Identifiers and Description

Gene Model Identifier

TTHERM_00683010

Standard Name

PLA1 (PhosphoLipase A)

Aliases

PreTt16138 | 103.m00129 | 3734.m00041

Description

PLA1 papain family cysteine protease; Lysosomal phospholipase A1; extracellular enzyme that may be secreted into the environment as part of an attack and defense system

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• cysteine-type peptidase activity (IEA) | GO:0008234
• phospholipase A1 activity (IMP) | GO:0008970

Biological Process

• proteolysis (IEA) | GO:0006508

Domains

• ( PF00112 ) Papain family cysteine protease
• ( PF08246 ) Cathepsin propeptide inhibitor domain (I29)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_17791.1	9.997093137033517e-262
	Description: papain family cysteine protease containing protein (322 aa)
Oxytricha	Contig322.1.g116	9.995951036711152e-55
	Description: Papain family cysteine protease
DictyBase	DDB_G0283867	2.9994376937714457e-52
	Description: cprC on chromosome: 4 position 1092858 to 1094270
WormBase	WBGene00000776	2.000704504372864e-47
	Description: locus:cpl-1 status:Confirmed UniProt:O45734 protein_id:CAB07275.1
Tetrahymena borealis	EI9_00149.1	2.000704504372864e-47
	Description: endonuclease/Exonuclease/phosphatase (276 aa)
Stentor Coeruleus	SteCoe_2628	1.462486227251231e-31
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:11030577: Hartmann M, Guberman A, Florin-Christensen M, Tiedtke A (2000) Screening for and characterization of phospholipase A1 hypersecretory mutants of Tetrahymena thermophila. Applied microbiology and biotechnology 54(3):390-6
2. Ref:10063621: Guberman A, Hartmann M, Tiedtke A, Florin-Christensen J, Florin-Christensen M (1999) A method for the preparation of Tetrahymena thermophila phospholipase A1 suitable for large-scale production. Journal of applied microbiology 86(2):226-30

Sequences

>TTHERM_00683010(coding)
ATGAACAAGACTCTCATCTTAGCTTTAGTTGGTGTTTTGGCTTTAACTGCCACCACCTTG
GTTGCTTTCCACAACCACTCTCACAACATCAGAGTTGACTAAGACCCCGCCACTCTCTTC
AAGCAATTCAAGCAAACTTACAATAAGAAGTATGCTGATCCTACTTTCGAAACCTACAGA
TTCGGTGTCTTCACCCAAAACTTAGAAATCGTCAAGACTGACTCTACTTTCGGTGTCACC
TAATTCATGGACTTAACTCCTGCTGAATTCGCTCAACAATTCCTCACTTTACACGAAAAG
GTTAACAGCACCGAAGTTTACAGAGCTTAAGGTGAAGCTACCGAAGTTGACTGGACTGCC
AAGGGTAAGGTCACCCCTGTTAAGAACTAAGGTTCTTGTGGTTCCTGCTGGGCTTTCTCC
ACCATTGGTGCCGTTGAATCTGCTCTTTTGATTGCTGGTCAAGGTGAATAAAACACTCTT
AACCTTGCTGAATAAGAATTAGTTGACTGTGCTAAGTCCCCCAAGTACGACTCTGAAGGT
TGCAACGGTGGTTGGATGGTTGAAGGTTTCAAGTACATCATCGACAACAAGATCTCCTAA
ACTGCTAACTATCCCTACACTGCTAAGGATGGTAAGTGCAAGGACACCTCTTCCTTCAAG
AAGTTCTCTATTTCTAAGTACGCTGAAATCCCCTAAGGTGACTGCAACTCCCTCAACTCT
GCCTTAGAACAAGGTCCTATCTCCGTTGCTGTTGATGCCACCAACTTCTAATTCTACACT
TCTGGTGTCTTTAAAAACTGCAAGGCCAACCTCAACCACGGTGTCCTCTTAGTTGCCAAC
GTTGACTCTTCTCTCAAGATCAAGAACTCCTGGGGTCCTTCTTGGGGTGAAAAGGGTTTC
ATCAGATTAGCTGCCGGTAACACTTGCGGTGTCTGCAATGCTGCCTCTTACCCTATTGTT
TGA

>TTHERM_00683010(gene)
ATGAACAAGACTCTCATCTTAGCTTTAGTTGGTGTTTTGGCTTTAACTGCCACCACCTTG
GTTGCTTTCCACAACCACTCTCACAACATCAGAGTTGACTAAGACCCCGCCACTCTCTTC
AAGCAATTCAAGCAAACTTACAATAAGAAGTATGCTGATCCTACTTTCGAAACCTACAGA
TTCGGTGTCTTCACCCAAAACTTAGAAATCGTCAAGACTGACTCTACTTTCGGTGTCACC
TAATTCATGGACTTAACTCCTGCTGAATTCGCTCAACAATTCCTCACTTTACACGAAAAG
GTTAACAGCACCGAAGTTTACAGAGCTTAAGGTGAAGCTACCGAAGTTGACTGGACTGCC
AAGGGTAAGGTCACCCCTGTTAAGAACTAAGGTTCTTGTGGTTCCTGCTGGGCTTTCTCC
ACCATTGGTGCCGTTGAATCTGCTCTTTTGATTGCTGGTCAAGGTGAATAAAACACTCTT
AACCTTGCTGAATAAGAATTAGTTGACTGTGCTAAGTCCCCCAAGTACGACTCTGAAGGT
TGCAACGGTGGTTGGATGGTTGAAGGTTTCAAGTACATCATCGACAACAAGATCTCCTAA
ACTGCTAACTATCCCTACACTGCTAAGGATGGTAAGTGCAAGGACACCTCTTCCTTCAAG
AAGTTCTCTATTTCTAAGTACGCTGAAATCCCCTAAGGTGACTGCAACTCCCTCAACTCT
GCCTTAGAACAAGGTCCTATCTCCGTTGCTGTTGATGCCACCAACTTCTAATTCTACACT
TCTGGTGTCTTTAAAAACTGCAAGGCCAACCTCAACCACGGTGTCCTCTTAGTTGCCAAC
GTTGACTCTTCTCTCAAGATCAAGAACTCCTGGGGTCCTTCTTGGGGTGAAAAGGGTTTC
ATCAGATTAGCTGCCGGTAACACTTGCGGTGTCTGCAATGCTGCCTCTTACCCTATTGTT
TGA

>TTHERM_00683010(protein)
MNKTLILALVGVLALTATTLVAFHNHSHNIRVDQDPATLFKQFKQTYNKKYADPTFETYR
FGVFTQNLEIVKTDSTFGVTQFMDLTPAEFAQQFLTLHEKVNSTEVYRAQGEATEVDWTA
KGKVTPVKNQGSCGSCWAFSTIGAVESALLIAGQGEQNTLNLAEQELVDCAKSPKYDSEG
CNGGWMVEGFKYIIDNKISQTANYPYTAKDGKCKDTSSFKKFSISKYAEIPQGDCNSLNS
ALEQGPISVAVDATNFQFYTSGVFKNCKANLNHGVLLVANVDSSLKIKNSWGPSWGEKGF
IRLAAGNTCGVCNAASYPIV