Identifiers and Description

Gene Model Identifier

TTHERM_00721830

Standard Name

HRS2 (histidyl-tRNA synthetase 2)

Aliases

PreTt18491 | 115.m00147

Description

HRS2 histidine-tRNA ligase; histidyl-tRNA synthetase family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• cytoplasm (IEA) | GO:0005737

Molecular Function

• aminoacyl-tRNA ligase activity (IEA) | GO:0004812
• ATP binding (IEA) | GO:0005524
• nucleotide binding (IEA) | GO:0000166

Biological Process

• translation (IEA) | GO:0006412
• tRNA aminoacylation for protein translation (IEA) | GO:0006418

Domains

• ( PF00587 ) tRNA synthetase class II core domain (G, H, P, S and T)
• ( PF00617 ) RasGEF domain
• ( PF03129 ) Anticodon binding domain
• ( PF06703 ) Microsomal signal peptidase 25 kDa subunit (SPC25)
• ( TIGR00442 ) histidyl-tRNA synthetase
• ( TIGR00443 ) ATP phosphoribosyltransferase, regulatory subunit
• ( TIGR01225 ) histidine ammonia-lyase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_09477.1	9.997093137033517e-262
	Description: histidyl-tRNA synthetase (933 aa)
Oxytricha	Contig9747.0.g58	9.997093137033517e-262
	Description: Histidyl-tRNA synthetase
Tetrahymena borealis	EI9_06074.1	9.997093137033517e-262
	Description: hypothetical protein (641 aa)
DictyBase	DDB_G0274159	1.9990846765523993e-155
	Description: hisS on chromosome: 2 position 4879244 to 4880801
SGD	YPR033C	1.999149254372995e-126
	Description: HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
WormBase	WBGene00002001	4.001709789838121e-126
	Description: locus:hars-1 Histidine--tRNA ligase status:Confirmed UniProt:P34183 protein_id:CAA93416.2
Stentor Coeruleus	SteCoe_32158	6.375869581278994e-59
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00721830(coding)
ATGGTGAAAATTATAGGTTTAAGAAACTTAAATAGAACTGAAATTCAAGAAGTAGTTTTT
GAAAACGAAGGTATTCAATTAGATGCTACTATTGTTAACGATTTCATATGCGAAACTAAA
GAAGCTCTTTTATCTCTTGATGAAATTAACAAAATAATTGATTTAAATTCTAGCAAATTA
TCATAGGCAATTCTCGATTTGAAGCTCGAGAAGGAAAGCAATTTTTCAAGAGGCTTCTTA
TTCATTCTTTCTTTAGCACTTACTAAGTCCAGAAAGAGCATTCGCAAGTCAACAATCGAA
TTCGTTCTTTCTACATTCAACGCATTTGTCAAGCCATCAGGTCTTTCTGTTAATCCTTAT
AACATTTTGAGAGTATTCTATGGTCAGTAAGGTATTACCGAAGCCTTAACAACTGCTGGA
ATTGCCCCAGTTTAACTTACAAAAGACGAAGTCGAACTTATTCTCTTAAGTGTTCAAAGT
ACATACGTCTCTGCTTTAACTTTATGGAATCTTTTTGGAACAAAGAATGTTTTGAAATTA
