Identifiers and Description

Gene Model Identifier

TTHERM_00758970

Standard Name

TTLL4A (Tubulin Tyrosine Ligase-Like )

Aliases

PreTt08194 | 124.m00112 | 3821.m00527

Description

TTLL4A tubulin tyrosine ligase family protein; Related to tubulin polyglutamylase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• acid-amino acid ligase activity (ISS) | GO:0016881
• tubulin-tyrosine ligase activity (IEA) | GO:0004835

Biological Process

• cellular protein modification process (IEA) | GO:0006464
• protein polyglutamylation (ISS) | GO:0018095

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_20876.1	9.997093137033517e-262
	Description: tubulin-tyrosine ligase (1079 aa)
WormBase	WBGene00001328	9.997093137033517e-262
	Description: locus:epi-1 status:Partially_confirmed UniProt:C1P640 protein_id:CAX65067.1
Oxytricha	Contig1070.1.g45	2.000319284850678e-127
	Description: Tubulin-tyrosine ligase family
WormBase	WBGene00014232	3.9989468726312675e-65
	Description: locus:ttll-4 Tubulin polyglutamylase ttll-4 status:Partially_confirmed UniProt:Q09647 protein_id:CAA87425.3
WormBase	WBGene00004880	3.9989468726312675e-65
	Description: locus:smg-2 Regulator of nonsense transcripts 1 status:Confirmed UniProt:O76512 protein_id:CCD73461.1
Stentor Coeruleus	SteCoe_5424	2.8946403116483003e-63
	Description: None
DictyBase	DDB_G0281541	8.99682777598231e-22
	Description: DDB_G0281541 on chromosome: 3 position 4627625 to 4629265

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15890843: Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B (2005) Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science (New York, N.Y.) 308(5729):1758-62

