Identifiers and Description

Gene Model Identifier

TTHERM_00688660

Standard Name

RebL1 (Retinoblastoma binding protein 4/7-like 1 (RebL1))

Aliases

PreTt23161 | 105.m00128 | 3737.m00041 | SSCH1

Description

Ortholog of histone-binding proteins RBBP4 and RBBP7. Contains WD-40 repeats. Subunit of multiple chromatin-related complexes including CAF1, Hat1, Rpd3 (Sin3), and MuvB (Nabeel-Shah et al., 2021).

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( PF00400 ) WD domain, G-beta repeat
  • ( PF08026 ) Bee antimicrobial peptide

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_41249.1 9.997093137033517e-262
Description: hypothetical protein (426 aa)
DictyBase DDB_G0282529 5.001257666360868e-155
Description: rbbD on chromosome: 3 position 5888997 to 5890360
WormBase WBGene00003036 1.99972299831384e-147
Description: locus:lin-53 Probable histone-binding protein lin-53 status:Confirmed UniProt:P90916 protein_id:CAB03178.1
Oxytricha Contig12239.0.g71 1.999382702437002e-145
Description: WD domain, G-beta repeat
SGD YEL056W 5.000145777691928e-76
Description: HAT2 Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
Stentor Coeruleus SteCoe_21068 1.1379798735078682e-50
Description: None

General Information

No. Gene Name(s) Paragraph Text
145 RebL1 RebL1 physically interacts with histone H4 and functions in multiple epigenetic regulatory pathways. Genome-wide analyses indicated that RebL1 binds within genic and intergenic regions. RebL1 depletion inhibited cellular growth and reduced the expression levels of multiple genes during Tetrahymena vegetative growth (Nabeel-Shah et al.2021).

Associated Literature

  1. Ref:37024975: Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2023) Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. Epigenetics & chromatin 16:10
  2. Ref:34086947: Nabeel-Shah S, Garg J, Saettone A, Ashraf K, Lee H, Wahab S, Ahmed N, Fine J, Derynck J, Pu S, Ponce M, Marcon E, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2021) Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila. Nucleic acids research ( ):

Sequences 

>TTHERM_00688660(coding)
ATGGCTGAAGAATTTAATGATGGTTATGAAAACCAAGCTATTAATGATGAATATAAGATA
TGGAAAAAAAATGCTCCTTTCCTATATGATATAGCAATAACACACGAATTAGAGTGGCCT
TCATTATCTGTATAGTGGCTACCTACTAAAGATATCCCTTAAGAAAGTGACTATGCAATT
CATAAACTGATTTTAGGAACTCATACATCTGGTTAGGATAAAGATTATTTGCTTATTGCC
AAGGTTAGATTGCCACTTGAAGAAACTGCTACAGATATTAGCGAATACCAAAATTAAGCA
AAAGAAGTCGGATAAACTGGTTTGTCAGCTGGAGAAAATAGAATAGAAATAGAAACAAAA
ATATTGCATGATGGAGAAATTAATAGAGCTAGATACATGCCTTAAAAGTATAATGTAATT
GCCACAAAAGTAACAAATGGTGAAATCCATGTTTTTGATTACACATAACATCCTACTACC
CCATAAAATGACTAAGTTCGCCCTTAGCTTAGACTCGTTGGTCATTCAGCAGAAGGTTAT
GGTATTTCTTGGAATCCTAAAAAACAAGGTTATATTGTTTCTGGTGGTTATGATAAAAAA
ATATGTATTTGGAATGTTGAAGCTGCTTCATAATTAAATTCATCTATTAGTCCTCTCCAT
GATATCGAATTTCATAAATCATGTGTAGAAGATGTTGCTTGGCACTAAATAAATCCTGAT
ATATTTGGTTCAGTTAGTGATGATCGTACTGTAGCTATATGGGATATGAGATAAAAATCA
AATGCAGGATTAATCAATCCAACTCATTGTACATAAGCTCATACTGGAGATATTTATTGT
TTAGATTTTAATCCTTTCAACGAATATTTATTTATTACAGGCTCAGAAGATAAAAATATT
GGATTTTGGGATATGAGAAACACATCTAAAAGATTACATACTTTTGTAGGACATACTGAT
CAAGTTTTGAGATGTGAATGGTCACCTTTCAATGTTGGTGTATTTTCTAGTTGTTCTGCT
GATAGAAGAGTTATTGTTTGGGATATCAGCAAATGTGGTTAGGAAATGAAAAATGAAGAT
TTAGTCGATGGACCTCCAGAGCTTCTATTTATGCATGGAGGCCACAGAGCAAAAGTAAAT
GATATCAGTTGGAATCAAAAAGAAAATTTAATTTTAGCTTCAGTTGAAGAAAATAACATA
TTGCAAGTTTGGCAAATGGCTAGAAATATATATGATGATACTGATGATGAAGTAATGAAA
GACTGA


