Identifiers and Description

Gene Model Identifier

TTHERM_00721450

Standard Name

MRE11 (Meiotic REcombination 11)

Aliases

PreTt18453 | 115.m00109

Description

MRE11 ser/thr phosphatase family protein; Ser/Thr protein phosphatase family protein; Mre11p is required for the repair of meiotic double-strand breaks and full chromosome pairing; homolog of budding yeast MRE11 and fission yeast RAD32

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Biological Process

• double-strand break repair (IMP) | GO:0006302
• homologous chromosome pairing at meiosis (IMP) | GO:0007129
• meiosis I (IMP) | GO:0007127

Domains

• ( PF00149 ) Calcineurin-like phosphoesterase
• ( PF04152 ) Mre11 DNA-binding presumed domain
• ( PF04259 ) Small, acid-soluble spore protein, gamma-type
• ( PF04702 ) Vicilin N terminal region
• ( PF04837 ) MbeB-like, N-term conserved region
• ( TIGR00040 ) phosphodiesterase, MJ0936 family
• ( TIGR00583 ) DNA repair protein (mre11)
• ( TIGR00619 ) exonuclease SbcCD, D subunit

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_17472.1	9.997093137033517e-262
	Description: Ser/Thr protein phosphatase (896 aa)
Tetrahymena borealis	EI9_07276.1	9.997093137033517e-262
	Description: hypothetical protein (1119 aa)
Oxytricha	Contig6051.0.g68	2.0004907641180118e-81
	Description: Calcineurin-like phosphoesterase
DictyBase	DDB_G0293546	1.9999590304423412e-72
	Description: mre11 on chromosome: 6 position 3016431 to 3018565
WormBase	WBGene00003405	1.9999167998962255e-60
	Description: locus:mre-11 Double-strand break repair protein mre-11 status:Partially_confirmed UniProt:Q23255 protein_id:CAA98292.2
Tetrahymena borealis	EI9_01449.1	1.9999167998962255e-60
	Description: protein kinase domain-containing protein (632 aa)
SGD	YMR224C	3.0014802379878627e-60
	Description: MRE11 Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved
Stentor Coeruleus	SteCoe_22784	2.6786369618080778e-33
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:26519827: Lukaszewicz A, Shodhan A, Loidl J (2015) Exo1 and Mre11 execute meiotic DSB end resection in the protist Tetrahymena. DNA repair 35( ):137-43
2. Ref:20422424: Lukaszewicz A, Howard-Till RA, Novatchkova M, Mochizuki K, Loidl J (2010) MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena. Chromosoma 119(5):505-18