Sequences

>TTHERM_00758970(coding)
ATGAGAGCACAATCAATGAATATCTAATTTACTAATGAATCTAGACAGTTTTAAACGCAA
AGCAAGCAGCAAAGATATATTTAGGAAGACAAAAGCTAATAGAATATAATCAAAAAATAC
CCGAATTATGCCTATGCTTTAACTACCGAAAATTCATATGTTTAATCAACTGCAAATAAT
CGATTTGGCTAAGGACTGATAGCACTTAAAAACAAAAGTGCTAATAACAAAAGACCTTTT
TAGCCTGCTCAAAAGATGATAAGCAGTAATGGGTTTATCCATCAAGATATGCCGCAGCTT
AGCGGGTCATTTTCACCAATGATCTTTGATACAAATCAAAGGATATTATAGAAACAACAA
AAATATCTGGAATCAATGCAAGCAAATAGCAACATAATAATTAATAAAGGAAAAATATAA
CAAAATAATAGAACTATTATGCCAGCAGGTACTTTTTATAGTAGATAGAACTAAGTTCCT
TCTCCACTATAAAAGAAGTTGAGTATTTACAATGAAAATTCTCTTTAGAGCGATAACCAA
ACTCAAGGAAATGAAATGAAGAGCTAGAATTCAAATAATATCAATGAGTACACTCAAGGA
AAGAATATAGAAAATAATAACAATTATTAAAAGTTGAGAGATGTCATCCAGTATGATAAA
CTGGAAAAATTAGGAACTAGTGTGATAGATGCAAGTTTAAGAAAGCAGCAACAAGATAAA
AAAAAGCAGTTAGAGTAGTTTCCAATGAGCAGCAATACCAACAAAGGAAAAGATGGTTCT
TAGAATAATTAAATATCGATATTCACTCAAAGCAGGATTAACACAAGTAATTAAATTGAG
AATATTTACCCAGAAGAAGAAGAGTGGGACATGATTTAGCTAAGATAAATTGGATAGACA
ACAAACCAGCAAGAACAGTAGAACCAAGCTGATTAGAAAAATGAGCAAAATTTATTAAGA
TAGTCTTCTCTTGATTTAGCTGAAAGTAATAGGAAATAAGGATATAATTCAATGGTAAAA
AGCAACATTATACAATCAAATCAAAATAATTAGAGATTTTAGCTAAATTCGCCTTCACCA
GTCTAATAAAAGGCTTTTCTTTCTCCATAAAGAAACGATGATAAATTAGCAAAGTCGATT
CAGCATAATTAGTAATTAACTTAAAGTTAAAAGAGTGCTATGGTAAAGCGCTCGTACTCA
GCAGTAAAAAATTCTACATAAATTAAAAAAGATGATATCGTGAACAACAATAGTAAGAAA
ATAAATCCAAATGATTTAATGATATTGAAAATAAAGGAGCAATGCACTTATAAAAAGTAT
ATAGATCCAATCAGAATTAAGAAGGAAAAGGCTAAACTCAAGTAATAAAGCGAAGTAAAA
AACAGAAAAATTAACTTTACAAGCACTATCACAGCAGGGTACCATTTAAAATCAACTTAA
GAGGCCTAACCTAAAATGAAATCTCTTAAGGATAGCATGGTCCCTGATGACTAGCTTAGC
AATAATCTTGATATACCTGCAGCAAGATAGTATGAAGAAGAAGATGATGACGATGATGAT
TCAATGATTATGAGCAATAATGATATCTCTTTAGATTTAGACGATGACGAAGACGAAAGT
AAGTAAATTTCCTCTCCTCTTGGAGGACTTGCTAGCACATAAGATTCTATCTAAAATAAT
AACTCATAAAAATCAAAAGTTAGCTTATTAAAATCTGTTTATTAAGGTCGTCCAGCAACT
ATTTTCTTTCCATACCACAAATCTTGTTAGCAGCCTTAGCCCAGAGACACTTCTCGTGCG
ATATAAATTTCAGATTTTGAGACAAAAAAATTCAATCTCAAATACAAAATTAATGGAGAG
AATCCATACAAATGTGTTGTTAAAGCATTTGAAGAGGCTGGGTTTGAAATGACAGAGGAA
AATGATTGGAATTGTGTGTGGTCATTGCCAAAAAAAGACAGAGTGAAATTTATGAACTAG
TTTTAGAAATAAAACCACTTTCCTGGTTGCTGGAATTTAGGAAGAAAAGATTTTATGTGG
AGATGCCTGAATAGAGTTAAGAGAAAATGCCCTAAGGAAATGGATTTTGTGCCTAACACA
TATTTATTATGTAACTCAGGAGATTGGGATAGATTTTTAGCTAGGAGAGATGAAGCAAGT
AAAAATACTTTGTGGATTTTAAAACCAGCTGATTAAGCATGTGGAAGAGGAGTTAAAGTA
ATCAGCAAAACGACTAAAGTTAAAAGGAAATCTAACAGAATTATATGTGATTACATAGCT
AACCCTCATCTCATTAATGGATTGAAATACGATTTACGTTTATATGTTCTAGTAACTAGT
TATGATCCTCTTAGGATTTATCTATACGAAGAAGGATTGACCCGTTTTGCTACAGAAAAA
TATAACACAAACACCAAAGAAATAAGTAAGAGGTTTGTCCATCTAACAAACTATAGTGTT
AATAAGCATGCTAAGAAGTTTGTCAAGAATACAAATCCAGAAGCAGATGGAGAGGGATCC
AAGTGGTCTTTGACAGCTTTAAAAGCAAAATATAAACAAATGGGAATAAACGTTGACGAA
TTATTTGGAAGAATTAAGGATATAATAATAAAAACATGTATTTCTGCAGAACCATAAATG
CTAGATATAGTAGCTAAATCTCAAGAACACAGAACTAATTGCTTTGAACTTTATGGGTTT
GACATATTAATTGATTCTTCTCTCAAACCTTGGATTTTAGAGGTAAATGTCTGCCCTTCT
TTAAGCTCTTCAAGTCCTTTAGATCGTAAGATTAAGCACTCATTGTTGGTTGATGTGTTA
AATATTATTGGCATTACACCATATGATAAAAAGTAATTCACAGAAGATAAAAAGAATAAT
CTTTTTACTCGAGCATTTAACTCAATATCTTCTACAATGCTTGACTGTAATGACTCCGAG
AAGGTCTCAAACGGCAAGAAGAATTTTAGTAAAAATATAAATGATATTTAAGATCTTACC
TATGAAAATTGCCTAGAAAAGCTTTCTCCTGAGAATTGGGAAGTATTATTTGAAACAGAT
GAAGAATTATACCGCAGAGGGCATTTTGAGAGAATTTATCCCCTACCTTCTAAAGAAAAG
CTTGATTATTATTCTCAATTTTTTGACTTCTAAAGATTTAATAATGTGATGGTGCAAAAA
TGGATTACTTCAAAATAAAATTTTCTAGAAAAAATACTTAAAAAAAAATATTAAACCGTT
GTTTGA

