Identifiers and Description

Gene Model Identifier

TTHERM_00700900

Standard Name

TPA2 (Tetrahymena P-type ATPase )

Aliases

PreTt14887 | 109.m00105

Description

TPA2 Na-H K antiporter P-type ATPase alpha subunit family protein; P-type ATPase; putative Na(+)/K(+) or H(+)/K(+) ATPase; constitutively expressed; expression upregulated at 37C and downregulated by starvation

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039
• membrane (IEA) | GO:0016020

Molecular Function

• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824
• hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (IEA) | GO:0016820
• P-type ion transporter activity (ISS) | GO:0015662
• P-type ion transporter activity (IEA) | GO:0015662

Biological Process

• ATP biosynthetic process (IEA) | GO:0006754
• metabolic process (IEA) | GO:0008152
• monoatomic cation transport (IEA) | GO:0006812

Domains

• ( PF00122 ) E1-E2 ATPase
• ( PF00689 ) Cation transporting ATPase, C-terminus
• ( PF00690 ) Cation transporter/ATPase, N-terminus
• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( PF06790 ) Uncharacterised protein family (UPF0259)
• ( PF07670 ) transporter gate domain protein
• ( PF07813 ) LTXXQ motif
• ( PF08282 ) haloacid dehalogenase-like hydrolase
• ( TIGR01106 ) Na,H/K antiporter P-type ATPase, alpha
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01482 ) Sucrose-phosphate phosphatase subfamily
• ( TIGR01487 ) SPP-like hydrolase, Archaeal
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( TIGR01497 ) K+-transporting ATPase, B subunit
• ( TIGR01511 ) copper-translocating P-type ATPase
• ( TIGR01512 ) cadmium-translocating P-type ATPase
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
• ( TIGR01523 ) potassium/sodium efflux P-type ATPase, fungal-type
• ( TIGR01524 ) magnesium-translocating P-type ATPase
• ( TIGR01525 ) heavy metal translocating P-type ATPase
• ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
• ( TIGR01657 ) P-type ATPase of unknown pump

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_24478	0
	Description: None
WormBase	WBGene00001137	9.997093137033517e-262
	Description: locus:eat-6 status:Confirmed UniProt:P90735 protein_id:CAB02694.1
Tetrahymena borealis	EI9_01247.1	9.997093137033517e-262
	Description: Na,H/K antiporter P-type ATPase, alpha subunit protein (1197 aa)
DictyBase	DDB_G0267924	9.997093137033517e-262
	Description: DDB_G0267924 on chromosome: 1 position 1128799 to 1132710
Oxytricha	Contig21999.0.g128	9.997093137033517e-262
	Description: E1-E2 ATPase
SGD	YGL167C	9.999453238338778e-112
	Description: PMR1 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease

General Information

No Data fetched for General Information

Associated Literature

1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
3. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60
4. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28

