Identifiers and Description

Gene Model Identifier

TTHERM_00683180

Standard Name

CHL1 (CHromosome Loss 1)

Aliases

PreTt16155 | 103.m00146 | 3734.m00058

Description

DNA repair helicase (rad3); DNA repair helicase; involved in nuclear excision repair; localizes to the micronucleus

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• micronucleus (IDA) | GO:0031040

Molecular Function

• ATP binding (IEA) | GO:0005524
• ATP-dependent DNA helicase activity (IEA) | GO:0004003
• DNA binding (IEA) | GO:0003677

Domains

• ( PF02671 ) Paired amphipathic helix repeat
• ( PF03789 ) ELK domain
• ( PF06733 ) DEAD_2
• ( TIGR00604 ) DNA repair helicase (rad3)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_17807.2	9.997093137033517e-262
	Description: DNA repair helicase (559 aa)
WormBase	WBGene00010839	4.9995060293141384e-98
	Description: locus:chl-1 status:Partially_confirmed UniProt:Q21489 protein_id:CAA88959.2
Tetrahymena borealis	EI9_00141.1	4.9995060293141384e-98
	Description: cyclic nucleotide-binding domain-containing protein (1222 aa)
SGD	YPL008W	1.999022616705709e-90
	Description: CHL1 Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member
Oxytricha	Contig5554.0.g99	5.9988196117913e-83
	Description: Helicase C-terminal domain
Stentor Coeruleus	SteCoe_25318	2.7487850079102147e-43
	Description: None
DictyBase	DDB_G0286621	6.0018235484001396e-36
	Description: fncJ on chromosome: 4 position 4729555 to 4732791

