Identifiers and Description

Gene Model Identifier

TTHERM_00718040

Standard Name

PKC2 (Protein Kinase C related protein)

Aliases

PreTt10899 | 114.m00134 | 3827.m00977

Description

PKC2 kinase domain protein; Protein kinase domain containing protein; Sequence similarity to a protein kinase family unique to Tetrahymena thermophila (Eisen et al. 2006); Serine/threonine-protein kinase Atg1-like

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• aleurone grain membrane (IEA) | GO:0032578
• chloroplast ribosome (IEA) | GO:0043253
• CURI complex (IEA) | GO:0032545
• EGFR-Grb2-Sos complex (IEA) | GO:0070620
• multivesicular body (IEA) | GO:0005771
• vacuolar membrane (IEA) | GO:0005774

Molecular Function

• 1-deoxy-D-xylulose-5-phosphate synthase activity (IEA) | GO:0008661
• 2-octaprenyl-6-methoxyphenol hydroxylase activity (IEA) | GO:0008681
• 6-phospho-beta-galactosidase activity (IEA) | GO:0033920
• 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (IEA) | GO:0008413
• aromatase activity (IEA) | GO:0008402
• arsenate reductase (glutaredoxin) activity (IEA) | GO:0008794
• axon guidance receptor activity (IEA) | GO:0008046
• carboxymethylenebutenolidase activity (IEA) | GO:0008806
• D-aspartate ligase activity (IEA) | GO:0034025
• G protein-coupled neurotensin receptor activity (IEA) | GO:0016492
• glutamate-putrescine ligase activity (IEA) | GO:0034024
• interleukin-12 receptor activity (IEA) | GO:0016517
• L-arabinose isomerase activity (IEA) | GO:0008733
• L(+)-tartrate dehydratase activity (IEA) | GO:0008730
• microtubule severing ATPase activity (IEA) | GO:0008568
• obsolete sodium-transporting two-sector ATPase activity (IEA) | GO:0015443
• peptidoglycan beta-N-acetylmuramidase activity (IEA) | GO:0033922
• phosphatidylcholine:cardiolipin O-linoleoyltransferase activity (IEA) | GO:0032577
• phosphatidylserine decarboxylase activity (IEA) | GO:0004609
• R-linalool synthase activity (IEA) | GO:0034008
• rhamnulose-1-phosphate aldolase activity (IEA) | GO:0008994
• Ser(Gly)-tRNA(Ala) hydrolase activity (IEA) | GO:0043908
• sphingomyelin phosphodiesterase activity (IEA) | GO:0004767
• sterol 14-demethylase activity (IEA) | GO:0008398
• type 4 neuropeptide Y receptor binding (IEA) | GO:0031844