Sequences

>TTHERM_00700900(coding)
ATGAGTTAAGTTAATGTCAGGTAGTCTGCCTCTCTCGTAAGAAAATTCGAAGAAATGAGG
CAGTCTATCTAAATCAACAACTCTATTCAGCAAATGAGATAGAGTTAATAGTACTAGACT
GGTATTCAAGAAAACTAAGATGGCAACAAAGTAGCCCATAGAAACGCAGACGTCCTCGAA
GAAATAGGTTTGAAGACTGAAGATGTCTTCATCAATAACAATGGAACATAGGTATAATAG
CAACAAGATCACCATGCTAAAGGCAAATAAATTTCTAAAGAAGACAAGTCTAAGAAAGAA
TTAGTCGAAAAAGTTGACCACAAGATTTCTCTTGAGGAACTTAGATAAAAGTATGAAACT
GACTACTAAAAGGGTCTTACCGAAGAATAAGCTGCTCATTTACTCAAAATTCATGGTGAG
AATAAACTTACTGAGAAGGTAAAAACTCCTTTCTGGGTTAAGATTCTTATTGAATTGACT
AATGGTTTCGCGCTCTTACTTTGGATCAGTGCTGGTTTATGTTTCCTTGCTTATGGCCTA
AGTCCTGATGATCCCTCTAACATCTATTTGGCTATTGTCATTCTCGTTGTCATCTTCATC
ACTACCGCTATTACTTTCCAACAGAATTCCAAGAGTGAAGCTCTGATGAACTCATTTAAA
AACTTCATTCCTGCAAAATGTATTGTAATCAGAGGAGGATAACCAAAGTCAATTGATGCA
GCTCACTTGGTTGTTGGTGATATAGTATCTATCAGATTGGGAGAGAAGATACCAGCTGAT
ATTCGTATCCTTGAATCAAATGAAATGAAAGTTGATAACTCACCTCTCACTGGTGAGTGC
GAACCTCTTTTGCGTACTGTTGAGTGCTCTCATCCCGAAAGTTATCTAGAAACCTCAAAT
ATTGCTTTCTTTGGTACTTTATGCAAAGAAGGTAATGGCAAAGGTATTGTCATTTGCACC
GGTGATAGAACTACTCTTGGATAAATCGCTGATTTGTCATCAGGTGAGAAAAAGGTTAAG
ACTCCTCTTCGTTAAGAACTTGACCGTTTTGTCATTTTAATTACTATCATCGCTATTTTC
CTTGGTGTTCTTTTCTTCTTGTTAGCCTACTTCTACATGAAATACGATTACATGGTTTGC
ATCGTTTTTGGTATTGGTATTCTTGTCGCTAACGTACCCGAAGGTTTATTGGGTTGCATT
ACCATTTCCTTGGCTATTACTGCTAAGAATCTCGCTGTAAAAAATGTTCTTGTTAAGAAT
CTAGAAGCTGTTGAAACCCTTGGTTCTACTTCTTGTATTTGCTCAGACAAAACTGGTACT
CTTACTCAGAATGTTATGTCTGTCAAGAATATGTGGTTTAAGGATAAGATTTACATGTGC
AAGAACAAAGTCCATCTTAAGCAAGGTGAAATTCCTGAGTACGATATCAACGATAACGAT
TTCTAAACCCTTCAAAAGGCTGCTATGTTGAGTAGTGAAGCTCGTTTTGATACCTCCTCA
GTTAAAGACCAATCTAACATCGACTACATAACATGTCCAGTTATGGGAGATGCCACCGAA
ACTGGTATCATTAGATTCTTTTAATACATTGATGATGTCAACAAATTCCGTGAAAGATAT
TAAATTGCTAAAAACCCTGATGGAACATACGGTAAAATGCCTTTTAACTCATAAGTTAAA
TTTGCATTGACCATCATTCAAGAATAGCTTCCTGGTAGCAACTACACTGTTTATATCAAA
GGTGCTCCTGAAAAGATTTGGAGTTACTGCAATTCAGTTATGATTAATGGCTAACCAAGT
