Identifiers and Description

Gene Model Identifier

TTHERM_00649380

Standard Name

VPS34 (Tetrahymena ortholog to yeast Vps34 and human PiK3c3 )

Aliases

PreTt09252 | 94.m00170 | 3677.m00078 | TtVPS34

Description

VPS34 phosphatidylinositol 3-kinase; A class III phosphatidylinositol 3-kinase involved in the nuclear degradation events of Programmed nuclear death (PND)

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• phosphatidylinositol 3-kinase complex (IEA) | GO:0005942

Molecular Function

• 1-phosphatidylinositol-3-kinase activity (IEA) | GO:0016303
• obsolete inositol or phosphatidylinositol kinase activity (IEA) | GO:0004428
• phosphotransferase activity, alcohol group as acceptor (IEA) | GO:0016773

Biological Process

• phosphatidylinositol phosphate biosynthetic process (IEA) | GO:0046854
• phosphatidylinositol-mediated signaling (IEA) | GO:0048015

Domains

• ( PF00454 ) Phosphatidylinositol 3- and 4-kinase
• ( PF00613 ) Phosphoinositide 3-kinase family, accessory domain (PIK domain)
• ( PF00792 ) Phosphoinositide 3-kinase C2

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_17891.1	9.997093137033517e-262
	Description: phosphatidylinositol 3- and 4-kinase (906 aa)
Tetrahymena borealis	EI9_06056.1	9.997093137033517e-262
	Description: hypothetical protein (781 aa)
Oxytricha	Contig7655.0.g67	1.9995317320402142e-140
	Description: Phosphatidylinositol 3- and 4-kinase
DictyBase	DDB_G0289601	6.001115222296727e-111
	Description: pikE on chromosome: 5 position 3005109 to 3008075
SGD	YLR240W	2.0006821221283624e-88
	Description: VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p
WormBase	WBGene00006932	2.999277470785175e-69
	Description: locus:vps-34 Phosphatidylinositol 3-kinase status:Confirmed UniProt:Q9TXI6 protein_id:CCD61195.1
WormBase	WBGene00001526	2.999277470785175e-69
	Description: locus:gck-1 status:Partially_confirmed UniProt:H2L0A1 protein_id:CCD72152.2
Stentor Coeruleus	SteCoe_27893	5.166420632837861e-55
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:24280724: Akematsu T, Fukuda Y, Attiq R, Pearlman RE (2014) Role of class III phosphatidylinositol 3-kinase during programmed nuclear death of Tetrahymena thermophila. Autophagy 10(2):209-25

