGCCTATCTAGTATTAACT
AATGATGGCAAATTATATAGCTATAATATAAAGAAAAAGTTGTTAAATTGGATGACAGAT
CTGAAAGTAGTTGTTAGCGAGCTCAAATTCAATAACGAAAAACAATAGTAGGATAATTAT
GGAATGGAAGATCAGCACTCTACTGAACTCTCTATTGCAGGAAATTAGGAATCTAACTTT
GAGAGATACGACTATTTTTTGCCCTCTTCTGATGGAAATTTTATCTTTTTAGCATCAGAT
TCTACTCCAATAAAAATTATGCGAGATGAAATAGACCAAGTTATTAAAATATGTCCAATG
AGTGGAAACGAGTCAAAATATATTGCATTTACCAAAGAAAAGATTCTTTTAGTCAATCCT
GAAAATGGGGAATTAGAGAAATTTGAAGATATTGAAGATGATTATGAAAACTATTTAAAT
CATTATATTATCAATATCAACTAGAAACTTATTAAGCAACTTAATATTTTTACCAAAAGA
GAAAATTGGGCTTTAACCAGCACAGATGTTAATTTGATGATTTATGAAGACTTTTTATAC
AAAGGATTATAAAAAAATCAGCTTACTGAAAATGAGGATTATATTTTTATGTAAGATTAG
CATTAAGATTTGAAAATTAAGCAAAAGCAATCAAAGATTAAAATAGTTGATTTCTAAACA
GATTAGGAAATTATTGCTATTTTTTCTGCAGTTGGATTTACAAACATGTTTTAAAAGAAT
GTCATAGTGCATAATCCTCTTATCAATACGTTCATATCTTCAGAATATGATAACACATAG
ATTTAAATAGGTGGAGAGAAAGGCATAGTTTCGTTTAATGAAGGGAGCAACTTTTAGCTA
ATACCATTGTAGATTTCTACAAAGCTAAAGAATTAGTGTTTAGAAAATAAGTAATGCAGA
GAAAGATTGATTTTTAGTGTTGATAAATTTGATGATAAAAATTATATCAGAGATGTTATG
ACTTGCATAGATAACCTCAGAAAGGGGAGAATGATGATTGAAGTTATATCTGATAGTAAG
GATATCTAGAATGCCAGCAATATTCCTAGTTAAGCATTCAATTTTGCTAAGGATAATAAA
ATTACAATATTCTTGCTGACATTCTTAATTATCTTGGTTATTATTCTGATTTTAAAAGAT
GAAAGAATTACTTCTATGTATAAAAGAAATAGTGGTCGTTCTGGAGGTAAATCTTCCAGT
TAAAAATAAAACTCCCAAGAAGAAGCTGATAAAGTCTTAGAAAAAATTAGCAAAGAGCAA
GAAGAAGAAATTAAAAAACAAAATGAGCAAAATAATAAATAAGAAAAAAAGAACCAAGAG
AGTAGCGAATAAAATGCAAATAAATTTAAAGGGCTTTAAATTAATAGAAATAAAGTTTTA
GGGTATGGGGCTTAAGGGACAGTTATTTTTGAAGGAACATTTTAAGGAAGAGAAATTGCA
GTCAAATAGTTACTTAAAGATAATAAAGACTTAGCTAGCAAGGAAATATAAATGTTGATT
AAGCTGCAACACAAAAATATAATTAAGTACTACTATTTTGAGGAAACAAAAGATCACATA
CTTCTTGGACTAGAAAAGTGTGTTGGAAGCATTAGCGATTTAATAGATTATGCAAATAGA
AAAAACAAGAAGAAAAGTGAGTAGGATTTGAAAGCTTTATATAATATAAAAACGGATTTT
TTCATTAAGTCAACTATGAAAAATACATTTAAAGACTGCTTAGAAGGATTGAGTTATTTG
CATAGCTAAGGTGTTATTCATAGAGATATAAAGCCAGAAAATATTTTAATTCACTACAAC
AAAGAAATTAAATTAGCTGATTTTGGACTTTCAAAGAATATTTCTAAAACGAATGTCATA
TTCACGAATGATATCGGCACATGGGGATGGAGACCACTAGAATAAATAGATAATTAACCA
CTTACATATAATACAGATGTTTTCTCTCTTGGCTGTGTATTCTATTACATATACACTTAA
GGAGGTCATCCTTTTGGAGAATAGAAAGAAAGGGAAAGAAACATAGCTAATTTTAAGTAC
AGCTTGAGAATGGAAGATGAAACCTTGAAAGACCTTATCCAAAAAATGATTCATAATGAT
CAAAGTAAAAGACTGACTGTAAAAGAATGCTTAAAGCATCCATATTTCTGGAATACCTTG
TAAAAGTTCTCTTTTATTTGCGAATTTAGTGACTACATAGAAACATTTGATACTGAAAAT
AAATATTCAGACTTGATTGAATAATAAGCAAAGTCTTTGAATGTTTTAGAAGGAAATAGA