GGCAGCGTAAGTTATGCATTCTTCTGCGAAAGTGGCTATATTAACACTGAATAATTCTTA
ACTGCTTATTCAGAAAAGAGAAGCTTACAAAGAAGCATTTCTCTTCTTGCCACTGAAATT
TAAAATTTATTATTCTCCAGCAGACTATCTAAAAAGAAAGCCACTTAAGAAATCACTTCT
TGGATAGAAATTGCAGGCACTGTTAGAAATGGTTTACAATCATTACTTGATTTCTTAGTA
GACGAATTAGCAGTTGAAAGTGATGATGTTAAAATTTAATCTTCAGGAGTTACTAACCAA
ATTGAGTTAAAGAATTTCATGGGTTTGAATAACTTATTAATTTCTTTACTTGGTAGTATC
AGTCTTTAGGCTATCAACACCTTAAATAGAATAGTTTCAAATGCTGGTCTTTTGGAAAAT
AAAGTAAAAACTCTTCTCGCTGAAGTTGTTTCTTATAACTCTTCACTTAATTTCAGTTAT
TTGACTGGCAATTATAAGGCATTAGGTGAAAACTTTATCCTTGCTCTTTAATTCGATAAG
TATATTTCTTATCTTTACCAAGCTATCCAATATGAATTCTTTGTTTCTTATTACACTTTA
CACGCTCTTAACAAGCAACTAAGCGAGAACAAAAAAGGAAAGGAAGATGATAGCAAAAAG
AAGAAGAAAGAAGTTAAGCTTTTGCAATTAGGTAAGGGAACAGAAGTAGTATTCAATGAA
GTTTAAGAAAAGTTTAAAATTGCTGGTGAAGAAAAGTGCTTAGAAGTAGAAGAGAATATC
AGCTAAAACTATTTCAGCTTACACAACAACTAGCTCTTAGCTTAAATCGATGAATTAATT
GCCCCTCGTAATGAAGAAAGACGTAAGCCTAAGATTCCTAAAGGTACAAGAGATTTCAAC
CCTCTTTAAATGGCAATCAAAAGAAAGGTTTTCAAGATCATTTAAGGTATTTTACTTCAA
CACGGTGCTGTTGAAATCGATACTCCTGTTTTTGAACTTAAGGAAACCCTTACTGGTAAG
TATGGTAATGACTCTAAATTGATTTACGATCTTGACGATTAAGGTGGTGAACTCTTATCT
CTTAGATACGATCTTACCGTTCCTTTTGCCCGTTTTCTTGCTACTCAATCTCTTACAAAC
TTCAAGAGATTCCACATTGCCAAGGTCTATAGAAGAGATTAACCTAACATGACTAAGGGA
AGATATAGAGAATTCTATCAATGCGATATCGATATTGCTGGTAATTACGATCCTATGATT
CCTGATGCTGAAATTATTAAGGTCGTCAATGATATTTTATAAGCATTAGAACTCGGCTCT
CCTTTCACTATTAAAGTTAACTCTCGTAAAATTTTGGATGCCATGATTGAGATAGCTGGT
GCTCCTCATTCTAAGTTCAAAACTATTTGTTCTTCAATCGACAAGCTTGATAAGGAACCT
TGGTCAGAAGTTAGAAGAGAATTAATTGAAGACAAAGGTCTTGATGTTGTTATTGTAGAT
AAATTAGGACATTTTGTTTCTTACAAGGGCAAGCCTTTTGAGTTATTATAAAAAATCAAG
GATGACAAATTATTTGATGCTTCCGAAGCTGGTAGATAGGGAGTATAAGAAATGACTCTT
CTTTTCGATTACTTAGAAGCTATGAACTGCCTTTCTAATGTTAGCTTTGATCTCTCATTG
GCAAGAGGACTTGATTACTATACAGGTATGATTTACGAAGCTGTTCTTGAAGGTGCTAAC
ATCGGCTCTATTGGTGGTGGTGGCCGTTATGATGGCTTAGTTGGAATGTTCTCTTCCAAA
TAAATTCCTTCAGTCGGTGGTTCTGTTGGTATTGAACGTGTTTTCAATATTTTGGAAGAA
CAATATAAGAAAAAATTATCAATCAGAGCAACTGAAACAGAATTTTTAGTTTGCACTGTT
GGTAATGGCTTATGCAAAGAAAAACTTAGATTAGTAAACGAAATGTGGGCTCGTGGACTC
AAGACTGAAATTATTTACTCAGAAAAACCTAAACCTAGAAAACAATTAGATTATGCTTAT
GAAAACTAAATTCCTTTCACTATCTGGTTAGGTGAAGAAGAAATTAAGGGAGGCTTTGTC
AAGGTTAAGTGTACCTACACCAAGGTAGAAGAACCTTGTCCAAGAGATAAGCTATTTGAA
ACACTCGAACAAAAACTTGTTCAATACCATGATGATTTAATTAATGATCGTGTTGTTTAT
ACTTATGAAGAAATTAAGGAAAATTGA