CAAATTGATTAAACATGGTAGAAGAAATTCAAAGCAGTCAATCTCACTTTTGGTAAGGGA
GGTGAAAGAGTTCTTGGATTTGCTAAGCTCCATTTACCTGCTGAAGATTTCCCTGAAGGC
TTTATTTTCAATGTTTCTTCACTTTAAAAATTCCCCTTCAAATTGGCTAATTTCTAGTTC
TGCGGTCTTATTTCATTGATGGATCCTCCTAAAACTAGAGTTCCCTATGCAATTTTGGAA
TGCAGATCTGCTGGTGTCAAAGTTATCATGGTTACAGGCGATCAACCTCCTACTGCTGCT
GCCATCGCCAAAGAAGTCAACATTATTCCTAAGGAAGTTATTACTAATGAAGATATCTTG
GAACAAAATCCCAGTAAAACTTGGTGGGAAGCAAGTGAAGAGTGCGAGGCTATCATTGTC
CATGGTGATAGAATCGTAGAATCGTTTGAGAAATCATTATCTGAGTAAAAATAAGAAAAC
TTCTACTTGCGTTAATGGGTAAAAAAACAATATTGCGTATTTGCAAGAACAACACCTGCT
CAAAAATTACAAATTGTAGATGCTTGCCAAATGGAAGGATTTATTGTCGCTGCAACAGGT
GATGGTGTCAACGACTCTCCTGCTATCAAGAAAGCTGATATTGGTATTTCAATGAACTTG
TCAGGATCTGATGTTACTAAAGATGCTGCTGATATGGTTTTAATTGATGATGATTTTGCT
TCTATTGTTTTGGGTGTTGAAGAAGGTAGAAAAATCTTCGATAACTTAAAGAAGACTGTT
GTCTATCTTCTTACTTCTAATATGACTGAAGTCGTTCCCTTCTTGGCTTTCATTATTTTG
GAATTACCTTTACCTCTCTCTAGTATTTACATGTTAGTTATTTGTGTCGGAACTGATGTT
TGGCCTGCCATTTCTTTAGCATATGAAGAAGCTGAACTTGATGTTATGACTAGAAGACCT
CGTCTAAAATCTGAACATCTTGTTTCTAATAAATTGATTACAATCGCTTACCTTCAAACT
GGTTAAATTGCAAGTGCAGCAGGATTCCTAGGTTACTATGTTGCATTTAACTATTTCGGT
TTCCCAGTCCTTTCATTATTTGGTATGGCTTCTGGATCAGGTTACAAACCACCCAAAAAT
GATTTCAACGAAAGCTACATCAATCCTATCACAAATTAGATAGACAAGAATTACAATACA
GAAATATATAAGATAACAGGAACTACTCGTTGTGACTAATTAAATAAAGATTAACAAGAT
AAATTAGACAAATTAAAATACACTGTAGACTGGTTTACTGTTACTGAAGGTAACTACGAT
TTAAGAAAGACATTTGTAAAATGTGATACAGATTCAGGTATTTTTGTTCCCATTTACAAA
TGGAGTGACTGCGATATTACCTTGAGTAAAAATAAATCACCTATCACTGACTAAACTGCC
TGTTATTCAACTGATGCTTAAAGATATGCATAAAGTGTCTACTTCATCAGTGTTGTCTTA
CTACAATGGTCAAATATCTTTGCTTGCAAGAGTAGATCAACAAGTTACTCAACCACAGCA
TTTAATTCTATTATGATTCATGGTGTCATCTTCGAAACTTGTTTAACCGTTTTCCTTTAA
TACGTCCCAGGAGTATAAGAAGTCTTCGGTGGTAGACCTCTATTCTTCTGGCTCTGGACA
CCAGCCTTAATTTTCAGTATAACTTTACTTGTTTATGATGAATTAAGAAAATTCCTTTGT
AGACATGTTAAGTGGTATTACAAATACTGTTACTGGTGA

