Identifiers and Description

Gene Model Identifier

TTHERM_00790530

Standard Name

BRE1 (E3 ubiquitin ligase BRE1)

Aliases

PreTt01343 | 133.m00068

Description

BRE1 zinc finger C3HC4 type (RING finger) protein; E3 ubiquitin ligase; required for H2B ubiquitylation

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• protein binding (IEA) | GO:0005515
• zinc ion binding (IEA) | GO:0008270

Biological Process

• obsolete histone ubiquitination (IDA) | GO:0016574

Domains

• ( PF00097 ) Zinc finger, C3HC4 type (RING finger)
• ( PF00435 ) Spectrin repeat
• ( PF00904 ) Involucrin repeat
• ( PF02370 ) M protein repeat
• ( PF05227 ) CHASE3 domain
• ( PF05911 ) Filament-like plant protein, long coiled-coil
• ( PF06009 ) Laminin Domain II
• ( PF08252 ) arg-2/CPA1 leader peptide
• ( PF08946 ) Osmosensory transporter coiled coil
• ( PF09006 ) Lung surfactant protein D coiled-coil trimerisation
• ( TIGR02641 ) gas vesicle protein GvpC repeat

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

• ( SD02309 ) Micronucleus: BRE1 homozygous for neo2 KO
• ( SD02788 ) Micronucleus: BRE1 homozygous for neo2 KO

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_05583.1	9.997093137033517e-262
	Description: zinc finger protein (1066 aa)
SGD	YDL074C	0.0000000000008001317446409227
	Description: BRE1 E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
WormBase	WBGene00007008	0.00000000019994075865167896
	Description: locus:rfp-1 E3 ubiquitin-protein ligase bre-1 status:Confirmed UniProt:P34537 protein_id:CCD73191.1
WormBase	WBGene00002203	0.00000000019994075865167896
	Description: locus:kin-20 Casein kinase I isoform delta status:Confirmed UniProt:Q20471 protein_id:CAD56585.4
DictyBase	DDB_G0274241	0.0000000010002658722841845
	Description: bre1 on chromosome: 2 position 4227111 to 4230916
Oxytricha	Contig22668.0.g8	0.0000009995106777214876
	Description: Zinc finger, C3HC4 type (RING finger)
Stentor Coeruleus	SteCoe_32891	0.00001670170079024566
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:19822522: Wang Z, Cui B, Gorovsky MA (2009) Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena. The Journal of biological chemistry 284(50):34870-9