TGGGATAAAAATGTAGATAAAAGTCTTATTTAAGATACTAAAGTGTTTAAATTCTACAAC
TATGGATAGGTTAAAGATCTTATCAGATTAATAAGGAACAGAAAAAGTCATTATCACGAG
CTTTCAGAGAGCTCTAAAGATATAGTAGGAGATACTCTTGATGATATGTTTAACTATTTT
GATGAAAGATTCCCTAAATTATTTATTTTTATGTATTATTTCTCACAAACTTAAAACTGG
GAATTACTAAGCTTTAAAAATAACTGA

>TTHERM_00641080(gene)
ATGATAATCTATTTCAATAGTTTTTTTAAGAAATTTGTTTAAAATTAAAAGTAAATAAGA
TTTATACTGCCTTATTTCATCATTAAGTTTATATAAATTATTAATACAAAATAAAACATG
AATAACTTTTAAAATTTCTTCAAAAAGTAAAAAAAACTTATTGCCATTTTTATATTACTT
TTATTAATAAATGGCACTTTAGCTTAGCATAGCAATAAAAAAAGCTAGACTCAGAATAAT
AGTTCTGAGACGGCTTTAACTCATTCTAAAGTAGACAAAGATGCCTATCTAGTATATCAT
TTATTTCATTCATCATTATTGTTGTTGTTTTAACTTTATAAGCCATAACAAATTTAAATT
TTATTTGATAGGTATTAACTAATGATGGCAAATTATATAGCTATAATATAAAGAAAAAGT
TGTTAAATTGGATGACAGATCTGAAAGTAGTTGTTAGCGAGCTCAAATTCAATAACGAAA
AACAATAGTAGGATAATTATGGAATGGAAGATCAGCACTCTACTGAACTCTCTATTGCAG
GAAATTAGGAATCTAACTTTGAGAGATACGACTATTTTTTGCCCTCTTCTGATGGAAATT
TTATCTTTTTAGCATCAGATTCTACTCCAATAGTACATACACAATAAACAAATAATTGAT
TAAATTTAAAATAAATATCATTATTTTTAGAAAATTATGCGAGATGAAATAGACCAAGTT
ATTAAAATATGTCCAATGAGTGGAAACGAGTCAAAATATATTGCATTTACCAAAGAAAAG
ATTCTTTTAGTCAATCCTGAAAATGGGGAATTAGAGAAATTTGAAGATATTGAAGATGAT
TATGAAAACTATTTAAATCATTATATTATCAATATCAACTAGAAACTTATTAAGCAACTT
AATATTTTTACCAAAAGAGAAAATTGGGCTTTAACCAGCACAGATGTTAATTTGATGATT
TATGAAGACTTTTTATACAAAGGATTATAAAAAAATCAGCTTACTGAAAATGAGGATTAT
ATTTTTATGTAAGATTAGCATTAAGATTTGAAAATTAAGCAAAAGCAATCAAAGATTAAA
ATAGTTGATTTCTAAACAGATTAGGAAATTATTGCTATTTTTTCTGCAGTTGGATTTACA
AACATGTTTTAAAAGAATGTCATAGTGCATAATCCTCTTATCAATACGTTCATATCTTCA
GAATATGTAAGATTTATTTATTGATTTTTTGTTGTTAAATTAAAATTTATTTTTTTTTAT
CAAGGATAACACATAGATTTAAATAGGTGGAGAGAAAGGCATAGTTTCGTTTAATGAAGG
GAGCAACTTTTAGCTAATACCATTGTAGATTTCTACAAAGCTAAAGAATTAGTGTTTAGA
AAATAAGTAATGCAGAGAAAGATTGATTTTTAGTGTTGATAAATTTGATGATAAAAATTA
TATCAGAGATGTTATGACTTGCATAGATAACCTCAGAAAGGGGAGAATGATGATTGAAGT
TATATCTGATAGTAAGGATATCTAGAATGCCAGCAATATTCCTAGTTAAGCATTCAATTT
TGCTAAGGATAATAAAATTACAATATTCTTGCTGACATTCTTAATTATCTTGGTTATTAT
TCTGATTTTAAAAGATGAAAGAATTACTTCTATGTATAAAAGAAATAGTGGTCGTTCTGG
AGGTAAATCTTCCAGTTAAAAATAAAACTCCCAAGAAGAAGCTGATAAAGTCTTAGAAAA
AATTAGCAAAGAGCAAGAAGAAGAAATTAAAAAACAAAATGAGCAAAATAATAAATAAGA
AAAAAAGAACCAAGAGAGTAGCGAATAAAATGCAAATAAATTTAAAGGGCTTTAAATTAA
TAGAAATAAAGTTTTAGGGTATGGGGCTTAAGGGACAGTTATTTTTGAAGGAACATTTTA
AGGTAATATTTAAGAATAAAAAATAGTTTTTGATTTAATAAATATTGTTTATGTGAATAT