Sequences

>TTHERM_00721450(coding)
ATGAAAAAAAATAACTTTGTTTTAACTTAGGTCGAAAAGAAAAATGTCTTTAAAGATTAG
GAAAATACTTTTAAGATATTAGTTGCCACTGATAACCATGTAGGATATAAAGAAAACGAC
CCTATTAGAGGGAACGACTCTTTTGAAGCTTTTGAAGAAGTATTAAAAATAGCAAAAAGC
GAAAAAGTAGACTTTTTACTTTTAGGAGGAGATCTTTTTCATGAGACCAATCCTTCTTAG
CAGTGTTTATATAAAATGCTAAATTTATTGGGTAATTATGTTTTAGGTGATGGCGAAATT
TTGTATGGGATATCGAATTATAATGATGTAAATTTTCAAGATTGCAATTTGAATATAGAA
TTGCCAATCTTTGTCATCCATGGTAATCATGACTACCCTTCAGATGAGTATGGAAATTTA
AGCGTAATAGACCTTCTTCACGCAACAAAATACCTCAATCACTTTGGAAAATTCTCCAAC
ATTGAATAAATAAAGGTTACTCCTATAATCTTCCAGAAAGGCAATACAACAGTAGCTTTG
TATGGAATTGGATACTTAAAAGATAAATACTTTCATAAAATGCTTGAGGAGGGTAAAATA
GAGTTTGTTAAACCTGAATAAATGGGGTATAAGGACACAGTGAATATTTTAGTCATTCAT
TAAAATAGATACAAAGGAATCAGATAAGGACAATCTTACAGAAATTGTGTGCATCCTGAA
TAATTTCCAGAGTGGATTGACTTTATAATTAGAGGTCACGAGCATGAATAAAAAGATGAT
ATAGATATTATGAAAGAATGTCCTATTGCTACTATTTAACCTGGCTCTACTATATTAACA
GCAATAGAAGATGTTTAGGCAACACCAAGAAGAGCTATATTATTTGAAATAAAAGGCCTT
GAAGCTAACTTTTAAGATATTACTCTAATTTAATCATATAGGCCAGTTTTATATGAGCAT
GTTGAATTAACTAGTGTAGTAAAAAAAGCAGGATTCGATTTAGATAATGAAGTACCTGCA
GATTAGGCTGTAGAAGAAGTTCTATGGCAATTTATTTAACAGTCTATCAACAATTTTAAA
ATAGTCTTGAAAGAAAATTTTCCAAACAGTCCTCATTTATTTGCTAAAAAACCTATTTTA
AGATTTAAAATTGAGCAAAGCAATTTTGATGTTTTTAACTTTCAAAGAATAGAATCTAAA
CTGTCAGACTTGGTTGCAAATCCAGGTGAAGTGCTTAAATTTTGGAAAAGAATAATAATT
AATCCTAAAACTATTAAAAATCCAAAATTAGAAGAAGATTTTATCAAAACTTTAAAAGGA
AAATCAGATTTTGATACAATAGGTAATGAAACTGTCAAGGATATTAAAGAATTATATGAA
GATAGGATTAAAAAAAATAAATCTATTTCATGCCTGCCGAGCAGTCTTATAATGGATACC
CTTGAAAAAGTTAATTTGAGGAATAGAAACTCTTCTATAGAAGACATAATCAAGAATTTA
CAAAATAAATTACAGGAAAATGTAGCTGTTTAGGAGGAGAAAGAAATAAGGAAGGTTAAT
GAACAATATCGTTAATAAATGAACAGCGTTTTATAAAAAATATCTACTAATATTGATGAG
AGATAAAAAGATAAAATAGATCTTGACTTAAAAAACAGTGATAAAATTATATACAAAACT
TTGATGAACAATTAATTTGATGATCTGAAACAAAGTTTAAATGAGAAAATAAGGACAAAA
GTGGCTGAGCTATTCATTCAAGACTTTTAATAGGATGGAGATAATGATATTGATATAGAA
AATAATAGTGATGGCTAATATAAGGAAAGTAGTACAAATAAAAAAAGTTTGAATTCTGAT
TAAATGGATAGTGAAGAAGAAGATAATAAAACTAGTAAAGTTAAAGGACGAGGAAGAAAA
AGAACTGAAAATAAATCTATCACAACGAAAAAGTAAGTCAAGGACTTTGAATTAGAAGAT
AATGATTATGAAAATGAAAATATACATGATGAGGAAGATGAAAATTAAATTTCATAATAG
AAAGGATTTAAAGGCAAATTTAAGAATAGCAAATTAGCCAAAGAAAAGGCAAACTAAAAC
TTGAAAAATAGATAAGAAATAAAAGTTGAAGATTCAAGTGATCAAGATGAAGAAAAAATT
GAAAAAGTAAATAGAAGAATAAAAAAAAGTGATAATAAAAGAGATTTCAATGCTGAAAAT
GAAAAACCTAATATGAAAAGTGGGTTTAAATAAAAAATGACATACGCTCAGTTATTCAAG
AAATAAAATAGAATGGATTAAGAAGAAGAAGAAGACTATGAAGAAAATTAATAAAGTGAT
GAAGATGCTTCACAGCAATCAGATTGTGAATTTGGGTTAAATGGAGAGAAATAAAAAATT
AGTTATAATATTGCTCATATTTCTGAAATACAAAAAAAGAACTAAAGCAATAAGTCTCTT
CCATTATTGCAAGTTCAATAAAAGAAAGAATAAAGTAGTGCTATTAAGATAGAGAATTCT
AGCAATACTAGGCAGAGTATTTTAAGCAAAAAAAAGCCCCAAGCACCACAAGATGAGCCA
AGAAGAGAGTAAAAAGAGCTGGATATAAGAGAATTGATGATGAAAAGAATGAATTAAGCA
AATGTTAAAAATTGA