Sequences

>TTHERM_00790530(coding)
ATGGAAAAGACTACAAAAGACGCTTTATCTTAGATTCCTAACAGTTAGACTAATAGTAGT
ACCACAGCAATAGGTGGTAATTCCGCTTCAAATGCAAATAATACAAACGCTGTTAGCAAA
TAGAGAGCATAGACTAATGCAGCTGCATTGCAAGATTTATAAAAGATAACAAAACAAAGA
GTGGAGAACTTTTTAAAGAATTTTGAAAATATCTATGCAGATGTTGCAATTGATTGTGCG
ACTTACGGTTAGAGGATGAATGATGCTGTGAAAAGTTTAGCTCAAAACAACGATGCAAAC
GAAACTATGCGTAGACTCTACAGAGAAAATAGCTAGCTGCAAACTAAGATAAAGGAATAG
GAATCTTACCTTTCTAAATCAGTACCCTTGGCAGATACAGAAAAGGATTTTATTATGAAC
TATTTTGGGAATCAAAGCAAGCAATACGAAGAGCTTCTTTAAAAGTACAATGAAGAAAGA
GAAATATCAGAGCGACTTTCACTTAGAATTCGTCAAAAAATGGACTACTGTGTCACATCA
ATTACAGCCAAAGTAGGACAAGATCCGAATCAGATTTTACAAAAAATAATTTAAAATAAT
GCAAATTCTGTTCTAGGTATTAATACGAATAATGCTGCTTCTATGAGTGGCAAAGAGAAT
CAAAATTAACCTAATTTGCTGTCAAGTCAGTCAAGCTAGAATCTCATTGTTTAATAACAG
CAGAATTAAATGGAAATTGAGGATCAGACTTCAAACGCTAATAATAATAATTCTTAGCAG
GAAAATAGATAAGAAGAGAAGGAAGGATATGAATGTATTTGTGGAGGCTATTAAACTGAA
TACTTTAGTTAAAAATATGAAGAAACCTTAAAGTAATTATTGGATACTCAATAAAAGCTA
ATAGCAACTTAAACAATAATCAATACATCTCCTTCATCTGTCATATCAACAGCTTTTACC
TAGCCAGTTGTTGTTCAAAACAGTTAAAATGGGAACAGCATGAGCACAAGCACAGTTAAT
GGGCTATAAACTACTTAGAGTTTGTAATAGCAGCAGCAATAATAATAAGAGCAGTCAACT
GGAAATTAAAATGGGTAATCAAATCAATAAACCAATGCAAGTGTGGATGCTGTAGCTAAC
AGTGATGGGAATAAGAATAATTGCTAAAACTTAGAATTAAATGGATCTGCAAGTGTTGGA
AGCAGCATACCTTGTTTGAAGAAATCGGAATCAATACAAATATAACAATAGCTGCTTTCT
CAACCTGCCTTGCTTACTTAAGTCAGCACTAATATCTAAGATGAGTTGTGTGATGGCAAG
TTGAGATTACCTATAACAGAGAAGCTGTAAATCTTATAGAAGCGTAATGAACAGCTAGTT
TAAGAGAAATCTGAATTAGAAAAGTATATGAGAGAAAGAGAAATCGACTTAAAAAACATG
GAAGATAAGTTCTTTAGATCAGGTGCTTACTAGTCACTTGCAACTCAGACAGAGGAGTTA
CTAAAGATTACAATTTAAATGAGAAGCTAACTGAAAGAAGCAAAATAATAGATAAGTGAC
ATCGAAAAACAACGTTTCAGAGAAATGTAGGAAGTGCTTACAAAATTCAAGGATGAAAAG
GAGACACTTTTGAAATAACTACACGAAGCTAGAGAGGGTGTTTACAAAACTTAGTTAGGA
GATGCTATGAGAGAGAATCTAACTTAGCACTTTAACTATAAAAAGTACACCTAGCCTTTG
GAAGATTAATTAGAGAAGGCAAGTGAAATTCTTACAATTGAAAGAGAACACAATAGAGAT
TTAGAGTAAAAAAAATAACAGCTAAATGAATAAATAATTCAATTATAAAAGCAGAATAGC
GATTTGCAAGCAAAGCTAAATGAAAAAGAACAACAAATAAATTACCTGCAAAGCCAAATG
GGCTTCACTGGCGAGAGCTATGTTGAAGATAAAATTTTTAAATATTAGAACCATAAAGAT
ACTTTAAAGCTTTTGGAAAAAGTAATGAACGATATGTGCAGTGCTGGTTAAATCAATTAA
GAATAAATTAAAAAATTCAGAGACCTTATCGAATATATAAGAAACAGAGAAGAGAAAATT
GTTTAACTGCAAAAGGTAAAGTAACAAAATGATATAGAAAAGAAAAAGTTATAATAAAAT
TAAGATGAAATATGGAAAGAATATGAAAATCTAGATAAGTCTTTTAGCTAGATGAAAGCA
AGATGTGATCAAGTTAACCAAGAATTAAAGTTAATTTAGGAAAGAGAACAAGGACTGGAA
TATAAAAATCTCGAAATCTAAATGCAGTTCTAAAAGGAAAAGCAGTCTTACTCAATCTTG
GTGGCAGCTGATCAGCAAAAAAAGGATAATACTAAAAACTTAATCGATAATCTTGAAGAT
TAAAACAAATAATTATTGTAATAAAACAGTAATCTATCATCAACTATTGAAGAAGTCAAC
TAGCAAAAGCAGCTTATCCAATAACAACTCGAAGAAAATACAGTGCTGTTGCTCGATACA
TAATAAAAGTTTGATCTTCTAAATAAAAAGTTTGGTGATATTAACGAAAAATATAACGAA
CTTATAGCAAACCATGAAAAAATCCAATAAAAATTGCAAACTGCTTACGAAGTCTTAGAC
AACAGCGAGTCTAAAAACACTTCTGCAGAAGTAGCACAACTAAAAGAAAAAATATAAAAT
ATGCGTCTATTGCTCTAATGCAGTTGCGGATAAAACTTCAAAGACACTATCTTATAAAAA
TGCTTGCATCCCTTTTGCAGAGAGTGCATTGATAAATAAATACGTCTTCGTTAGAGAACT
TGCCCAAAGTGCCGTACAGCCTTTGGTCAAAACGACGTTAAAACGTTATATCTAAGTCAT
TGA