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00683180(coding)
ATGAACAATAGAAGCACAAATAATGATTTAAAAGACAAAATTAAATAAAGCTTTCCTTAC
AATCCTTACGATATTTAATTAGAGTTTAGTTTGAACTTGTATGAGTCTTTGAATGTGAAG
AAGCTTTGTATATTTGAAAGTCCTACTGGTACAGGTAAGAGTTTGAGCTTAATTTGTGGC
GCGTTTAATTGGTTTAAAGATAACTAAGAAAACTACGATTTGATTAAAGGTTTCAAAGAA
AGGAGAGACAAAATTTTATTAGGAGAAGTCAATATAGATAGTAAAAAAGAAGAATCAAAT
AGCTTGCCTGCATGGCTAACGAATATAAATGATATTAATAGAAGTATTTTTTACGAAAAA
ATTTAAATATAAAAAAATAAATTAGCTTAAAAAGCAAAATCTCTTAAGGAATTTTAGATG
TTCAGAAAAGAAAAAATGAAAATAAGATATGAAGAGTACAAAAAAAATATTATCAAATAA
TAAAAGAACAATGAATAAGATAAAAAAGAGCATTAAGATGAAGATGAGTAATACTATGTG
AACTGGAAAGAAGAATAGGGAGGTGATGCAGAAATAGATATTGAATCCATGATCGAAGAT
TACAAGAAATCTAAAAGTCAAATTAGATAAAACAATGAATAAGATGAAAATGATAATGAA
AACACTACTATAAAAATAATTTATGCTAGTAGAACTCATAGTTAGATAAAATAATTTGTA
TAAGAAATATTGAAAACGAAATTTAAAGATATGAGAGTTATAACTTTAGGAAGTAGATAA
AATCTTTGCTTGAAATTTGATGAATAATCTAAACAATCTTTACAATAAATAGATGATTAT
TGCTAAAAAGCAATAGGAATTAATAAGACTGATAAGTCAGTTCCTCGTTGTGAGTACTTC
ACTAATTTAAAATTATTGCAAGATGATATTGATTATTTGTTTTTACATAATATTCACACT
TTGGATTAAATGAGATCTGAATCTCTCAACAATCAAGTGTGTCCTTACTATTTATCTAAA
AGAAGTGTTATTGATGCTGAAGTAATTTGCGTTCCTTATGTAACGTTGCTAGATGAAAAC
ATGAGAATAAATTCTAATATTGATATAACAAATTCTATCATTTTATTTGATGAATCACAC
AATATTCTAGAAAGTTTAAGTGGGATTAATTCTGTAGAAGTTACATATAAAAGAATTTTC
TAGGCATTTGTTTAGCTATTAACTTATTATGATAAGTTTTGCAGGAGACTTAACCCTAAG
AATGCCTTATTTATATAAAATATTAAAAACTTGTGTTTAGACCTGCTTAAATTCATCAAA
GCAGAAATAGATTTAAATGCTTCAATCAAATCTGAGCAAGATTATGTTAAAATTAACAAC
ATTTAGCTACTTCTCAAGCTCAATATGGACAGGATTGATTTCTTTTAAATTAAAAAATTT
ACTCAAGAGACTAGATTAGGTTAAAAAATACACTTTTTTTCTCAATCTCCTAAATATGTT
CCATCATAAATACCGCCTTAGGTTAACAAAAGTCTTAAAGACATAAATATTTAAGAATTA
TTAAAGAATAGCCCATATATGGTTGTAGAAAATGTTATGAATTTTCTTTGGAAAATGCAA
GATTCTATAAGCAAGAGTGAAAAGTATTCAATAATTATAAAAAATATTTCTAAAATTGAA
GAATCTTCTATTTAGCTGATGTGCTTAGATGTTATAGAACCTTTGTATAAAGTTATTCAG
GAAAGTGCTTGTGTAGTTTTAGCTGGAGGAACCATGGAACCTTTAAGTGAATTTGAATTA
CTAATCAATTAAGTTGGAAAGAATAACTTTAAACACTTCTCATGTGGTCACATAATTGAT
GAAGAAAATTGTTCTGTATTTTGTGTAAGCACTTTAGTTGAACAGTCTGATAAACCACTG
ATTTTCAATTACCAAAATAAAAAAGATGATTAATTATTTTAAAACTCAATAGATATTATT
CATTAATTAGCTCAAACAATTCCTGACGGTCTAGTTATTTTTGTATAAAGCTATACGTTT
CTAGAGAAACTAAAGAGCATCCTCTTAGAAAACTAAAATTTACTTTAATAAATCTAATAA
TATAAAAAAATATATATGGACGATAAAGATAATTCAAACAACACAATACTCGAAAAATAC
TAAAAAGAAATAAATAAAGAAAAAGAAATTGGAAGCAAAAAGAATGGCGCAATTTTAATC
TCTGTAATAGGTGGGAGACTAAGTGAAGGGATAAATTTTAGTGATTAACTTGCAAGGTGC
GTTGTAGTATTTGGAATGCCCTATTCAAATATTAAAAGTGCCGAATTAATAGAAAAAATG
AATCACTATGATTCCATATCAAAAAAAAATAACTTTAGCTTTAGTGGAAATGATTATTAT
GAAAATTTGTGTATGAAATCTGTGAACTAAGCAATTGGCAGGTCTATAAGACACAAAGAT
GATTATTCAGTTATACTCTTAATTGATTAGAGATTTTCTCAAGAAAAAAATATCAATAGA
TTATCAAGTTGGATTAAAAAAAGAGTAAAGCCAGCTCATTCTTTTGAAAGTACCAAAAAA
AATATTAAAATTTTTTTCGAAAAAAAACAACAACATAAGATTTGA