Biological Process

• absorption of visible light (IEA) | GO:0016038
• allantoate transport (IEA) | GO:0015719
• cell wall modification involved in fruit ripening (IEA) | GO:0009829
• ceramide phosphoethanolamine metabolic process (IEA) | GO:1905371
• cytosine transport (IEA) | GO:0015856
• female courtship behavior (IEA) | GO:0008050
• heme A biosynthetic process (IEA) | GO:0006784
• heme biosynthetic process (IEA) | GO:0006783
• induction of apoptosis by extracellular signals (IEA) | GO:0008624
• interleukin-28A secretion (IEA) | GO:0072628
• mitotic anaphase A (IEA) | GO:0000091
• mitotic metaphase (IEA) | GO:0000089
• negative regulation of cellular glucuronidation (IEA) | GO:2001030
• negative regulation of complement-dependent cytotoxicity (IEA) | GO:1903660
• negative regulation of epithelial cell-cell adhesion involved in epithelium migration (IEA) | GO:1903682
• negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
• obsolete negative regulation of adhesion of symbiont to host epithelial cell (IEA) | GO:1905227
• obsolete negative regulation of response to extracellular stimulus (IEA) | GO:0032105
• obsolete regulation of glucose-6-phosphatase activity (IEA) | GO:0032114
• ommochrome biosynthetic process (IEA) | GO:0006727
• phagocytosis (IEA) | GO:0006909
• photoreceptor cell morphogenesis (IEA) | GO:0008594
• placenta blood vessel development (IEA) | GO:0060674
• plant-type cell wall modification (IEA) | GO:0009827
• positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
• positive regulation of chemokine (C-C motif) ligand 2 secretion (IEA) | GO:1904209
• positive regulation of double-strand break repair via nonhomologous end joining (IEA) | GO:2001034
• positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization (IEA) | GO:0061646
• positive regulation of peroxisome proliferator activated receptor signaling pathway (IEA) | GO:0035360
• positive regulation of response to water deprivation (IEA) | GO:1902584
• positive regulation of wound healing, spreading of epidermal cells (IEA) | GO:1903691
• priming of cellular response to stress (IEA) | GO:0080136
• propan-2-ol biosynthetic process (IEA) | GO:1902640
• protein localization to old growing cell tip (IEA) | GO:1903858
• regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902641
• regulation of complement-dependent cytotoxicity (IEA) | GO:1903659
• regulation of iron ion transmembrane transporter activity (IEA) | GO:1904254
• regulation of L-arginine import into cell (IEA) | GO:1902826
• regulation of phosphorus utilization (IEA) | GO:0006795
• regulation of shoot apical meristem development (IEA) | GO:1902183
• response to codeine (IEA) | GO:1905233
• response to iron(III) ion (IEA) | GO:0010041
• response to reactive oxygen species (IEA) | GO:0000302
• tertiary alcohol biosynthetic process (IEA) | GO:1902645
• ureteric bud formation (IEA) | GO:0060676
• VCP-NPL4-UFD1 AAA ATPase complex assembly (IEA) | GO:1904210

Domains

• ( PF00069 ) Protein kinase domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No.	Gene Name(s)	Paragraph Text
2237	PKC2	PKC2 shares homology with a number of Protein Kinase C related proteins in other ciliated prokaryotes. PKC2 contains only one single domain across its entire 517 amino acids. It conserves most of the protein kinase domain, and contains a 241 amino acid region with unknown function. PKC2 appears to play a role in amplifying the message of signal transduction pathways by phosphorylating serine and threonine. This induces a conformational change in a targeted protein and subsequently leads to a cellular response. Paragraph by: Jacqueline Kroll and Rachel Brunetti (undergraduates), Keck Science Department, The Claremont Colleges.