>TTHERM_00721830(gene)
ATGGTGAAAATTATAGGTTTAAGAAACTTAAATAGAACTGAAATTCAAGAAGTAGTTTTT
GAAAACGAAGGTATTCAATTAGATGCTACTATTGTTAACGATTTCATATGCGAAACTAAA
GAAGCTCTTTTATCTCTTGATGAAATTAACAAAATAATTGATTTAAATTCTAGCAAATTA
TCATAGGCAATTCTCGATTTGAAGCTCGAGAAGGAAAGCAATTTTTCAAGAGGCTTCTTA
TTCATTCTTTCTTTAGCACTTACTAAGTCCAGAAAGAGCATTCGCAAGTCAACAATCGAA
TTCGTTCTTTCTACATTCAACGCATTTGTCAAGCCATCAGGTCTTTCTGTTAATCCTTAT
AACATTTTGAGAGTATTCTATGGTCAGTAAGGTATTACCGAAGCCTTAACAACTGCTGGA
ATTGCCCCAGTTTAACTTACAAAAGACGAAGTCGAACTTATTCTCTTAAGTGTTCAAAGT
ACATACGTCTCTGCTTTAACTTTATGGAATCTTTTTGGAACAAAGTAATTTTATTATCCA
GCTTTAATAATAAATGAAAAAGTATTTAAATGATGGAAACAAACTTACTTTCTAAATTTC
ATAGCAAGGCAATATTTTAGATAATTTAGTGAGATATTTAAATTATTTAATTTAATTGAA
AAATTTTTATTTCAATAATATTGCTTTATTTTTTAGAATAAAATTAAAATTATAAATATT
TTATAGAATATTCTTGTAAAAAAATTATTGTTTAAATTAAATAGGAATGTTTTGAAATTA
GGCAGCGTAAGTTATGCATTCTTCTGCGAAAGTGGCTATATTAACACTGAATAATTCTTA
ACTGCTTATTCAGAAAAGAGAAGCTTACAAAGAAGCATTTCTCTTCTTGCCACTGAAATT
TAAAATTTATTATTCTCCAGCAGACTATCTAAAAAGAAAGCCACTTAAGAAATCACTTCT
TGGATAGAAATTGCAGGCACTGTTAGAAATGGTTTACAGTAATTATAAACTAAATTTTAA
ATACTTTAATTTTAGCAAATTAATTTAGATAATTTACAAATAAACAATTTTATTATAAAA
AAATATAATAAAAATTAAGAATTTATGTCATTTAGATTAAATAATAATAATATCAGTTAT
TATTTATAATATCGCAAATATTTAGCTATAATAAATATTATTTTATTAAATCTTTAAATG
AATAATGGAGATATAAATAATATTGTAGCAAGTAGTTATTGTTGAAAAAAGGATATATCA
TTTATTTTTTAAATATTTATTTTTTTTATTAATTATTAAAAATATTTTGTTTTAACTAAT
GAATAGATCATTACTTGATTTCTTAGTAGACGAATTAGCAGTTGAAAGTGATGATGTTAA
AATTTAATCTTCAGGAGTTACTAACCAAATTGAGTTAAAGAATTTCATGGGTTTGAATAA
CTTATTAATTTCTTTACTTGGTAGTATCAGTCTTTAGGCTATCAACACCTTAAATAGAAT
AGTTTCAAATGCTGGTCTTTTGGAAAATAAAGTAAAAACTCTTCTCGCTGAAGTTGTTTC
TTATAACTCTTCACTTAATTTCAGTTATTTGACTGGCAATTATAAGGCATTAGGTGAAAA
CTTTATCCTTGCTCTTTAATTCGATAAGTATATTTCTTATCTTTACCAAGCTATCCAATA
TGAATTCTTTGTTTCTTATTACACTTTACACGCTCTTAACAAGCAACTAAGCGAGAACAA
AAAAGGAAAGGAAGATGATAGCAAAAAGAAGAAGAAAGAAGTTAAGCTTTTGCAATTAGG
TAAGGGAACAGAAGTAGTATTCAATGAAGTTTAAGAAAAGTTTAAAATTGCTGGTGAAGA
AAAGTGCTTAGAAGTAGAAGAGAATATCAGCTAAAACTATTTCAGCTTACACAACAACTA
GCTCTTAGCTTAAATCGATGAATTAATTGCCCCTCGTAATGAAGAAAGACGTAAGCCTAA
GATTCCTAAAGGTACAAGAGATTTCAACCCTCTTTAAATGGCAATCAAAAGAAAGGTTTT
CAAGATCATTTAAGGTATTTTACTTCAACACGGTGCTGTTGAAATCGATACTCCTGTTTT
TGAACTTAAGGAAACCCTTACTGGTAAGTATGGTAATGACTCTAAATTGATTTACGATCT
TGACGATTAAGGTGGTGAACTCTTATCTCTTAGATACGATCTTACCGTTCCTTTTGCCCG
TTTTCTTGCTACTCAATCTCTTACAAACTTCAAGAGATTCCACATTGCCAAGGTAATTTA
AGAATTATAAAAAGCAGCTTATTATAATATTTGATTTTTTAGGTCTATAGAAGAGATTAA
CCTAACATGACTAAGGGAAGATATAGAGAATTCTATCAATGCGATATCGATATTGCTGGT
AATTACGATCCTATGATTCCTGATGCTGAAATTATTAAGGTCGTCAATGATATTTTATAA
GCATTAGAACTCGGCTCTCCTTTCACTATTAAAGTTAACTCTCGTAAAATTTTGGATGCC
ATGATTGAGATAGCTGGTGCTCCTCATTCTAAGTTCAAAACTATTTGTTCTTCAATCGAC
AAGCTTGATAAGGTAACTAATAATATAGAATTAATGTATTTTTACTAAAATAATAATAAT
AAATAAAAAAATAGGAACCTTGGTCAGAAGTTAGAAGAGAATTAATTGAAGACAAAGGTC
TTGATGTTGTTATTGTAGATAAATTAGGACATTTTGTTTCTTACAAGGGCAAGCCTTTTG
AGTTATTATAAAAAATCAAGGATGACAAATTATTTGATGCTTCCGAAGCTGGTAGATAGG
GAGTATAAGAAATGACTCTTCTTTTCGATTACTTAGAAGCTATGAACTGCCTTTCTAATG
TTAGCTTTGATCTCTCATTGGCAAGAGGACTTGATTACTATACAGGTAAAAAAGCAAATA
AATTTAGTTAAATATCTAAAATATATTTATTTATTTATTAGGTATGATTTACGAAGCTGT
TCTTGAAGGTGCTAACATCGGCTCTATTGGTGGTGGTGGCCGTTATGATGGCTTAGTTGG
AATGTTCTCTTCCAAATAAATTCCTTCAGTCGGTGGTTCTGTTGGTATTGAACGTGTTTT
CAATATTTTGGAAGAACAATATAAGAAAAAATTATCAATCAGAGCAACTGAAACAGAATT
TTTAGTTTGCACTGTTGGTAATGGCTTATGCAAAGAAAAACTTAGATTAGTAAACGAAAT
GTGGGCTCGTGGACTCAAGACTGAAATTATTTACTCAGAAAAACCTAAACCTAGAAAACA
ATTAGATTATGCTTATGAAAACTAAATTCCTTTCACTATCTGGTTAGGTGAAGAAGAAAT
TAAGGGAGGCTTTGTCAAGGTTAAGGTAAAACCTATCACCTTTTTTTAAATTATTTTTTT
GATTAAATAAAGCTTTTTTTATTTTAAAAATAATTATTCTAATTTTTATTTTTAATATTA
AATAGTGTACCTACACCAAGGTAGAAGAACCTTGTCCAAGAGATAAGCTATTTGAAACAC
TCGAACAAAAACTTGTTCAATACCATGATGATTTAATTAATGATCGTGTTGTTTATACTT
ATGAAGAAATTAAGGAAAATTGA