Sequences

>TTHERM_00649380(coding)
ATGAAAAAAGGACCAACAGAATATATTCAACATACTCTTTTAGATTAACTTCCAGTAAAG
TTTAAAATATGCTGCATTAATGATTAAAAAAAAGTCTTGAGATACTTTTTTAATGACGAA
GATGGTAGCAGTAAATTAGAAAATTTGGAAGCAATGGTAACAGCTTAATTAGTTGTAAAT
GAAAAAAAAATATAGCCAGCATAGCAAACACTATTTATTGATAGGATGCTTTTTGAATAG
AATATTATTTTTAATTATAAGTACAAAGATTTGAGTTATAATTCTATTATTGCAATTACA
TTATGGTGTTCCCAAAAAAATAAAGATGAAAAAAAACCTTTGGGATGCACAACTATAAGT
CTTTTTGATGATTAATTTCGTTTGAGATAAGGGAAATATCATTTATATATATGGCCAGAT
ACTCTACCTGATACTTCTTATACTTCTATAACTCCTGGATTAGTGACTGATGATAATATC
AAGTAGATCAATTTCTCACATTAAAAAACAGAATAGGCCTTTACAAATGTAAATAAATTT
CCATAAAAGACTGGCTCATCTATCCATAGAAACTAACTTAAAGAATAGCTTGATCTTTAA
AAAATTTATGCTTTTCAAAAGATCCCTAGTGCCTTCCTTGAAATAGATTTTCCAAATTTT
GAAACATTGGTGCTTTACCAAGAGCCAGAATACATAATTGATAATGATTTAAGTTCTAAA
GAAATAAACAATTCTTAATCTAATTCATCAACAAATTCCAATCAATAATCACTTACTGGT
GGTAAATCTTCTAAGTTTTTTATATAAGAAGTAGATTTTTCAGAATGCGTAGTTACATCT
GATTTTGATTATGAGAATCGTAAAGATGATTTAATTTAAGAGCAAACTGCCCTTATTATT
AGAGAAGATGAAAATCCTTAATAGCTAAAACCATCTAAAAATGAATTACAAATTATAGAA
AATTCAATAAAAAAACCCATTTTAGGCGAATTGAAGCAAGATGAGAAGCTCTTATTTTAT
AGATTTAGATACTCTTTGGTTTAGAATCCTGAGGCCTTAGTAAAGTTTTTGCACTCAATT
AATTGGGATAACTAAAAAGAATTAAATGAAGCTAAGAAATTATTGAAAATTTGGGCAAAA
TGCTCATACGGAGATGCTTTGCACTTACTTTCAAGCTCATTTTGTGCAAACGAGTTCTAT
AATAAAAAATATAAAAAGCCATAAGATACTGCAATATATATACGTAAATATGCTTGTGAA
TAACTGGAAAAAGAATAAACATCAACAATTTGTTCAATTCTATTGTAGCTTACACAAGCT
TTAAGATATGAACCTTTTGATTATTAAAAAAGTCATCTTGCTTAATTTTTAGTAAAAAAG
GCATGCGAAAACACAGAAATAGCTACACTGTTTTATTGGTATCTTTTAGTCGAATGTGAT
AAAGAAATGGACTTAAAAGAAAAAGCAAAACTTAGTTCTACTAACTAAAAAGTGTAGGAA
TGGTTTAATTAAGTATTTGAAAGGATGAATGAAGAATTGGAGGAAAAATGTGAAGAAAAC
CATTAAGTTTTAAGTCTTTAGTCAGAATTTAGATAGAAACTAAGACAAATTGTCGCTTCT
ATGGCTAAAAAAGACAGAACTTAAAAAATAGAAATTATCAAAAAAAAGCTTGCATCAGAG
GAATTTAAAAGACCTAACTTTAAAGAACATCCTTTTTGTTTAAACCCAAATTTAATGATT
GTAGAATCAATTCATTAGCAATCAACTGTTTTTAAGAGTGCTATGGCTCCAATAAAAATG
ACATTTACATCTTACCCAATTGGTTAAAAGGAGAAGGAAGGCAAAGTAGAAATGATCTAT
AAGAACGGTGATGATTTGAGACAAGATTAGCTTGTTATGTAAATATTTAACCTCATGGAT
GGATTACTTAAAGGAGTTGGTTAGGATTTCAGGCTAATGCCTTATAAGGTACTTGCATGT
TCAAAAAACGATGGATTTATGGAATTCGTGCCTAATTCTACTACTATTTAGGATTTGCTA
AAAGGAGGCAAGTAATTTTCTTAGTATTTGTAAAACTTAGCTGCAAATCCCGAAAATCCT
ATATACGAAGAATACAAACGCTTAAGAATGTAAAATGATGAATAAGGAAAGCTAAGTAAT
ATAGAATATGTCAGTCAAAAAATAATGGAAAATTATATGCTCAGTTGCGCAGGTTATAGT
GTAATGACTTATTTCTTAGGTGTGGGTGATCGTCACTTAGAAAATTTGATGGTTGATATT
ACAGGAAAATTTTTCCATATTGATTTTGGGTTTATTCTAGGACAAGATCCTAAACCTTAC
CCACCACCTTTGAAATTATGTAGATAAATGATCGAAGGTATGGGAGGAAAGGATAGTAAA
GTTTATGCAGAATTTAGAAAGAAATGTGTACATGCTTACATATATTTAAGAAAATATGCT
AAATTGATTGTAAATTTATTCCATTTAATGATAGACTCAGGTATTAAGGATATGAGTATT
GAAGCACTCGAAAAGTTAGCTGAGAAATTTTACTTGGATTTCAACGATACTCAAGCAGAG
CTGCATTTCTTGAATATTTTAGATGAAAGTGAAACAGCTCTTTTTGCTAGAGTTACAGAT
ATGATTCATAAATGGGCCACTTATTGGAGAGCTTGA

