Identifiers and Description

Gene Model Identifier

TTHERM_00672190

Standard Name

THD13 (Tetrahymena Histone Deacetylase 13)

Aliases

PreTt10965 | 101.m00120

Description

THD13 Sir2 family transcriptional regulator; Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones; homolog of Rattus norvegicus SIRT3

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF00220 ) Neurohypophysial hormones, N-terminal Domain
• ( PF01023 ) S-100/ICaBP type calcium binding domain
• ( PF01344 ) Kelch motif
• ( PF02146 ) Sir2 family
• ( PF04640 ) PLATZ transcription factor
• ( PF07646 ) Kelch motif

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_14307.1	9.997093137033517e-262
	Description: hypothetical protein (944 aa)
WormBase	WBGene00006940	9.997093137033517e-262
	Description: locus:wee-1.3 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 status:Confirmed UniProt:O18209 protein_id:CAB16484.1
Oxytricha	Contig20663.0.g91	2.9992476920535046e-16
	Description: Kelch motif
WormBase	WBGene00002186	0.0002999184360822198
	Description: locus:kel-10 Kelch repeat-containing protein kel-10 status:Confirmed UniProt:P34569 protein_id:CAA83141.3
WormBase	WBGene00007513	0.0002999184360822198
	Description: locus:wht-2 status:Partially_confirmed UniProt:P90746 protein_id:CAB05682.3

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00672190(coding)
ATGATTGATAACTAAAGCGTAAACTAAGAGGGGCAGAACATTTCTTATTCTTGCTAAATT
AGCAATTGCCCAATTAGTAAAAATGGAAACTTTAATGAAGGAGATATTAAATTTTGCACT
GATTGCAATAAACTAATATGCAACACTTGCATAACTAGTCATGATGAAAACCACACCATT
ATTGAAGGTGCTAATTTCGCTTTCATTCAAGAGAATATGTCCAAAGTCCTTCCTAATTTA
GGGAATCTGAGCCCAATTTTGCAAAGTAATAACTTAAATATAAGTAGTGATTCTAAGATG
ATAAGTGAAGATACTCTTCCTGATACAGAGGAAAAAAAAGTTTAAGAGAAATAGAATTTT
AACTATAAATAGCAGCCTTAGTTTTTATAAAAAATAAACGACGATGATGATGAGGATGAT
GATGATAGTGATAGTGATGACGATGATCATATTATGAAAATGAAAAATTTCAGCAATATT
GCTGCATAACTTAAAAATTTAAAAAATGACAGTGATGAAGAAGAGGAGGATGATGAAGAT
GATGATGAAATAAACTTTATAAGCCAAGCTGCAAGTAAATTAACTACTATAGGAAAAGTA
TCTAACTCACCAACAAATACTATGTTTGTAGAATATAACACAAAACCTCCAAGTGAAAAT
CAATTTGATTTTAATTAATAACAATAAATAAATAATGCGAGCTATAAATAGTCAGGTATA
ATGAATGGTACAAACTTTCTTTAAGTTCCTCAAGATTTTAATAATGTAAAACGTATAATC
AACTAAAATTCTTACTAGAATAACAATTATTCAATTAATATAAATGGAGCGAATGGATAT
CAAAACCAGGAATTTAACTCAAACAAATTGTATTAAAATCAGTATGCTCTAACAGAGCTG
TAGAAGGTCTTTTTATAAAAAGAAAAATATTACAATTTGGTGAGCTAGTTTTACAAATAA
AACAAACCAAATAAGAATTTAGTTACTAAAAAGATAGCAGCACAATAAATAAAGAAAAAA
AGAAAAGCTAAAGATGATTTGGGTGGCGATAATGAAAATGATGAAAGTAAAAATTAAGAA
TAAGAAGATATTCCTATTCCTCAAGTTTAAGACCATGTGAAAGAATCTAATAAGAAGTTA
GGGTTACAGGAATTAAAAAATCGTTCTAAGTAGCTCTATGAAGAATTAAAAGCTAAATCT
GATTTGATTTTTAAGGAAATAAAACACCACATTCATGGTGTTCAATACGAGAGAGATGAA
ACAGATAGAATTAATAAATATAAGAAATATGCTCTTGAAGGCATTGAGAGTTATTTCCTC
TATCTTAAAGACTAATTTAAAATTGAGTATTCTAAATTGAAGAAATGTAAAAAGAGAGAA
TAACTAAGTAAAATGATGAACAAAGTAATAGATTGTATAGAAAAATATCAATACTATTCG
GACTAGAAAGATTTTCTTGAATTTATGAACAAAAACTATGATTACTATTTGAATAATATT
GAATTACTCTTACATGAAATTTAAAAAGAGGGCAATGATTTCCCTCCTCAATATAAAATA
GTCTATGAAAATCTCTATGACATATTTTTCTCTCTTATAAGTTACATCTCATTGAACTTG
CCTAACTAAAAAACTTATAGTCAATTTACTTAACCCATAATAAAGACTTAAAGCTCGAAA
TATTTGGTCATCCCTATTCACTATCCAAATAAAAAAATAGTTGGAATATTTAACTGCAGA
AGTAACGAATTAGAATAAATCGAATATGATTGCTCTTAGACTATGGATTTCTAGAAGTAT
AGCAACTTTTAATTGGTTAATGATAGCGATTTTATTTACTTTATTGGAGGAGTAATATTT
AACAAAGAGAAGAGCACCTTTAATCCTAGTTAAAAGTGTTTCAAAATGAGTAGACATTCA
GGGGAAATTATAGCCCTAAAAGACATGCCTTATCCTAAAATGAAGTTTGGAACAATTATG
ATTGGTAATTTTATTTATGTTTTTGGAGGTTTACAAACTCAAGAAAAGCACCGTACCAAT
ACTTGTGAAAAATATGACATTAACACTAACACATGGAAAATATTACCTGTGATGCAAATG
AACAGAGTATGCCCAGTAGTCTCATCTTTCACCACTATAGGTAGTGGCTTTAATTAAAAG
CAATTAATTTACTTATTCGGTGGCATGGAAGACAAAAACAACATTAATTAATCTATTGAA
GTCTTCGACTAAAAGCTAGATATTTGGATTGACTTCTTATAAAAACCAGCAAATAGTAGA
TGCTATATCCCAAAACAACTTGGTTATGGAGTTTAAATTAATTAAGAATAAATCTTAATT
ATCGGAGGTTTATCTGGAAGAAAGCAAAAACCTACATCATAAACTTATGTGTATAATGTT
TCTAAAAATTCCATATGTAATTTAAGTTTAGACTCTTTACCAACAGGAATAATTAAAGAC
TCTTTCACTGGAATGCCTGTTGTTTATGATAACTCAATTTTCCTTCTTAACACTCAAATA
AGCTAATACTTCCCTTCACTAAAATAATTATAAGGAGTAACCAATGTTATAAAGATAGGA
TTGAATCAATAAGAAATTTTAGCAACTCATTGTTTTTGA