>TTHERM_00688660(gene)
ATGGCTGAAGGTATATGATAAATTAAAGTTTAATAATATATGATAATAATGCCTATTATA
AATAAATAAATTCCATTATTTCAATCAAGCAAATAAATAAATTGATACTTAATAATGATG
ACTTAGTTAATTAATGATCATTCATTTTAAAATATAAAGAATTTAATGATGGTTATGAAA
ACCAAGCTATTAATGATGAATATAAGATATGGAAAAAAAATGCTCCTTTCCTATATGATA
TAGCAATAACACACGAATTAGAGTGGCCTTCATTATCTGTATAGTGGCTACCTACTAAAG
ATATGTAACAATTTTTATAATTTAAATTAATTAGATGATTAATTAATATTTTTAGAATTC
AAATAATGTTAGTTAAAAAGATAGTTAAAATTTAAAATAGAATACTTAATAACTAAAATA
AATAATTAAAAAAATATTATAGCCCTTAAGAAAGTGACTATGCAATTCATAAACTGATTT
TAGGAACTCATACATCTGGTTAGGATAAAGATTATTTGCTTATTGCCAAGGTAATTAGTT
AATTATATAAGATAAGAAATAATTAAAAGCAATGCTAAATATGTTAGCAGACAAATAAAA
TTAAAAGAAAGTCTTTCAACATATCACATTACATTTGAATATAATAGCTCCTTAAATGAG
ATTCATTTTAAAACAATTGAATTATTTATATTTTAAATTTCCATATAAAGGTTAGATTGC
CACTTGAAGAAACTGCTACAGATATTAGCGAATACCAAAATTAAGCAAAAGAAGTCGGAT
AAACTGGTTTGTCAGCTGGAGAAAATAGAATAGAAATAGAAACAAAAATATTGCATGATG
GAGAAATTAATAGAGCTAGATACATGCCTTAAAAGTATAATGTAATTGCCACAAAAGTAA
CAAATGGTGAAATCCATGTTTTTGATTACACATAACATCCTACTACCCCATAAAATGACT
AAGTTCGCCCTTAGCTTAGACTCGTTGGTCATTCAGCAGAAGGTTATGGTATTTCTTGGA
ATCCTAAAAAACAAGTAAAGATAAAAATAATTTTTAAAGAAATTTTAATTAAAAGCTTTA
TAGTTTTTGATATATTAAATAATTATTAAAATAGATATTTATTGCGATAAATAAAACTTA
TTAAAATTTTTAATTAGGGTTATATTGTTTCTGGTGGTTATGATAAAAAAATATGTATTT
GGAATGTTGAAGCTGCTTCATAATTAAATTCATCTATTAGTCCTCTCCATGATATCGAAT
TTCATAAATCATGTGTAGAAGATGTTGCTTGGCACTAAATAAATCCTGATATATTTGGTT
CAGTTAGTGATGATCGTACTGTAGCTATGTAAAAAATTAATTTTATTTTAAAATTATCTA
AATGATTTTTTACTATTACTTTGATTCATAAGATGCCTTTTTTATTTTCTATTTTCTTGA
TAACCTTTGTTTAAATATTTTTTTTATTTAAAGATGGGATATGAGATAAAAATCAAATGC
AGGATTAATCAATCCAACTCATTGTACATAAGCTCATACTGGAGATATTTATTGTTTAGA
TTTTAATCCTTTCAACGAATATTTATTTATTACAGGCTCAGAAGATAAAAATATTGGATT
TTGGGATATGAGAAACACATCTAAAAGATTACATACTTTTGTAGGACATACTGATCAAGT
AAAGATTCTTAAATTATTTAATTATTGATCAAAATTATTTAGCATAAATAAAAAATTATC
ATTTTTAGGATAGGATAAAATTCTAAATATCAAAATAATTGTTGGATTTATTTATTATCT
TTAAATTTGAAATAACATTTTAAAACTAATTAATTGATGTGAAAATTTTAAATAGGTTTT
GAGATGTGAATGGTCACCTTTCAATGTTGGTGTATTTTCTAGTTGTTCTGCTGATAGAAG
AGTTATTGTTTGGGATATCAGCAAATGTGGTTAGGAAATGAAAAATGAAGATTTAGTCGA
TGGACCTCCAGAGCTTCTATTTATGCATGGAGGCCACAGAGCAAAAGTAAATGATATCAG
TTGGAATCAAAAAGAAAATTTAATTTTAGCTTCAGTTGAAGAAAATAACATATTGCAAGT
TTGGCAAATGGTAAATTTAAATATATTAAATGAATTTAAATAAATAATCTAATTAAAAAA
TAATAAAGGCTAGAAATATATATGATGATACTGATGATGAAGTAATGAAAGACTGA


>TTHERM_00688660(protein)
MAEEFNDGYENQAINDEYKIWKKNAPFLYDIAITHELEWPSLSVQWLPTKDIPQESDYAI
HKLILGTHTSGQDKDYLLIAKVRLPLEETATDISEYQNQAKEVGQTGLSAGENRIEIETK
ILHDGEINRARYMPQKYNVIATKVTNGEIHVFDYTQHPTTPQNDQVRPQLRLVGHSAEGY
GISWNPKKQGYIVSGGYDKKICIWNVEAASQLNSSISPLHDIEFHKSCVEDVAWHQINPD
IFGSVSDDRTVAIWDMRQKSNAGLINPTHCTQAHTGDIYCLDFNPFNEYLFITGSEDKNI
GFWDMRNTSKRLHTFVGHTDQVLRCEWSPFNVGVFSSCSADRRVIVWDISKCGQEMKNED
LVDGPPELLFMHGGHRAKVNDISWNQKENLILASVEENNILQVWQMARNIYDDTDDEVMK
D