>TTHERM_00721450(gene)
ATGAAAAAAAATAACTTTGTTTTAACTTAGGTCGAAAAGAAAAATGTCTTTAAAGATTAG
GAAAATACTTTTAAGATATTAGTTGCCACTGATAACCATGTAGGATATAAAGAAAACGAC
CCTATTAGAGGGAACGACTCTTTTGAAGCTTTTGAAGAAGTATTAAAAATAGCAAAAAGC
GAAAAAGTAGACTTTTTACTTTTAGGAGGAGATCTTTTTCATGAGACCAATCCTTCTTAG
CAGTGTTTATATAAAATGCTAAATTTATTGGGTAATTATGTTTTAGGTGATGGCGAAATT
TTGTATGGGATATCGAATTATAATGATGTAAATTTTCAAGATTGCAATTTGAATATAGAA
TTGCCAATCTTTGTCATCCATGGTAATCATGACTACCCTTCAGATGAGTATGGAAATTTA
AGCGTAATAGACCTTCTTCACGCAACAAAATACCTCAATCACTTTGGAAAATTCTCCAAC
ATTGAATAAATAAAGGTATAAAATATTTTAATGATTTAATCAATATAAAATAAATTTATT
TAATAAGAGATAAAGCTATTTATTGCCAATTAAAGTTAATCATTGTGAGAAATTAAGAAG
AAAAAAAATATTCTTAAAATATTTTATTAAAACTAATTTAAAGATAATAAAATAAATAAA
TTTTAGAAAATTAACACAAATTTAATTTATTTTATTCAAATTAATTTACCTCAAAATAGT
TACTTTATAAAATATTAAGAAGAGTTTTATATAAAATTAACAAATACTTACCAATCAGCT
TAGTTCCAAATTAATTATTTTATTTAAATTAATTATTTTTCAATTAAAATATTGAAATTT
TAATTATTTAATAATGATGTCCTGAAGATTGAATCATATAATATACAGAACTTATATAAT
AAAAAGAAGAAAAACTAATATTAATTAGAAGGTCTCTATCTAAATATTTACTTTTGAAAT
AAAAAATAGGTTACTCCTATAATCTTCCAGAAAGGCAATACAACAGTAGCTTTGTATGGA
ATTGGATACTTAAAAGATAAATACTTTCATAAAATGCTTGAGGAGGGTAAAATAGAGTTT
GTTAAACCTGAATAAATGGGGTATAAGGACACAGTGAATATTTTAGTCATTCATTAAAAT
AGATACAAAGGAATCAGATAAGGACAATCTTACAGAAATTGTGTGCATCCTGAATAATTT
CCAGAGTGGATTGACTTTATAATTAGAGGTCACGAGGTAACATATTAATTAAAAATAATC
GTAATCCATATAATTTTTTTTAACTGAAAGCATGAATAAAAAGATGATATAGATATTATG
AAAGAATGTCCTATTGCTACTATTTAACCTGGCTCTACTATATTAACAGCAATAGAAGAT
GTTTAGGCAACACCAAGAAGAGCTATATTATTTGAAATAAAAGGCCTTGAAGCTAACTTT
TAAGATATTACTCTAATTTAATCATATAGGCCAGTTTTATATGAGCATGTTGAATTAACT
AGTGTAGTAAAAAAAGCAGGATTCGATTTAGATAATGAAGTACCTGCAGATTAGGCTGTA
GAAGAAGTTCTATGGCAATTTATTTAACAGTCTATCAACAATTTTAAAATAGTCTTGAAA
GAAAATTTTCCAAACAGTCCTCATTTATTTGCTAAAAAACCTATTTTAAGATTTAAAATT
GAGCAAAGCAATTTTGATGTTTTTAACTTTCAAAGGTAAATAAATGCTTAAAAAATTATT
TCTTAAAAGCTTGTTTGAATATTTTTATTATCAAAAATCATTTATTATTTTCATGATTTA
TGATTTTTGTTACAATCCAATCAAAGATTAATTTAATTTTAATTAAATTTTCAATTTATT
CATTCATATATAAACTTTTTATTTAAAAATTTTCTTTAAATTGTACAAATGCTTTTTTGT
TTTAATAATGCTTATTAAATTAAATTAAAAGAATAGAATCTAAACTGTCAGACTTGGTTG
CAAATCCAGGTGAAGTGCTTAAATTTTGGAAAAGAATAATAATTAATCCTAAAACTATTA
AAAATCCAAAATTAGAAGAAGATTTTATCAAAACTTTAAAAGGAAAATCAGATTTTGATA
CAATAGGTAATGAAACTGTCAAGGATATTAAAGAATTATATGAAGATAGGATTAAAAAAA
ATAAATCTATTTCATGCCTGCCGAGCAGTCTTATAATGGATACCCTTGAAAAAGTTAATT
TGAGGAATAGAAACTCTTCTATAGAAGACATAATCAAGAATTTACAAAATAAATTACAGG
AAAATGTAGCTGTTTAGGAGGAGAAAGAAATAAGGAAGGTTAATGAACAATATCGTTAAT
AAATGAACAGCGTTTTATAAAAAATATCTACTAATATTGATGAGAGATAAAAAGATAAAA
TAGATCTTGACTTAAAAAACAGTGATAAAATTATATACAAAACTTTGATGAACAATTAAT
TTGATGATCTGAAACAAAGTTTAAATGAGAAAATAAGGACAAAAGTGGCTGAGCTATTCA
TTCAAGACTTTTAATAGGATGGAGATAATGATATTGATATAGAAAATAATAGTGATGGCT
AATATAAGGAAAGTAGTACAAATAAAAAAAGTTTGAATTCTGATTAAATGGATAGTGAAG
AAGAAGATAATAAAACTAGTAAAGTTAAAGGACGAGGAAGAAAAAGAACTGAAAATAAAT
CTATCACAACGAAAAAGTAAGTCAAGGACTTTGAATTAGAAGATAATGATTATGAAAATG
AAAATATACATGATGAGGAAGATGAAAATTAAATTTCATAATAGAAAGGATTTAAAGGCA
AATTTAAGAATAGCAAATTAGCCAAAGAAAAGGCAAACTAAAACTTGAAAAATAGATAAG
AAATAAAAGTTGAAGATTCAAGTGATCAAGATGAAGAAAAAATTGAAAAAGTAAATAGAA
GAATAAAAAAAAGTGATAATAAAAGAGATTTCAATGCTGAAAATGAAAAACCTAATATGA
AAAGTGGGTTTAAATAAAAAATGACATACGCTCAGTTATTCAAGAAATAAAATAGAATGG
ATTAAGAAGAAGAAGAAGACTATGAAGAAAATTAATAAAGTGATGAAGATGCTTCACAGC
AATCAGATTGTGAATTTGGGTTAAATGGAGAGAAATAAAAAATTAGTTATAATATTGCTC
ATATTTCTGAAATACAAAAAAAGAACTAAAGCAATAAGTCTCTTCCATTATTGCAAGTTC
AATAAAAGAAAGAATAAAGTAGTGCTATTAAGATAGAGAATTCTAGCAATACTAGGCAGA
GTATTTTAAGCAAAAAAAAGCCCCAAGCACCACAAGATGAGCCAAGAAGAGAGTAAAAAG
AGCTGGATATAAGAGAATTGATGATGAAAAGAATGAATTAAGCAAATGTTAAAAATTGA

