Identifiers and Description

Gene Model Identifier

TTHERM_00721450

Standard Name

MRE11 (Meiotic REcombination 11)

Aliases

PreTt18453 | 115.m00109

Description

MRE11 ser/thr phosphatase family protein; Ser/Thr protein phosphatase family protein; Mre11p is required for the repair of meiotic double-strand breaks and full chromosome pairing; homolog of budding yeast MRE11 and fission yeast RAD32; Calcineurin-like phosphoesterase domain, ApaH type

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Biological Process

• double-strand break repair (IMP) | GO:0006302
• homologous chromosome pairing at meiosis (IMP) | GO:0007129
• meiosis I (IMP) | GO:0007127

Domains

• ( PF00149 ) Calcineurin-like phosphoesterase
• ( PF04152 ) Mre11 DNA-binding presumed domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:26519827: Lukaszewicz A, Shodhan A, Loidl J (2015) Exo1 and Mre11 execute meiotic DSB end resection in the protist Tetrahymena. DNA repair 35( ):137-43
2. Ref:20422424: Lukaszewicz A, Howard-Till RA, Novatchkova M, Mochizuki K, Loidl J (2010) MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena. Chromosoma 119(5):505-18

Sequences

>TTHERM_00721450(coding)
ATGAAAAAAAATAACTTTGTTTTAACTTAGGTCGAAAAGAAAAATGTCTTTAAAGATTAG
GAAAATACTTTTAAGATATTAGTTGCCACTGATAACCATGTAGGATATAAAGAAAACGAC
CCTATTAGAGGGAACGACTCTTTTGAAGCTTTTGAAGAAGTATTAAAAATAGCAAAAAGC
GAAAAAGTAGACTTTTTACTTTTAGGAGGAGATCTTTTTCATGAGACCAATCCTTCTTAG
CAGTGTTTATATAAAATGCTAAATTTATTGGGTAATTATGTTTTAGGTGATGGCGAAATT
TTGTATGGGATATCGAATTATAATGATGTAAATTTTCAAGATTGCAATTTGAATATAGAA
TTGCCAATCTTTGTCATCCATGGTAATCATGACTACCCTTCAGATGAGTATGGAAATTTA
AGCGTAATAGACCTTCTTCACGCAACAAAATACCTCAATCACTTTGGAAAATTCTCCAAC
ATTGAATAAATAAAGGTTACTCCTATAATCTTCCAGAAAGGCAATACAACAGTAGCTTTG
TATGGAATTGGATACTTAAAAGATAAATACTTTCATAAAATGCTTGAGGAGGGTAAAATA
GAGTTTGTTAAACCTGAATAAATGGGGTATAAGGACACAGTGAATATTTTAGTCATTCAT
TAAAATAGATACAAAGGAATCAGATAAGGACAATCTTACAGAAATTGTGTGCATCCTGAA