>TTHERM_00700900(gene)
ATGAGTTAAGTTAATGTCAGGTAGTCTGCCTCTCTCGTAAGAAAATTCGAAGAAATGAGG
CAGTCTATCTAAATCAACAACTCTATTCAGCAAATGAGATAGAGTTAATAGTACTAGACT
GGTATTCAAGAAAACTAAGATGGCAACAAAGTAGCCCATAGAAACGCAGACGTCCTCGAA
GAAATAGGTTTGAAGACTGAAGATGTCTTCATCAATAACAATGGAACATAGGTATAATAG
CAACAAGATCACCATGCTAAAGGCAAATAAATTTCTAAAGAAGACAAGTCTAAGAAAGAA
TTAGTCGAAAAAGTTGACCACAAGATTTCTCTTGAGGAACTTAGATAAAAGTATGAAACT
GACTACTAAAAGGGTCTTACCGAAGAATAAGCTGCTCATTTACTCAAAATTCATGGTGAG
AATAAACTTACTGAGAAGGTAAAAACTCCTTTCTGGGTTAAGATTCTTATTGAATTGACT
AATGGTTTCGCGCTCTTACTTTGGATCAGTGCTGGTTTATGTTTCCTTGCTTATGGCCTA
AGTCCTGATGATCCCTCTAACATCTATTTGGCTATTGTCATTCTCGTTGTCATCTTCATC
ACTACCGCTATTACTTTCCAACAGAATTCCAAGAGTGAAGCTCTGATGAACTCATTTAAA
AACTTCATTCCTGCAAAATGTATTGTAATCAGAGGAGGATAACCAAAGTCAATTGATGCA
GCTCACTTGGTTGTTGGTGATATAGTATCTATCAGATTGGGAGAGAAGATACCAGCTGAT
ATTCGTATCCTTGAATCAAATGAAATGAAAGTTGATAACTCACCTCTCACTGGTGAGTGC
GAACCTCTTTTGCGTACTGTTGAGTGCTCTCATCCCGAAAGTTATCTAGAAACCTCAAAT
ATTGCTTTCTTTGGTACTTTATGCAAAGAAGGTAATGGCAAAGGTATTGTCATTTGCACC
GGTGATAGAACTACTCTTGGATAAATCGCTGATTTGTCATCAGGTGAGAAAAAGGTTAAG
ACTCCTCTTCGTTAAGAACTTGACCGTTTTGTCATTTTAATTACTATCATCGCTATTTTC
CTTGGTGTTCTTTTCTTCTTGTTAGCCTACTTCTACATGAAATACGATTACATGGTTTGC
ATCGTTTTTGGTATTGGTATTCTTGTCGCTAACGTACCCGAAGGTTTATTGGGTTGCATT
ACCATTTCCTTGGCTATTACTGCTAAGAATCTCGCTGTAAAAAATGTTCTTGTTAAGAAT
CTAGAAGCTGTTGAAACCCTTGGTTCTACTTCTTGTATTTGCTCAGACAAAACTGGTACT
CTTACTCAGAATGTTATGTCTGTCAAGAATATGTGGTTTAAGGATAAGATTTACATGTGC
AAGAACAAAGTCCATCTTAAGCAAGGTGAAATTCCTGAGTACGATATCAACGATAACGAT
TTCTAAACCCTTCAAAAGGCTGCTATGTTGAGTAGTGAAGCTCGTTTTGATACCTCCTCA
GTTAAAGACCAATCTAACATCGACTACATAACATGTCCAGTTATGGGAGATGCCACCGAA
ACTGGTATCATTAGATTCTTTTAATACATTGATGATGTCAACAAATTCCGTGAAAGATAT
TAAATTGCTAAAAACCCTGATGGAACATACGGTAAAATGCCTTTTAACTCATAAGTTAAA
TTTGCATTGACCATCATTCAAGAATAGCTTCCTGGTAGCAACTACACTGTTTATATCAAA
GGTGCTCCTGAAAAGATTTGGAGTTACTGCAATTCAGTTATGATTAATGGCTAACCAAGT
CAAATTGATTAAACATGGTAGAAGAAATTCAAAGCAGTCAATCTCACTTTTGGTAAGGGA
GGTGAAAGAGTTCTTGGATTTGCTAAGCTCCATTTACCTGCTGAAGATTTCCCTGAAGGC
TTTATTTTCAATGTTTCTTCACTTTAAAAATTCCCCTTCAAATTGGCTAATTTCTAGTTC
TGCGGTCTTATTTCATTGATGGATCCTCCTAAAACTAGAGTTCCCTATGCAATTTTGGAA
TGCAGATCTGCTGGTGTCAAAGTTATCATGGTTACAGGCGATCAACCTCCTACTGCTGCT
GCCATCGCCAAAGAAGTCAACATTATTCCTAAGGAAGTTATTACTAATGAAGATATCTTG
GAACAAAATCCCAGTAAAACTTGGTGGGAAGCAAGTGAAGAGTGCGAGGCTATCATTGTC
CATGGTGATAGAATCGTAGAATCGTTTGAGAAATCATTATCTGAGTAAAAATAAGAAAAC
TTCTACTTGCGTTAATGGGTAAAAAAACAATATTGCGTATTTGCAAGAACAACACCTGCT
CAAAAATTACAAATTGTAGATGCTTGCCAAATGGAAGGATTTATTGTCGCTGCAACAGGT
GATGGTGTCAACGACTCTCCTGCTATCAAGAAAGCTGATATTGGTATTTCAATGAACTTG
TCAGGATCTGATGTTACTAAAGATGCTGCTGATATGGTTTTAATTGATGATGATTTTGCT
TCTATTGTTTTGGGTGTTGAAGAAGGTAGAAAAATCTTCGATAACTTAAAGAAGACTGTT
GTCTATCTTCTTACTTCTAATATGACTGAAGTCGTTCCCTTCTTGGCTTTCATTATTTTG
GAATTACCTTTACCTCTCTCTAGTATTTACATGTTAGTTATTTGTGTCGGAACTGATGTT
TGGCCTGCCATTTCTTTAGCATATGAAGAAGCTGAACTTGATGTTATGACTAGAAGACCT
CGTCTAAAATCTGAACATCTTGTTTCTAATAAATTGATTACAATCGCTTACCTTCAAACT
GGTTAAATTGCAAGTGCAGCAGGATTCCTAGGTTACTATGTTGCATTTAACTATTTCGGT
TTCCCAGTCCTTTCATTATTTGGTATGGCTTCTGGATCAGGTTACAAACCACCCAAAAAT
GATTTCAACGAAAGCTACATCAATCCTATCACAAATTAGATAGACAAGAATTACAATACA
GAAATATATAAGATAACAGGAACTACTCGTTGTGACTAATTAAATAAAGATTAACAAGAT
AAATTAGACAAATTAAAATACACTGTAGACTGGTTTACTGTTACTGAAGGTAACTACGAT
TTAAGAAAGACATTTGTAAAATGTGATACAGATTCAGGTATTTTTGTTCCCATTTACAAA
TGGAGTGACTGCGATATTACCTTGAGTAAAAATAAATCACCTATCACTGACTAAACTGCC
TGTTATTCAACTGATGCTTAAAGATATGCATAAAGTGTCTACTTCATCAGTGTTGTCTTA
CTACAATGGTCAAATATCTTTGCTTGCAAGAGTAGATCAACAAGTTACTCAACCACAGCA
TTTAATTCTATTATGATTCATGGTGTCATCTTCGAAACTTGTTTAACCGTTTTCCTTTAA
TACGTCCCAGGAGTATAAGAAGTCTTCGGTGGTAGACCTCTATTCTTCTGGCTCTGGACA
CCAGCCTTAATTTTCAGTATAACTTTACTTGTTTATGATGAATTAAGAAAATTCCTTTGT
AGACATGTTAAGTGGTATTACAAATACTGTTACTGGTGA