>TTHERM_00672190(gene)
ATGATTGATAACTAAAGCGTAAACTAAGAGGGGCAGAACATTTCTTATTCTTGCTAAATT
AGCAATTGCCCAATTAGTAAAAATGGAAACTTTAATGAAGGAGATATTAAATTTTGCACT
GATTGCAATAAACTAATATGCAACACTTGCATAACTAGTCATGATGAAAACCACACCATT
ATTGAAGGTGCTAATTTCGCTTTCATTCAAGAGAATATGTCCAAAGTCCTTCCTAATTTA
GGGAATCTGAGCCCAATTTTGCAAAGTAATAACTTAAATATAAGTAGTGATTCTAAGATG
ATAAGTGAAGATACTCTTCCTGATACAGAGGAAAAAAAAGTTTAAGAGAAATAGAATTTT
AACTATAAATAGCAGCCTTAGTTTTTATAAAAAATAAACGACGATGATGATGAGGATGAT
GATGATAGTGATAGTGATGACGATGATCATATTATGAAAATGAAAAATTTCAGCAATATT
GCTGCATAACTTAAAAATTTAAAAAATGACAGTGATGAAGAAGAGGAGGATGATGAAGAT
GATGATGAAATAAACTTTATAAGCCAAGCTGCAAGTAAATTAACTACTATAGGAAAAGTA
TCTAACTCACCAACAAATACTATGTTTGTAGAATATAACACAAAACCTCCAAGTGAAAAT
CAATTTGATTTTAATTAATAACAATAAATAAATAATGCGAGCTATAAATAGTCAGGTATA
ATGAATGGTACAAACTTTCTTTAAGTTCCTCAAGATTTTAATAATGTAAAACGTATAATC
AACTAAAATTCTTACTAGAATAACAATTATTCAATTAATATAAATGGAGCGAATGGATAT
CAAAACCAGGAATTTAACTCAAACAAATTGTATTAAAATCAGTATGCTCTAACAGAGCTG
TAGAAGGTCTTTTTATAAAAAGAAAAATATTACAATTTGGTGAGCTAGTTTTACAAATAA
AACAAACCAAATAAGAATTTAGTTACTAAAAAGATAGCAGCACAATAAATAAAGAAAAAA
AGAAAAGCTAAAGATGATTTGGGTGGCGATAATGAAAATGATGAAAGTAAAAATTAAGAA
TAAGAAGATATTCCTATTCCTCAAGTTTAAGACCATGTGAAAGAATCTAATAAGAAGTTA
GGGTTACAGGAATTAAAAAATCGTTCTAAGTAGCTCTATGAAGAATTAAAAGCTAAATCT
GATTTGATTTTTAAGGAAATAAAACACCACATTCATGGTGTTCAATACGAGAGAGATGAA
ACAGATAGAATTAATAAATATAAGAAATATGCTCTTGAAGGCATTGAGAGTTATTTCCTC
TATCTTAAAGACTAATTTAAAATTGAGTATTCTAAATTGAAGAAATGTAAAAAGAGAGAA
TAACTAAGTAAAATGATGAACAAAGTAATAGATTGTATAGAAAAATATCAATACTATTCG
GACTAGAAAGATTTTCTTGAATTTATGAACAAAAACTATGATTACTATTTGAATAATATT
GAATTACTCTTACATGAAATTTAAAAAGAGGGCAATGATTTCCCTCCTCAATATAAAATA
GTCTATGAAAATCTCTATGACATATTTTTCTCTCTTATAAGTTACATCTCATTGAACTTG
CCTAACTAAAAAACTTATAGTCAATTTACTTAACCCATAATAAAGACTTAAAGCTCGAAA
TATTTGGTCATCCCTATTCACTATCCAAATGTAATGTTTGTTTCTATTACTTGAAATATC
CTTTCGAATTCAAAAGAAAATATTTTAGAAATATCTAACAAAAGCTATTTTGAATAAAAA
ATAATTTTAAAAAAATTAATTTAAAAATTTTTAATTTTAAAGAAAAAAATAGTTGGAATA
TTTAACTGCAGAAGTAACGAATTAGAATAAATCGAATATGATTGCTCTTAGACTATGGAT
TTCTAGAAGTATAGCAACTTTTAATTGGTTAATGATAGCGATTTTATTTACTTTATTGGA
GGAGTAATATTTAACAAAGAGAAGAGCACCTTTAATCCTAGTTAAAAGTGTTTCAAAATG
AGTAGACATTCAGGGGAAATTATAGCCCTAAAAGACATGCCTTATCCTAAAATGAAGTTT
GGAACAATTATGATTGGTAATTTTATTTATGTTTTTGGAGGTTTACAAACTCAAGAAAAG
CACCGTACCAATACTTGTGAAAAATATGACATTAACACTAACACATGGAAAATATTACCT
GTGATGCAAATGAACAGAGTATGCCCAGTAGTCTCATCTTTCACCACTATAGGTAGTGGC
TTTAATTAAAAGCAATTAATTTACTTATTCGGTGGCATGGAAGACAAAAACAACATTAAT
TAATCTATTGAAGTCTTCGACTAAAAGCTAGATATTTGGATTGACTTCTTATAAAAACCA
GCAAATAGTAGATGCTATATCCCAAAACAACTTGGTTATGGAGTTTAAATTAATTAAGAA
TAAATCTTAATTATCGGAGGTAATAAATAAATTTATTTATTTCAAATAATTAAACAACTC
ATTGAATTTTTATTTAAAAATGTTTTTTAAATTAATTAGGTTTATCTGGAAGAAAGCAAA
AACCTACATCATAAACTTATGTGTATAATGTTTCTAAAAATTCCATATGTAATTTAAGTT
TAGACTCTTTACCAACAGGAATAATTAAAGACTCTTTCACTGGAATGCCTGTTGTTTATG
ATAACTCAATTTTCCTTCTTAACACTCAAATAAGCTAATACTTCCCTTCACTAAAATAAT
TATAAGGAGTAACCAATGTTATAAAGATAGGATTGAATCAATAAGAAATTTTAGCAACTC
ATTGTTTTTGA