Associated Literature

1. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences

>TTHERM_00718040(coding)
ATGTAAAATAGAATTTTCGTAGGATAAAAGAGTAAATACTAACAAAATAAAAATACTATA
ATATAAGGAGGATAGGCCTAAATATATTTTGCGATTGATTCAAAAAATTATTAGCAGGTA
GTAATTAAAGAATACTTTAAGGATTCAAGCTTTTAAGTAGATTATGAAGTCTTAAAAAAG
ATTTAAGATAAATATTCTGAAAACTTAGAAAATTTAGTCAAAATATATGACTAAAGTAGT
GAAAAGGAAAAAATGAAATTTATAGTAATTGAATACTGCAATGAAGGGGATCTCTATACT
TATCACATTAAAAAATAATAAGAAGTTTAGACATTTGAATAAGCACTAGAAGTTATAGAT
ATTGCAATTTAAATTACTAAAGGAATGATGATATTAAAAGAACTAAACCTAGCGCATAGA
GATTTAAAGCCTGAAAATATATTGATCCATAATGATGGAGAAAAAATTATAGCTAAAATA
TCAGATTATGGACTAACTAAAGAGGTATAAAGAGATTTGAAATCAATTGTAGGAACACCA
AATTATATGGCTCCTGAAATACTATCTGCTTATAAGAAAGGCTCAGTATATGACGATAAA
ATAGACGTTTGGTCTTTTGGATTAATTTTATATGAAATGTTTACTTGCAAGTAAATATTT
AAAGGTGATTAAAAATAGATCTTTAATTAACTCATTCACTACAATGACATAATTGATTAA
CTTTTATTTTAAGATAAATTTTAAGATGTTAGTAAATTGGTTATAAGATGCCTTTAAAAA
GATCCTAAAAATAGACCTGATTTTAAATAAATATAAACTGAATTAATATAAATATAAAAT
AATTTTTCATTTTCAGTAATTGATTCTTAAGCAAAAGAATTAGATTATTCTTAATAGTCA
ATCATTTAAAATGAATAGAAAGATCAATTCAATAATTAATAAATTTATTTTGCTGGGTAA
AACAAAAATTAGAATCAACTAAATATCACAAAGGATAATGATCAAATTAAAATGCAAAAT
TAATTAAAAAACTGTCAAAATCAAAGGCAGTTTGTAAATGATCAATATTCTAACAAATAA
TTTTAAGTCCATAACAATAAAATAGAAAAAAAATAAAACAACTAAATGCATAAGTAATAA
AATAACATTTGTTCATATATGAACAACGTAAACTAAGAAAAAAATATACAAATATAAAGC
GAAATACAAAAGTACAATTTTAAGTCAATAGAATTAAGGAAAATCGAAAAAATTATTAAC
ATAAAAAAACTTTTGATAAAATATGGATATATAAATGGCGTTTGTGATGTGGACTAATCA
ATGTATAAATGTATTGTTATAGGTGATAGTATTGTTGAAATCCTTTCACCTTTAATATTA
TAATTTATTTTACAATTTAATAGAGATTGTCTATAAGATATTAAAAATTTAGTAGAAAAA
GAATAATTTGAATAGAAGTAGTTAGAAAAATAAATCGATATATTGATTGATCTGTTTAAG
GAGAACTCTTAAATGTAAAATAATTTAGTTAGAAATGTTATACAAGACCTGTTTCAAAAA
TCGGTTTCTGCATAAAATATATTTGAGATAATATAAATATTTCTTAATAATTTAATTTAG
CAATAAAGAAAAAGAAATTTAAATGAGGTTGATAAGCTAATTCAAAAAAAATAAACCATA
AATATAGAACCAAATTTAAAGCTAACTTTTGTATAGAATTATAATTAAATTACTTTTGAA
AATAATAACTATCAAATAATAATCACTAATTAGTTTAAATCTAATAAAAAATATGCTATT
TTAGTTCCTCATCAGACATATAAATACTTATTTAAAAGTTGA