>TTHERM_00700900(protein)
MSQVNVRQSASLVRKFEEMRQSIQINNSIQQMRQSQQYQTGIQENQDGNKVAHRNADVLE
EIGLKTEDVFINNNGTQVQQQQDHHAKGKQISKEDKSKKELVEKVDHKISLEELRQKYET
DYQKGLTEEQAAHLLKIHGENKLTEKVKTPFWVKILIELTNGFALLLWISAGLCFLAYGL
SPDDPSNIYLAIVILVVIFITTAITFQQNSKSEALMNSFKNFIPAKCIVIRGGQPKSIDA
AHLVVGDIVSIRLGEKIPADIRILESNEMKVDNSPLTGECEPLLRTVECSHPESYLETSN
IAFFGTLCKEGNGKGIVICTGDRTTLGQIADLSSGEKKVKTPLRQELDRFVILITIIAIF
LGVLFFLLAYFYMKYDYMVCIVFGIGILVANVPEGLLGCITISLAITAKNLAVKNVLVKN
LEAVETLGSTSCICSDKTGTLTQNVMSVKNMWFKDKIYMCKNKVHLKQGEIPEYDINDND
FQTLQKAAMLSSEARFDTSSVKDQSNIDYITCPVMGDATETGIIRFFQYIDDVNKFRERY
QIAKNPDGTYGKMPFNSQVKFALTIIQEQLPGSNYTVYIKGAPEKIWSYCNSVMINGQPS
QIDQTWQKKFKAVNLTFGKGGERVLGFAKLHLPAEDFPEGFIFNVSSLQKFPFKLANFQF
CGLISLMDPPKTRVPYAILECRSAGVKVIMVTGDQPPTAAAIAKEVNIIPKEVITNEDIL
EQNPSKTWWEASEECEAIIVHGDRIVESFEKSLSEQKQENFYLRQWVKKQYCVFARTTPA
QKLQIVDACQMEGFIVAATGDGVNDSPAIKKADIGISMNLSGSDVTKDAADMVLIDDDFA
SIVLGVEEGRKIFDNLKKTVVYLLTSNMTEVVPFLAFIILELPLPLSSIYMLVICVGTDV
WPAISLAYEEAELDVMTRRPRLKSEHLVSNKLITIAYLQTGQIASAAGFLGYYVAFNYFG
FPVLSLFGMASGSGYKPPKNDFNESYINPITNQIDKNYNTEIYKITGTTRCDQLNKDQQD
KLDKLKYTVDWFTVTEGNYDLRKTFVKCDTDSGIFVPIYKWSDCDITLSKNKSPITDQTA
CYSTDAQRYAQSVYFISVVLLQWSNIFACKSRSTSYSTTAFNSIMIHGVIFETCLTVFLQ
YVPGVQEVFGGRPLFFWLWTPALIFSITLLVYDELRKFLCRHVKWYYKYCYW