>TTHERM_00649380(gene)
ATGAAAAAAGGACCAACAGAATATATTCAACATACTCTTTTAGATTAACTTCCAGTAAAG
TTTAAAATATGCTGCATTAATGATTAAAAAAAAGTCTTGAGGTAATTTATAATTTTAGTA
AAATCATTAATCTTAATATAAAGCCAATTTATTATTCTAAAATAAAGAAAATTACGAAAT
AAAACTCAGTTTAAAAATTATTTTACCCAAAAAATTTGTTAAACTAATTTAATTTTTTCG
CTAAAACATTTTAGCCAATCAAAAATATAGATCTAAAAATTTTTCTTTGAATAAATTTGT
AAAATAGATACTTTTTTAATGACGAAGATGGTAGCAGTAAATTAGAAAATTTGGAAGCAA
TGGTAACAGCTTAATTAGTTGTAAATGAAAAAAAAATATAGCCAGCATAGCAAACACTAT
TTATTGATAGGATGCTTTTTGAATAGAATATTATTTTTAATTATAAGTACAAAGATTTGA
GTTATAATTCTATTATTGCAATTACATTATGGTGTTCCCAAAAAAATAAAGATGAAAAAA
AACCTTTGGGATGCACAACTATAAGTCTTTTTGATGATTAATTTCGTTTGAGATAAGGGA
AATATCATTTATATATATGGCCAGATACTCTACCTGATACTTCTTATACTTCTATAACTC
CTGGATTAGTGACTGATGATAATATCAAGTAGATCAATTTCTCACATTAAAAAACAGAAT
AGGCCTTTACAAATGTAAATAAATTTCCATAAAAGACTGGCTCATCTATCCATAGAAACT
AACTTAAAGAATAGCTTGATCTTTAAAAAATTTATGCTTTTCAAAAGATCCCTAGTGCCT
TCCTTGAAATAGATTTTCCAAATTTTGAAACATTGGTGCTTTACCAAGAGCCAGAATACA
TAATTGATAATGATTTAAGTTCTAAAGAAATAAACAATTCTTAATCTAATTCATCAACAA
ATTCCAATCAATAATCACTTACTGGTGGTAAATCTTCTAAGTTTTTTATATAAGAAGTAG
ATTTTTCAGAATGCGTAGTTACATCTGATTTTGATTATGAGAATCGTAAAGATGATTTAA
TTTAAGAGCAAACTGCCCTTATTATTAGAGAAGATGAAAATCCTTAATAGCTAAAACCAT
CTAAAAATGAATTACAAATTATAGAAAATTCAATAAAAAAACCCATTTTAGGCGAATTGA
AGCAAGATGAGAAGCTCTTATTTTATAGATTTAGGTTATTCTTTTAAATAATTTATTTTT
TGATGAATTTTTATGTCAAAAACTTTTCAATTTTATGATTAAAATTAAAAATTATTTTTA
TTTTTTTTGTAATTAAATTTTATTTTATTTTATTTTAGATACTCTTTGGTTTAGAATCCT
GAGGCCTTAGTAAAGTTTTTGCACTCAATTAATTGGGATAACTAAAAAGAATTAAATGAA
GCTAAGAAATTATTGAAAATTTGGGCAAAATGCTCATACGGAGATGCTTTGCACTTACTT
TCAAGCTCATTTTGTGCAAACGAGTTCTATAATAAAAAATATAAAAAGCCATAAGATACT
GCAATATATATACGTAAATATGCTTGTGAATAACTGGAAAAAGAATAAACATCAACAATT
TGTTCAATTCTATTGTAGCTTACACAAGCTTTAAGATATGAACCTTTTGATTATTAAAAA
AGTCATCTTGCTTAATTTTTAGTAAAAAAGGCATGCGAAAACACAGAAATAGCTACACTG
TTTTATTGGTAATTAAATTGTTTACTTAATTTAAATCTTGATATTATTTATTCTTTATAT
ATGCTAATAATCTAATTAATTTTAGCTTACAGCTTAACAGAAAAATTATTTATAATTTAA
TTAAGGTATCTTTTAGTCGAATGTGATAAAGAAATGGACTTAAAAGAAAAAGCAAAACTT
AGTTCTACTAACTAAAAAGTGTAGGAATGGTTTAATTAAGTATTTGAAAGGATGAATGAA
GAATTGGAGGAAAAATGTGAAGAAAACCATTAAGTTTTAAGTCTTTAGTCAGAATTTAGA
TAGAAACTAAGACAAATTGTCGCTTCTATGGCTAAAAAAGACAGAACTTAAAAAATAGAA
ATTATCAAAAAAAAGCTTGCATCAGAGGAATTTAAAAGACCTAACTTTAAAGAACATCCT
TTTTGTTTAAACCCAAATTTAATGATTGTAGAATCAATTCATTAGCAATCAACTGTTTTT
AAGAGTGCTATGGCTCCAATAAAAATGACATTTACATCTTACCCAATTGGTAATCTTAAT
TAAAATTTGAAATAATTTTACATTACACATAAATATCAATTATTTATCAATCATCTTTTA
TTTATAAGCTTTAAAAATTCAGTTTACATTCAAGTACTATTTAATTGAATAAAATTTCAT
TTCGATTCAAGCAACAAAAAAAGAAAATATCCATTTAATTTTTTTTTTACAATTGTAAGT
TATGTATTCCTATCAAATATTTGAAAGCAACAACTTACAACTTAATTAACAATATTTTAT
CCTAAAAAATAATGAATAATGCTTAAAATAATTAAAATACTAATCCATAAAATACAAATA
AAATACTACATTTCACACAATCACAATCAAGAAAAATAATGATAAAAATTTATTATTATT
AGCTGTTTAAAAAATAAACTATGCAAACTAATTTATTAGAATTTTATTAATAATCAATTA
ATATTCGTTTAAATTAATTTACAATCTAGTTAAGCTATAGAGCGGACTTAACTTCTAATA
GAGAATAACTACCCTTATAAATTCAGTTTTTATAATGAAAATATATCTTAAAAAGTCTTT
TATAACCCAATATCAAAAATAAAACAAAAGATATTTTGTCATATTTTATATTTAAAAAGA
AATTTTTACTTTTTATGATTCAATATAAAAAGTTTTACTAGATAAATTGGGTTTTCAATT
TCTTTTATAGAATTTAATCTGATTAATACTGCTTCTTTTAAAACTAAGAGTGAATCATGA
ACAAACTTTCATTTTAATTTTACAAAAGGTTAAAAGGAGAAGGAAGGCAAAGTAGAAATG
ATCTATAAGAACGGTGATGATTTGAGACAAGATTAGCTTGTTATGTAAATATTTAACCTC
ATGGATGGATTACTTAAAGGAGTTGGTTAGGATTTCAGGCTAATGCCTTATAAGGTACTT
GCATGTTCAAAAAACGATGGATTTATGGAATTCGTGCCTAATTCTACTACTATTTAGGAT
TTGCTAAAAGGAGGCAAGTAATTTTCTTAGTATTTGTAAAACTTAGCTGCAAATCCCGAA
AATCCTATATACGAAGAATACAAACGCTTAAGAATGTAAAATGATGAATAAGGAAAGCTA
AGTAATATAGAATATGTCAGTCAAAAAATAATGGAAAATTATATGCTCAGTTGCGCAGGT
TATAGTGTAATGACTTATTTCTTAGGTGTGGGTGATCGTCACTTAGAAAATTTGATGGTT
GATATTACAGGAAAATTTTTCCATATTGATTTTGGGTTTATTCTAGGACAAGATCCTAAA
CCTTACCCACCACCTTTGAAATTATGTAGATAAATGATCGAAGGTATGGGAGGAAAGGAT
AGTAAAGTTTATGCAGAATTTAGAAAGAAATGTGTACATGCTTACATATATTTAAGAAAA
TATGCTAAATTGATTGTAAATTTATTCCATTTAATGATAGACTCAGGTATTAAGGATATG
AGTATTGAAGCACTCGAAAAGTTAGCTGAGAAATTTTACTTGGATTTCAACGATACTCAA
GCAGAGCTGCATTTCTTGAATATTTTAGATGAAAGTGAAACAGCTCTTTTTGCTAGAGTT
ACAGATATGATTCATAAATGGGCCACTTATTGGAGAGCTTGA