>TTHERM_00721830(protein)
MVKIIGLRNLNRTEIQEVVFENEGIQLDATIVNDFICETKEALLSLDEINKIIDLNSSKL
SQAILDLKLEKESNFSRGFLFILSLALTKSRKSIRKSTIEFVLSTFNAFVKPSGLSVNPY
NILRVFYGQQGITEALTTAGIAPVQLTKDEVELILLSVQSTYVSALTLWNLFGTKNVLKL
GSVSYAFFCESGYINTEQFLTAYSEKRSLQRSISLLATEIQNLLFSSRLSKKKATQEITS
WIEIAGTVRNGLQSLLDFLVDELAVESDDVKIQSSGVTNQIELKNFMGLNNLLISLLGSI
SLQAINTLNRIVSNAGLLENKVKTLLAEVVSYNSSLNFSYLTGNYKALGENFILALQFDK
YISYLYQAIQYEFFVSYYTLHALNKQLSENKKGKEDDSKKKKKEVKLLQLGKGTEVVFNE
VQEKFKIAGEEKCLEVEENISQNYFSLHNNQLLAQIDELIAPRNEERRKPKIPKGTRDFN
PLQMAIKRKVFKIIQGILLQHGAVEIDTPVFELKETLTGKYGNDSKLIYDLDDQGGELLS
LRYDLTVPFARFLATQSLTNFKRFHIAKVYRRDQPNMTKGRYREFYQCDIDIAGNYDPMI
PDAEIIKVVNDILQALELGSPFTIKVNSRKILDAMIEIAGAPHSKFKTICSSIDKLDKEP
WSEVRRELIEDKGLDVVIVDKLGHFVSYKGKPFELLQKIKDDKLFDASEAGRQGVQEMTL
LFDYLEAMNCLSNVSFDLSLARGLDYYTGMIYEAVLEGANIGSIGGGGRYDGLVGMFSSK
QIPSVGGSVGIERVFNILEEQYKKKLSIRATETEFLVCTVGNGLCKEKLRLVNEMWARGL
KTEIIYSEKPKPRKQLDYAYENQIPFTIWLGEEEIKGGFVKVKCTYTKVEEPCPRDKLFE
TLEQKLVQYHDDLINDRVVYTYEEIKEN