TAATTTCCAGAGTGGATTGACTTTATAATTAGAGGTCACGAGCATGAATAAAAAGATGAT
ATAGATATTATGAAAGAATGTCCTATTGCTACTATTTAACCTGGCTCTACTATATTAACA
GCAATAGAAGATGTTTAGGCAACACCAAGAAGAGCTATATTATTTGAAATAAAAGGCCTT
GAAGCTAACTTTTAAGATATTACTCTAATTTAATCATATAGGCCAGTTTTATATGAGCAT
GTTGAATTAACTAGTGTAGTAAAAAAAGCAGGATTCGATTTAGATAATGAAGTACCTGCA
GATTAGGCTGTAGAAGAAGTTCTATGGCAATTTATTTAACAGTCTATCAACAATTTTAAA
ATAGTCTTGAAAGAAAATTTTCCAAACAGTCCTCATTTATTTGCTAAAAAACCTATTTTA
AGATTTAAAATTGAGCAAAGCAATTTTGATGTTTTTAACTTTCAAAGAATAGAATCTAAA
CTGTCAGACTTGGTTGCAAATCCAGGTGAAGTGCTTAAATTTTGGAAAAGAATAATAATT
AATCCTAAAACTATTAAAAATCCAAAATTAGAAGAAGATTTTATCAAAACTTTAAAAGGA
AAATCAGATTTTGATACAATAGGTAATGAAACTGTCAAGGATATTAAAGAATTATATGAA
GATAGGATTAAAAAAAATAAATCTATTTCATGCCTGCCGAGCAGTCTTATAATGGATACC
CTTGAAAAAGTTAATTTGAGGAATAGAAACTCTTCTATAGAAGACATAATCAAGAATTTA
CAAAATAAATTACAGGAAAATGTAGCTGTTTAGGAGGAGAAAGAAATAAGGAAGGTTAAT
GAACAATATCGTTAATAAATGAACAGCGTTTTATAAAAAATATCTACTAATATTGATGAG
AGATAAAAAGATAAAATAGATCTTGACTTAAAAAACAGTGATAAAATTATATACAAAACT
TTGATGAACAATTAATTTGATGATCTGAAACAAAGTTTAAATGAGAAAATAAGGACAAAA
GTGGCTGAGCTATTCATTCAAGACTTTTAATAGGATGGAGATAATGATATTGATATAGAA
AATAATAGTGATGGCTAATATAAGGAAAGTAGTACAAATAAAAAAAGTTTGAATTCTGAT
TAAATGGATAGTGAAGAAGAAGATAATAAAACTAGTAAAGTTAAAGGACGAGGAAGAAAA
AGAACTGAAAATAAATCTATCACAACGAAAAAGTAAGTCAAGGACTTTGAATTAGAAGAT
AATGATTATGAAAATGAAAATATACATGATGAGGAAGATGAAAATTAAATTTCATAATAG
AAAGGATTTAAAGGCAAATTTAAGAATAGCAAATTAGCCAAAGAAAAGGCAAACTAAAAC
TTGAAAAATAGATAAGAAATAAAAGTTGAAGATTCAAGTGATCAAGATGAAGAAAAAATT
GAAAAAGTAAATAGAAGAATAAAAAAAAGTGATAATAAAAGAGATTTCAATGCTGAAAAT
GAAAAACCTAATATGAAAAGTGGGTTTAAATAAAAAATGACATACGCTCAGTTATTCAAG
AAATAAAATAGAATGGATTAAGAAGAAGAAGAAGACTATGAAGAAAATTAATAAAGTGAT
GAAGATGCTTCACAGCAATCAGATTGTGAATTTGGGTTAAATGGAGAGAAATAAAAAATT
AGTTATAATATTGCTCATATTTCTGAAATACAAAAAAAGAACTAAAGCAATAAGTCTCTT
CCATTATTGCAAGTTCAATAAAAGAAAGAATAAAGTAGTGCTATTAAGATAGAGAATTCT
AGCAATACTAGGCAGAGTATTTTAAGCAAAAAAAAGCCCCAAGCACCACAAGATGAGCCA
AGAAGAGAGTAAAAAGAGCTGGATATAAGAGAATTGATGATGAAAAGAATGAATTAAGCA
AATGTTAAAAATTGA