>TTHERM_00683180(gene)
ATGAACAATAGAAGCACAAATAATGATTTAAAAGACAAAATTAAATAAAGCTTTCCTTAC
AATCCTTACGATATTTAATTAGAGTTTAGTTTGAACTTGTATGAGTCTTTGAATGTGAAG
AAGCTTTGTATATTTGAAAGTCCTACTGGTACAGGTAAGAGTTTGAGCTTAATTTGTGGC
GCGTTTAATTGGTTTAAAGATAACTAAGAAAACTACGATTTGATTAAAGGTTTCAAAGAA
AGGAGAGACAAAATTTTATTAGGAGAAGTCAATATAGATAGTAAAAAAGAAGAATCAAAT
AGCTTGCCTGCATGGCTAACGAATATAAATGATATTAATAGAAGTATTTTTTACGAAAAA
ATTTAAATATAAAAAAATAAATTAGCTTAAAAAGCAAAATCTCTTAAGGAATTTTAGATG
TTCAGAAAAGAAAAAATGAAGTGAATTAATTTTTTTAGAGAAAATATGTCTTAAAAAATA
TTTTTGTTTAATAAATTTTTAGAATAAGATATGAAGAGTACAAAAAAAATATTATCAAAT
AATAAAAGAACAATGAATAAGATAAAAAAGAGCATTAAGATGAAGATGAGTAATACTATG
TGAACTGGAAAGAAGAATAGGGAGGTGATGCAGAAATAGATATTGAATCCATGATCGAAG
ATTACAAGAAATCTAAAAGTCAAATTAGATAAAACAATGAATAAGATGAAAATGATAATG
AAAACACTACTATAAAAATAATTTATGCTAGTAGAACTCATAGTTAGATAAAATAATTTG
TATAAGAAATATTGAAAACGAAATTTAAAGATATGAGAGTTATAACTTTAGGAAGTAGAT
AAAATCTTTGCTTGAAATTTGATGAATAATCTAAACAATCTTTACAATAAATAGATGATT
ATTGCTAAAAAGCAATAGGAATTAATAAGACTGATAAGTCAGTTCCTCGTTGTGAGTACT
TCACTAATTTAAAATTATTGCAAGATGATATTGATTATTTGTTTTTACATAATATTCACA
CTTTGGATTAAATGAGATCTGAATCTCTCAACAATCAAGTAAAAAATATTAAACATAAAT
AAATAATTACTTTCATTATTTCAAAAAGTAAGTTGGAGATAAAACAAACTATCAATTTAT
TAATTATGTCTTTCTATTTTCTAATATCTAAAAATATCAAAATTATCAAGAAAAATGTTG
ATATAATTTAATAAAATTAGTGGATGAAATTATTAATAAGTTAACATATAAAAATAAATA
AAGGAAATTTTTATTTATAATAAATTAAAAAGGTGTGTCCTTACTATTTATCTAAAAGAA
GTGTTATTGATGCTGAAGTAATTTGCGTTCCTTATGTAACGTTGCTAGATGAAAACATGA
GAATAAATTCTAATATTGATATAACAAATTCTATCATTTTATTTGATGAATCACACAATA
TTCTAGAAAGTTTAAGTGGGATTAATTCTGTAGAAGTTACATATAAAAGAATTTTCTAGG
CATTTGTTTAGCTATTAACTTATTATGATAAGTTTTGCAGGAGACTTAACCCTAAGAATG
CCTTATTTATATAAAATATTAAAAACTTGTGTTTAGACCTGCTTAAATTCATCAAAGCAG
AAATAGATTTAAATGCTTCAATCAAATCTGAGCAAGATTATGTTAAAATTAACAACATTT
AGCTACTTCTCAAGCTCAATATGGACAGGATTGATTTCTTTTAAATTAAAAAATTTACTC
AAGAGACTAGATTAGGTTAAAAAATACACTTTTTTTCTCAATCTCCTAAATATGTTCCAT
CATAAATACCGCCTTAGGTTAACAAAAGTCTTAAAGACATAGTAATTAATTTCATTTAAT
ATAATTAAAACTATTTAATATTTTTTAAATTAAAATTAACTAGAATATTTAAGAATTATT
AAAGAATAGCCCATATATGGTTGTAGAAAATGTTATGAATTTTCTTTGGAAAATGCAAGA
TTCTATAAGCAAGAGTGAAAAGTATTCAATAATTATAAAAAATATTTCTAAAATTGAAGA
ATCTTCTATTTAGCTGATGTGCTTAGATGTTATAGAACCTTTGTATAAAGTTATTCAGGA
AAGTGCTTGTGTAGTTTTAGCTGGAGGAACCATGGAACCTTTAAGTGAATTTGAATTACT
AATCAATTAAGTTGGAAAGAATAACTTTAAACACTTCTCATGTGGTCACATAATTGATGA
AGAAAATTGTTCTGTATTTTGTGTAAGCACTTTAGTTGAACAGTCTGATAAACCACTGAT
TTTCAATTACCAAAATAAAAAAGATGATTAATTATTTTAAAACTCAATAGATATTATTCA
TTAATTAGCTCAAACAATTCCTGACGGTCTAGTTATTTTTGTATAAAGCTATACGTTTCT
AGAGAAACTAAAGAGCATCCTCTTAGAAAACTAAAATTTACTTTAATAAATCTAATAATA
TAAAAAAATATATATGGACGATAAAGATAATTCAAACAACACAATACTCGAAAAATACTA
AAAAGAAATAAATAAAGAAAAAGAAATTGGAAGCAAAAAGAATGGCGCAATTTTAATCTC
TGTAATAGGTGGGAGACTAAGTGAAGGTAACTTAATTTTAATTTAATTTAGAAAAAGATA
TTATAAAATTTACTTTATAGATCTAACTCTAATTTTTTTTAAAGGGATAAATTTTAGTGA
TTAACTTGCAAGGTGCGTTGTAGTATTTGGAATGCCCTATTCAAATATTAAAAGTGCCGA
ATTAATAGAAAAAATGAATCACTATGATTCCATATCAAAAAAAAATAACTTTAGCTTTAG
TGGAAATGATTATTATGAAAATTTGTGTATGAAATCTGTGAACTAAGCAATTGGCAGGTC
TATAAGACACAAAGATGATTATTCAGTTATACTCTTAATTGATTAGAGATTTTCTCAAGA
AAAAAATATCAATAGATTATCAAGTTGGATTAAAAAAAGAGTAAAGCCAGCTCATTCTTT
TGAAAGTACCAAAAAAAATATTAAAATTTTTTTCGAAAAAAAACAACAACATAAGATTTG
A