>TTHERM_00718040(gene)
AATTTAGATAAATATAATAAAAATAGTAAATCCATCAAATTATAAATGTAAAATAGAATT
TTCGTAGGATAAAAGAGTAAATACTAACAAAATAAAAATACTATAATATAAGGAGGATAG
GCCTAAATATATTTTGCGATTGATTCAAAAAATTATTAGCAGGTAGTAATTAAAGAATAC
TTTAAGGATTCAAGCTTTTAAGTAGATTATGAAGTCTTAAAAAAGATTTAAGATAAATAT
TCTGAAAACTTAGAAAATTTAGTCAAAATATATGACTAAAGTAGTGAAAAGGAAAAAATG
AAATTTATAGTAATTGAATACTGCAATGAAGGGGATCTCTATACTTATCACATTAAAAAA
TAATAAGAAGTTTAGACATTTGAATAAGCACTAGAAGTTATAGATATTGCAATTTAAATT
ACTAAAGGAATGATGATATTAAAAGAACTAAACCTAGCGCATAGAGATTTAAAGCCTGAA
AATATATTGATCCATAATGATGGAGAAAAAATTATAGCTAAAATATCAGATTATGGACTA
ACTAAAGAGGTATAAAGAGATTTGAAATCAATTGTAGGAACACCAAATTATATGGCTCCT
GAAATACTATCTGCTTATAAGAAAGGCTCAGTATATGACGATAAAATAGACGTTTGGTCT
TTTGGATTAATTTTATATGAAATGTTTACTTGCAAGTAAATATTTAAAGGTGATTAAAAA
TAGATCTTTAATTAACTCATTCACTACAATGACATAATTGATTAACTTTTATTTTAAGAT
AAATTTTAAGATGTTAGTAAATTGGTTATAAGATGCCTTTAAAAAGATCCTAAAAATAGA
CCTGATTTTAAATAAATATAAACTGAATTAATATAAATATAAAATAATTTTTCATTTTCA
GTAATTGATTCTTAAGCAAAAGAATTAGATTATTCTTAATAGTCAATCATTTAAAATGAA
TAGAAAGATCAATTCAATAATTAATAAATTTATTTTGCTGGGTAAAACAAAAATTAGAAT
CAACTAAATATCACAAAGGATAATGATCAAATTAAAATGCAAAATTAATTAAAAAACTGT
CAAAATCAAAGGCAGTTTGTAAATGATCAATATTCTAACAAATAATTTTAAGTCCATAAC
AATAAAATAGAAAAAAAATAAAACAACTAAATGCATAAGTAATAAAATAACATTTGTTCA
TATATGAACAACGTAAACTAAGAAAAAAATATACAAATATAAAGCGAAATACAAAAGTAC
AATTTTAAGTCAATAGAATTAAGGAAAATCGAAAAAATTATTAACATAAAAAAACTTTTG
ATAAAATATGGATATATAAATGGCGTTTGTGATGTGGACTAATCAATGTATAAATGTATT
GTTATAGGTGATAGTATTGTTGAAATCCTTTCACCTTTAATATTATAATTTATTTTACAA
TTTAATAGAGATTGTCTATAAGATATTAAAAATTTAGTAGAAAAAGAATAATTTGAATAG
AAGTAGTTAGAAAAATAAATCGATATATTGATTGATCTGTTTAAGGAGAACTCTTAAATG
TAAAATAATTTAGTTAGAAATGTTATACAAGACCTGTTTCAAAAATCGGTTTCTGCATAA
AATATATTTGAGATAATATAAATATTTCTTAATAATTTAATTTAGCAATAAAGAAAAAGA
AATTTAAATGAGGTTGATAAGCTAATTCAAAAAAAATAAACCATAAATATAGAACCAAAT
TTAAAGCTAACTTTTGTATAGAATTATAATTAAATTACTTTTGAAAATAATAACTATCAA
ATAATAATCACTAATTAGTTTAAATCTAATAAAAAATATGCTATTTTAGTTCCTCATCAG
ACATATAAATACTTATTTAAAAGTTGATTTGTTCTGTTTCTTTTTCTTCTTGAAAGGTTA
TTTTTTGTTTAAATGCATTAATTCGAATAATAAAAATATCTATCCGTCTGTCTTTCTTTT
TATAGTAAAAATTTAATTAATTTTACTTTTCTCCTAAATATTTTAATAAACAGCTTTTG

>TTHERM_00718040(protein)
MQNRIFVGQKSKYQQNKNTIIQGGQAQIYFAIDSKNYQQVVIKEYFKDSSFQVDYEVLKK
IQDKYSENLENLVKIYDQSSEKEKMKFIVIEYCNEGDLYTYHIKKQQEVQTFEQALEVID
IAIQITKGMMILKELNLAHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKSIVGTP
NYMAPEILSAYKKGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQKQIFNQLIHYNDIIDQ
LLFQDKFQDVSKLVIRCLQKDPKNRPDFKQIQTELIQIQNNFSFSVIDSQAKELDYSQQS
IIQNEQKDQFNNQQIYFAGQNKNQNQLNITKDNDQIKMQNQLKNCQNQRQFVNDQYSNKQ
FQVHNNKIEKKQNNQMHKQQNNICSYMNNVNQEKNIQIQSEIQKYNFKSIELRKIEKIIN
IKKLLIKYGYINGVCDVDQSMYKCIVIGDSIVEILSPLILQFILQFNRDCLQDIKNLVEK
EQFEQKQLEKQIDILIDLFKENSQMQNNLVRNVIQDLFQKSVSAQNIFEIIQIFLNNLIQ
QQRKRNLNEVDKLIQKKQTINIEPNLKLTFVQNYNQITFENNNYQIIITNQFKSNKKYAI
LVPHQTYKYLFKS