Identifiers and Description

Gene Model Identifier

TTHERM_00705240

Standard Name

HHP1 (H1/HP1-like )

Aliases

PreTt26879 | 111.m00100 | 3744.m00021

Description

HHP1 heterochromatin protein; HP1-like phosphoprotein; implicated in the establishment and/or maintenance of starvation-induced chromatin assembly and gene expression; localized to the macronucleus; contains a chromoshadow domain and a chromodomain; nonessential

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• chromatin (IDA) | GO:0000785
• chromatin (IEA) | GO:0000785
• macronucleus (IDA) | GO:0031039
• nucleus (IEA) | GO:0005634

Molecular Function

• chromatin binding (IEA) | GO:0003682
• obsolete transcription activator activity (IMP) | GO:0016563

Biological Process

• cellular response to starvation (IMP) | GO:0009267
• chromatin assembly or disassembly (IMP) | GO:0006333
• chromatin assembly or disassembly (IEA) | GO:0006333
• chromatin silencing (ISS) | GO:0006342
• positive regulation of DNA-templated transcription (IMP) | GO:0045893

Domains

• ( PF00385 ) Chromo (CHRromatin Organisation MOdifier) domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_17724.1	1.9990449803848145e-49
	Description: heterochromatin-associated protein 1-like protein (178 aa)
WormBase	WBGene00008741	1.9990449803848145e-49
	Description: Uncharacterized serine carboxypeptidase F13S12.6 status:Confirmed UniProt:P52715 protein_id:CAA88947.1
WormBase	WBGene00000414	0.000000600201742947405
	Description: locus:cec-1 Chromo domain-containing protein cec-1 status:Confirmed UniProt:P34618 protein_id:CCD66162.1
Oxytricha	Contig9832.0.g37	0.0000007997233352734267
	Description: Chromo (CHRromatin Organisation MOdifier) domain
DictyBase	DDB_G0268134	0.000050024383570459175
	Description: DDB_G0268134 on chromosome: 1 position 1521691 to 1526501

General Information

No Data fetched for General Information

Associated Literature

1. Ref:10207086: Huang H, Smothers JF, Wiley EA, Allis CD (1999) A nonessential HP1-like protein affects starvation-induced assembly of condensed chromatin and gene expression in macronuclei of Tetrahymena thermophila. Molecular and cellular biology 19(5):3624-34
2. Ref:9811850: Huang H, Wiley EA, Lending CR, Allis CD (1998) An HP1-like protein is missing from transcriptionally silent micronuclei of Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America 95(23):13624-9

Sequences

>TTHERM_00705240(coding)
ATGACAAAAGTTTACGAAGTAGAAAATATTATAGGACATAGAAAAAAAGGAAGTTAGATT
GAATACCATATCTAATGGAAAGGCTACTCTCTCAAATAAGCTACTTATGAACCTGCTAAA
AATATTTTAGATAAGAATATGCTTAAAAAATACCAATAAAAGCATTTACTTAGCAATGAT
AAACCTTAGACACCCATTAAGAAATCAATTAAAAAAGGAGCTTCAACTCATTAAACACGT
AAATCTAGCTCAACTACTAAGAGAAGTGTTAAAAAATCAGTTGAAAAAGCATCTAATCCT
AAATCTACTCCTAAATTAGATAAAAAAGCATTAGATCCAGTGAAGGAAATTCATAATTAT
TAAAAGGATGTCAGTAAACTTCTTTTAAAGAGTGATATAACCTCCATATTGCACGTTTTT
AAGGATGATGGAAAATCTCTTTACACAGTCACAATTGGAAAACATCCTAAATAATATTTA
GTATCAAGTAGCTAAATTGCTAAGTATGCTTCTCCCGATCTCATAGTTAGATTCTATGAA
AAGCTAATCCGCTGA

>TTHERM_00705240(gene)
ATGACAAAAGTTTACGAAGTAGAAAATATTATAGGACATAGAAAAAAAGGAAGTTAGATT
GAATACCATATCTAATGGAAAGGCTACTCTCTCAAATAAGCTACTTATGAACCTGCTAAA
AATATTTTAGATAAGAATATGCTTAAAAAATACCAATAGTAATCCCTTACAATTACATCA
ATTAATAAATCAACCATAATTTATTAATTAATATAAGCAAATGGTTGAATAATTTTTTTA
ACTTCAATTTTAATTATATTTAGAAAGCATTTACTTAGCAATGATAAACCTTAGACACCC
ATTAAGAAATCAATTAAAAAAGGAGCTTCAACTCATTAAACACGTAAATCTAGCTCAACT
ACTAAGAGAAGTGTTAAAAAATCAGTTGAAAAAGCATCTAATCCTAAATCTACTCCTAAA
TTAGATAAAAAAGCATTAGATCCAGTGTAAGAAATTTAAATAGAAATGAGCAAACAAACT
GTTATACTTAAAATTAAATTAATTTAAATAAATAGGAAGGAAATTCATAATTATTAAAAG
GATGTCAGTAAACTTCTTTTAAAGAGTGATATAACCTCCATATTGCACGTTTTTAAGGAT
GATGGAAAATCTCTTTACACAGTCACAATTGGAAAACATCCTAAATAATATTTAGTATCA
AGTAGCTAAATTGCTAAGTATGCTTCTCCCGATCTCATAGTTAGATTCTATGAAAAGCTA
ATCCGCTGA

>TTHERM_00705240(protein)
MTKVYEVENIIGHRKKGSQIEYHIQWKGYSLKQATYEPAKNILDKNMLKKYQQKHLLSND
KPQTPIKKSIKKGASTHQTRKSSSTTKRSVKKSVEKASNPKSTPKLDKKALDPVKEIHNY
QKDVSKLLLKSDITSILHVFKDDGKSLYTVTIGKHPKQYLVSSSQIAKYASPDLIVRFYE
KLIR