AGGAAGAGAAATTGCAGTCAAATAGTTACTTAAAGATAATAAAGACTTAGCTAGCAAGGA
AATATAAATGTTGATTAAGCTGCAACACAAAAATATAATTAAGTACTACTATTTTGAGGA
AACAAAAGATCACATACTTCTTGGACTAGAAAAGTGTGTTGGAAGCATTAGCGATTTAAT
AGATTATGCAAATAGAAAAAACAAGAAGAAAAGTGAGTAGGATTTGAAAGCTTTATATAA
TATAAAAACGGATTTTTTCATTAAGTCAACTATGAAAAATACATTTAAAGACTGCTTAGA
AGGATTGAGTTATTTGCATAGCTAAGGTGTTATTCATAGAGATATAAAGCCAGAAAATAT
TTTAATTCACTACAACAAAGAAATTAAATTAGCTGATTTTGGACTTTCAAAGAATATTTC
TAAAACGAATGTCATATTCACGAATGATATCGGCACATGGGGATGGAGACCACTAGAATA
AATAGATAATTAACCACTTACATATAATACAGATGTTTTCTCTCTTGGCTGTGTATTCTA
TTACATATACACTTAAGGAGGTCATCCTTTTGGAGAATAGTAATTTCATAACATTAAAAA
AATAGAAAATTAAGAAATAATGTTTAAAAAAATAAATAGGAAAGAAAGGGAAAGAAACAT
AGCTAATTTTAAGTACAGCTTGAGAATGGAAGATGAAACCTTGAAAGACCTTATCCAAAA
AATGATTCATAATGATCAAAGTAAAAGACTGACTGTAAAAGAATGCTTAAAGCATCCATA
TTTCTGGAATACCTTGTAAAAGTTCTCTTTTATTTGCGAATTTAGTGACTACATAGAAAC
ATTTGGTAACTTTAAATCAAAATATTTACTTTTATATTTTAGTGAATATTGATAATTGTA
ATAAATTTAGATACTGAAAATAAATATTCAGACTTGATTGAATAATAAGCAAAGTCTTTG
AATGTTTTAGAAGGAAATAGATGGGATAAAAATGTAGATAAAAGTCTTATTTAAGATACT
AAAGTGTTTAAATTCTACAACTATGGATAGGTTAAAGATCTTATCAGAGTAAATTTTTCA
AATAAGATTTTTTTTAATAATGAATTTTTTAAATAGTTAATAAGGAACAGAAAAAGTCAT
TATCACGAGCTTTCAGAGAGCTCTAAAGATATAGTAGGAGATACTCTTGATGATATGTTT
AACTATTTTGATGAAAGATTCCCTAAATTATTTATTTTTATGTATTATTTCTCACAAACT
TAAAACTGGGAATTACTAAGCTTTAAAAATAACTGA

>TTHERM_00641080(protein)
MIIYFNSFFKKFVQNQKQIRFILPYFIIKFIQIINTKQNMNNFQNFFKKQKKLIAIFILL
LLINGTLAQHSNKKSQTQNNSSETALTHSKVDKDAYLVLTNDGKLYSYNIKKKLLNWMTD
LKVVVSELKFNNEKQQQDNYGMEDQHSTELSIAGNQESNFERYDYFLPSSDGNFIFLASD
STPIKIMRDEIDQVIKICPMSGNESKYIAFTKEKILLVNPENGELEKFEDIEDDYENYLN
HYIININQKLIKQLNIFTKRENWALTSTDVNLMIYEDFLYKGLQKNQLTENEDYIFMQDQ
HQDLKIKQKQSKIKIVDFQTDQEIIAIFSAVGFTNMFQKNVIVHNPLINTFISSEYDNTQ
IQIGGEKGIVSFNEGSNFQLIPLQISTKLKNQCLENKQCRERLIFSVDKFDDKNYIRDVM
TCIDNLRKGRMMIEVISDSKDIQNASNIPSQAFNFAKDNKITIFLLTFLIILVIILILKD
ERITSMYKRNSGRSGGKSSSQKQNSQEEADKVLEKISKEQEEEIKKQNEQNNKQEKKNQE
SSEQNANKFKGLQINRNKVLGYGAQGTVIFEGTFQGREIAVKQLLKDNKDLASKEIQMLI
KLQHKNIIKYYYFEETKDHILLGLEKCVGSISDLIDYANRKNKKKSEQDLKALYNIKTDF
FIKSTMKNTFKDCLEGLSYLHSQGVIHRDIKPENILIHYNKEIKLADFGLSKNISKTNVI
FTNDIGTWGWRPLEQIDNQPLTYNTDVFSLGCVFYYIYTQGGHPFGEQKERERNIANFKY
SLRMEDETLKDLIQKMIHNDQSKRLTVKECLKHPYFWNTLQKFSFICEFSDYIETFDTEN
KYSDLIEQQAKSLNVLEGNRWDKNVDKSLIQDTKVFKFYNYGQVKDLIRLIRNRKSHYHE
LSESSKDIVGDTLDDMFNYFDERFPKLFIFMYYFSQTQNWELLSFKNN