>TTHERM_00790530(gene)
ATGGAAAAGACTACAAAAGACGCTTTATCTTAGATTCCTAACAGTTAGACTAATAGTAGT
ACCACAGCAATAGGTGGTAATTCCGCTTCAAATGCAAATAATACAAACGCTGTTAGCAAA
TAGAGAGCATAGACTAATGCAGCTGCATTGCAAGATTTATAAAAGATAACAAAACAAAGA
GTGGAGAACTTTTTAAAGAATTTTGAAAATATCTATGCAGATGTTGCAATTGATTGTGCG
ACTTACGGTTAGAGGATGAATGATGCTGTGAAAAGTTTAGCTCAAAACAACGATGCAAAC
GAAACTATGCGTAGACTCTACAGAGAAAATAGCTAGCTGCAAACTAAGATAAAGGAATAG
GAATCTTACCTTTCTAAATCAGTACCCTTGGCAGATACAGAAAAGGATTTTATTATGAAC
TATTTTGGGAATCAAAGCAAGCAATACGAAGAGCTTCTTTAAAAGTACAATGAAGAAAGA
GAAATATCAGAGCGACTTTCACTTAGAATTCGTCAAAAAATGGACTACTGTGTCACATCA
ATTACAGCCAAAGTAGGACAAGATCCGAATCAGATTTTACAAAAAATAATTTAAAATAAT
GCAAATTCTGTTCTAGGTATTAATACGAATAATGCTGCTTCTATGAGTGGCAAAGAGAAT
CAAAATTAACCTAATTTGCTGTCAAGTCAGTCAAGCTAGAATCTCATTGTTTAATAACAG
CAGAATTAAATGGAAATTGAGGATCAGACTTCAAACGCTAATAATAATAATTCTTAGCAG
GAAAATAGATAAGAAGAGAAGGAAGGATATGAATGTATTTGTGGAGGCTATTAAACTGAA
TACTTTAGTTAAAAATATGAAGAAACCTTAAAGTAATTATTGGATACTCAATAAAAGCTA
ATAGCAACTTAAACAATAATCAATACATCTCCTTCATCTGTCATATCAACAGCTTTTACC
TAGCCAGTTGTTGTTCAAAACAGTTAAAATGGGAACAGCATGAGCACAAGCACAGTTAAT
GGGCTATAAACTACTTAGAGTTTGTAATAGCAGCAGCAATAATAATAAGAGCAGTCAACT
GGAAATTAAAATGGGTAATCAAATCAATAAACCAATGCAAGTGTGGATGCTGTAGCTAAC
AGTGATGGGAATAAGAATAATTGCTAAAACTTAGAATTAAATGGATCTGCAAGTGTTGGA
AGCAGCATACCTTGTTTGAAGAAATCGGAATCAATACAAATATAACAATAGCTGCTTTCT
CAACCTGCCTTGCTTACTTAAGTCAGCACTAATATCTAAGATGAGTTGTGTGATGGCAAG
TTGAGATTACCTATAACAGAGAAGCTGTAAATCTTATAGAAGCGTAATGAACAGCTAGTT
TAAGAGAAATCTGAATTAGAAAAGTATATGAGAGAAAGAGAAATCGACTTAAAAAACATG
GAAGATAAGTTCTTTAGATCAGGTGCTTACTAGTCACTTGCAACTCAGACAGAGGAGTTA
CTAAAGATTACAATTTAAATGAGAAGCTAACTGAAAGAAGCAAAATAATAGATAAGTGAC
ATCGAAAAACAACGTTTCAGAGAAATGTAGGAAGTGCTTACAAAATTCAAGGATGAAAAG
GAGACACTTTTGAAATAACTACACGAAGCTAGAGAGGGTGTTTACAAAACTTAGTTAGGA
GATGCTATGAGAGAGAATCTAACTTAGCACTTTAACTATAAAAAGTACACCTAGCCTTTG
GAAGATTAATTAGAGAAGGCAAGTGAAATTCTTACAATTGAAAGAGAACACAATAGAGAT
TTAGAGTAAAAAAAATAACAGCTAAATGAATAAATAATTCAATTATAAAAGCAGAATAGC
GATTTGCAAGCAAAGCTAAATGAAAAAGAACAACAAATAAATTACCTGCAAAGCCAAATG
GGCTTCACTGGCGAGAGCTATGTTGAAGATAAAATTTTTAAATATTAGAACCATAAAGAT
ACTTTAAAGCTTTTGGAAAAAGTAATGAACGATATGTGCAGTGCTGGTTAAATCAATTAA
GAATAAATTAAAAAATTCAGAGACCTTATCGAATATATAAGAAACAGAGAAGAGAAAATT
GTTTAACTGCAAAAGGTAAAGTAACAAAATGATATAGAAAAGAAAAAGTTATAATAAAAT
TAAGATGAAATATGGAAAGAATATGAAAATCTAGATAAGTCTTTTAGCTAGATGAAAGCA
AGATGTGATCAAGTTAACCAAGAATTAAAGTTAATTTAGGAAAGAGAACAAGGACTGGAA
TATAAAAATCTCGAAATCTAAATGCAGTTCTAAAAGGAAAAGCAGTCTTACTCAATCTTG
GTGGCAGCTGATCAGCAAAAAAAGGATAATACTAAAAACTTAATCGATAATCTTGAAGAT
TAAAACAAATAATTATTGTAATAAAACAGTAATCTATCATCAACTATTGAAGAAGTCAAC
TAGCAAAAGCAGCTTATCCAATAACAACTCGAAGAAAATACAGTGCTGTTGCTCGATACA
TAATAAAAGTTTGATCTTCTAAATAAAAAGTTTGGTGATATTAACGAAAAATATAACGAA
CTTATAGCAAACCATGAAAAAATCCAATAAAAATTGCAAACTGCTTACGAAGTCTTAGAC
AACAGCGAGTCTAAAAACACTTCTGCAGAAGTAGCACAACTAAAAGAAAAAATATAAAAT
ATGCGTCTATTGCTCTAATGCAGTTGCGGATAAAACTTCAAAGACACTATCTTATAAAAA
TGCTTGCATCCCTTTTGCAGAGAGTGCATTGATAAATAAATACGTCTTCGTTAGAGAACT
TGCCCAAAGTGCCGTACAGCCTTTGGTCAAAACGACGTTAAAACGTTATATCTAAGTCAT
TGA

