Identifiers and Description

Gene Model Identifier

TTHERM_00691720

Standard Name

ICT1 (Integral-membrane Cation Transporter 1)

Aliases

PreTt03010 | 106.m00150 | 3674.m00063

Description

ICT1 NRAMP (natural resistance-associated macrophage protein) metal ion transporter family protein; NRAMP family Mn2+/Fe2+ transporters containing protein

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

Biological Process

Domains

  • ( PF01461 ) 7TM chemoreceptor
  • ( PF01566 ) Natural resistance-associated macrophage protein
  • ( PF07690 ) transporter, major facilitator family
  • ( PF07695 ) 7TM diverse intracellular signalling
  • ( TIGR01197 ) metal ion transporter, metal ion

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_17571.1 9.997093137033517e-262
Description: NRAMP family Mn2+/Fe2+ transporters containing protein (488 aa)
Oxytricha Contig20600.0.g69 3.999836123447869e-144
Description: Natural resistance-associated macrophage protein
DictyBase DDB_G0276973 2.0007666164339447e-112
Description: nramp1 on chromosome: 2 position 7564058 to 7565770
WormBase WBGene00004876 6.000988504514371e-99
Description: locus:smf-1 NRAMP-like transporter smf-1 status:Confirmed UniProt:Q21434 protein_id:CCD70800.1
SGD YOL122C 9.002663577881587e-59
Description: SMF1 Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins

General Information

No. Gene Name(s) Paragraph Text
43 ICT1 Tetrahymena thermophila ICT1 is homologous to the natural resistance-associated macrophage protein (NRAMP) family, composed of membrane proteins that are divalent cation transporters. It contains one domain (E-value=3.7x10-108), which is located in the middle of the protein. Given the function of the homologous proteins, it is likely that ICT1 is an integral membrane protein and functions as a cation transporter. Paragraph by: Alec Koh and Katherine Tully (undergraduates), Keck Science Department, Claremont McKenna College and Scripps College.

Associated Literature

No Data fetched for Associated Literature

Sequences 

>TTHERM_00691720(coding)
ATGGCTGAAGTAGGATAGAACAATATCAATTCTGGAACTGTTAACAGCAATGATCATTAA
GAGAAAATTAATGTAAAGTTTTCATTAAGGGAATTTTTCTAATATTTTGGACCAGGCTTA
CTCGTAGCTATCGCTTACATCGATCCTGGTAATTTGGCTGGTGATATGGATGCAGGTTTA
AATGGTAAATATCACTTGTTATGGGTACTTTTCTTATCAACACTCTTAGGTTTCTTCTTT
TAAAACCGTGCTATGATGATTGGTTTGGTTACTGGAAAAGATATGGCTAAATTATGTCGC
TACTATTATCCTAAAAAAATGTCTATCTTGTTATGGATTATGGCTGAAATCGCTATTATA
GGCAGTGATATTCAAGAAGTATTAGGATCTGCTATTGCATTATAAATTCTTTTTGGACTC
AAATTATGGATCGGAGTTATCTTAACTATTTCTTCTACTATTCTTATTTTATTAATAAAA
TATGTTGGTATGCGCTTTTTAGAATTAATCTTTGGTATTCTTATAGGAACTATGGCTATT
TGCTTCTTTATTGATCTTGGTTACATTGCTCCTAATTTCGGTGAATTAATGGAAGGAATG
TTTGTCCCTTACATCCCATCATCTGCACTCACTTCCATGGTTGGTTTAATAGGTGCTGTC
CTCATGCCTCACAATCTATATCTTCATTCATCTCTTGTTTATGAAAAGAAGATTTCCAGA
AATGACAGACCTCTTCTCCATAAATCCATTTTTTATTTCAAAATTGAAACAGGTATCTCT
CTCCTAATTTCTTTCTTCATAAACATGGCAGTCATTGGTACTTTTGCTAATTGGTACAAT
AGTGGAACAGATATTGATTTAAGCTCTGCTGCCACAGTCCTTGAAGAAAACTTTGGTGCA
GCTGCCAAGTACATTTGGGGTATCGGTTTATTGGCTGCTGGTTAATCATCAACTTTAACT
GGTACTCTTGCTGGTTAATTTGTCATGTCTGGATTTGTTAAAATGAGAGTAAGCAAGTTC
AAAAGAGCTTTTATTACTCGTGCTATTGCAATCGTTCCTGCTATTGTTATAGCTTTTATT
GCTGATGATGAAGACTTTAATAACTATTTAAATATTCTTCAAGCAATACAACTTCCCTTT
GCCGTTATTCCACTTCTTAAGCTTTCAATGGATAGAGAACTCATGGGTGAATTTACTATT
GGTAAAGTTCAATTAACTTTATTGAGTGTCCTTTCCGCTGCTATTGTAGGAGTAAACTAT
TACGCATCAGTACCTGATGAAGTAAACTGGTCTGAAGCTTGGATCTATATCATTCTCGTA
GTTATGGTTTTATACTTTATCTTTTTAGGAATCGTGCTTTTCACTAAAATTAAAGATACT
AAGGACGTCAAATAAAGTATGCTATCAAATCATAAGCAATCTTTAATTTAAGATGATGAA
TAATATCATGTTAAATAATGA