>TTHERM_00672190(protein)
MIDNQSVNQEGQNISYSCQISNCPISKNGNFNEGDIKFCTDCNKLICNTCITSHDENHTI
IEGANFAFIQENMSKVLPNLGNLSPILQSNNLNISSDSKMISEDTLPDTEEKKVQEKQNF
NYKQQPQFLQKINDDDDEDDDDSDSDDDDHIMKMKNFSNIAAQLKNLKNDSDEEEEDDED
DDEINFISQAASKLTTIGKVSNSPTNTMFVEYNTKPPSENQFDFNQQQQINNASYKQSGI
MNGTNFLQVPQDFNNVKRIINQNSYQNNNYSININGANGYQNQEFNSNKLYQNQYALTEL
QKVFLQKEKYYNLVSQFYKQNKPNKNLVTKKIAAQQIKKKRKAKDDLGGDNENDESKNQE
QEDIPIPQVQDHVKESNKKLGLQELKNRSKQLYEELKAKSDLIFKEIKHHIHGVQYERDE
TDRINKYKKYALEGIESYFLYLKDQFKIEYSKLKKCKKREQLSKMMNKVIDCIEKYQYYS
DQKDFLEFMNKNYDYYLNNIELLLHEIQKEGNDFPPQYKIVYENLYDIFFSLISYISLNL
PNQKTYSQFTQPIIKTQSSKYLVIPIHYPNKKIVGIFNCRSNELEQIEYDCSQTMDFQKY
SNFQLVNDSDFIYFIGGVIFNKEKSTFNPSQKCFKMSRHSGEIIALKDMPYPKMKFGTIM
IGNFIYVFGGLQTQEKHRTNTCEKYDINTNTWKILPVMQMNRVCPVVSSFTTIGSGFNQK
QLIYLFGGMEDKNNINQSIEVFDQKLDIWIDFLQKPANSRCYIPKQLGYGVQINQEQILI
IGGLSGRKQKPTSQTYVYNVSKNSICNLSLDSLPTGIIKDSFTGMPVVYDNSIFLLNTQI
SQYFPSLKQLQGVTNVIKIGLNQQEILATHCF