>TTHERM_00790530(protein)
MEKTTKDALSQIPNSQTNSSTTAIGGNSASNANNTNAVSKQRAQTNAAALQDLQKITKQR
VENFLKNFENIYADVAIDCATYGQRMNDAVKSLAQNNDANETMRRLYRENSQLQTKIKEQ
ESYLSKSVPLADTEKDFIMNYFGNQSKQYEELLQKYNEEREISERLSLRIRQKMDYCVTS
ITAKVGQDPNQILQKIIQNNANSVLGINTNNAASMSGKENQNQPNLLSSQSSQNLIVQQQ
QNQMEIEDQTSNANNNNSQQENRQEEKEGYECICGGYQTEYFSQKYEETLKQLLDTQQKL
IATQTIINTSPSSVISTAFTQPVVVQNSQNGNSMSTSTVNGLQTTQSLQQQQQQQQEQST
GNQNGQSNQQTNASVDAVANSDGNKNNCQNLELNGSASVGSSIPCLKKSESIQIQQQLLS
QPALLTQVSTNIQDELCDGKLRLPITEKLQILQKRNEQLVQEKSELEKYMREREIDLKNM
EDKFFRSGAYQSLATQTEELLKITIQMRSQLKEAKQQISDIEKQRFREMQEVLTKFKDEK
ETLLKQLHEAREGVYKTQLGDAMRENLTQHFNYKKYTQPLEDQLEKASEILTIEREHNRD
LEQKKQQLNEQIIQLQKQNSDLQAKLNEKEQQINYLQSQMGFTGESYVEDKIFKYQNHKD
TLKLLEKVMNDMCSAGQINQEQIKKFRDLIEYIRNREEKIVQLQKVKQQNDIEKKKLQQN
QDEIWKEYENLDKSFSQMKARCDQVNQELKLIQEREQGLEYKNLEIQMQFQKEKQSYSIL
VAADQQKKDNTKNLIDNLEDQNKQLLQQNSNLSSTIEEVNQQKQLIQQQLEENTVLLLDT
QQKFDLLNKKFGDINEKYNELIANHEKIQQKLQTAYEVLDNSESKNTSAEVAQLKEKIQN
MRLLLQCSCGQNFKDTILQKCLHPFCRECIDKQIRLRQRTCPKCRTAFGQNDVKTLYLSH