>TTHERM_00691720(gene)
ATGGCTGAAGTAGGATAGAACAATATCAATTCTGGAACTGTTAACAGCAATGATCATTAA
GAGAAAATTAATGTAAAGTTTTCATTAAGGGAATTTTTCTAATATTTTGGACCAGGCTTA
CTCGTAGCTATCGCTTACATCGATCCTGGTAATTTGGCTGGTGATATGGATGCAGGTTTA
AATGGTAAATATCACTTGTTATGGGTACTTTTCTTATCAACACTCTTAGGTTTCTTCTTT
TAAAACCGTGCTATGATGATTGGTTTGGTTACTGGAAAAGATATGGCTAAATTATGTCGC
TACTATTATCCTAAAAAAATGTCTATCTTGTTATGGATTATGGCTGAAATCGCTATTATA
GGCAGTGATATTCAAGAAGTATTAGGATCTGCTATTGCATTATAAATTCTTTTTGGACTC
AAATTATGGATCGGAGTTATCTTAACTATTTCTTCTACTATTCTTATTTTATTAATAAAA
TATGTTGGTATGCGCTTTTTAGAATTAATCTTTGGTATTCTTATAGGAACTATGGCTATT
TGCTTCTTTATTGATCTTGGTTACATTGCTCCTAATTTCGGTGAATTAATGGAAGGAATG
TTTGTCCCTTACATCCCATCATCTGCACTCACTTCCATGGTTGGTTTAATAGGTGCTGTC
CTCATGCCTCACAATCTATATCTTCATTCATCTCTTGTTTATGAAAAGAAGATTTCCAGA
AATGACAGACCTCTTCTCCATAAATCCATTTTTTATTTCAAAATTGAAACAGGTATCTCT
CTCCTAATTTCTTTCTTCATAAACATGGCAGTCATTGGTACTTTTGCTAATTGGTACAAT
AGTGGAACAGATATTGATTTAAGCTCTGCTGCCACAGTCCTTGAAGAAAACTTTGGTGCA
GCTGCCAAGTACATTTGGGGTATCGGTTTATTGGCTGCTGGTTAATCATCAACTTTAACT
GGTACTCTTGCTGGTTAATTTGTCATGTCTGGATTTGTTAAAATGAGAGTAAGCAAGTTC
AAAAGAGCTTTTATTACTCGTGCTATTGCAATCGTTCCTGCTATTGTTATAGCTTTTATT
GCTGATGATGAAGACTTTAATAACTATTTAAATATTCTTCAAGCAATACAACTTCCCTTT
GCCGTTATTCCACTTCTTAAGCTTTCAATGGATAGAGAACTCATGGGTGAATTTACTATT
GGTAAAGTTCAATTAACTTTATTGAGTGTCCTTTCCGCTGCTATTGTAGGAGTAAACTAT
TACGCATCAGTACCTGATGAAGTAAACTGGTCTGAAGCTTGGATCTATATCATTCTCGTA
GTTATGGTTTTATACTTTATCTTTTTAGGAATCGTGCTTTTCACTAAAATTAAAGATACT
AAGGACGTCAAATAAAGTATGCTATCAAATCATAAGCAATCTTTAATTTAAGATGATGAA
TAATATCATGTTAAATAATGA


>TTHERM_00691720(protein)
MAEVGQNNINSGTVNSNDHQEKINVKFSLREFFQYFGPGLLVAIAYIDPGNLAGDMDAGL
NGKYHLLWVLFLSTLLGFFFQNRAMMIGLVTGKDMAKLCRYYYPKKMSILLWIMAEIAII
GSDIQEVLGSAIALQILFGLKLWIGVILTISSTILILLIKYVGMRFLELIFGILIGTMAI
CFFIDLGYIAPNFGELMEGMFVPYIPSSALTSMVGLIGAVLMPHNLYLHSSLVYEKKISR
NDRPLLHKSIFYFKIETGISLLISFFINMAVIGTFANWYNSGTDIDLSSAATVLEENFGA
AAKYIWGIGLLAAGQSSTLTGTLAGQFVMSGFVKMRVSKFKRAFITRAIAIVPAIVIAFI
ADDEDFNNYLNILQAIQLPFAVIPLLKLSMDRELMGEFTIGKVQLTLLSVLSAAIVGVNY
YASVPDEVNWSEAWIYIILVVMVLYFIFLGIVLFTKIKDTKDVKQSMLSNHKQSLIQDDE
QYHVKQ