Identifiers and Description

Gene Model Identifier

TTHERM_00660180

Standard Name

HMGB1 (High MoBility group 1)

Aliases

PreTt23762 | 98.m00105 | 3736.m00006 | HMGB

Description

HMGB1 HMGB high mobility group (HMG) box protein; High-Mobility-Group (HMG) protein; induces negative supercoiling of DNA in vitro; present in both macro, and micronuclei but with elevated expression during both macronuclear S phase and endoreplication of developing new macronuclei; High Mobility Group Box (HMGB)

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

Biological Process

Domains

  • ( PF00505 ) HMG (high mobility group) box

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:31932604: Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J (2020) Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila. Scientific reports 10(1):168
  2. Ref:8264578: Wu M, Allis CD, Sweet MT, Cook RG, Thatcher TH, Gorovsky MA (1994) Four distinct and unusual linker proteins in a mitotically dividing nucleus are derived from a 71-kilodalton polyprotein, lack p34cdc2 sites, and contain protein kinase A sites. Molecular and cellular biology 14(1):10-20
  3. Ref:8417323: Wang T, Allis CD (1993) An abundant high-mobility-group-like protein is targeted to micronuclei in a cell cycle-dependent and developmentally regulated fashion in Tetrahymena thermophila. Molecular and cellular biology 13(1):163-73
  4. Ref:1589033: Lilley DM (1992) DNA--protein interactions. HMG has DNA wrapped up. Nature 357(6376):282-3
  5. Ref:1480473: Wang T, Allis CD (1992) Replication-dependent and independent regulation of HMG expression during the cell cycle and conjugation in Tetrahymena. Nucleic acids research 20(24):6525-33
  6. Ref:1991550: Schulman IG, Wang TT, Stargell LA, Gorovsky MA, Allis CD (1991) Cell-cell interactions trigger the rapid induction of a specific high mobility group-like protein during early stages of conjugation in Tetrahymena. Developmental biology 143(2):248-57
  7. Ref:1986218: Schulman IG, Wang T, Wu M, Bowen J, Cook RG, Gorovsky MA, Allis CD (1991) Macronuclei and micronuclei in Tetrahymena thermophila contain high-mobility-group-like chromosomal proteins containing a highly conserved eleven-amino-acid putative DNA-binding sequence. Molecular and cellular biology 11(1):166-74
  8. Ref:2514183: Suda M, Hayashi H (1989) A protein that accumulates during starvation in Tetrahymena nuclei. Journal of biochemistry 106(4):612-5
  9. Ref:2760016: Hayashi T, Hayashi H, Iwai K (1989) Tetrahymena HMG nonhistone chromosomal protein. Isolation and amino acid sequence lacking the N- and C-terminal domains of vertebrate HMG 1. Journal of biochemistry 105(4):577-81
  10. Ref:2476991: Hamana K, Kawada K (1989) Release of nucleosomes from nuclei by bleomycin-induced DNA strand scission. Biochemistry international 18(5):971-9
  11. Ref:3584238: Schulman IG, Cook RG, Richman R, Allis CD (1987) Tetrahymena contain two distinct and unusual high mobility group (HMG)-like proteins. The Journal of cell biology 104(6):1485-94
  12. Ref:3109974: Prasanna P, Holmlund CE (1987) Identification in Tetrahymena pyriformis of 3-hydroxy-3-methyl glutaryl coenzyme a lyase: its purification and properties. The International journal of biochemistry 19(4):385-9
  13. Ref:3671074: Roth SY, Schulman IG, Cook RG, Allis CD (1987) The complete amino acid sequence of an HMG-like protein isolated from the macronucleus of Tetrahymena. Nucleic acids research 15(19):8112
  14. Ref:6849878: Levy-Wilson B, Denker MS, Ito E (1983) Isolation, characterization, and postsynthetic modifications of tetrahymena high mobility group proteins. Biochemistry 22(7):1715-21
  15. Ref:6258140: Hamana K, Zama M (1980) Selective release of HMG nonhistone proteins during DNase digestion of Tetrahymena chromatin at different stages of the cell cycle. Nucleic acids research 8(22):5275-88
  16. Ref:117005: Hamana K, Iwai K (1979) High mobility group nonhistone chromosomal proteins also exist in Tetrahymena. Journal of biochemistry 86(3):789-94

Sequences 

>TTHERM_00660180(coding)
ATGTCTAAAGCTGCTAGCCAATACGCAACTCTCGAAGATCTCCCCTCCAAGCCCAAGAGA
CCCCAAACCGGTTTCTTCATCTACAAGAGTGAAGTCTTTGCCAAGAGAAGAACTGAGTGC
CCCAACTTGAAGGTCCCTGAAATCGTCTCTAAAATTAGTGAAGAATACAAGGCCTTACCT
GAAAAGGAGAAGTAAAAATACGAAGAAGCCTACAGAAAGGAAAAGGCCACCTACGATAAG
TAAAACGACCAATGGAAAGAGAAGTATGGTGATATCGAAAAGTCCTTGAAGGATTAGGCT
AAGAAGGCCCTCAAGGAAAAGACCAAAAAGTCCAAGGCTGCTGAAAAGGAACTTGAAAAG
AGCAAGAAGAAGGCTCCCGCTGCTGCCCCTGCCAAGAAGGACGATAAGAAGGCTCCCGCT
AAGAAGAAATGA



>TTHERM_00660180(gene)
AAATAATTAAAAAACAATATAAAAAAACTAATATCAATGTCTAAAGCTGCTAGCCAATAC
GCAACTCTCGAAGATCTCCCCTCCAAGCCCAAGAGACCCCAAACCGGTTTCTTCATCTAC
AAGAGTGAAGTCTTTGCCAAGAGAAGAACTGAGTGCCCCAACTTGAAGGTCCCTGAAATC
GTCTCTAAAATTAGTGAAGAATACAAGGCCTTACCTGAAAAGGAGAAGTAAAAATACGAA
GAAGCCTACAGAAAGGAAAAGGCCACCTACGATAAGTAAAACGACCAATGGAAAGAGAAG
TATGGTGATATCGAAAAGTCCTTGAAGGATTAGGCTAAGAAGGCCCTCAAGGAAAAGACC
AAAAAGTCCAAGGCTGCTGAAAAGGAACTTGAAAAGAGCAAGAAGAAGGCTCCCGCTGCT
GCCCCTGCCAAGAAGGACGATAAGAAGGCTCCCGCTAAGAAGAAATGAGAAGGTTCTGAA
CCTGGAAACTTCTTTTTCGACTAAAGGAGCTTAAGCTGATTGACTTGCTAGTAATGATAA
AGGCTGAAAAATTAAAGCTGCTGCACAACAAGCTAAAATTTGCTGTAGTCTCCCTATTTC
ATATTATTAATTAATACTACTACTCAGTTATTTATAATTATTATCATCAGTCAACTTAAT
TCTTTTTGCAATGTATATTCTTTACTTTATTTGTTTGTTAGTGTCTCTTGAGTTTTTTTA
ACATAT



>TTHERM_00660180(protein)
MSKAASQYATLEDLPSKPKRPQTGFFIYKSEVFAKRRTECPNLKVPEIVSKISEEYKALP
EKEKQKYEEAYRKEKATYDKQNDQWKEKYGDIEKSLKDQAKKALKEKTKKSKAAEKELEK
SKKKAPAAAPAKKDDKKAPAKKK