>TTHERM_00721450(protein)
MKKNNFVLTQVEKKNVFKDQENTFKILVATDNHVGYKENDPIRGNDSFEAFEEVLKIAKS
EKVDFLLLGGDLFHETNPSQQCLYKMLNLLGNYVLGDGEILYGISNYNDVNFQDCNLNIE
LPIFVIHGNHDYPSDEYGNLSVIDLLHATKYLNHFGKFSNIEQIKVTPIIFQKGNTTVAL
YGIGYLKDKYFHKMLEEGKIEFVKPEQMGYKDTVNILVIHQNRYKGIRQGQSYRNCVHPE
QFPEWIDFIIRGHEHEQKDDIDIMKECPIATIQPGSTILTAIEDVQATPRRAILFEIKGL
EANFQDITLIQSYRPVLYEHVELTSVVKKAGFDLDNEVPADQAVEEVLWQFIQQSINNFK
IVLKENFPNSPHLFAKKPILRFKIEQSNFDVFNFQRIESKLSDLVANPGEVLKFWKRIII
NPKTIKNPKLEEDFIKTLKGKSDFDTIGNETVKDIKELYEDRIKKNKSISCLPSSLIMDT
LEKVNLRNRNSSIEDIIKNLQNKLQENVAVQEEKEIRKVNEQYRQQMNSVLQKISTNIDE
RQKDKIDLDLKNSDKIIYKTLMNNQFDDLKQSLNEKIRTKVAELFIQDFQQDGDNDIDIE
NNSDGQYKESSTNKKSLNSDQMDSEEEDNKTSKVKGRGRKRTENKSITTKKQVKDFELED
NDYENENIHDEEDENQISQQKGFKGKFKNSKLAKEKANQNLKNRQEIKVEDSSDQDEEKI
EKVNRRIKKSDNKRDFNAENEKPNMKSGFKQKMTYAQLFKKQNRMDQEEEEDYEENQQSD
EDASQQSDCEFGLNGEKQKISYNIAHISEIQKKNQSNKSLPLLQVQQKKEQSSAIKIENS
SNTRQSILSKKKPQAPQDEPRREQKELDIRELMMKRMNQANVKN