>TTHERM_00758970(gene)
ATGAGAGCACAATCAATGAATATCTAATTTACTAATGAATCTAGACAGTTTTAAACGCAA
AGCAAGCAGCAAAGATATATTTAGGAAGACAAAAGCTAATAGAATATAATCAAAAAATAC
CCGAATTATGCCTATGCTTTAACTACCGAAAATTCATATGTTTAATCAACTGCAAATAAT
CGATTTGGCTAAGGACTGATAGCACTTAAAAACAAAAGTGCTAATAACAAAAGACCTTTT
TAGCCTGCTCAAAAGATGATAAGCAGTAATGGGTTTATCCATCAAGATATGCCGCAGCTT
AGCGGGTCATTTTCACCAATGATCTTTGATACAAATCAAAGGATATTATAGAAACAACAA
AAATATCTGGAATCAATGCAAGCAAATAGCAACATAATAATTAATAAAGGAAAAATATAA
CAAAATAATAGAACTATTATGCCAGCAGGTACTTTTTATAGTAGATAGAACTAAGTTCCT
TCTCCACTATAAAAGAAGTTGAGTATTTACAATGAAAATTCTCTTTAGAGCGATAACCAA
ACTCAAGGAAATGAAATGAAGAGCTAGAATTCAAATAATATCAATGAGTACACTCAAGGA
AAGAATATAGAAAATAATAACAATTATTAAAAGTTGAGAGATGTCATCCAGTATGATAAA
CTGGAAAAATTAGGAACTAGTGTGATAGATGCAAGTTTAAGAAAGCAGCAACAAGATAAA
AAAAAGCAGTTAGAGTAGTTTCCAATGAGCAGCAATACCAACAAAGGAAAAGATGGTTCT
TAGAATAATTAAATATCGATATTCACTCAAAGCAGGATTAACACAAGTAATTAAATTGAG
AATATTTACCCAGAAGAAGAAGAGTGGGACATGATTTAGCTAAGATAAATTGGATAGACA
ACAAACCAGCAAGAACAGTAGAACCAAGCTGATTAGAAAAATGAGCAAAATTTATTAAGA
TAGTCTTCTCTTGATTTAGCTGAAAGTAATAGGAAATAAGGTATTACTTTTATTAGCAAA
ATATTAAATTTGATCATCTTAATTTTTATTAAATATTATTAAAGGATATAATTCAATGGT
AAAAAGCAACATTATACAATCAAATCAAAATAATTAGAGATTTTAGCTAAATTCGCCTTC
ACCAGTCTAATAAAAGGCTTTTCTTTCTCCATAAAGAAACGATGATAAATTAGCAAAGTC
GATTCAGCATAATTAGTAATTAACTTAAAGTTAAAAGAGTGCTATGGTAAAGCGCTCGTA
CTCAGCAGTAAAAAATTCTACATAAATTAAAAAAGATGATATCGTGAACAACAATAGTAA
GAAAATAAATCCAAATGATTTAATGATATTGAAAATAAAGGAGCAATGCACTTATAAAAA
GTATATAGATCCAATCAGAATTAAGAAGGAAAAGGCTAAACTCAAGTAATAAAGCGAAGT
AAAAAACAGAAAAATTAACTTTACAAGCACTATCACAGCAGGGTACCATTTAAAATCAAC
TTAAGAGGCCTAACCTAAAATGAAATCTCTTAAGGATAGCATGGTCCCTGATGACTAGCT
TAGCAATAATCTTGATATACCTGCAGCAAGATAGTATGAAGAAGAAGATGATGACGATGA
TGATTCAATGATTATGAGCAATAATGATATCTCTTTAGATTTAGACGATGACGAAGACGA
AAGTAAGTAAATTTCCTCTCCTCTTGGAGGACTTGCTAGCACATAAGATTCTATCTAAAA
TAATAACTCATAAAAATCAAAAGTTAGCTTATTAAAATCTGTTTATTAAGGTCGTCCAGC
AACTATTTTCTTTCCATACCACAAATCTTGTTAGCAGCCTTAGCCCAGAGACACTTCTCG
TGCGATATAAATTTCAGATTTTGAGACAAAAAAATTCAATCTCAAATACAAAGTAAAAAA
AAATTATTTAAAATTATAAAAAAATATTTTTGCTTTTTATCAAAGCAGTAAAAATGTAAC
CAGCAAAAATAAATCTAGTTCATTCTAAATTTCTACCAAAAATTAAATACATTTTTAAAA
TTATTTAAATGTATTTTATCATGCATGAAAAATAATAAGTCTTTATTTAAATAAATAGAT
TAATGGAGAGAATCCATACAAATGTGTTGTTAAAGCATTTGAAGAGGCTGGGTTTGAAAT
GACAGAGGAAAATGATTGGAATTGTGTGTGGTCATTGCCAAAAAAAGACAGAGTGAAATT
TATGAACTAGTTTTAGAAATAAAACCACTTTCCTGGTTGCTGGAATTTAGGAAGAAAAGA
TTTTATGTGGAGATGCCTGAATAGAGTTAAGAGAAAATGCCCTAAGGAAATGGATTTTGT
GCCTAACACATATTTATTATGTAACTCAGGAGATTGGGATAGATTTTTAGCTAGGAGAGA
TGAAGCAAGTAAAAATACTTTGTGGATTTTAAAACCAGCTGATTAAGCATGTGGAAGAGG
AGTTAAAGTAATCAGCAAAACGACTAAAGTTAAAAGGAAATCTAACAGAATTATATGTGA
TTACATAGCTAACCCTCATCTCATTAATGGATTGAAATACGATTTACGTTTATATGTTCT
AGTAACTAGTTATGATCCTCTTAGGATTTATCTATACGAAGAAGGATTGACCCGTTTTGC
TACAGAAAAATATAACACAAACACCAAAGAAATAAGTAAGAGGTTTGTCCATCTAACAAA
CTATAGTGTTAATAAGCATGCTAAGAAGTTTGTCAAGAATACAAATCCAGAAGCAGATGG
AGAGGGATCCAAGTGGTCTTTGACAGCTTTAAAAGCAAAATATAAACAAATGGGAATAAA
CGTTGACGAATTATTTGGAAGAATTAAGGATATAATAATAAAAACATGTATTTCTGCAGA
ACCATAAATGCTAGATATAGTAGCTAAATCTCAAGAACACAGAACTAATTGCTTTGAACT
TTATGGGTTTGACATATTAATTGATTCTTCTCTCAAACCTTGGATTTTAGAGGTAAATGT
CTGCCCTTCTTTAAGCTCTTCAAGTCCTTTAGATCGTAAGATTAAGCACTCATTGTTGGT
TGATGTGTTAAATATTATTGGCATTACACCATATGATAAAAAGTAATTCACAGAAGATAA
AAAGAATAATCTTTTTACTCGAGCATTTAACTCAATATCTTCTACAATGCTTGACTGTAA
TGACTCCGAGAAGGTCTCAAACGGCAAGAAGAATTTTAGTAAAAATATAAATGATATTTA
AGATCTTACCTATGAAAATTGCCTAGAAAAGCTTTCTCCTGAGAATTGGGAAGTATTATT
TGAAACAGATGAAGAATTATACCGCAGAGGGCATTTTGAGAGAATTTATCCCCTACCTTC
TAAAGAAAAGCTTGATTATTATTCTCAATTTTTTGACTTCTAAAGATTTAATAATGTGAT
GGTGCAAAAATGGATTACTTCAAAATAAAATTTTCTAGAAAAAATACTTAAAAAAAAATA
TTAAACCGTTGTTTGA