>TTHERM_00683180(protein)
MNNRSTNNDLKDKIKQSFPYNPYDIQLEFSLNLYESLNVKKLCIFESPTGTGKSLSLICG
AFNWFKDNQENYDLIKGFKERRDKILLGEVNIDSKKEESNSLPAWLTNINDINRSIFYEK
IQIQKNKLAQKAKSLKEFQMFRKEKMKIRYEEYKKNIIKQQKNNEQDKKEHQDEDEQYYV
NWKEEQGGDAEIDIESMIEDYKKSKSQIRQNNEQDENDNENTTIKIIYASRTHSQIKQFV
QEILKTKFKDMRVITLGSRQNLCLKFDEQSKQSLQQIDDYCQKAIGINKTDKSVPRCEYF
TNLKLLQDDIDYLFLHNIHTLDQMRSESLNNQVCPYYLSKRSVIDAEVICVPYVTLLDEN
MRINSNIDITNSIILFDESHNILESLSGINSVEVTYKRIFQAFVQLLTYYDKFCRRLNPK
NALFIQNIKNLCLDLLKFIKAEIDLNASIKSEQDYVKINNIQLLLKLNMDRIDFFQIKKF
TQETRLGQKIHFFSQSPKYVPSQIPPQVNKSLKDINIQELLKNSPYMVVENVMNFLWKMQ
DSISKSEKYSIIIKNISKIEESSIQLMCLDVIEPLYKVIQESACVVLAGGTMEPLSEFEL
LINQVGKNNFKHFSCGHIIDEENCSVFCVSTLVEQSDKPLIFNYQNKKDDQLFQNSIDII
HQLAQTIPDGLVIFVQSYTFLEKLKSILLENQNLLQQIQQYKKIYMDDKDNSNNTILEKY
QKEINKEKEIGSKKNGAILISVIGGRLSEGINFSDQLARCVVVFGMPYSNIKSAELIEKM
NHYDSISKKNNFSFSGNDYYENLCMKSVNQAIGRSIRHKDDYSVILLIDQRFSQEKNINR
LSSWIKKRVKPAHSFESTKKNIKIFFEKKQQHKI