>TTHERM_00649380(protein)
MKKGPTEYIQHTLLDQLPVKFKICCINDQKKVLRYFFNDEDGSSKLENLEAMVTAQLVVN
EKKIQPAQQTLFIDRMLFEQNIIFNYKYKDLSYNSIIAITLWCSQKNKDEKKPLGCTTIS
LFDDQFRLRQGKYHLYIWPDTLPDTSYTSITPGLVTDDNIKQINFSHQKTEQAFTNVNKF
PQKTGSSIHRNQLKEQLDLQKIYAFQKIPSAFLEIDFPNFETLVLYQEPEYIIDNDLSSK
EINNSQSNSSTNSNQQSLTGGKSSKFFIQEVDFSECVVTSDFDYENRKDDLIQEQTALII
REDENPQQLKPSKNELQIIENSIKKPILGELKQDEKLLFYRFRYSLVQNPEALVKFLHSI
NWDNQKELNEAKKLLKIWAKCSYGDALHLLSSSFCANEFYNKKYKKPQDTAIYIRKYACE
QLEKEQTSTICSILLQLTQALRYEPFDYQKSHLAQFLVKKACENTEIATLFYWYLLVECD
KEMDLKEKAKLSSTNQKVQEWFNQVFERMNEELEEKCEENHQVLSLQSEFRQKLRQIVAS
MAKKDRTQKIEIIKKKLASEEFKRPNFKEHPFCLNPNLMIVESIHQQSTVFKSAMAPIKM
TFTSYPIGQKEKEGKVEMIYKNGDDLRQDQLVMQIFNLMDGLLKGVGQDFRLMPYKVLAC
SKNDGFMEFVPNSTTIQDLLKGGKQFSQYLQNLAANPENPIYEEYKRLRMQNDEQGKLSN
IEYVSQKIMENYMLSCAGYSVMTYFLGVGDRHLENLMVDITGKFFHIDFGFILGQDPKPY
PPPLKLCRQMIEGMGGKDSKVYAEFRKKCVHAYIYLRKYAKLIVNLFHLMIDSGIKDMSI
EALEKLAEKFYLDFNDTQAELHFLNILDESETALFARVTDMIHKWATYWRA