>TTHERM_00721450(gene)
TTTACTTAATAAAGATACATATTATTTTGTTTTTTAGATTTACTGCTAAACATAAATTAT
TAATTAATTATTTGATAATTCATCTATTTATTATTAAGCCAATTATTATTAAACAAGCAA
ACTATCAATAAGATGAAAAAAAATAACTTTGTTTTAACTTAGGTCGAAAAGAAAAATGTC
TTTAAAGATTAGGAAAATACTTTTAAGATATTAGTTGCCACTGATAACCATGTAGGATAT
AAAGAAAACGACCCTATTAGAGGGAACGACTCTTTTGAAGCTTTTGAAGAAGTATTAAAA
ATAGCAAAAAGCGAAAAAGTAGACTTTTTACTTTTAGGAGGAGATCTTTTTCATGAGACC
AATCCTTCTTAGCAGTGTTTATATAAAATGCTAAATTTATTGGGTAATTATGTTTTAGGT
GATGGCGAAATTTTGTATGGGATATCGAATTATAATGATGTAAATTTTCAAGATTGCAAT
TTGAATATAGAATTGCCAATCTTTGTCATCCATGGTAATCATGACTACCCTTCAGATGAG
TATGGAAATTTAAGCGTAATAGACCTTCTTCACGCAACAAAATACCTCAATCACTTTGGA
AAATTCTCCAACATTGAATAAATAAAGGTTACTCCTATAATCTTCCAGAAAGGCAATACA
ACAGTAGCTTTGTATGGAATTGGATACTTAAAAGATAAATACTTTCATAAAATGCTTGAG
GAGGGTAAAATAGAGTTTGTTAAACCTGAATAAATGGGGTATAAGGACACAGTGAATATT
TTAGTCATTCATTAAAATAGATACAAAGGAATCAGATAAGGACAATCTTACAGAAATTGT
GTGCATCCTGAATAATTTCCAGAGTGGATTGACTTTATAATTAGAGGTCACGAGCATGAA
TAAAAAGATGATATAGATATTATGAAAGAATGTCCTATTGCTACTATTTAACCTGGCTCT
ACTATATTAACAGCAATAGAAGATGTTTAGGCAACACCAAGAAGAGCTATATTATTTGAA
ATAAAAGGCCTTGAAGCTAACTTTTAAGATATTACTCTAATTTAATCATATAGGCCAGTT
TTATATGAGCATGTTGAATTAACTAGTGTAGTAAAAAAAGCAGGATTCGATTTAGATAAT
GAAGTACCTGCAGATTAGGCTGTAGAAGAAGTTCTATGGCAATTTATTTAACAGTCTATC
AACAATTTTAAAATAGTCTTGAAAGAAAATTTTCCAAACAGTCCTCATTTATTTGCTAAA
AAACCTATTTTAAGATTTAAAATTGAGCAAAGCAATTTTGATGTTTTTAACTTTCAAAGA
ATAGAATCTAAACTGTCAGACTTGGTTGCAAATCCAGGTGAAGTGCTTAAATTTTGGAAA
AGAATAATAATTAATCCTAAAACTATTAAAAATCCAAAATTAGAAGAAGATTTTATCAAA
ACTTTAAAAGGAAAATCAGATTTTGATACAATAGGTAATGAAACTGTCAAGGATATTAAA
GAATTATATGAAGATAGGATTAAAAAAAATAAATCTATTTCATGCCTGCCGAGCAGTCTT
ATAATGGATACCCTTGAAAAAGTTAATTTGAGGAATAGAAACTCTTCTATAGAAGACATA
ATCAAGAATTTACAAAATAAATTACAGGAAAATGTAGCTGTTTAGGAGGAGAAAGAAATA
AGGAAGGTTAATGAACAATATCGTTAATAAATGAACAGCGTTTTATAAAAAATATCTACT
AATATTGATGAGAGATAAAAAGATAAAATAGATCTTGACTTAAAAAACAGTGATAAAATT
ATATACAAAACTTTGATGAACAATTAATTTGATGATCTGAAACAAAGTTTAAATGAGAAA
ATAAGGACAAAAGTGGCTGAGCTATTCATTCAAGACTTTTAATAGGATGGAGATAATGAT
ATTGATATAGAAAATAATAGTGATGGCTAATATAAGGAAAGTAGTACAAATAAAAAAAGT
TTGAATTCTGATTAAATGGATAGTGAAGAAGAAGATAATAAAACTAGTAAAGTTAAAGGA
CGAGGAAGAAAAAGAACTGAAAATAAATCTATCACAACGAAAAAGTAAGTCAAGGACTTT
GAATTAGAAGATAATGATTATGAAAATGAAAATATACATGATGAGGAAGATGAAAATTAA
ATTTCATAATAGAAAGGATTTAAAGGCAAATTTAAGAATAGCAAATTAGCCAAAGAAAAG
GCAAACTAAAACTTGAAAAATAGATAAGAAATAAAAGTTGAAGATTCAAGTGATCAAGAT
GAAGAAAAAATTGAAAAAGTAAATAGAAGAATAAAAAAAAGTGATAATAAAAGAGATTTC
AATGCTGAAAATGAAAAACCTAATATGAAAAGTGGGTTTAAATAAAAAATGACATACGCT
CAGTTATTCAAGAAATAAAATAGAATGGATTAAGAAGAAGAAGAAGACTATGAAGAAAAT
TAATAAAGTGATGAAGATGCTTCACAGCAATCAGATTGTGAATTTGGGTTAAATGGAGAG
AAATAAAAAATTAGTTATAATATTGCTCATATTTCTGAAATACAAAAAAAGAACTAAAGC
AATAAGTCTCTTCCATTATTGCAAGTTCAATAAAAGAAAGAATAAAGTAGTGCTATTAAG
ATAGAGAATTCTAGCAATACTAGGCAGAGTATTTTAAGCAAAAAAAAGCCCCAAGCACCA
CAAGATGAGCCAAGAAGAGAGTAAAAAGAGCTGGATATAAGAGAATTGATGATGAAAAGA
ATGAATTAAGCAAATGTTAAAAATTGAATTATTTTTTAGCAGCTTTCATTGATTGATTAA
GAGTTAAATTATTTTAATAATATTTAAAATAAAAACATTATTAGGTAATTACATTCAAAT
TATACATTTAAAATAAATGAAAATAAATTGCTTTATACTAAATTAATTTAATTACTTATT
GTCTAAGCTTATTAATTAATAAAAATTAATATTCTTGTTGTGTT