>TTHERM_00758970(protein)
MRAQSMNIQFTNESRQFQTQSKQQRYIQEDKSQQNIIKKYPNYAYALTTENSYVQSTANN
RFGQGLIALKNKSANNKRPFQPAQKMISSNGFIHQDMPQLSGSFSPMIFDTNQRILQKQQ
KYLESMQANSNIIINKGKIQQNNRTIMPAGTFYSRQNQVPSPLQKKLSIYNENSLQSDNQ
TQGNEMKSQNSNNINEYTQGKNIENNNNYQKLRDVIQYDKLEKLGTSVIDASLRKQQQDK
KKQLEQFPMSSNTNKGKDGSQNNQISIFTQSRINTSNQIENIYPEEEEWDMIQLRQIGQT
TNQQEQQNQADQKNEQNLLRQSSLDLAESNRKQGYNSMVKSNIIQSNQNNQRFQLNSPSP
VQQKAFLSPQRNDDKLAKSIQHNQQLTQSQKSAMVKRSYSAVKNSTQIKKDDIVNNNSKK
INPNDLMILKIKEQCTYKKYIDPIRIKKEKAKLKQQSEVKNRKINFTSTITAGYHLKSTQ
EAQPKMKSLKDSMVPDDQLSNNLDIPAARQYEEEDDDDDDSMIMSNNDISLDLDDDEDES
KQISSPLGGLASTQDSIQNNNSQKSKVSLLKSVYQGRPATIFFPYHKSCQQPQPRDTSRA
IQISDFETKKFNLKYKINGENPYKCVVKAFEEAGFEMTEENDWNCVWSLPKKDRVKFMNQ
FQKQNHFPGCWNLGRKDFMWRCLNRVKRKCPKEMDFVPNTYLLCNSGDWDRFLARRDEAS
KNTLWILKPADQACGRGVKVISKTTKVKRKSNRIICDYIANPHLINGLKYDLRLYVLVTS
YDPLRIYLYEEGLTRFATEKYNTNTKEISKRFVHLTNYSVNKHAKKFVKNTNPEADGEGS
KWSLTALKAKYKQMGINVDELFGRIKDIIIKTCISAEPQMLDIVAKSQEHRTNCFELYGF
DILIDSSLKPWILEVNVCPSLSSSSPLDRKIKHSLLVDVLNIIGITPYDKKQFTEDKKNN
LFTRAFNSISSTMLDCNDSEKVSNGKKNFSKNINDIQDLTYENCLEKLSPENWEVLFETD
EELYRRGHFERIYPLPSKEKLDYYSQFFDFQRFNNVMVQKWITSKQNFLEKILKKKYQTV
V