>TTHERM_00721450(protein)
MKKNNFVLTQVEKKNVFKDQENTFKILVATDNHVGYKENDPIRGNDSFEAFEEVLKIAKS
EKVDFLLLGGDLFHETNPSQQCLYKMLNLLGNYVLGDGEILYGISNYNDVNFQDCNLNIE
LPIFVIHGNHDYPSDEYGNLSVIDLLHATKYLNHFGKFSNIEQIKVTPIIFQKGNTTVAL
YGIGYLKDKYFHKMLEEGKIEFVKPEQMGYKDTVNILVIHQNRYKGIRQGQSYRNCVHPE
QFPEWIDFIIRGHEHEQKDDIDIMKECPIATIQPGSTILTAIEDVQATPRRAILFEIKGL
EANFQDITLIQSYRPVLYEHVELTSVVKKAGFDLDNEVPADQAVEEVLWQFIQQSINNFK
IVLKENFPNSPHLFAKKPILRFKIEQSNFDVFNFQRIESKLSDLVANPGEVLKFWKRIII
NPKTIKNPKLEEDFIKTLKGKSDFDTIGNETVKDIKELYEDRIKKNKSISCLPSSLIMDT
LEKVNLRNRNSSIEDIIKNLQNKLQENVAVQEEKEIRKVNEQYRQQMNSVLQKISTNIDE
RQKDKIDLDLKNSDKIIYKTLMNNQFDDLKQSLNEKIRTKVAELFIQDFQQDGDNDIDIE
NNSDGQYKESSTNKKSLNSDQMDSEEEDNKTSKVKGRGRKRTENKSITTKKQVKDFELED
NDYENENIHDEEDENQISQQKGFKGKFKNSKLAKEKANQNLKNRQEIKVEDSSDQDEEKI
EKVNRRIKKSDNKRDFNAENEKPNMKSGFKQKMTYAQLFKKQNRMDQEEEEDYEENQQSD
EDASQQSDCEFGLNGEKQKISYNIAHISEIQKKNQSNKSLPLLQVQQKKEQSSAIKIENS
SNTRQSILSKKKPQAPQDEPRREQKELDIRELMMKRMNQANVKN